Anemia is the most widespread hematological disease, therefore the search for new approaches to erythropoiesis regulation in the body remains an extremely urgent problem. We studied the effect of long-term reduction of deuterium level in the internal milieu of the body on hemoglobin production and parameters of erythropoiesis in sexually mature male Wistar rats. The animals consumed water with deuterium content decreased to 10 ppm for 2 months. After 1 month, an increase of hemoglobin synthesis in erythrocytes was detected, and after 2 months we observed intensification of erythropoiesis. Since the observed processes occurred in healthy animals with initially normal indices of hematopoiesis, the obtained data allow us to consider the reduction of deuterium level in the internal milieu of the body as a factor of erythropoiesis regulation and a possible option of its alternative non-pharmacological regulators.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Safiri S, Kolahi AA, Noori M, Nejadghaderi SA, Karamzad N, Bragazzi NL, Sullman MJM, Abdollahi M, Collins GS, Kaufman JS, Grieger JA. Burden of anemia and its underlying causes in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019. J. Hematol. Oncol. 2021;14(1):185. https://doi.org/10.1186/s13045-021-01202-2
Trukhan DI, Yurenev GL, Chusova NA. Iron deficiency anemia: actual aspects of diagnostics and treatment in real clinical practice of therapist. Terapiya. 2019;5(1):172-181. Russian. https://doi.org/10.18565/therapy.2019.1.172-181
Cappellini MD, Musallam KM, Taher A.T. Iron deficiency anaemia revisited. J. Intern. Med. 2020;287(2):153-170. https://doi.org/10.1111/joim.13004
Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. Lancet. 2021;397:233-248. https://doi.org/10.1016/S0140-6736(20)32594-0
Kozin SV, Lyasota OM, Kravtsov AA, Chikhirzhina EV, Ivlev VA, Popov KA, Dorohova AA, Malyshko VV, Moiseev AV, Drozdov AV, Dzhimak SS. Shift of Prooxidant–Antioxidant Balance in Laboratory Animals at Five Times Higher Deuterium Content in Drinking Water. Biophysics. 2023;68(2):289-294. https://doi.org/10.1134/S0006350923020112
Syroeshkin AV, Antipova NV, Zlatska AV, Zlatskiy IA, Skylska MD, Grebennikova TV, Goncharuk VV. The effect of the deuterium depleted water on the biological activity of the eukaryotic cells. J. Trace Elem. Med. Biol. 2018;50:629-633. https://doi.org/10.1016/j.jtemb.2018.05.004
Yaglova NV, Timokhina EP, Obernikhin SS, Yaglov VV. Emerging Role of Deuterium/Protium Disbalance in Cell Cycle and Apoptosis. Int. J. Mol. Sci. 2023;24(4):3107. https://doi.org/10.3390/ijms24043107
Yaglova NV, Obernikhin SS, Timokhina EP, Nazimova SV, Yaglov VV. Reactive alterations in thymic lymphocytopoiesis to short-term decrease in deuterium content in the body. Bull. Exp. Biol. Med. 2022;173(4):494-496. https://doi.org/10.1007/s10517-022-05568-2
Kozin S, Skrebitsky V, Kondratenko R, Kravtsov A, Butina E, Moiseev A, Malyshko V, Baryshev M, Elkina A, Dzhimak S. Electrophysiological Activity and Survival Rate of Rats Nervous Tissue Cells Depends on D/H Isotopic Composition of Medium. Molecules. 2021;26(7):2036. https://doi.org/10.3390/molecules26072036
Yaglova NV, Obernikhin SS, Timokhina EP, Yaglov VV. Response of pituitary—thyroid axis to a short-term shift in deuterium content in the body. Bull. Exp. Biol. Med. 2021;171(2):262-264. https://doi.org/10.1007/s10517-021-05208-1
Mustafina OK, Trushina EN, Shumakova AA, Arianova EA, Tyshko NV, Pashorina VA. Hematologic indices in different age Wistar rats, receiving a balanced semi-synthetic vivary diet. Voprosy Pitaniya. 2013;82(2):10-16. Russian.
Kafina MD, Paw BH. Intracellular iron and heme trafficking and metabolism in developing erythroblasts. Metallomics. 2017;9(9):1193-1203. https://doi.org/10.1039/c7mt00103g
Dzhimak SS, Basov AA, Fedulova LV, Didikin AS, Bikov IM, Arcybasheva OM, Naumov GN, Baryshev MG. Correction of Metabolic Processes in Rats during Chronic Endotoxicosis using Isotope (D/H) Exchange Reactions. Izv. Akad. Nauk Ser. Biol. 2015;5:518-527.
Frentiu AA, Mao K, Caruana CB, Raveendran D, Perry LA, Penny-Dimri JC, Ramson DM, Segal R, Bellomo R, Smith JA, Liu Z. The Prognostic Significance of Red Cell Distribution Width in Cardiac Surgery: A Systematic Review and Meta-Analysis. J. Cardiothorac. Vasc. Anesth. 2023;37(3):471-479. https://doi.org/10.1053/j.jvca.2022.11.015
Olariu L, Petcu M, Tulcan C, Chis-Buiga I, Pup M, Florin M, Brudiu I. Deuterium Depleted Water-Antioxidant or Prooxidant. Lucrari Stiintifice Medicina Veterinara. 2007;XL:265-269.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 12, pp. 805-808, December, 2023
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Timokhina, E.P., Yaglova, N.V., Obernikhin, S.S. et al. Effect of Long-Term Reduction of Deuterium Content in the Body on Hemoglobin Production and Parameters of Erythropoiesis. Bull Exp Biol Med 176, 824–826 (2024). https://doi.org/10.1007/s10517-024-06117-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-024-06117-9