Effect of a new antioxidant enoxifol exhibiting antiplatelet activity in vitro and in vivo on hemostasis parameters was assessed in laboratory rats with experimental diabetes mellitus. Gliclazide, a hypoglycemic agent with antiplatelet properties, and pentoxifylline, a preparation improving blood rheology, were used as the reference drugs. Enoxifol produced a pronounced inhibitory effect on platelet aggregation in rats with experimental diabetes comparable to the effect of gliclazide and decreased blood viscosity thus demonstrating a significant effect comparable to that of pentoxifylline. In view of the fact that oxidative stress is a pathogenetic components of vascular complications in diabetes, it can be assumed that improvement of hemostasis parameters under the effect of enoxifol is determined by its antiplatelet and antioxidant activities.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
V. A. Anisimova, A. A. Spasov, O. V. Ostrovskii, et al., Khim.-Farm. Zh., 36, No. 12, 3-8 (2002).
V. A. Anisimova, A. A. Spasov, I. E. Tolpygin, et al., Khim.-Farm. Zh., 44, No. 3, 8-13 (2010).
Z. A. Gabbasov, E. G. Popov, I. Yu. Gavrilova, et al., Lab. Delo, No. 10, 15-18 (1989).
N. A. Dobrovolskii, Yu. M. Lopukhin, A. S. Parfenov, and A. V. Peshkov, Blood Viscosity Analyzer. Rheological Investigation in Medicine [in Russian], Moscow (1997).
M. V. Kudryashova, Yu. V. Dovglyuk, I. E. Mishina, et al., Kardiologiya, 50, No. 5, 9-12 (2010).
A. V. Murav’yev and S. V. Cheporov, Haemorheology (Experimental and Clinical Issues of Blood Rheology) [in Russian], Yaroslavl’ (2009).
A. S. Parfenov, A. V. Peshkov, N. A. Dobrovolskii, Blood Viscosity Analyzer AKR-2. Assessment of Blood Rheological Properties [in Russian], Moscow (1994).
A. A. Spasov, A. F. Kucheryavenko, V. A. Kosolapov, and V. A. Anisimova, Bull. Exp. Biol. Med., 155, No. 6, 775-777 (2013).
A. Elenga, S. Yu. Shtrygol’, S. B. Nazarov, and N. Kinkembo, Eksp. Klin. Farmakol., 65, No. 1, 37-40 (2002).
A. M. Cerbone, N. Macarone-Palmieri, G. Saldalamacchia, et al., Acta Diabetol., 46, No. 4, 253-261 (2009).
A. D. Chougale, S. N. Panaskar, P. M. Gurao, and A. U. Arvindekar, Asian J. Biochem., 2, No. 6, 402-408 (2002).
I. Hagedorn, T. Vögtle, and B. Nieswandt, Hemostaseologie, 30, No. 3, 127-135 (2010).
R. D. Lopes, J. Thromb. Thrombolysis, 31, No. 3, 306-309 (2011).
R. Madan, B. Gupt, S. Saluja, et al., J. Ascoc. Physicians India, 58, 481-484 (2010).
A. Natarajan, A. G. Zaman, and S. M. Marshall, Diab.Vasc. Dis. Res., 5, No. 2, 138-144 (2008).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 12, pp. 721-724, December, 2015
Rights and permissions
About this article
Cite this article
Kucheryavenko, A.F., Spasov, A.A. & Anisimova, V.A. Effect of a New Antioxidant Enoxifol on Platelet Aggregation and Blood Rheological Properties in Rats with Experimental Diabetes Mellitus. Bull Exp Biol Med 160, 759–762 (2016). https://doi.org/10.1007/s10517-016-3303-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3303-8