After removal of the primary tumor node, tumor-specific activity appears in the serum that blocks tumor growth in mice. This activity is observed at the time interval when activity of the tumor growth-stimulating factor is not determined. Administration of blood serum (0.1 ml) from mice with removed tumor to mice with CaO1 adenocarcinoma for 14 days led first to a stop of its growth, and then to tumor regression. The animals cured of adenocarcinoma lived for at least one year without signs of relapse. The cured animals did not develop resistance to repeated tumor transplantation. Repeated transplantation led to the growth of the new tumor. No cellular immune response was observed on histological slides of the regressing tumor. It was concluded that a serum factor is required for the growth of a tumor in the body and the state of the serum with blocked activity of this tumor-stimulating factor can be used for tumor treatment in oncology patients. This is the first result in the syngeneic system, when the tumor was cured by syngeneic serum proteins.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Sitdikova SM, Amandzholov BS, Kiselevskii MV, Donenko FV. Specificity of relapses and metastases of experimental transplanted Ehrlich carcinoma and B16 melanoma. Bull. Exp. Biol. Med. 2007;143(1):80-82. doi: https://doi.org/10.1007/s10517-007-0022-1
Sitdikova SM, Amandzholov BS, Serebryakova MV, Zhdanovich MY, Kiselevskii MV, Donenko FV. Peculiarities of hemoglobin interaction with serum proteins of mice with Ehrlich carcinoma. Bull. Exp. Biol. Med. 2006;141(5):624-627. doi: https://doi.org/10.1007/s10517-006-0237-6
Sitdikova SM, Kiselevskii MV, Sel’chuk VY, Amandzholov BS, Kurbatova EA, Donenko FV. Evaluation of immunotherapy efficiency in mouse CaO-1 ovarian carcinoma treated by vaccines based on dendritic cells. Bull Exp Biol Med. 2009;147(2):226-228. doi: https://doi.org/10.1007/s10517-009-0480-8
Donenko FV, Kiselevskii MV. Efferth T. Quantitative regulation of melanoma growth in the host by tumor-specific serpins in blood serum is a main reason for inefficient tumor treatment. Breakthroughs in Melanoma Research. Tanaka Y, ed. Intech, 2011. P. 509-532.
Donenko FV, Kiselewskii MV, Efferth T. Surgical removal of primary tumors fosters distant metastasis. 7 May 2018. [URL: https://stm.sciencemag.org/content/10/436/eaan3464/tab-e-letters].
Donenko FV, Sitdikova SM, Kabieva AO, Moroz LV. The characteristics of Ehrlich carcinoma recurrence and metastasis. Biull. Eksp. Biol. Med. 1992;114(12):652-654.
Donenko FV, Sitdikova SM, Syrtsev AV, Gradyushko AT, Kiselevsky MV, Serebryakova MV, Efferth T. Hemoglobinassociated proteins isolated from blood serum of Еhrlich carcinoma- bearing mice. Int. J. Oncol. 2008;32(4):885-893. doi: https://doi.org/10.3892/ijo.32.4.885
Donenko FV, Ziganshin RH, Anisimova NY, Voyushin KE, Sitdikova SM, Amandzholov BS, Kiselevskii MV, Efferth T. Identification of serpin (alpha-1-antitrypsin) as serum growth inhibitory factor in murine Ehrlich carcinoma by proteomics. Cancer Genomics Proteomics. 2010;7(3):147-156.
Donenko FV, Ziganshin RK, Sitdikova SM, Amandzholov BS, Kiselevskii MV, Efferth T. Induction of resistance to murine tumor development is associated with alterations in glycosylation of blood serum proteines. Mol. Med. Rep. 2009;2(3):487- 495. doi: https://doi.org/10.3892/mmr_00000126
Fisher B, Gunduz N, Coyle J, Rudock C, Saffer E. Presence of a growth-stimulating factor in serum following primary tumor removal in mice. Cancer Res. 1989;49(8):1996-2001.
Kormosh NG, Davidova TV, Kopyltsov VN, Serebryakova MV, Kabieva AO, Voyushin KE, Sitdikova SM, Amandzholov BS, Kiselevskii MV, Donenko FV. Conformational changes in inter-α-trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma. Mol. Med. Rep. 2015;12(3):4483-4493. doi: https://doi.org/10.3892/mmr.2015.3961
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 8, pp. 223-227, August, 2021
Rights and permissions
About this article
Cite this article
Donenko, F.V., Sitdikova, S.M., Dolzhikova, Y.I. et al. Cure of Mice with Advanced Ovarian Adenocarcinoma CaO1 by the Serum Blood Proteins. Bull Exp Biol Med 172, 191–194 (2021). https://doi.org/10.1007/s10517-021-05361-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-021-05361-7