The content of the soluble form of protein of the key point of immunity B7-H3 (sB7-H3) in the blood plasma of 75 patients with epithelial ovarian cancer before treatment was measured by ELISA. It is known that B7-H3 belongs to the immunoglobulin superfamily (B7 molecule family) and is involved in the regulation of the immune response mediated by T cells. The sB7-H3 concentration correlated with the clinical and morphological parameters of ovarian cancer. The content of sB7-H3 was higher at the later stages of the disease, in the presence of ascites, and in patients with poorly differentiated ovarian cancer. It was revealed that increased plasma content of sB7-H3 in patients with epithelial ovarian cancer is associated with unfavorable prognosis of the disease. Therefore, sB7-H3 can be used as a prognostic marker in ovarian cancer patients.
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Chapoval AI, Shcherbakova NS, Shcherbakov DN, Chapoval SP. Immune checkpoints of the B7 family. Part 1. General characteristics and first representatives: B7-1, B7-2, B7-H1, B7-H2, and B7-DC. Russ. J. Bioorgan. Chem. 2019;45(4):225-240.
Benzon B, Zhao SG, Haffner MC, Takhar M, Erho N, Yousefi K, Hurley P, Bishop JL, Tosoian J, Ghabili K, Alshalalfa M, Glavaris S, Simons BW, Tran P, Davicioni E, Karnes RJ, Boudadi K, Antonarakis ES, Schaeffer EM, Drake CG, Feng F, Ross AE. Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis. Prostate Cancer Prostatic Dis. 2017;20(1):28-35. doi: https://doi.org/10.1038/pcan.2016.49
Castellanos J.R, Purvis I.J, Labak C.M, Guda M.R, Tsung A.J, Velpula K.K, Asuthkar S. B7-H3 role in the immune landscape of cancer. Am. J. Clin. Exp. Immunol. 2017;6(4):66-75.
Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2001;2(3):269-274. doi: https://doi.org/10.1038/85339
Chen W, Hou Z, Li C, Xiong S, Liu H. Cloning and characterization of porcine 4Ig-B7-H3: a potent inhibitor of porcine T-cell activation. PLoS One. 2011;6(6):e21341. doi: https://doi.org/10.1371/journal.pone.0021341
Dong P, Xiong Y, Yue J, Hanley SJB, Watari H. B7H3 As a promoter of metastasis and promising therapeutic target. Front. Oncol. 2018;8:264. doi: https://doi.org/10.3389/fonc.2018.00264
Kobori H, Hashiguchi M, Piao J, Kato M, Ritprajak P, Azuma M. Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites. Immunology. 2010;130(3):363-373. doi: https://doi.org/10.1111/j.1365-2567.2009.03236.x
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer. 2012;12(4):252-264. doi: https://doi.org/10.1038/nrc3239
Steinberger P, Majdic O, Derdak SV, Pfistershammer K, Kirchberger S, Klauser C, Zlabinger G, Pickl WF, Stöckl J, Knapp W. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J. Immunol. 2004;172(4):2352-2359. doi: https://doi.org/10.4049/jimmunol.172.4.2352
Sun J, Chen LJ, Zhang GB, Jiang JT, Zhu M, Tan Y, Wang HT, Lu BF, Zhang XG. Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol. Immunother. 2010;59(8):1163-1171. doi: https://doi.org/10.1007/s00262-010-0841-1
Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, Zhou Y, Wang H, Shen B, Zhang X. Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system. PLoS One. 2011;6(9):e24751. doi: https://doi.org/10.1371/journal.pone.0024751
Vigdorovich V, Ramagopal UA, Lázár-Molnár E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC. Structure and T cell inhibition properties of B7 family member, B7-H3. Structure. 2013;21(5):707-717. doi: https://doi.org/10.1016/j.str.2013.03.003
Xie C, Liu D, Chen Q, Yang C, Wang B, Wu H. Soluble B7-H3 promotes the invasion and metastasis of pancreatic carcinoma cells through the TLR4/NF-κB pathway. Sci. Rep. 2016;6:27528. doi: https://doi.org/10.1038/srep27528
Yan R, Yang S, Gu A, Zhan F, He C, Qin C, Zhang X, Feng P. Murine b7-h3 is a co-stimulatory molecule for T cell activation. Monoclon. Antib. Immunodiagn. Immunother. 2013;32(6):395-398. doi: https://doi.org/10.1089/mab.2013.0052
Zhang J, Liu L, Han S, Li Y, Qian Q, Zhang Q, Zhang H, Yang Z, Zhang Y. B7-H3 is related to tumor progression in ovarian cancer. Oncol. Rep. 2017;38(4):2426-2434. doi: https://doi.org/10.3892/or.2017.5858
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 4, pp. 486-489, April, 2021
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Kovaleva, O.V., Belova, T.P., Korotkova, E.A. et al. Soluble B7-H3 in Ovarian Cancer and Its Predictive Value. Bull Exp Biol Med 171, 472–474 (2021). https://doi.org/10.1007/s10517-021-05253-w
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DOI: https://doi.org/10.1007/s10517-021-05253-w