We studied the possibility of using membrane fabricated from type 1 collagen isolated from cattle tissues (group 1) or porcine tissues (group 2) for replacement of the resected bladder wall defect in rabbits in order to retain functional volume of the organ. Satisfactory take of both types of collagen membranes with formation of competent anastomosis was observed. Histological studies revealed inflammatory process in the bladder wall at the site of contact with the implanted membrane (more pronounced in case of membranes from cattle tissues) that decreased by day 21 of the experiment. Bladder tissue ingrowth into the implant from was observed starting from day 14. The bladder capacity decreased in 7 days after surgery in both groups, presumably because of increasing tone of the organ wall resulting from surgical trauma and inflammation. In group 2, the bladder volume increased by day 14 after surgery and returned to normal by day 21, whereas in group 1 it remained below the control despite a trend to increase. These findings confirm good prospects of using collagen-1 membranes for plastic repair of the urinary bladder, the membranes from porcine collagen being more preferable.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Begma AN, Begma IV, Khomyakova EK. Experience in the use of collagen dressings and meturakol sponges in surgical practice. Russ. Med. Zh. 2014;22(17):1248-1252. Russian.
Ivanova LA, Sychenikov IA, Kondrat’eva TS. Collagen in the Dosage Forms of Technology. Moscow, 1984. Russian.
Kamalov AA, Maksimov VA, Kirpatovsky VI, Kudryavtsev YuV, Karpov VK, Tokarev FV, Kamalov DM, Burov VN, Okhobotov DA. Building of defects of the bladder wall by membrane, created on the basis of type I collagen (an experimental study). Urologiya. 2012(6):33-37. Russian.
Loran OB, Zaitsev AV, Lipskii VS. Diagnosis and Therapy of Interstitial Edema in Women. Saratov, 2001. Russian.
Shchukina EV, Sapozhnikova AI. Collagen in medicine and cosmetology. Natur. Farmakol. Kosmetol. 2005(4):29-34. Russian.
Biers SM, Venn SN, Greenwell TJ. The past, present and future of augmentation cystoplasty. BJU Int. 2012;109(9):1280-1293.
Caione P, Boldrini R, Salerno A, Nappo SG. Bladder augmentation using acellular collagen biomatrix: a pilot experience in exstrophic patients. Pediatr. Surg. Int. 2012;28(4):421-428.
Castellan M, Gosalbez R, Bar-Yosef Y, Labbie A. Complications after use of gastric segments for lower urinary tract reconstruction. J. Urol. 2012;187(5):1823-1827.
Chen W, Shi C, Yi S, Chen B, Zhang W, Fang Z, Wei Z, Jiang S, Sun X, Hou X, Xiao Z, Ye G, Dai J. Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. J. Urol. 2010;183(6):2432-2439.
Joseph DB, Borer JG, De Filippo RE, Hodges SJ, McLorie GA. Autologous cell seeded biodegradable scaffold for augmentation cystoplasty: phase II study in children and adolescents with spina bifida. J. Urol. 2014;191(5):1389-1395.
Lin HK, Madihally SV, Palmer B, Frimberger D, Fung KM, Kropp BP. Biomatrices for bladder reconstruction. Adv. Drug Deliv. Rev. 2015;82-83:47-63.
Roelofs LA, Kortmann BB, Oosterwijk E, Eggink AJ, Tiemessen DM, Crevels AJ, Wijnen RM, Daamen WF, van Kuppevelt TH, Geutjes PJ, Feitz WF. Tissue engineering of diseased bladder using a collagen scaffold in a bladder exstrophy model. BJU Int. 2014;114(3):447-457.
Sharifiaghdas F, Naji M, Sarhangnejad R, Rajabi-Zeleti S, Mirzadeh H, Zandi M, Saeed M. Comparing supportive properties of poly lactic-co-glycolic acid (PLGA), PLGA/collagen and human amniotic membrane for human urothelial and smooth muscle cells engineering. Urol. J. 2014;11(3):1620-1628.
Veeratterapillay R, Thorpe AC, Harding C. Augmentation cystoplasty: Contemporary indications, techniques and complications. Indian J. Urol. 2013;29(4):322-327.
Zhu WD, Xu YM, Feng C, Fu Q, Song LJ. Different bladder defects reconstructed with bladder acellular matrix grafts in a rabbit model. Urologe A. 2011;50(11):1420-1425.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 7, pp. 117-122, July, 2016
Rights and permissions
About this article
Cite this article
Kirpatovskii, V.I., Efimenko, A.Y., Sysoeva, V.Y. et al. Collagen-1 Membrane for Replacing the Bladder Wall. Bull Exp Biol Med 162, 102–106 (2016). https://doi.org/10.1007/s10517-016-3556-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3556-2