We studied aldehyde dehydrogenase activity in erythrocytes from healthy rats and animals with thermal trauma after NO inhalation. NO had an activating effect on catalytic properties of aldehyde dehydrogenase in healthy rats and burned animals. The effect of NO was more pronounced during burn disease.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
A. F. Vanin, Nitrogen oxide in biomedical studies. Vestn. Ross. Akad. Med. Nauk, No. 4, 3-5 (2000).
V. G. Granik and N. B. Grigor’ev, Nitrogen Oxide (NO). A New Way to Drug Searching [in Russian], Moscow (2004).
V. I. Karelin, N. Buranov, O. A. Pimenov, V. D. Selemir, and A. S. Shirshin, A Plazmochemical Device for NO therapy. Medial’, No. 4, 46 (2013).
A. K. Martusevich, A. G. Soloveva, and S., Peretyagin, Influence of free and bound nitric oxide on properties of erythrocytes aldehyde dehydrogenase. Vopr. Biol., Med. Farm. Khimii, 12, No. 11, 60-65 (2014).
A. K. Martusevich , A. G. Solov’yova, S., Peretyagin, V. I. Karelin, and V. D. Selemir, influence of NO-containing gas flow on various parameters of energy metabolism in erythrocytes. Bull. Exp. Biol. Med., 158, No. 1, 34-36 (2014).
E. G. DeMaster, B. Redfern, B. J. Quast, T. Dahlseid, and H. T. Nagasawa, Mechanism for the inhibition of aldehyde dehydrogenase by nitric oxide. Alcohol., 14, No. 2, 181-189 (1997).
H. L. Fung, Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved? Annu. Rev. Pharmacol. Toxicol., 44, 67-85 (2004).
L. Godoy, R. Gonzalez-Duarte, and R. Albalat, S-Nitrosogluthathione reductase activity of amphioxus ADH3: insights into the nitric oxide metabolism. Int. J. Biol. Sci., 2, No. 3, 117-124 (2006).
A. Gries, C. Bode, K. Peter, A. Herr, H. Böhrer, J. Motsch, and E. Martin, Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo. Circulation, 97, No. 15, 1481-1487 (1998).
C. N. Hall and J. Garthwaite, What is the real physiological NO concentration in vivo? Nitric Oxide, 21, No. 2, 92-103 (2009).
V. Koppaka, D. C. Thompson, Y. Chen, M. Ellermann, K. C. Nicolaou, R. O. Juvonen, D. Petersen, R. A. Deitrich, T. D. Hurley, and V. Vasiliou, Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacol. Rev., 64, No. 3, 520-539 (2012).
P. Kumar; Committee on Fetus and Newborn; American Academy of Pediatrics, Use of inhaled nitric oxide in preterm infants. Pediatrics, 133, No. 1, 164-170 (2014).
B. S. Lang, A. C. Gorren, G. Oberdorfer, M. V. Wenzl, C. M. Furdui, L. B. Poole, B. Mayer, and K. Gruber, Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. J. Biol. Chem., 287, No. 45, 38,124-38,134 (2012).
B. Mayer and M. Beretta, The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles. Br. J. Pharmacol., 155, No. 2, 170-184 (2008).
A. V. Vorobyov, A. K. Martusevich, A. G. Solovyova, A. M. Razmakhov, A. S. Luzan, and A. D. Dmitriev, Physical and biochemical characteristics of biological fluids in rats with modeled thermal injury. Bull. Exp. Biol. Med., 147, No. 4, 424-426 (2009).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 1, pp. 9-12, January, 2016
Rights and permissions
About this article
Cite this article
Martusevich, A.K., Solov’eva, A.G. & Peretyagin, S.P. Modification of the Catalytic Properties of Erythrocyte Aldehyde Dehydrogenase in Rats after Nitric Oxide Inhalation. Bull Exp Biol Med 161, 4–6 (2016). https://doi.org/10.1007/s10517-016-3331-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3331-4