The correlation of histological features of papillary thyroid cancer with clinical and morphological prognostic factors and cause-specific mortality was analyzed in a case-control study within a cohort of patients from the Altai Regional Oncology Center (25 cases with lethal outcome and 64 follow-up controls). Significant variability was revealed in the histological structure of papillary thyroid cancer with the prevalence of classic (62%) and less frequent follicular (19%), tall cell (8%), and solid (7%) variants. In comparison with the classic variant, the solid variant was more often associated with male sex and large tumor size; follicular and tall cell variant was associated with more frequent metastases to regional lymph nodes; follicular and solid variants were associated with an increased proportion of cases with disease stages III-IV. The main differences reflecting the effect of histological factor on the disease outcome were associated with the solid variant of papillary thyroid cancer that was detected in 21% of lethal cases and only in 2% of control subjects. The detection of this variant can be of importance as an additional prognostic factor of the postoperative survival in papillary thyroid cancer.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Gervald VYa, Klimachev VV, Ivanov AA, Ragulina VD, Avdalyan AM, Bobrov IP, Lazarev AF. Thyroid cancer. Mezhdunarod. Nauch. Issled. Zh. 2014;(8-3):17-18. Russian.
Shi X, Liu R, Basolo F, Giannini R, Shen X, Teng D, Guan H, Shan Z, Teng W, Musholt TJ, Al-Kuraya K, Fugazzola L, Colombo C, Kebebew E, Jarzab B, Czarniecka A, Bendlova B, Sykorova V, Sobrinho-Simões M, Soares P, Shong YK, Kim TY, Cheng S, Asa SL, Viola D, Elisei R, Yip L, Mian C, Vianello F, Wang Y, Zhao S, Oler G, Cerutti JM, Puxeddu E, Qu S, Wei Q, Xu H, O’Neill CJ, Sywak MS, Clifton-Bligh R, Lam AK, Riesco-Eizaguirre G, Santisteban P, Yu H, Tallini G, Holt EH, Vasko V, Xing M. Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants. J. Clin. Endocrinol. Metab. 2016;101(1):264-274. https://doi.org/10.1210/jc.2015-2917
Bogolyubova AV, Abrosimov AYu, Selivanova LS, Belousov PV. Histopatological and molecular genetic characteristics of clinically aggressive variants of papillary thyroid carcinoma. Arkh. Patol. 2019;81(1):46-51. Russian. https://doi.org/10.17116/patol20198101146
Nath MC, Erickson LA. Aggressive variants of papillary thyroid carcinoma: hobnail, tall cell, columnar, and solid. Adv. Anat. Pathol. 2018;25(3):172-179. https://doi.org/10.1097/PAP.0000000000000184
Bai Y, Kakudo K, Jung CK. Updates in the Pathologic Classification of Thyroid Neoplasms: a review of the World Health Organization Classification. Endocrinol. Metab. (Seoul). 2020;35(4):696-715. https://doi.org/10.3803/EnM.2020.807
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A. Papillary thyroid cancer-aggressive variants and impact on management: a narrative review. Adv. Ther. 2020;37(7):3112-3128. https://doi.org/10.1007/s12325-020-01391-1
Ho AS, Luu M, Barrios L, Chen I, Melany M, Ali N, Patio C, Chen Y, Bose S, Fan X, Mallen-St Clair J, Braunstein GD, Sacks WL, Zumsteg ZS. Incidence and mortality risk spectrum across aggressive variants of papillary thyroid carcinoma. JAMA Oncol. 2020;6(5):706-713. https://doi.org/10.1001/jamaoncol.2019.6851
Chang H, Kim SM, Chun KW, Kim BW, Lee YS, Chang HS, Hong SW, Park CS. Clinicopathologic features of solid variant papillary thyroid cancer. ANZ J. Surg. 2014;84(5):380-382. https://doi.org/10.1111/ans.12307
Ganly I, Ibrahimpasic T, Rivera M, Nixon I, Palmer F, Patel SG, Tuttle RM, Shah JP, Ghossein R. Prognostic implications of papillary thyroid carcinoma with tall-cell features. Thyroid. 2014;24(4):662-670. https://doi.org/10.1089/thy.2013.0503
Russo M, Malandrino P, Moleti M, Vermiglio F, Violi MA, Marturano I, Minaldi E, Vigneri R, Pellegriti G, Regalbuto C. Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods. J. Endocrinol. Invest. 2017;40(11):1235-1241. https://doi.org/10.1007/s40618-017-0688-9
Zaridze DG, Stilidi IS, Kaprin AD, Maksimovich DM. Over-diagnosis of thyroid cancer. Prak. Onkol. 2020;21(4):312-326. Russian. https://doi.org/10.31917/2104312
Lazarev AF, Shoikhet YaN, Pisareva LF, Petrova VD, Terekhova SA. The factor of ionizing radiation and thyroid cancer in women in the Altai krai. Ross. Onkol. Zh. 2017;22(4):224-228. Russian. https://doi.org/10.18821/1028-9984-2017-22-4-224-228
Nikiforov YE, Erickson LA, Nikiforova MN, Caudill CM, Lloyd RV. Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior. Am. J. Surg. Pathol. 2001;25(12):1478-1484. https://doi.org/10.1097/00000478-200112000-00002
Ohashi R, Kawahara K, Namimatsu S, Igarashi T, Sakatani T, Sugitani I, Naito Z. Clinicopathological significance of a solid component in papillary thyroid carcinoma. Histopathology. 2017;70(5):775-781. https://doi.org/10.1111/his.13132
Vuong HG, Odate T, Duong UNP, Mochizuki K, Nakazawa T, Katoh R, Kondo T. Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta-analysis. Head Neck. 2018;40(7):1588-1597. https://doi.org/10.1002/hed.25123
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 11, pp. 606-613, November, 2022
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Ivanov, A.A., Bakarev, M.A. & Lushnikova, E.L. Histological Variants of Papillary Thyroid Cancer in Relation to Clinical and Morphological Parameters and Prognosis. Bull Exp Biol Med 174, 647–652 (2023). https://doi.org/10.1007/s10517-023-05762-w
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-023-05762-w