We studied the role of endogenous melatonin in the development and functioning of T cells that produce IL-17 (Th17) and regulatory T cells (Treg) during pregnancy. The study was performed ex vivo and in vitro with auto-serum as the source of endogenous melatonin under conditions of blockade of melatonin-dependent signaling. Participation of the hormone in the regulation of differentiation of both CD4+RORγt+ and CD4+FoxP3+T cells and their key products IL-17A and TGF-β was demonstrated. It is known that the normal gestational process is accompanied by a decrease in Th17/Treg ratio due to hormonal changes. The sensitivity of the studied subpopulations to melatonin during pregnancy can affect its outcome.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 10, pp. 459-463, October, 2017
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Glebezdina, N.S., Olina, A.A., Nekrasova, I.V. et al. Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy. Bull Exp Biol Med 164, 462–465 (2018). https://doi.org/10.1007/s10517-018-4013-1
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DOI: https://doi.org/10.1007/s10517-018-4013-1