Ninety-four lung adenocarcinoma samples obtained during surgeries were examined using a combination of immunohistochemical staining for Ki-67 antigen and silver nitrate staining for argyrophilic nucleolar organizer (Ag-NOR) proteins. In lung adenocarcinoma, we studied the correlation between the area of Ag-NOR proteins in Ki-67+ cells and clinical and morphological TNM parameters: maximum tumor diameter (T) and stage of the disease and tumor differentiation degree (N). Survival of patients with small area of Ag-NOR proteins in Ki-67+ cells was higher that in patients with great area of these proteins. The area of Ag-NOR proteins in Ki-67+ cells is an independent prognostic factor in lung adenocarcinoma. The area of Ag-NOR proteins in Ki-67+ cells correlates with clinical and morphological TNM parameters and survival of patients with lung adenocarcinoma.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 3, pp. 169–173, July, 2014
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Lazarev, A.F., Kobyakov, D.S., Avdalyan, A.M. et al. Relationship of Argyrophilic Proteins of Nucleolal Organizer Regions in Ki-67+ Cells with Clinical and Morphological Parameters in Lung Adenocarcinoma. Bull Exp Biol Med 158, 145–149 (2014). https://doi.org/10.1007/s10517-014-2710-y
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DOI: https://doi.org/10.1007/s10517-014-2710-y