Abstract
The applications of nanotechnology in biomedicine have gained considerable attentions in recent years owing to the great enhancement of therapeutic efficiency. Integration of self-assembly into nanotechnology has brought tremendous convenience during the formation of nano-carriers. Based on distinctive methods of self-assembly, nano-therapeutics have been developed to an impressive stage with the ability to perform site-specific delivery with temporal and spatial control. This review focuses on the recent advances in the preparing methods for nano-therapeutics, and their applications in the treatments of diseases.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Salomon, J. A.; Wang, H.; Freeman, M. K. Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the global burden of disease study. Lancet 2013, 381(9867), 628–628
Porter, R. The nature of suffering and the goals of medicine. Hist. Phil. Life Sci. 1997, 19(2), 297–298
Liu, Y.; Li, J.; Lu, Y. Enzyme therapeutics for systemic detoxification. Adv. Drug Deliv Rev. 2015, 90(1), 24–39
Duncan, R. Polymer conjugates as anticancer nanomedicines. Nat. Rev. Cancer. 2006, 6(9), 688–701
Farokhzad, O. C.; Langer, R. Impact of nanotechnology on drug delivery. ACS Nano. 2009, 3(1), 16–20
Zhang, L.; Gu, F. X.; Chan, J. M.; Wang, A. Z. Nanoparticles in medicine: Therapeutic applications and developments. Clin. Pharmacol. Ther. 2008, 83(5), 761–769
Ferrari, M. Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 2005, 5(3), 161–171
Singh, K. K. Nanotechnology in cancer detection and treatment. Technol. Cancer Res. T. 2005, 4(6), 583–583
Couvreur, P.; Vauthier, C. Nanotechnology: intelligent design to treat complex disease. Pharm. Res. 2006, 23(7), 1417–1450
Bertrand, N.; Wu, J.; Xu, X.; Kamaly, N. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv. Drug Delivery Rev. 2014, 66(1), 2–25
Ozin, G. A.; Hou, K.; Lotsch, B. V.; Cademartiri, L. Nanofabrication by self-assembly. Mater. Today 2009, 12(5), 12–23
Mastrangeli, M.; Abbasi, S.; Varel, C.; Van Hoof, C. Self-assembly from milli-to nanoscales: methods and applications. J. Micromech Microeng. 2009, 19(8), DOI: 10.1088/0960-1317/19/8/083001
Bishop, K. J.; Wilmer, C. E.; Soh, S.; Grzybowski, B. A. Nanoscale forces and their uses in self-assembly. Small 2009, 5(14), 1600–1630
Peer, D.; Karp, J. M.; Hong, S.; FaroKhzad, O. C. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007, 2(12), 751–760
Letchford, K.; Burt, H. A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes. Eur. J. Pharm. Biopharm. 2007, 65(3), 259–269
Chandler, D. Interfaces and the driving force of hydrophobic assembly. Nature 2005, 437(7059), 640–647
Wang, C.; Wang, Z.; Zhang, X. Amphiphilic building blocks for self-assembly: From amphiphiles to supra-amphiphiles. Acc. Chem. Res. 2012, 45(4), 608–618
Hill, J. P.; Shrestha, L. K.; Ishihara, S.; Ji, Q. Self-assembly: from amphiphiles to chromophores and beyond. Molecules 2014, 19(6), 8589–8609
Rösler, A.; Vandermeulen, G. W. M.; Klok, H. A. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv. Drug Deliver. Rev. 2012, 64(1), 270–279
Xiong, X. B.; Binkhathlan, Z.; Molavi, O.; Lavasanifar, A. Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery. Acta Biomater. 2012, 8(6), 2017–2033
Aziz, Z. A. B. A.; Ahmad, A.; Mohd-Setapar, S. H.; Hassan, H. Recent advances in drug delivery of polymeric nano-micelles. Curr. Drug Metab. 2017, 18(1), 16–29
Allain, V.; Bourgaux, C.; Couvreur, P. Self-assembled nucleolipids: From supramolecular structure to soft nucleic acid and drug delivery devices. Nucleic Acids Res. 2012, 40(5), 1891–1903
Chen, Y.; Liang, G. Enzymatic self-assembly of nanostructures for theranostics. Theranostics 2012, 2(2), 139–147
Mai, Y.; Eisenberg, A. Self-assembly of block copolymers. Chem. Soc. Rev. 2012, 41(18), 5969–5985
Kim, J. K.; Yang, S. Y.; Lee, Y.; Kim, Y. Functional nanomaterials based on block copolymer self-assembly. Prog. Polym. Sci. 2010, 35(11), 1325–1349
Zhang, Z.; Ma, R.; Shi, L. Cooperative macromolecular self-assembly toward polymeric assemblies with multiple and bioactive functions. Acc. Chem. Res. 2014, 47(4), 1426–1437
Wu, W.; Wu, D.; Li, S.; Lin, Z. Doxorubicin loaded ph-sensitive micelles for potential tumor therapy. J. Control. Release 2013, 172(1), e72–E73
Cheng, T.; Ma, R.; Zhang, Y.; Ding, Y. A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake. Chem. Commun. 2015, 51(81), 14985–14988
Breus, V. V.; Heyes, C. D.; Tron, K.; Nienhaus, G. U. Zwitterionic biocompatible quantum dots for wide ph stability and weak nonspecific binding to cells. ACS Nano 2009, 3(9), 2573–2580
Arvizo, R. R.; Miranda, O. R.; Thompson, M. A.; Pabelick, C. M. Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Lett. 2010, 10(7), 2543–2548
Deshpande, M. C.; Davies, M. C.; Garnett, M. C.; Williams, P. M. The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes. J. Control. Release 2004, 97(1), 143–156
Yuan, Y. Y.; Mao, C. Q.; Du, X. J.; Du, J. Z. Surface charge switchable nanoparticles based on zwitterionic polymer for enhanced drug delivery to tumor. Adv. Mater. 2012, 24(40), 5476–5480
Du, J. Z.; Sun, T. M.; Song, W. J.; Wu, J. A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery. Angew. Chem. Int. Ed. 2010, 49(21), 3621–3626
Xiong, M. H.; Bao, Y.; Yang, X. Z.; Wang, Y. C. Lipase-sensitive polymeric triple-layered nanogel for "on-demand" drug delivery. J. Am. Chem. Soc. 2012, 134(9), 4355–4362
Du, J. Z.; Du, X. J.; Mao, C. Q.; Wang, J. Tailor-made dual ph-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery. J. Am. Chem. Soc. 2011, 133(44), 17560–17563
Pereverzeva, E.; Treschalin, I.; Bodyagin, D.; Maksimenko, O. Intravenous tolerance of a nanoparticle-based formulation of doxorubicin in healthy rats. Toxicol. Lett. 2008, 178(1), 9–19
Harker, W. G.; Sikic, B. I. Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line mes-sa. Cancer Res. 1985, 45(9), 4091–4096
Cheng, T.; Liu, J.; Ren, J.; Huang, F. Green tea catechin-based complex micelles combined with doxorubicin to overcome cardiotoxicity and multidrug resistance. Theranostics 2016, 6(9), 1277–1292
Sharma, A.; Sharma, U. S. Liposomes in drug delivery: Progress and limitations. Int. J. Pharmaceut. 1997, 154(2), 123–140
Wang, Y.; Miao, L.; Satterlee, A.; Huang, L. Delivery of oligonucleotides with lipid nanoparticles. Adv. Drug Deliver. Rev. 2015, 87(1), 68–80
Goins, B.; Phillips, W. T.; Bao, A. Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy. Expert Opin. Drug Deliver. 2016, 13(6), 873–889
Sercombe, L.; Veerati, T.; Moheimani, F.; Wu, S. Y. Advances and challenges of liposome assisted drug delivery. Front Pharmacol. 2015, 6, DOI:10.3389/fphar.2015.00286
Barenholz, Y. Liposome application: Problems and prospects. Curr. Opin. Colloid Interface Sci. 2001, 6(1), 66–77
Kraft, J. C.; Freeling, J. P.; Wang, Z.; Ho, R. J. Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems. J. Pharm. Sci. 2014, 103(1), 29–52
Chang, H. I.; Yeh, M. K. Clinical development of liposome-based drugs: Formulation, characterization, and therapeutic efficacy. Int. J. Nanomed. 2012, 7(1), 49–60
Yang, F.; Jin, C.; Jiang, Y.; Li, J. Liposome based delivery systems in pancreatic cancer treatment: From bench to bedside. Cancer Treat Rev. 2011, 37(8), 633–642
Mo, R.; Jiang, T.; Gu, Z. Recent progress in multidrug delivery to cancer cells by liposomes. Nanomedicine 2014, 9(8), 1117–1120
Immordino, M. L.; Dosio, F.; Cattel, L. Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential. Int. J. Nanomed. 2006, 1(3), 297–315
Wang, H.; Zhang, S.; Liao, Z.; Wang, C. Peglated magnetic polymeric liposome anchored with tat for delivery of drugs across the blood-spinal cord barrier. Biomaterials 2010, 31(25), 6589–6596
Suntres, Z. E. Liposomal antioxidants for protection against oxidant-induced damage. J. Toxicol. 2011, DOI:10.1155/2011/152474
Zhang, X.; Guo, S.; Fan, R.; Yu, M. Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells. Biomaterials 2012, 33(29), 7103–7114
Wang, H.; Zhao, P.; Su, W.; Wang, S. PLGA/polymeric liposome for targeted drug and gene co-delivery. Biomaterials 2010, 31(33), 8741–8748
Jiang, T.; Mo, R.; Bellotti, A.; Zhou, J. Gel-liposome-mediated co-delivery of anticancer membrane-associated proteins and small-molecule drugs for enhanced therapeutic efficacy. Adv. Funct. Mater. 2014, 24(16), 2295–2304
Mo, R.; Jiang, T. Y.; Gu, Z. Enhanced anticancer efficacy by atp-mediated liposomal drug delivery. Angew. Chem. Int Ed. 2014, 53(23), 5815–5820
Schafer, J.; Hobel, S.; Bakowsky, U.; Aigner, A. Liposome-polyethylenimine complexes for enhanced DNA and sirna delivery. Biomaterials 2010, 31(26), 6892–6900
Rengan, A. K.; Bukhari, A. B.; Pradhan, A.; Malhotra, R. In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer. Nano Lett. 2015, 15(2), 842–848
Hubbell, J. A.; Chilkoti, A. Nanomaterials for drug delivery. Science 2012, 337(6092), 303–305
Park, J. H.; Lee, S.; Kim, J. H.; Park, K. Polymeric nanomedicine for cancer therapy. Prog. Polym. Sci. 2008, 33(1), 113–137
Tong, R.; Cheng, J. Anticancer polymeric nanomedicines. Polym. Rev. 2007, 47(3), 345–381
Huang, P.; Wang, D.; Su, Y.; Huang, W. Combination of small molecule prodrug and nanodrug delivery: Amphiphilic drug-drug conjugate for cancer therapy. J. Am. Chem. Soc. 2014, 136(33), 11748–56
Hu, M.; Huang, P.; Wang, Y.; Su, Y. Synergistic combination chemotherapy of camptothecin and floxuridine through self-assembly of amphiphilic drug-drug conjugate. Bioconjugate. Chem. 2015, 26(12), 2497–2506
Zhang, T.; Huang, P.; Shi, L.; Su, Y. Self-assembled nanoparticles of amphiphilic twin drug from floxuridine and bendamustine for cancer therapy. Mol. Pharm. 2015, 12(7), 2328–2336
Ma, Y.; Mou, Q.; Sun, M.; Yu, C. Cancer theranostic nanoparticles self-assembled from amphiphilic small molecules with equilibrium shift-induced renal clearance. Theranostics 2016, 6(10), 1703–1716
Mou, Q.; Ma, Y.; Zhu, X.; Yan, D. A small molecule nanodrug consisting of amphiphilic targeting ligand-chemotherapy drug conjugate for targeted cancer therapy. J. Control. Release 2016, 230(1), 34–44
Wang, Y.; Huang, P.; Hu, M.; Huang, W. Self-delivery nanoparticles of amphiphilic methotrexate-gemcitabine prodrug for synergistic combination chemotherapy via effect of deoxyribonucleotide pools. Bioconjugate. Chem. 2016, 27(11), 2722–2733
Pack, D. W.; Hoffman, A. S.; Pun, S.; Stayton, P. S. Design and development of polymers for gene delivery. Nat. Rev. Drug Discov. 2005, 4(7), 581–93
Xu, Z. P.; Zeng, Q. H.; Lu, G. Q.; Yu, A. B. Inorganic nanoparticles as carriers for efficient cellular delivery. Chem Eng. Sci. 2006, 61(3), 1027–1040
Lacerda, L.; Raffa, S.; Prato, M.; Bianco, A. Cell-penetrating cnts for delivery of therapeutics. Nano Today 2007, 2(6), 38–43
Mao, S.; Sun, W.; Kissel, T. Chitosan-based formulations for delivery of DNA and sirna. Adv. Drug Deliver. Rev. 2010, 62(1), 12–27
Chapel, J. P.; Berret, J. F. Versatile electrostatic assembly of nanoparticles and polyelectrolytes: Coating, clustering and layer-by-layer processes. Curr. Opin. Colloid Interface Sci. 2012, 17(2), 97–105
Shmueli, R. B.; Anderson, D. G.; Green, J. J. Electrostatic surface modifications to improve gene delivery. Expert Opin. Drug Deliver. 2010, 7(4), 535–550
Mulligan, R. C. The basic science of gene therapy. Science 1993, 260(5110), 926–32
Liu, Y.; Du, J.; Choi, J. S.; Chen, K. J. A high-throughput platform for formulating and screening multifunctional nanoparticles capable of simultaneous delivery of genes and transcription factors. Angew. Chem. Int. Ed. 2016, 55(1), 169–173
Verma, I. M.; Somia, N. Gene therapy—promises, problems and prospects. Nature 1997, 389(6648), 239–42
Kircheis, R.; Wightman, L.; Wagner, E. Design and gene delivery activity of modified polyethylenimines. Adv. Drug Deliver. Rev. 2001, 53(3), 341–358
Harris, T. J.; Green, J. J.; Fung, P. W.; Langer, R. Tissue-specific gene delivery via nanoparticle coating. Biomaterials 2010, 31(5), 998–1006
Liu, Y.; Wang, H.; Kamei, K. I.; Yan, M. Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles. Angew. Chem. Int. Ed. 2011, 50(13), 3058–3062
Won, Y. W.; Adhikary, P. P.; Lim, K. S.; Kim, H. J. Oligopeptide complex for targeted non-viral gene delivery to adipocytes. Nat. Mater. 2014, 13(12), 1157–1164
Ariga, K.; Lvov, Y. M.; Kawakami, K.; Ji, Q. Layer-by-layer self-assembled shells for drug delivery. Adv. Drug Deliver. Rev. 2011, 63(9), 762–771
Ariga, K.; Yamauchi, Y.; Rydzek, G.; Ji, Q. Layer-by-layer nanoarchitectonics: Invention, innovation, and evolution. Chem Lett. 2014, 43(1), 36–68
Fujii, N.; Fujimoto, K.; Michinobu, T.; Akada, M. The simplest layer-by-layer assembly structure: Best paired polymer electrolytes with one charge per main chain carbon atom for multi layered thin films. Macromolecules 2010, 43(8), 3947–3955
Lvov, Y.; Onda, M.; Ariga, K.; Kunitake, T. Ultrathin films of charged polysaccharides assembled alternately with linear polyions. J. Biomat. Sci. Polym. E 1998, 9(4), 345–355
Katagiri, K.; Hamasaki, R.; Ariga, K.; Kikuchi, J. Layered paving of vesicular nanoparticles formed with cerasome as a bioinspired organic-inorganic hybrid. J. Am. Chem. Soc. 2002, 124(27), 7892–7893
Elbakry, A.; Zaky, A.; Liebkl, R.; Rachel, R. Layer-by-layer assembled gold nanoparticles for sirna delivery. Nano Lett. 2009, 9(5), 2059–2064
Saurer, E. M.; Flessner, R. M.; Sullivan, S. P.; Prausnitz, M. R. Layer-by-layer assembly of DNA- and protein-containing films on microneedles for drug delivery to the skin. Biomacromolecules 2010, 11(11), 3136–3143
Morton, S. W.; Shah, N. J.; Quadir, M. A.; Deng, Z. J. Osteotropic therapy via targeted layer-by-layer nanoparticles. Adv. Healthc. Mater. 2014, 3(6), 867–75
Shutava, T. G.; Balkundi, S. S.; Vangala, P.; Steffan, J. J. Layer-by-layer-coated gelatin nanoparticles as a vehicle for delivery of natural polyphenols. ACS Nano 2009, 3(7), 1877–1885
Agarwal, A.; Lvov, Y.; Sawant, R.; Torchilin, V. Stable nanocolloids of poorly soluble drugs with high drug content prepared using the combination of sonication and layer-by-layer technology. J. Control. Release 2008, 128(3), 255–260
Pargaonkar, N.; Lvov, Y. M.; Li, N.; Steenekamp, J. H. Controlled release of dexamethasone from microcapsules produced by polyelectrolyte layer-by-layer nanoassembly. Pharm. Res. 2005, 22(5), 826–835
Deng, Z. J.; Morton, S. W.; Ben-Akiva, E.; Dreaden, E. C. Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and sirna for potential triple-negative breast cancer treatment. ACS Nano 2013, 7(11), 9571–9584
Poon, Z.; Chang, D.; Zhao, X.; Hammond, P. T. Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia. ACS Nano 2011, 5(6), 4284–4292
Kim, B. S.; Park, S. W.; Hammond, P. T. Hydrogen-bonding layer-by-layer assembled biodegradable polymeric micelles as drug delivery vehicles from surfaces. ACS Nano 2008, 2(2), 386–392
Ma, X.; Zhao, Y. Biomedical applications of supramolecular systems based on host-guest interactions. Chem. Rev. 2015, 115(15), 7794–7839
Karim, A. A.; Dou, Q.; Li, Z.; Loh, X. J. Emerging supramolecular therapeutic carriers based on host-guest interactions. Chem. Asian J. 2016, 11(9), 1300–1321
Hu, J.; Liu, S. Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications. Acc. Chem. Res. 2014, 47(7), 2084–2095
Zhang, J.; Ma, P. X. Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective. Adv. Drug Deliver. Rev. 2013, 65(9), 1215–1233
Wang, L.; Li, L. L.; Fan, Y. S.; Wang, H. Host-guest supramolecular nanosystems for cancer diagnostics and therapeutics. Adv. Mater. 2013, 25(28), 3888–3898
Challa, R.; Ahuja, A.; Ali, J.; Khar, R. K. Cyclodextrins in drug delivery: An updated review. AAPS PharmSciTech. 2005, 6(2), e329–E357
Stella, V. J.; Rajewski, R. A. Cyclodextrins: Their future in drug formulation and delivery. Pharm. Res-Dordr. 1997, 14(5), 556–567
Gref, R.; Amiel, C.; Molinard, K.; Daoud-Mahammed, S. New self-assembled nanogels based on host-guest interactions: Characterization and drug loading. J. Control. Release 2006, 111(3), 316–324
Zhang, J.; Ma, P. X. Polymeric core-shell assemblies mediated by host-guest interactions: versatile nanocarriers for drug delivery. Angew. Chem. Int. Ed. 2009, 48(5), 964–968
Hu, Q. D.; Tang, G. P.; Chu, P. K. Cyclodextrin-based host-guest supramolecular nanoparticles for delivery: from design to applications. Acc. Chem. Res. 2014, 47(7), 2017–2025
Wang, H.; Wang, S.; Su, H.; Chen, K. J. A supramolecular approach for preparation of size-controlled nanoparticles. Angew. Chem. Int. Ed. 2009, 48(24), 4344–4318
Ang, C.Y.; Tan, S. Y.; Wang, X.; Zhang, Q. Supramolecular nanoparticle carriers self-assembled from cyclodextrin-and adamantane-functionalized polyacrylates for tumor-targeted drug delivery. J. Mater. Chem. B 2014, 2(13), 1879–1890
Qu, D. H.; Wang, Q. C.; Zhang, Q. W.; Ma, X. Photoresponsive host-guest functional systems. Chem. Rev. 2015, 115(15), 7543–7588
Dan, Z.; Cao, H.; He, X.; Zeng, L. Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy. Int. J. Pharm. 2015, 483(1-2), 63–68
Zhang, W.; Li, Y.; Sun, J. H.; Tan, C. P. Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chem. Commun. 2015, 51(10), 1807–1810
Wang, Y.; Li, D.; Jin, Q.; Ji, J. pH-responsive supramolecular prodrug micelles based on cucurbit 8 uril for intracellular drug delivery. J Control. Release 2015, 213(1), e134–E135
Yu, G.; Jie, K.; Huang, F. Supramolecular amphiphiles based on host-guest molecular recognition motifs. Chem. Rev. 2015, 115(15), 7240–7303
Yang, B.; Dong, X.; Lei, Q.; Zhuo, R. Host-guest interaction-based self-engineering of nano-sized vesicles for co-delivery of genes and anticancer drugs. ACS Appl. Mater. Interfaces 2015, 7(39), 22084–22094
Liu, Y.; Yu, C.; Jin, H.; Jiang, B. A supramolecular janus hyperbranched polymer and its photoresponsive self-assembly of vesicles with narrow size distribution. J. Am. Chem. Soc. 2013, 135(12), 4765–4770
Li, Y.; Liu, Y.; Ma, R.; Xu, Y. A g-quadruplex hydrogel via multicomponent self-assembly: Formation and zero-order controlled release. ACS Appl. Mater. Interfaces 2017, 9(15), 13056–13067
Zhao, L.; Qu, R.; Li, A.; Ma, R. Cooperative self-assembly of porphyrins with polymers possessing bioactive functions. Chem. Commun. 2016, 52(93), 13543–13555
Gu, Z.; Biswas, A.; Zhao, M.; Tang, Y. Tailoring nanocarriers for intracellular protein delivery. Chem. Soc. Rev. 2011, 40(7), 3638–3655
Yan, M.; Ge, J.; Liu, Z.; Ouyang, P. Encapsulation of single enzyme in nanogel with enhanced biocatalytic activity and stability. J. Am. Chem. Soc. 2006, 128(34), 11008–11009
Yan, M.; Du, J.; Gu, Z.; Liang, M. A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat. Nanotechnol. 2010, 5(1), 48–53
Gu, Z.; Yan, M.; Hu, B.; Joo, K. I. Protein nanocapsule weaved with enzymatically degradable polymeric network. Nano Lett. 2009, 9(12), 4533–4538
Wen, J.; Anderson, S. M.; Du, J.; Yan, M. Controlled protein delivery based on enzyme-responsive nanocapsules. Adv. Mater. 2011, 23(39), 4549–53
Liang, S.; Liu, Y.; Jin, X.; Liu, G. Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins. Nano Res. 2016, 9(4), 1022–1031
Zhao, M.; Hu, B.; Gu, Z.; Joo, K. I. Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex. Nano Today 2013, 8(1), 11–20
Tian, H.; Du, J.; Wen, J.; Liu, Y. Growth-factor nanocapsules that enable tunable controlled release for bone regeneration. ACS Nano 2016, 10(8), 7362–7369
Liu, C.; Wen, J.; Meng, Y.; Zhang, K. Efficient delivery of therapeutic mirna nanocapsules for tumor suppression. Adv. Mater. 2015, 27(2), 292–297
Peer, D.; Karp, J. M.; Hong, S.; FaroKHzad, O. C. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007, 2(12), 751–760
Wang, M.; Thanou, M. Targeting nanoparticles to cancer. Pharmacol. Res. 2010, 62(2), 90–99
DeSantis, C. E.; Lin, C. C.; Mariotto, A. B.; Siegel, R. L. Cancer treatment and survivorship statistics, 2014. CA: A Cancer Journal for Clinicians 2014, 64(4), 252–271
Sun, T. M.; Zhang, Y. S.; Pang, B.; Hyun, D. C. Engineered nanoparticles for drug delivery in cancer therapy. Angew. Chem. Int. Ed. 2014, 53(46), 12320–12364
Liu, Y.; Li, J.; Lu, Y. F. Enzyme therapeutics for systemic detoxification. Adv. Drug Deliver. Rev. 2015, 90, 24–39
Bae, Y. H.; Park, K. Targeted drug delivery to tumors: myths, reality and possibility. J. Control. Release 2011, 153(3), 198–205
LaVan, D. A.; McGuire, T.; Langer, R. Small-scale systems for in vivo drug delivery. Nat. Biotechnol. 2003, 21(10), 1184–1191
Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Control. Release 2008, 126(3), 187–204
Wang, G.; Uludag, H. Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles. Expert Opin. Drug Deliver. 2008, 5(5), 499–515
Gao, H.; Cheng, T.; Liu, J.; Liu, J. Self-regulated multifunctional collaboration of targeted nanocarriers for enhanced tumor therapy. Biomacromolecules 2014, 15(10), 3634–3642
Shuhendler, A. J.; Prasad, P.; Leung, M.; Rauth, A. M. A novel solid lipid nanoparticle formulation for active targeting to tumor alpha(v)beta(3) integrin receptors reveals cyclic rgd as a double-edged sword. Adv. Healthc. Mater. 2012, 1(5), 600–608
Cheng, T. J.; Ma, R. J.; Zhang, Y. M.; Ding, Y. X. A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake. Chem. Commun. 2015, 51(81), 14985–14988
Falamarzian, A.; Lavasanifar, A. Optimization of the hydrophobic domain in poly(ethylene oxide)- poly(epsilon-caprolactone) based nano-carriers for the solubilization and delivery of amphotericin b. Colloids and Surfaces B-Biointerfaces 2010, 81(1), 313–320
Gao, H. J.; Xiong, J.; Cheng, T. J.; Liu, J. J. In vivo biodistribution of mixed shell micelles with tunable hydrophilic/hydrophobic surface. Biomacromolecules 2013, 14(2), 460–467
Wang, H. X.; Yang, X. Z.; Sun, C. Y.; Mao, C. Q. Matrix metalloproteinase 2-responsive micelle for sirna delivery. Biomaterials 2014, 35(26), 7622–7634
Sun, C. Y.; Shen, S.; Xu, C. F.; Li, H. J. Tumor acidity-sensitive polymeric vector for active targeted sirna delivery. J. Am. Chem. Soc. 2015, 137(48), 15217–15224
Guan, X.; Guo, Z.; Lin, L.; Chen, J. Ultrasensitive pH triggered charge/size dual-rebound gene delivery system. Nano Lett. 2016, 16(11), 6823–6831
Wakebayashi, D.; Nishiyama, N.; Yamasaki, Y.; Itaka, K. Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: Their preparation and gene transfecting efficiency against cultured HEPG2 cells. J. Control. Release 2004, 95(3), 653–664
Harada, A.; Kataoka, K. Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymers. J. Control. Release 2001, 72(1-3), 85–91
Dufresne, M. H.; Leroux, J. C. Study of the micellization behavior of different order amino block copolymers with heparin. Pharm. Res. 2004, 21(1), 160–169
Biswas, A.; Joo, K. I.; Liu, J.; Zhao, M. X. Endoprotease-mediated intracellular protein delivery using nanocapsules. ACS Nano 2011, 5(2), 1385–1394
Liu, Y.; Wang, H.; Kamei, K.; Yan, M. Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles. Angew. Chem. Int. Ed. 2011, 50(13), 3058–3062
Govender, T.; Stolnik, S.; Xiong, C.; Zhang, S. Drug-polyionic block copolymer interactions for micelle formation: Physicochemical characterisation. J. Control. Release. 2001, 75(3), 249–258
Safra, T.; Muggia, F.; Jeffers, S.; Tsao-Wei, D. D. Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m(2). Ann Oncol. 2000, 11(8), 1029–1033
Cho, K. J.; Wang, X.; Nie, S. M.; Chen, Z. Therapeutic nanoparticles for drug delivery in cancer. Clin. Cancer Res. 2008, 14(5), 1310–1316
Koudelka, S.; Turanek, J. Liposomal paclitaxel formulations. J. Control. Release 2012, 163(3), 322–334
Lim, W. T.; Leong, S. S.; Toh, C. K.; Ang, C. S. A phase i pharmacokinetic study of a liposomal formulation of paclitaxel administered weekly to Asian patients with solid malignancies. J. Clin. Oncol. 2009, 27(15), 2581.
Markman, M. Pegylated liposomal doxorubicin in the treatment of cancers of the breast and ovary. Expert Opin. Pharmaco. 2006, 7(11), 1469–1474
Gaspar, M. M.; Perez-Soler, R.; Cruz, M. E. Biological characterization of l-asparaginase liposomal formulations. Cancer Chemother. Pharmacol. 1996, 38(4), 373–377
Felgner, P. L.; Holm, M.; Chan, H. Cationic liposome mediated transfection. Proc. West Pharmacol. Soc. 1989, 32, 115–121
Felgner, P. L.; Ringold, G. M. Cationic liposome-mediated transfection. Nature 1989, 337(6205), 387–388
Murray, K. D.; McQuillin, A.; Stewart, L.; Etheridge, C. J. Cationic liposome-mediated DNA transfection in organotypic explant cultures of the ventral mesencephalon. Gene Ther. 1999, 6(2), 190–197
Kim, J. K.; Choi, S. H.; Kim, C. O.; Park, J. S. Enhancement of polyethylene glycol (PEG)-modified cationic liposomemediated gene deliveries: effects on serum stability and transfection efficiency. J. Pharm. Pharmacol. 2003, 55(4), 453–460
Zhu, L.; Kate, P.; Torchilin, V. P. Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting. ACS Nano 2012, 6(4), 3491–3498
Anonymous. Classification and diagnosis of diabetes. Diabetes Care 2015, 38(Suppl. 1), S8–S16
Craft, S. The role of metabolic disorders in alzheimer disease and vascular dementia: Two roads converged. Arch. Neurol. 2009, 66(3), 300–305
Canivell, S.; Gomis, R. Diagnosis and classification of autoimmune diabetes mellitus. Autoimmun. Rev. 2014, 13(4-5), 403–407
Abdi, H.; Hosseinpanah, F.; Azizi, F.; Hadaegh, F. Screening for dysglycemia: a comment on classification and diagnosis of diabetes in american diabetes association standards of medical care in diabetes-2016. Arch. Iran. Med. 2017, 20(6), 389–389
Yang, H.; Zhang, C.; Li, C.; Liu, Y. Glucose-responsive polymer vesicles templated by alpha-CD/PEG inclusion complex. Biomacromolecules 2015, 16(4), 1372–1381
Yang, H.; Ma, R.; Yue, J.; Li, C. A facile strategy to fabricate glucose-responsive vesicles via a template of thermo-sensitive micelles. Polym. Chem. 2015, 6(20), 3837–3846
Zhao, L.; Xiao, C. S.; Wang, L. Y.; Gai, G. Q. Glucose-sensitive polymer nanoparticles for self-regulated drug delivery. Chem. Commun. 2016, 52(49), 7633–7652
Wang, B. L.; Ma, R. J.; Liu, G.; Li, Y. Glucose-responsive micelles from self-assembly of poly(ethylene glycol)-b-poly(acrylic acid-co-acrylamidophenylboronic acid) and the controlled release of insulin. Langmuir 2009, 25(21), 12522–12528
Cambre, J. N.; Sumerlin, B. S. Biomedical applications of boronic acid polymers. Polymer 2011, 52(21), 4631–4643
Liu, G.; Ma, R. J.; Ren, J.; Li, Z. A glucose-responsive complex polymeric micelle enabling repeated on-off release and insulin protection. Soft Matter 2013, 9(5), 1636–1644
Selkoe, D. J.; Schenk, D. Alzheimer’s disease: Molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol 2003, 43, 545–84
Small, D. H.; Losic, D.; Martin, L. L.; Turner, B. J. Alzheimer’s disease therapeutics: new approaches to an ageing problem. IUBMB Life. 2004, 56(4), 203–208
Anand, R.; Gill, K. D.; Mahdi, A. A. Therapeutics of alzheimer’s disease: Past, present and future. Neuropharmacology 2014, 76, 27–50
Rafii, M. S. Preclinical alzheimer’s disease therapeutics. J. Alzheimers Dis. 2014, 42(Suppl. 4), S545–S549
Kelleher-Andersson, J. Discovery of neurogenic, alzheimer’s disease therapeutics. Curr. Alzheimer Res. 2006, 3(1), 55–62
Boada, M.; Ortiz, P.; Anaya, F.; Hernandez, I. Amyloid-targeted therapeutics in alzheimer’s disease: Use of human albumin in plasma exchange as a novel approach for a beta mobilization. Drug News Perspect. 2009, 22(6), 325–339
Shvaloff, A.; Neuman, E.; Guez, D. Lines of therapeutics research in alzheimer’s disease. Psychopharmacol. Bull. 1996, 32(3), 343–352
Hardy, J.; Selkoe, D. J. Medicine—he amyloid hypothesis of alzheimer’s disease: Progress and problems on the road to therapeutics. Science 2002, 297(5580), 353–356
Dennis, J.; Selkoe, M. D. The therapeutics of Alzheimer’s disease: Where we stand and where we are heading. Ann. Neurol. 2013, 74(3), 328–336
Horwich, A. L. Molecular chaperones in cellular protein folding: The birth of a field. Cell 2014, 157(2), 285–288
Baneyx, F.; Thomas, J. G. Collaboration of major and minor molecular chaperones in cellular protein folding. Abstracts of Papers of the American Chemical Society. 2000, 219, U179–U180
Huang, F.; Wang, J. Z.; Qu, A. T.; Shen, L. L. Maintenance of amyloid beta peptide homeostasis by artificial chaperones based on mixed-shell polymeric micelles. Angew. Chem. Int. Ed. 2014, 53(34), 8985–8990
Wang, J.; Song, Y.; Sun, P.; An, Y. Reversible interactions of proteins with mixed shell polymeric micelles: Tuning the surface hydrophobic/hydrophilic balance toward efficient artificial chaperones. Langmuir 2016, 32(11), 2737–2749
Huang, F.; Shen, L.; Wang, J.; Qu, A. Effect of the surface charge of artificial chaperones on the refolding of thermally denatured lysozymes. ACS Appl. Mater. Interfaces 2016, 8(6), 3669–3678
Wang, J.; Yin, T.; Huang, F.; Song, Y. Artificial chaperones based on mixed shell polymeric micelles: Insight into the mechanism of the interaction of the chaperone with substrate proteins using forster resonance energy transfer. ACS Appl. Mater. Interfaces 2015, 7(19), 10238–10249
Watanabe, K.; Nakamura, K.; Akikusa, S.; Okada, T. Inhibitors of fibril formation and cytotoxicity of beta-amyloid peptide composed of KLVFF recognition element and flexible hydrophilic disrupting element. Biochem. Biophys. Res. Commun. 2002, 290(1), 121–124
Tjernberg, L. O.; Naslund, J.; Lindqvist, F.; Johansson, J. Arrest of beta-amyloid fibril formation by a pentapeptide ligand. J. Biol. Chem. 1996, 271(15), 8545–8
Liu, F. F.; Du, W. J.; Sun, Y.; Zheng, J. Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-beta protein. Front. Chem. Sci. Eng. 2014, 8(4), 433–444
Qu, A. T.; Huang, F.; Li, A.; Yang, H. R. The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity. Chem. Commun. 2017, 53(7), 1289–1292
Vonghia, L.; Leggio, L.; Ferrulli, A.; Bertini, M. Acute alcohol intoxication. Eur. J. Intern. Med. 2008, 19(8), 561–567
Kantrow, S. P.; Shen, Z.; Zhang, P.; Ramsey, J. Acute alcohol intoxication, lung permeability and host defense. Alcohol. Clin. Exp. Res. 2008, 32(6), 172a–172a.
Gerstman, M. D.; Merry, A. F.; McIlroy, D. R.; Hannam, J. A. Acute alcohol intoxication and bispectral index monitoring. Acta Anaesth. Scand. 2015, 59(8), 1015–1021
Sellers, E. M.; Kalant, H. Drug-therapy-alcohol intoxication and withdrawal. New Eng. J. of Med. 1976, 294(14), 757–762
Robertson, C. C.; Sellers, E. M. Alcohol intoxication and alcohol withdrawal syndrome. Postgrad. Med. 1978, 64(6), 133–138
Sellers, E. M.; Kalant, H. Alcohol intoxication and withdrawal. New. Engl. J. Med. 1976, 294(14), 757–762
Shpilenya, L. S.; Muzychenko, A. P.; Gasbarrini, G.; Addolorato, G. Metadoxine in acute alcohol intoxication: A double-blind, randomized, placebo-controlled study. Alcohol. Clin. Exp. Res. 2002, 26(3), 340–346
Liu, Y.; Du, J. J.; Yan, M.; Lau, M. Y. Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication. Nat. Nanotechnol. 2013, 8(3), 187–192
Munoz-Bonilla, A.; Fernandez-Garcia, M. Polymeric materials with antimicrobial activity. Prog. Polym. Sci. 2012, 37(2), 281–339
Pelgrift, R. Y.; Friedman, A. J. Nanotechnology as a therapeutic tool to combat microbial resistance. Adv. Drug Deliver. Rev. 2013, 65(13-14), 1803–1815
Zhang, L.; Pornpattananangkul, D.; Hu, C. M. J.; Huang, C. M. Development of nanoparticles for antimicrobial drug delivery. Currt. Med. Chem. 2010, 17(6), 585–594
Zhang, Y.; Chan, H. F.; Leong, K. W. Advanced materials and processing for drug delivery: the past and the future. Adv. Drug Deliver. Rev. 2013, 65(1), 104–120
Peltonen, L. I.; Kinnari, T. J.; Aarnisalo, A. A.; Kuusela, P. Comparison of bacterial adherence to polylactides, silicone, and titanium. Acta Oto-Laryngologica 2007, 127(6), 587–593
Kornman, K. S. Controlled-release local delivery antimicrobials in periodontics: prospects for the future. J Periodontol. 1993, 64(8 Suppl), 782–791
Smith, A. W. Biofilms and antibiotic therapy: Is there a role for combating bacterial resistance by the use of novel drug delivery systems? Adv. Drug Deliver. Rev. 2005, 57(10), 1539–1550
Hittinger, M.; Juntke, J.; Kletting, S.; Schneider-Daum, N. Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models. Adv. Drug Deliver. Rev. 2015, 85, 44–56
Arthur, T. D.; Cavera, V. L.; Chikindas, M. L. On bacteriocin delivery systems and potential applications. Future Microbiol. 2014, 9(2), 235–248
Herbrecht, R.; Denning, D. W.; Patterson, T. F.; Bennett, J. E. Voriconazole versus amphotericin b for primary therapy of invasive aspergillosis. New Engl. J. Med. 2002, 347(6), 408–415
Walsh, T. J.; Teppler, H.; Donowitz, G. R.; Maertens, J. A. Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia. New Engl. J. Med. 2004, 351(14), 1391–1402
Kim, H. J.; Jones, M. N. The delivery of benzyl penicillin to staphylococcus aureus biofilms by use of liposomes. J. Liposome Res. 2004, 14(3-4), 123–139
Pinto-Alphandary, H.; Andremont, A.; Couvreur, P. Targeted delivery of antibiotics using liposomes and nanoparticles: Research and applications. Int. J. Antimicrob. Agents 2000, 13(3), 155–168
Onyeji, C. O.; Nightingale, C. H.; Marangos, M. N. Enhanced killing of methicillin-resistant staphylococcus aureus in human macrophages by liposome-entrapped vancomycin and teicoplanin. Infection 1994, 22(5), 338–342
Schumacher, I.; Margalit, R. Liposome-encapsulated ampicillin: Physicochemical and antibacterial properties. J. Pharm. Sci. 1997, 86(5), 635–641
Huang, F.; Gao, Y.; Zhang, Y.; Cheng, T. Silver-decorated polymeric micelles combined with curcumin for enhanced antibacterial activity. ACS Appl Mater Interfaces 2017, 9(20), 16881–16890
Chu, L.; Gao, H.; Cheng, T.; Zhang, Y. A charge-adaptive nanosystem for prolonged enhanced in vivo antibiotic delivery. Chem. Commun. 2016, 52(37), 6265–6268
Shah, L. K.; Amiji, M. M. Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS. Pharm. Res. 2006, 23(11), 2638–2645
Mosqueira, V. C. F.; Loiseau, P. M.; Bories, C.; Legrand, P. Efficacy and pharmacokinetics of intravenous nanocapsule formulations of halofantrine in plasmodium berghei-infected mice. Antimicrob. Agents Ch. 2004, 48(4), 1222–1228
Liu, Y.; Busscher, H. J.; Zhao, B. R.; Li, Y. F. Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms. ACS Nano 2016, 10(4), 4779–4789
Li, Y. M.; Liu, G. H.; Wang, X. R.; Hu, J. M. Enzyme-responsive polymeric vesicles for bacterial-strainselective delivery of antimicrobial agents. Angew. Chem. Int. Ed. 2016, 55(5), 1760–1764
Hasan, J.; Crawford, R. J.; Lvanova, E. P. Antibacterial surfaces: the quest for a new generation of biomaterials. Trends in Biotechnol. 2013, 31(5), 31–40
Insua, I.; Liamas, E.; Zhang, Z. Y.; Peacock, A. F. A. Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers. Polym. Chem. 2016, 7(15), 2684–2690.
Acknowledgments
This work was financially supported by the Thousand Talents Program for Young Professionals, the National Natural Science Foundation of China (No. 51673100), and the Fundamental Research Funds for the Central Universities.
Author information
Authors and Affiliations
Corresponding author
Additional information
Invited review for special issue of “Supramolecular Self-Assembly”
Rights and permissions
About this article
Cite this article
Zheng, CX., Zhao, Y. & Liu, Y. Recent Advances in Self-assembled Nano-therapeutics. Chin J Polym Sci 36, 322–346 (2018). https://doi.org/10.1007/s10118-018-2078-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10118-018-2078-y