Abstract
Objectives
Pediatric hemifacial spasm has been rarely reported in the literature, which contains only 44 cases. Although microvascular decompression (MVD) has been widely regarded as effective therapy for hemifacial spasm, the etiology and surgical treatment of pediatric patients are seldom reported. We report our experience with MVD for pediatric hemifacial spasm patients and review the literature with emphasis on the difference from adults.
Methods
This retrospective report included 4 pediatric HFS patients, who underwent MVD in our department between January 2014 and May 2021 and then reviewed all the pediatric hemifacial spasm literature on “pubmed” with emphasis on the clinical data.
Results
Our series included 1 boy and 3 girls with an average age of 15.6 ± 3.2 years old; their onset ages were from 7 to 16 years old (11.6 ± 4.3). Three patients achieved immediate excellent outcomes and 1 achieved poor immediately and became good 6 months later. During the operation, all the 4 patients were found compressed by anterior inferior cerebellar artery (AICA). The incidence of pediatric atypical hemifacial spasm patients is 12.5% among the 48 reported cases, which is much higher than adults. Among all the reported 48 cases including ours, the singular artery neurovascular conflictions account for 27/48(56%), the singular vein and combined artery/vein conflictions in 12/48(25%) and the cisternal conflictions in 5/48(10.4%) patients.
Conclusions
The etiology of pediatric hemifacial spasm is still neurovascular conflict, of which combined artery/vein and singular venous compression patterns have a higher proportion, which might explain higher incidence of pediatric atypical hemifacial spasm and less favorable postoperative outcome. Sufficient arachnoid release, full exploration and decompression along the facial nerve are necessary, which would help to increase the excellent postoperative cure rate among pediatric patients.
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Introduction
Hemifacial spasm (HFS) has a prevalence of approximately 10 per 100,000, which is defined as unilateral, involuntary, irregular clonic or tonic contractions of the facial muscles innervated by the ipsilateral seventh cranial nerve [1, 2]. The high postoperative efficacy of microvascular decompression (MVD) surgery has confirmed the neurovascular conflict theory. HFS is most common in middle-aged and older patients [3,4,5], which is caused by the elongation and tortuosity of the vascular loop and sagging of the brain accompanying the aging process, however, which could not adequately explain HFS in those pediatric patients, which has been rarely reported in the literature because of its low occurrence in childhood and adolescence (Table 1). However, the postoperative outcome of pediatric HFS patients is worse than adults [6,7,8,9,10,11,12]. If age is a major determinant of the HFS, there may be clinical differences including etiology, symptom, offending vessels and surgery nuances between the pediatric and elderly HFS patients. Clarification of these questions would help to understand the pathophysiology and improve the cure rate of hemifacial spasm in children. This study was designed to answer the above questions.
Materials and methods
All patients enrolled in this study gave written consent. Here, the 4 HFS patients (≤ 18 years old) who underwent MVD procedures between January 2014 and May 2021 were enrolled in this study. All patients have undergone medical treatment including carbamazepine or oxcarbazepine preoperatively and in vain. Each patient underwent three-dimensional time-of-flight magnetic resonance imaging (3D-TOF MRI) examination before surgery. The medical records including demographics, intraoperative findings, postoperative outcomes and complications were all reviewed. All patients were followed up by telephone interview. The postoperative outcomes were divided into three categories as follows: (1) excellent: complete spasm relief without medication; (2) good: substantial relief but with minimal persistent twitch without medication or complete relief with well-tolerated medication; (3) poor: little or no relief or severe twitch despite medication [13].
Surgical technique
All procedures were performed via a lateral retrosigmoid suboccipital approach, during which a small craniotomy was performed to expose the edges of the sigmoid and transverse sinus. The dura was opened and cerebrospinal fluid was allowed to empty. After careful dissection of the arachnoid membrane and gentle retraction of the flocculus, the root exit zone (REZ) of the facial nerve was observed. Any offending vessel was dissected away from the facial nerve. Several pieces of Teflon sponge were interpositioned between the offending vessel and REZ. During manipulation of the seventh and eighth nerves, brainstem auditory-evoked potentials were closely monitored to assess hearing loss and facial electromyography to assess the lateral spread response phenomenon, thereby achieving complete decompression. The dura was closed, with several muscle pieces interposed between the interrupted sutures to prevent cerebrospinal fluid leakage [14].
Results
This series included 1 boy and 3 girls with an average age of 15.6 ± 3.2 years old; their onset ages were from 7 to 16 years old(11.6 ± 4.3). Three patients achieved immediate excellent outcomes and 1 achieved poor immediately and became good 6 months later. Through the review, 48 patients including our 4 patients were enrolled in this study. The incidence of pediatric atypical hemifacial spasm was 12.5% among the 48 reported cases, which is much higher than adults. Among all the 48 cases, no serious complications occurred. In our 4 cases, no complications occurred. Among the reported 44 cases, the complications included 1 cerebrospinal fluid leak, 1 chemical meningitis, 3 temporary mild facial paresis, 1 temporary moderate delayed facial paralysis and 1 moderate hearing impairment.
Intraoperative findings in MVDs
During the operation, all the 4 patients were found compressed by anterior inferior cerebellar artery (AICA), 2 at REZ (Fig. 1), 2 at REZ and cisternal part (CP) intraoperatively (Fig. 2 and Table 1). Among all the reported 48 cases including ours, the singular artery conflictions account for 27/48 (56%), the singular vein and combined artery/vein conflictions in 12/48(25%), the cisternal conflictions in 5/48(10.4%) patients (Table 2).
Discussion
HFS is primarily a problem of middle-aged and older patients [3], in which the offending vessels tend to be elongated and redundant. However, such age-related arterial vasculature changes are absent in children. Thus, the etiology of HFS caused by vascular compression in pediatric and young adolescents is still controversial, which has been debated for a long time. It has been 77 years since Ehni and WOLTMAN [15] firstly report pediatric HFS in 1945, since then several theories have been raised. The anatomical variations of the vessels and thickening of the arachnoid membrane at the cerebellopontine angle were both considered be the main cause possibly [6,7,8,9,10,11,12]. The thickened-arachnoid theory could explain the neuro-vascular theory despite the absence of atherosclerotic changes, which was adhered to the arteries and nerves. We all know that the arachnoidal thickening could be caused by encephalitis, meningitis or subarachnoid hemorrhage. However, it is unusual in the pediatric HFS patients according to the literature [6,7,8,9,10,11,12]. Although the other reasons such as trauma, CPA occupation, infections and vascular abnormalities could also cause HFS, the neurovascular confliction is still the main reason [16] (Table 1). Among our cases, we questioned every patient and found no infection or trauma.
We truly find some difference in clinical symptoms and surgery details between pediatric and adult HFS patients. According to our study and literature review, we had two valuable findings. Although the limited reported cases, we found a higher incidence of atypical hemifacial spasm than adults, whose incidence rate was reported around 1.3% [17]. However, the incidence of pediatric atypical hemifacial spasm is 12.5% among the 48 reported cases. We guess it might be related to the different offending vessel and neurovascular confliction on site, for the reason that the incidence of alone/combined venous compression was much higher than adults, which was 25% of the pediatric hemifacial patients. The incidence of cistern neurovascular confliction was also higher, which was 10.4%.
Through our study, we believe that two factors including crowed cerebellopontine angle (CPA) and easy attrition of the neurovascular interfaces may play important roles in the young HFS patients. Our 3D-TOF MRI delineated a crowded CPA space in the posterior fossa, which increased the chance of neurovascular confliction. Our study regarding the mechanism of HFS demonstrated that attrition of the neurovascular interfaces is necessary for HFS. We believe that the precondition for generating this hyperexcitability is the attrition of the neurovascular interfaces due to mutual friction with pulsation, which is the hinged between the sympathetic nerves in the offending artery wall and the demyelinated nerve root in close contact with each other [18].
The MVD surgery in pediatric HFS patients needs more skills because of the narrow operative space and complex vascular compression. During the operation, excessive stretching of the cerebellum could easily increase the incidence of postoperative complications. A caudorostral approach seems to be an alternative to reduce traction and increase exposure. Combined artery/vein and singular venous compression patterns play an important role in the pediatric patients. The postoperative outcome of pediatric hemifacial spasm seemed to be less favorable because of the different conflict sites and patterns from adults. We should pay more attention to venous and combined vascular decompression during the MVD operation.
Conclusion
The etiology of pediatric hemifacial spasm is still neurovascular conflict, of which combined artery/vein and singular venous compression patterns have a higher proportion, which might explain higher incidence of pediatric atypical hemifacial spasm and less favorable postoperative outcome. Sufficient arachnoid release, full exploration and decompression along the facial nerve are necessary, which would help to increase the excellent postoperative cure rate among pediatric patients.
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This study was supported by funding from the Shanghai Science and Technology Committee (19YF1432300).
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Jia, A., Dou, N. & Zhong, J. Microvascular decompression for pediatric-onset hemifacial spasm: case series and literature review. Childs Nerv Syst 38, 1307–1312 (2022). https://doi.org/10.1007/s00381-022-05521-8
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DOI: https://doi.org/10.1007/s00381-022-05521-8