Abstract
Background and aim
FKBP1A, a gene encoding the FK506-binding protein 1A, has emerged as a significant player in cancer progression and prognosis. This study aimed to comprehensively investigate the multifaceted role of FKBP1A in cancer, focusing on its differential expression patterns, prognostic implications, genetic alterations, and associations with the tumor microenvironment.
Methods and results
Using large-scale datasets, including GTEx, TCGA, HPA, and cBioPortal, we analyzed FKBP1A expression across normal tissues and various cancer types. Our findings revealed that FKBP1A exhibited aberrant upregulation in most human cancers, making it a potential biomarker for malignancy. Moreover, FKBP1A expression correlated with poor overall survival, disease-specific survival, disease-free interval, and progression-free interval in several cancers, indicating its prognostic significance. Genetic alteration analysis showed that FKBP1A gene amplification was prevalent, particularly in ovarian cancer. Furthermore, FKBP1A expression was associated with tumor mutational burden and microsatellite instability, highlighting its potential involvement in tumor-immune response. Notably, FKBP1A expression positively correlated with stromal and immune cell scores, suggesting its role in shaping the tumor microenvironment. Additionally, according to the functional enrichment analysis, experimental validation in lung adenocarcinoma confirmed the role of FKBP1A through the regulation of EGFR signaling by apoptosis, which is consistent with drug sensitivity analysis to some extent.
Conclusion
In conclusion, FKBP1A exhibits differential expression in cancer, serves as a prognostic indicator, undergoes genetic alterations, and influences the tumor-immune microenvironment. These findings shed light on the multifaceted role of FKBP1A in cancer development and progression, suggesting its potential as a therapeutic target and guidance of clinical drugs selection, and provide valuable insights into patient prognosis for interventions based on pharmaceuticals.
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Data availability
The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors.
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Acknowledgements
This research benefits from the help and support in many aspects, and here, we would like to express our deep gratitude to Dr. Yue-Yuan Zheng, Scientific Research Center, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Funding
This research was supported by the National Natural Science Foundation of China (Grant No. 81971470, 32170913, and 32370982), the Shenzhen Science and Technology Innovation Committee Programs (JCY20190809143803732 and JCYJ20210324120602008).
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BH and YC supervised the study; YZ and HX collected the data and performed the analysis and experiments; YZ, HX, SP and HT wrote the paper. BH and YC revised the paper. All authors read and approved the final manuscript.
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Zhang, Y., Xu, H., Pi, S. et al. The prognostic and immunological role of FKBP1A in an integrated muti-omics cancers analysis, especially lung cancer. J Cancer Res Clin Oncol 149, 16589–16608 (2023). https://doi.org/10.1007/s00432-023-05362-1
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DOI: https://doi.org/10.1007/s00432-023-05362-1