Abstract
Psychotic symptoms have been found to be relatively common among adults with borderline personality disorder (BPD), and to be a marker of BPD severity, but are not recognised in daily clinical practice in these patients. This study is the first to examine the prevalence of psychotic symptoms in 15–18-year olds with BPD features. It was hypothesised that adolescents with full-threshold BPD would have significantly more psychotic symptoms than adolescents with sub-threshold BPD features, and that both these groups would have significantly more psychotic symptoms than adolescents with no BPD features. A total of 171 psychiatric outpatients, aged 15–18 years, were assessed using a structured interview for DSM-IV personality disorder and categorised into three groups: no BPD features (n = 48), sub-threshold BPD features (n = 80), and full-threshold BPD (n = 43). The groups were compared on measures of psychopathology and functioning (e.g. Youth Self Report, Symptom Check List-90-R, SOFAS). Adolescents with full-threshold BPD reported more psychotic symptoms than the sub-threshold BPD group (p < .001), and both these groups reported more psychotic symptoms than those with no BPD features (p < .001). Adolescents with full-threshold BPD reported more confusion (p < .01), paranoia (p < .001), visual hallucinations (p < .001) and strange thoughts (p < .01), than the other two groups. Psychotic symptoms predicted group membership, determined by BPD severity, after adjusting for other psychopathology and functional impairment (p < .01). Assessment of unusual perceptual experiences, paranoia or odd thoughts is highly clinically relevant in adolescents with BPD features, as these symptoms are associated with a more severe clinical presentation of BPD.
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Introduction
Psychotic symptoms are commonly reported among adult individuals with borderline personality disorder (BPD) [1, 2]. Historically, their clinical significance has often been dismissed, in part because they were believed to be of short duration, transient in nature, and to not significantly affect patients’ lives [2]. Consequently, there is little information about the frequency and character of psychotic symptoms, and their functional consequences, during the clinical onset of BPD. This is especially important for early detection and treatment because the transition from childhood to adulthood is the peak period for the onset of BPD and the major psychotic disorders and it is also the period during which BPD features are at their most severe [3,4,5].
Recent studies of adults with BPD have used standardised instruments assessing for psychotic symptoms. Auditory verbal hallucinations (AVHs) were found to occur in 22–50% of patients with BPD and to be phenomenologically indistinguishable from, and significantly more distressing and negative in content than, AVHs among individuals with schizophrenia [2, 6,7,8,9]. When present in BPD, AVHs were also found to be associated with greater suicidal ideation and more suicide attempts and hospitalisations [10]. Retrospective assessment indicates that the mean age of onset AVHs in BPD is 16 years and that they are commonly enduring, and not transient in nature [2, 6, 11].
Delusions and unusual thought content have also been found to be correlated with AVHs among adults with BPD [12]. One study found that sub-threshold and full-threshold psychotic symptoms were most prevalent earlier in the course of BPD, when BPD features were at their most severe and which diminished over 16-year follow-up [13].
Among samples of adolescents in the community and in psychiatric outpatient and inpatient settings, psychotic symptoms (attenuated or full-threshold) have been reported to be common across multiple diagnoses and to be an important marker of severity of psychopathology, poor functioning, greater number of co-occurring disorders, and suicidality [14,15,16,17]. Among youth meeting ‘ultra-high-risk’ criteria for transition to psychosis, the presence of co-occurring BPD was not associated with any change in the rate of transition to psychosis, thereby suggesting that these diagnoses might co-occur and progress independently [18]. However, comparatively, little is known about the precise rates of psychotic symptoms in adolescents with BPD. This is in part due to the dismissal of these symptoms as being pseudo or quasi in nature, as they have not been recognised as true psychotic symptoms [13].
This study is the first to examine psychotic symptoms among three groups of 15–18-year olds: those with no BPD features, those with sub-threshold BPD features, and those with full-syndrome BPD. It was hypothesised that: (1) the sub-threshold BPD and full-threshold BPD groups would have significantly more psychotic symptoms than the no BPD group; (2) the full-threshold BPD group would have significantly more psychotic symptoms than the sub-threshold BPD group; (3) psychotic symptoms would be a significant predictor of group membership (i.e. no BPD, sub-threshold BPD, full-threshold BPD) after adjusting for other psychopathology and functional impairment.
Method
Participants
The sample is described in detail elsewhere [19]. Briefly, participants were outpatients recruited from Orygen Youth Health, the State Government-funded specialist mental health service for western metropolitan Melbourne, Australia between March 1998 and July 1999 (n = 101), and between November 2000 and September 2002 (n = 76). Participants were aged between 15 and 18 years at baseline assessment. They were excluded if they met DSM-IV criteria for mental retardation, psychotic disorder other than psychosis NOS. A further six participants were excluded because they had missing values for the Youth Self Report/Young Adult Self Report, reducing the sample to N = 171. Participants were categorised into three groups, based on the number of DSM-IV BPD criteria: 48 with no BPD (0 criteria), 80 with sub-threshold BPD (1–4 criteria), and 43 with full-threshold BPD (≥ 5 criteria).
Procedure
This study was approved by the North-Western Mental Health Behavioural and Psychiatric Research and Ethics Committee (E/98/003), and Melbourne Health (HREC1999.008). Participants, and their parent/guardian (if under 18 years) provided written informed consent. Eligible participants underwent a comprehensive psychopathology interview that included the collection of demographic data, administration of the Structured Clinical Interview for DSM-IV (SCID) Axis I and Axis II disorders, the Social and Occupational Functioning Assessment Scale (SOFAS), the Symptom Checklist-90-Revised (SCL-90-R), and depending on the participant’s age, either the Youth Self Report questionnaire (YSR; < 18 years), or the Young Adult Self Report Questionnaire (YASR; ≥ 18 years).
The DSM-IV SCID II is a reliable and valid measure of BPD in adolescents and young people [20, 21]. A personality disorder feature was scored positive if it had been present for 2 years and did not occur exclusively during a DSM-IV Axis I disorder. This is 1 year longer than what is normally required for adolescents in the DSM-IV. Criterion A of antisocial personality disorder (age ≥ 18 years) was ignored in making a diagnosis. Personality disorder not otherwise specified was defined as nine positive personality disorder features across any personality disorder domain, or if a participant lacked only one feature to meet a specific personality disorder diagnosis but had two additional features from any other personality disorder domain. These criteria are more stringent than what is specified in the DSM-IV.
At 2 years, participants were followed up using the SCID I and SCID II to reassess for a diagnosis for psychotic disorder and for the number of BPD criteria, to explore the transition rates to psychosis over time.
Measures
Residential postcode was used to determine socioeconomic status according to a social disadvantage scale ranking every postcode in the state of Victoria, Australia. The tertiles of the ranks (i.e. low, middle, and high socioeconomic status) were used for analyses.
The DSM-IV SCID I and SCID II were administered to determine diagnosis. General psychosocial functioning was assessed using the SOFAS [22]. The YSR [23] is a self-report questionnaire that measures a wide range of child and adolescent psychopathology, including psychotic symptoms, among 11–18-year olds. It includes 112 items addressing emotional and behavioural problems in the past 6 months, rated on a 3-point Likert scale (0 = not true, 1 = somewhat or sometimes true, 2 = very true or often true). The YASR [24] was constructed to assess psychopathology for young adults between 18 and 28 years, and has comparable items to the YSR. In accordance with recent studies [25,26,27], the thought problems subscale of the YSR/YASR was used to measure psychotic symptoms. This subscale reflects the mean score of the following nine items: ‘I can’t get my mind off certain thoughts’ (item 9), ‘I deliberately try to hurt or kill myself’ (item 18), ‘I hear sounds or voices that other people think aren’t there’ (item 40), ‘Parts of my body twitch or make nervous movements’ (item 46), ‘I repeat certain acts over and over’ (item 66), ‘I see things that other people think aren’t there’ (item 70), ‘I do things other people think are strange’ (item 84), ‘I have thoughts that other people would think are strange’ (item 85), and ‘I have trouble sleeping’ (item 100).
In addition, single items were selected for analysis that had face validity for psychosis [27, 28] (5, 21), like ‘I feel confused or in a fog’ (item 13), ‘I feel that others are out to get me’ (item 34), ‘I hear sounds or voices that other people think aren’t there’ (item 40), ‘I see things that other people think aren’t there’ (item 70), ‘I do things other people think are strange’ (item 84), ‘I have thoughts that other people would think are strange’ (item 85), and ‘I am suspicious’ (item 89).
The SCL-90-R [29] is a self-report questionnaire, which assesses for severity of psychopathology during the previous 7 days in individuals aged at least 13 years. It contains 90 items, which are rated on a 5-point Likert scale (0 = not at all to 4 = extremely). In this study, the paranoid ideation and psychoticism subscales were used as measures of psychotic symptoms, and the Global Severity Index (GSI) was used as a measure of overall psychopathology.
Data analysis
Based on N = 171, all variables showed less than 5% missing values. Missing values in the SOFAS, the SCL-90-R GSI, the SCL-90-R paranoid ideation and the SCL-90-R psychoticism were replaced using the expectation–maximisation method. The YSR/YASR thought problems subscale and items, as well as the SCL-90-R paranoid ideation and psychoticism subscales, were tested for univariate outliers. Outliers defined as a z score of ≥ 3.29 were identified and excluded for the YSR/YASR thought problems subscale (one outlier), item 40 (one outlier), and item 70 (six outliers), as well as for the SCL-90-R psychoticism (three outliers).
Group comparisons were conducted for descriptive demographic and clinical variables. The Pearson’s χ2 test was applied for categorical variables and the Kruskal–Wallis H test for continuous variables. A non-parametric test was chosen for continuous variables, because they were not normally distributed, as indicated by a significant Shapiro–Wilk test. Group analyses of single YSR/YASR items were collapsed from, 0 = not true, 1 = somewhat or sometimes true, and 2 = very true or often true, into 0 = not true and 1 = true. Group differences in response proportions (not true/true) were tested using Pearson’s χ2 test. Post hoc cell-wise comparisons were performed, using adjusted residuals to calculate exact p values and a Bonferroni-adjusted alpha level of .0083 to control for inflated Type-I error.
A sequential multinomial logistic regression was performed to predict group membership (no BPD, subthreshold BPD, full-threshold BPD), first on the basis of overall psychopathology (SCL-90-R GSI) and functional impairments (SOFAS), and then after the addition of psychotic symptoms (YSR/YASR thought problems). No multicollinearity was evident, as determined by tolerance values above the usual cut-off of .20. Using the Box–Tidwell approach, a violation of the assumption of linearity of the logit was detected for the YSR/YASR thought problems. Thus, the square root transformed variable was used for the regression analyses.
Results
The three groups did not differ in sex, age, or socioeconomic status (see Table 1). In contrast, a significant group effect was found for occupation, the number of current DSM-IV Axis I diagnoses, the number of current DSM-IV Axis II diagnoses, the number of BPD criteria, the SCL-90-R GSI, and the SOFAS score. Post hoc pairwise comparisons revealed that the full-threshold BPD group was less likely to be studying or working than the sub-threshold BPD group or the group with no BPD criteria (p = .004); whereas, no significant difference was found between the sub-threshold BPD group and the group with no BPD criteria. The two BPD groups presented with significantly more current Axis I diagnoses (p ≤ .05) and current Axis II diagnoses (p < .05), and significantly higher levels of overall psychopathology (p < .05), than the group with no BPD criteria. The full-threshold BPD group had significantly more current Axis I diagnoses and current Axis II diagnoses, as well as significantly higher levels of overall psychopathology (p < .01) than the sub-threshold BPD group (p < .001). The sub-threshold and full-threshold BPD groups showed significantly lower SOFAS scores than the group with no BPD criteria (p ≤ .005). No significant differences in SOFAS score were found between the sub-threshold BPD group and the full-threshold BPD group (p = .145).
Group differences in psychotic symptoms
There was a significant group effect for the YSR/YASR thought problems subscale as a general index for psychotic symptoms, as well as for the SCL-90-R Paranoid Ideation and Psychoticism subscales (see Table 1). Post hoc pairwise comparisons revealed that the two BPD groups reported significantly more psychotic symptoms than the group with no BPD criteria (p ≤ .001). The full-threshold BPD group reported more psychotic symptoms than the subthreshold BPD group (p < .001). In addition, the full-threshold BPD group experienced significantly more paranoid ideation and psychoticism than both the sub-threshold BPD group (p = .001) and the no BPD group (p < .001). No significant group differences in paranoid ideation and psychoticism were found between the sub-threshold BPD group and the no BPD group (p = .822 and p = .218, respectively). The full-threshold BPD group presented with higher psychoticism scores than the no BPD group (p = .001). No significant group differences were found for psychoticism when comparing the sub-threshold BPD group with the no BPD group (p = .131), or the full-threshold BPD group with the sub-threshold BPD group (p = .143).
When the single YSR/YASR psychosis items were analysed, there was a significant group effect for items 13, 34, 40, 70, 84, 85, and 89 (Table 2). Post hoc cell-wise comparisons revealed that the full-threshold BPD group responded significantly more frequently with true to feeling confused (item 13, p = .003), feeling others are out to get them (item 34, p < .001), having visual hallucinations (item 70, p = .001), and strange thoughts (item 85, p = .003), than the two other groups. In addition, the groups with sub-threshold or full-threshold BPD endorsed the auditory hallucination item significantly more frequently (item 40, p = .004), than the group with no BPD criteria. No significant post hoc cell-wise differences were found regarding strange behaviour (item 84) and suspiciousness (item 89, p > .0083).
The regression analysis based on overall psychopathology and functional impairments only showed an adequate model fit, χ2(330) = 322.75, p = .602, using the Pearson criterion. After the addition of psychotic symptoms, the model fit was χ2(334) = 322.28, p = .516, Nagelkerke R2= .36. Comparison of log-likelihood ratios for the models, with and without psychotic symptoms, showed statistically significant improvement with the addition of psychotic symptoms, χ2(2) = 35.00, p < .05. Correct classification rates were 54.2% for the no BPD group, 66.3% for the sub-threshold BPD group, and 37.2% for full-threshold BPD; the overall correct classification rate was 55.6%. Table 3 shows that the full-threshold BPD group was significantly more likely to have higher levels of functional impairment, overall psychopathology, and psychotic symptoms than the no BPD group, and was significantly more likely to have higher levels of psychotic symptoms than the sub-threshold BPD group.
2-year follow-up
At baseline, one participant met criteria for both full-threshold BPD and psychotic disorder not otherwise specified (NOS). At 2-year follow-up, this participant still met criteria for psychotic disorder NOS, but had only sub-threshold BPD. A total of 7/171 (4.1%) made the transition to a diagnosis of psychotic disorder NOS at 2 years. Two of these had full-threshold BPD at baseline, one of whom still met BPD criteria at 2 years, with the other becoming sub-threshold over time. Three of these participants had sub-threshold BPD at baseline, two of these continued to have sub-threshold BPD at 2 years, and the other developed full-threshold BPD.
Discussion
This study is the first to examine psychotic symptoms among adolescents with sub- or full-threshold BPD, providing important information about the early stages of BPD, proximal to its clinical onset. The study hypotheses were supported by the major findings: (1) a high proportion of 15–18-year olds with BPD either sub- or full-threshold BPD experienced psychotic symptoms; (2) that psychotic symptoms predicted group membership, defined by BPD severity; (3) that greater BPD severity (i.e. number of BPD criteria) was associated with more severe psychotic symptoms. These results validate the experience of adolescents with BPD who experience psychotic symptoms, and highlight the need for these symptoms to be clinically recognised and treated.
As hypothesised, the full-threshold BPD group had higher scores on the thought problems subscale, compared with the sub-threshold BPD group, and both these groups had higher thought problems scores than the no BPD group. The full-threshold BPD group also reported higher scores on the paranoid ideation and psychoticism subscales, along with more confusion, paranoia, visual hallucinations and strange thoughts, than either the sub-threshold or no BPD groups. Both BPD groups had significantly more auditory hallucinations than the no BPD group.
These findings are consistent with growing evidence that many adult patients with BPD report psychotic symptoms, even though these symptoms are not core diagnostic features of this disorder. In the current study, the reported rate of auditory hallucinations among adolescents with full-threshold BPD was 37.2%, and 18.6% of these young people reported visual hallucinations. This rate is comparable with the rates reported among adults with BPD for auditory (22–50%) and visual (30%) hallucinations [8, 9]. Similarly, 72.1% of young people with full-threshold BPD reported paranoid ideation and 65.1% reported suspiciousness, which is comparable with rates reported among adults with BPD of 29–87% [8, 13] and 71% [13], respectively. There was also a high rate of general thought problems, including confusion (93%) and strange thoughts (58.5%) among those with full-threshold BPD, which is consistent with the rates reported among adults with BPD for odd thinking (86%) [13]. These findings demonstrate that psychotic symptoms are common among young people with BPD, early in the course of the disorder.
The current findings highlight and extend previous findings that young people with sub-threshold BPD features have more severe mental illness and poorer social and occupational functioning than individuals with no BPD features [30] by also demonstrating the higher likelihood of psychotic symptoms among young people with sub-threshold BPD features. Psychotic symptoms predicted group membership, defined by BPD severity (i.e. number of BPD criteria), after adjusting for overall psychopathology and functional impairment and greater severity of BPD was associated with greater overall psychopathology, including greater number of DSM-IV Axis I and Axis II disorders and poorer psychosocial functioning. These findings are consistent with those from population studies indicating that psychotic symptoms are important risk markers for a wide range of non-psychotic psychopathological disorders, in particular for severe psychopathology characterised by multiple co-occurring diagnoses [15], and that young people with psychotic experiences are known to have worse global functioning than those without, even when compared with young people with psychopathology who do not report psychotic experiences [31]. Importantly, persistent psychotic experiences have been associated with increased risk of non-suicidal self-injury and suicide attempts among school-based adolescents [32], poor functioning and coping in adolescents with mental illness [33]. More specifically, AVHs have been associated with greater suicidal ideation and more suicide attempts and hospitalisations among adults with BPD [10], together with a self-reported history of childhood abuse and neglect [8].
The 2-year follow-up data did not reveal any relationship between the number of BPD criteria and emerging psychotic disorder. This is consistent with the findings from a study of young people meeting ‘Ultra-High Risk’ criteria for psychosis (i.e. attenuated psychotic symptoms), in which co-occurring BPD or BPD features did not influence the risk of short-term transition to psychosis or the risk of developing a non-affective psychotic disorder [18].
The current study has several limitations. This study was not primarily designed to assess for psychotic symptoms and was limited to the YSR/YASR and SCL-90-R at baseline, and it did not include a measure of symptom severity. The DSM-IV SCID I was the only measure used to assess for these symptoms at 2-year follow-up. Furthermore, participants were initially excluded if they had a schizophrenia spectrum or other psychotic disorder, which prevented the investigation of co-occurring BPD and psychotic disorder in this patient group. However, a strength of this approach was that clinical controls were similarly excluded and no participant met diagnostic criteria for a DSM-IV psychotic disorder. Future studies in this age group would benefit from more comprehensive measurement of psychotic symptoms, along with longitudinal assessment given the bidirectional associations between psychotic experiences and DSM-IV mental disorders [34].
The primary clinical implication of these findings is the need for further studies using more appropriate instruments for the assessment of psychotic symptoms and also for treatment studies in young people. A previous pilot study of combined specialist BPD and first-episode psychosis early intervention treatment in this age group demonstrated that this was feasible [35]. As yet, no study has explored the effectiveness of antipsychotic medication for these symptoms, even though it is regularly prescribed [36], or conducted a randomised controlled trial of cognitive behaviour therapy for the treatment of auditory verbal hallucinations. This is a much needed area of investigation.
Overall, these findings indicate that psychotic symptoms, such as hallucinations, paranoia, and thought problems are present early in the course of BPD, are common, and occur at comparable rates to those reported among adults with BPD. Moreover, psychotic symptoms are clinically important among young people with BPD features, as these symptoms appear to be an indicator of more severe psychopathology and greater functional impairment. Future studies need to investigate appropriate treatments for these symptoms and whether reducing these symptoms might lead to improved psychopathological and functional outcomes for young people with BPD.
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Acknowledgements
Dr. Marialuisa Cavelti is supported by the Swiss National Science Foundation, and the Gottfried and Julia Bangerter-Rhyner-Foundation.
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Funding was received for Dr Marialuisa Cavelti as stated in the acknowledgements.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Thompson, K.N., Cavelti, M. & Chanen, A.M. Psychotic symptoms in adolescents with borderline personality disorder features. Eur Child Adolesc Psychiatry 28, 985–992 (2019). https://doi.org/10.1007/s00787-018-1257-2
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DOI: https://doi.org/10.1007/s00787-018-1257-2