β-Phenylglutamic acid hydrochloride (RGPU-135, neuroglutam) in doses of 13-650 mg/kg suppressed depressive behavior of animals in the Porsolt test (i.e. produced antidepressant properties), reduced anxiety in the open-field, elevated plus maze, and Vogel conflict tests (i.e. produced anxiolytic effects). RGPU-135 in doses of 26-130 mg/kg exhibited more pronounced antidepressant action and in doses of 26 and 52 mg/kg had more pronounced anxiolytic effects. RGPU-135 in doses of 13-78 mg/kg increased locomotor and exploratory activity of animals in the open-field test. Activating effects of this agent decreased with increasing the dose. RGPU-135 in the subtoxic dose (650 mg/kg) suppressed locomotor activity of animals (produced sedative effect).
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References
V. V. Bagmetova, Yu. V. Chernysheva, O. V. Merkushenkova, et al., Eksp. Klin. Farmakol., 76, No. 3, 7-9 (2013).
L. I. Bugaeva, I. N. Tyurenkov, V. V. Bagmetova, et al., Vestn. VolgGMU, No. 3, 30-33 (2012).
L. I. Bugaeva, I. N. Tyurenkov, V. V. Bagmetova, et al., Vestn. VolgGMU, No. 4, 34-37 (2012).
Manual for Experimental (Preclinical) Testing of New Pharmacological Agents [in Russian], Ed. R. U. Khabriev, Moscow (2005).
V. I. Petrov, I. N. Tyurenkov, V. V. Bagmetova, et al., Patent RF No. 2429834, A Substance with Antidepressant, Anxiolytic, Neuroprotective, and Immunomodulatory Effects. Byull. Izobr., No. 27, September 27, 2011.
I. N. Tyurenkov, V. V. Bagmetova, Yu. V. Chernysheva, et al., Vestn. VolgGMU, No. 3, 30-33 (2012).
I. N. Tyurenkov, V. V. Bagmetova, Yu. V. Chernysheva, et al., Funament. Issled., No. 3, 167-172 (2013).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 8, pp. 195-200, August, 2014
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Tyurenkov, I.N., Bagmetova, V.V., Chernyshova, Y.V. et al. Dose-Dependent Effects of β-Phenylglutamic Acid Hydrochloride (RGPU-135, Neuroglutam) on Animal Behavior. Bull Exp Biol Med 158, 229–233 (2014). https://doi.org/10.1007/s10517-014-2729-0
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DOI: https://doi.org/10.1007/s10517-014-2729-0