Abstract
In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane (WPU)/heparin release coating system (WPU/heparin) is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), thrombin time (TT), hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Lelah, M.D. and Cooper, S.L., “Polyurethanes in medicine”, CRC Press, Boca Raton, 1986, p.225
Ritter, H., “Desk reference of functional polymers, syntheses and applications”, American Chemical Society, Washington, 1997, p.103
Qi, P., Yang, Y., Maitz, F.M. and Huang, N., Chinese Sci. Bull., 2013, 58(35): 4362
Zhang, H., She, Y., Zheng, X. and Chen, H.Y., Chinese J. Polym. Sci., 2014, 32(10): 1363
Xing, Q., Li, R.B., Zhang, X.Q., Zhang, L.Y. and Wang, D.J., Chinese J. Polym. Sci., 2015, 33(9): 1294
Sask, K.N., Berry, L.R., Chan, A.K. and Brash, J.L., Langmuir, 2011, 28(4): 2099
Aksoy, E.A., Hasirci, V., Hasirci, N., Motta, A., Fedel, M. and Migliaresi, C., J. Bioact. Compat. Polym., 2008, 23(6): 505
Han, D.K., Jeong, S.Y., Ahn, K.D., Kim, Y.H. and Min, B.G., J. Biomater. Sci., Polym. Ed., 1993, 4(6): 579
Tan, M., Feng, Y., Wang, H., Zhang, L., Khan, M., Guo, J., Chen, Q. and Liu, J., Macromol. Res., 2013, 21(5): 541
Yuan, J., Yuan, Y.L., Shen, J., Lin, S.C., Zhu, W. and Fang, J.L., Chinese J. Polym. Sci., 2003, 21(4): 419
Hirsh, J., Raschke, R., Warkentin, T.E., Dalen, J.E., Deykin, D. and Poller, L., Chest J., 1995,108(4_Supplement): 258S
Mulloy, B., Hogwood, J. and Gray, E., Biologicals, 2010, 38(4): 459
Kim, Y.J., Kang, I.K., Huh, M.W. and Yoon, S.C., Biomaterials, 2000, 21(2): 121
Bernacca, G., Gulbransen, M., Wilkinson, R. and Wheatley, D., Biomaterials, 1998, 19(13): 1151
Bae, J.S., Seo, E.J. and Kang, I.K., Biomaterials, 1999, 20(6): 529
Sung, Y.K., Kim, Y.J. and Kim, S.W., Chinese J. Polym. Sci., 1999, 17(2): 113
Moon, H.T., Lee, Y.K., Han, J.K. and Byun, Y., Biomaterials, 2001, 22(3): 281
Schreiber, A.B., Kenney, J., Kowalski, W.J., Friesel, R., Mehlman, T. and Maciag, T., Proc. Natl. Acad. Sci., 1985, 82(18): 6138
Marconi, W., Galloppa, A., Martinelli, A. and Piozzi, A., J. Mater. Sci. Mater. Med., 1994, 5(11): 779
Tong, F., Chen, X., Chen, L., Zhu, P., Luan, J., Mao, C., Bao, J. and Shen, J., J. Mater. Chem. B, 2013, 1(4): 447
Song, N.J., Jiang, X., Li, J.H., Li, J.S. and Fu, Q., Chinese J. Polym. Sci., 2013, 31(10): 1451
Jiang, X., Yu, F., Wang, Z., Li, J., Tan, H., Ding, M. and Fu, Q., J. Biomater. Sci., Polym. Ed., 2010, 21(12): 1637
Jiang, X., Li, J., Ding, M., Tan, H., Ling, Q., Zhong, Y. and Fu, Q., Eur. Polym. J., 2007, 43(5): 1838
Smith, P., Mallia, A. and Hermanson, G., Anal. Biochem., 1980, 109(2): 466
Ding, M., Li, J., Fu, X., Zhou, J., Tan, H., Gu, Q. and Fu, Q., Biomacromolecules, 2009, 10(10): 2857
Yang, H., Xu, H., Zhu, G., Ouyang, C., Wang, X. and Xu, W., Proc. Inst. Mech. Eng. H, 2011, 225(4): 421
Shriver, Z., Capila, I., Venkataraman, G. and Sasisekharan, R., “Heparin-a century of progress”, Springer, Berlin Heidelberg, 2012, p.159
Jiang, H., Wang, X., Li, C., Li, J., Xu, F., Mao, C., Yang, W. and Shen, J., Langmuir, 2011, 27(18): 11575
Author information
Authors and Affiliations
Corresponding authors
Additional information
This work was financially supported by the National Natural Science Foundation of China (Nos. 51173118, 51273124 and 51273126), the National Science Fund for Distinguished Young Scholars of China (No. 51425305), the Youth Science and Technology Innovation Team of Sichuan Province (No. 2015TD0001), and State Key Laboratory of Polymer Materials Engineering (No. sklpme2014-2-03).
These two authors contributed equally to this work.
Rights and permissions
About this article
Cite this article
Song, Yq., Gao, Yl., Pan, Zc. et al. Preparation and characterization of controlled heparin release waterborne polyurethane coating systems. Chin J Polym Sci 34, 679–687 (2016). https://doi.org/10.1007/s10118-016-1787-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10118-016-1787-3