Abstract
Background
It is a complete objective and subjective comparative study between two techniques of septorhinoplasty in patients undergoing primary rhinoplasty for crooked nose deformity.
Methods
Forty patients having crooked nose deformity were randomly divided into 2 groups exhibiting two different techniques of correction. Patients were randomly divided into 2 group:
Group 1: 20 patients underwent correction of crooked nose by performing bilateral triple osteotomies + Septoplasty
Group 2: 20 patients underwent correction of crooked nose by performing bilateral triple osteotomies as well as placement of spreader grafts + Septoplasty
Objective and subjective assessment of patients in preoperative and postoperative period was done by various scales and scores.
Results
Both the groups showed improvement in facial angles, ROE score, nasal airflow, and NOSE score. But, group 2 patients were more satisfied than group 1 patients in terms of both aesthetic appearance of nose and breathing function.
Conclusion
It is very well known to the authors that aesthetic result of rhinoplasty is not just dependant on one technique. Keeping this in mind, we conclude that as group 2 patients were more satisfied with their overall results, the additional step of spreader graft placement helped these patients with the complaints associated with crooked nose deformity. However, we also emphasize that additional studies on larger numbers of patients should be performed to compare and know other intricacies of each technique that may play minor or major roles in deciding the success of each technique.
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Introduction
Rhinoplasty [rhinos (nose) + plassein (to shape)] is a surgical procedure, which helps in not just improving the appearance of nose, but also improves the function of the nose, helping the patient look as well as breathe better. The term ‘crooked nose’ is being referred to as a twisted nose which represents complex deformity of anatomical components of nose, leading to cosmetic and functional disturbances. Rhinoplasty done for crooked nose deformity correction comprises of mobilization and realignment of nasal tissues which can be unpredictable because of the destabilization nature of these surgical techniques and the wound healing processes [1].
Composite grafts, including skin/mucosa and cartilage, spreader grafts, and spreader flaps are different types of techniques used for managing the midvault [2]. Sheen, in 1984, was the first surgeon who used spreader grafts to prevent the functional collapse of the nasal internal valve following reduction rhinoplasty [3]. Osteotomies were first implemented to narrow the open roof that followed a major hump reduction and initially consisted of a lateral osteotomy placed in the nasofacial groove. Subsequently, a medial osteotomy that paralleled the septum was added to ensure total mobilization of the lateral wall, and correct the convexity of the crooked nose [4].
There is a paucity of data on comparison of two techniques of primary rhinoplasty. Hence, we aim to study and compare the preoperative and postoperative objective as well as subjective findings of both the functional and aesthetic component of nose in patients undergoing septorhinoplasty for the crooked nose deformity.
Material and Methods
We did a prospective study to analyse 40 patients of either sex with crooked nose deformity who had undergone primary rhinoplasty from 2014 to 2017 after obtaining ethical clearance from the institute.
Study subjects were randomly allocated into two groups of 20 patients each:
Group 1: 20 patients underwent correction of crooked nose by performing bilateral triple osteotomies + Septoplasty
Group 2: 20 patients underwent correction of crooked nose by performing bilateral triple osteotomies as well as placement of spreader grafts + Septoplasty
Inclusion Criteria
Patients having contour deformities-lateral depression, dorsal deformities and/or deviated nose with or without deviated nasal septum, dorsal hump, or tip deformity were included in the study.
Exclusion Criteria
The following patients were excluded from the study: -
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1)
Patients with external nasal deformity associated with cleft lip and palate,
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2)
Isolated dorsal hump,
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3)
Isolated saddle nose deformity,
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4)
Patients having unstable mental status,
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5)
Patients having unrealistic expectations,
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6)
Previous history of rhinoplasty,
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7)
Autoimmune or connective tissue diseases (if family history or other history suggestive),
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8)
Neoplastic or polypoidal coexisting disease,
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9)
Poor perioperative risk profile,
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10)
Major cardiovascular and respiratory disease, and
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11)
Skin disease over dorsum of nose.
Patients were fully explained about the deformity, surgical procedure, risks, benefits and outcome. A complete informed consent about the procedure of rhinoplasty was taken.
Evaluation of the Patient
A detailed history was recorded and physical examination was performed in all the patients at the time of initial presentation, including anterior and posterior rhinoscopy. Routine investigations were sent. Tools used to evaluate the patient in the preoperative period and postoperative period to record and compare were—
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Measurement of various angles like nasofacial, nasolabial, nasal deviation alignment angle (NDAA), etc., for objective evaluation of aesthetic appearance of nose.
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ROE (Rhinoplasty Outcome evaluation) score for the subjective evaluation of aesthetic appearance of nose.
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Rhinomanometry for the objective evaluation of nasal obstruction.
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NOSE (Nasal Obstruction Symptom Evaluation) questionnaire for subjective evaluation of nasal obstruction.
Objective Evaluation of Aesthetic Appearance of Nose Using Facial Angles/Dimensions
The nasofrontal angle (NFR), between the frontal bone and the nasion, is formed by the intersection of the tangent to the glabella and the nasal dorsal line, transecting any intervening hump. The nasofacial angle (NFA) is created by the intersection of the nasal dorsal line with a vertical facial plane at the nasion. The nasolabial (columellar-labial) angle (CLA), the slope between the columella and philtrum is created by the intersection of lines tangent to the columella segment and upper lip segment. The tip angle, the slope of the tip of the nose relative to plane of the face is approximately produced by a line from tip (T) to Vertical Facial Plane (Fig. 1a) [5].
Nasal deviation alignment angle (NDAA) is defined as the deviation of the nose from the longitudinal midline. This is a vertical line drawn from the nasion. In a true ‘straight’ nose, this line will align with the nasal tip (Fig. 1b). In our study, the ‘normal’ value for NDAA was set at 0° [6].
The Goode method determines the facially proportionate projection of the nasal tip (the distance of the nose’s tip from the face), when the projection of the nasal tip should be 55–60% of the distance between the nasion (nasofrontal junction) and the tip defining point (Fig. 1c) [7].
Subjective Evaluation of Aesthetic Appearance of Nose Using ROE (Rhinoplasty Outcome Evaluation) Score
The ROE score provides an assessment of patient’s satisfaction before and after septorhinoplasty. The ROE questionnaire used is composed of six questions (5 about nose shape and 1 about nasal breathing). Each question is scored by the patient on a scale from 0 to 4, where 0 is the most negative answer and 4 the most positive one (Fig. 2a). The ROE scale is scored from 1 to 24 points. A score of ≥ 12 out of 24 is considered ‘normal’ and a score of < 12 reflects patient’s dissatisfaction regarding the aesthetics of his/her nose. Patients were judged to be satisfied after surgery if the ROE score was above 12 or if their score did not decrease after surgery [8]. The ROE questionnaire was completed by the patient a day before surgery and then at 6 months after surgery.
Objective Evaluation of Nasal Obstruction by Rhinomanometry
Rhinomanometry was performed before surgery and at 6 months after surgery. The same rhinomanometer was used for all patients (ATMOS® Rhino 31 Rhinomanometer). Anterior rhinomanometry during spontaneous breathing was performed. In order to limit the influence of the nasal cycle on rhinomanometry data, the nasal resistance and nasal airflow values used were recorded for left nasal cavity, right nasal cavity and also combined resistance of both nasal cavities as a mean of the readings at pressure of 75, 150 and 300 Pascals (Pa). Nasal resistance was reported in Pa/cm3/sec and flow in cm3/sec. Resistance between 0.30 and 0.49 Pa/cm3/sec was designated as mild obstruction, resistance between 0.50 and 0.80 as moderate obstruction, and resistance > 0.80 Pa/cm3/sec indicated severe obstruction [8, 9].
Subjective Evaluation of Nasal Obstruction by NOSE Scale (Nasal Obstruction Symptom Evaluation Scale)
The NOSE scale is a graduated 20-point scale; the result is multiplied by 5 to give a final total out of 100 [10]. A score of 100 indicates complete nasal obstruction. A NOSE score under 25 is considered normal, between 25 and 50 denotes mild to moderate nasal obstruction, and above 50 denotes severe nasal obstruction (Fig. 2b) [11]. The NOSE questionnaire was completed by the patient a day before surgery and again at 6 months after surgery.
Photographs
The standard facial photographs were taken, for the documentation of the accurate extent of nasal deformity and basic framework of the bony and cartilaginous vault of the nose, which included Frontal view; Right and Left lateral views; Right and Left oblique views; Basal view (worm’s eye view).
Surgical Procedure
Patients were admitted a day before the surgery. All the patients were taken up under general anaesthesia. Patient was laid in supine position with head end elevated to about 20 degree and the local site was prepared with povidone iodine solution. Neuro-patties soaked in vasoconstrictive agent were placed inside the nasal cavities and were removed after 15 minutes.
Surgical Approach
Nasal dorsum, lateral nasal walls, nasofacial grooves, septum was infiltrated with a mixture of 2% lidocaine and 1:200000 epinephrine. The surgical procedure was done through an open (external) approach.
The general sequence followed was:
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1.
Inverted V incision over the mid columella (Midcolumellar incision)
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2.
Bilateral infracartilaginous (marginal) incisions connected with a columellar incision, followed by the dissection.
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Raise a columellar flap
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Midline dorsal surface dissection
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Exposing anterior septal angle.
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Management of septal deformity
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Septoplasty
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Caudal septal repositioning
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Correction of septal L-strut
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Hump Reduction (if hump present)
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Detachment of the upper lateral cartilages from the septum
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Management of deformed nasal bones
Group 1: Patients underwent septoplasty along with medial, transverse, and lateral osteotomies.
Group 2: Patients underwent septoplasty, medial, transverse, and lateral osteotomies, along with placement of spreader grafts on both sides of septum in all the patients. Thickness of spreader grafts was sometimes unequal to achieve good dorsal lines.
Technique of Performing Triple Osteotomies
For Lateral Osteotomy
A stab incision was given at the midpoint between vestibule and medial canthus. The tip of 2 mm osteotome was firmly pressed against the bone. Periosteum was not elevated for any possibility of disrupting the lacrimal sac or damage to the medial canthus ligament. It was incised cleanly with tip of osteotome by moving the osteotome up and down at the proposed line of osteotomy and perforation of bone was done with 2 mm sharp osteotome. From a single skin stab incision, bone was perforated at 2 mm distance with tap-tap stroke of the mallet taking care not to damage the underlying mucosa of the bone. The change of sound of the tapping of osteotome signals that internal cortical bone has been broken. There is also a give way feeling which warns the surgeon against the undue perforation of nasal mucosa. The multiple site bone perforation was done by moving the osteotome from caudal to cephalic direction to give a low-to-low lateral osteotomy.
For Transverse Osteotomy
A midpoint was selected between medial canthus and nasion and a stab incision was given. Periosteum was incised with the tip of osteotome and perforating osteotomy was done as described earlier to meet the upper end of lateral osteotomy laterally, and the cephalic end of medial osteotomy medially.
For Medial Osteotomy
In all the cases, straight 4 mm sharp osteotome was engaged para-median to mid-line in order to safeguard the keystone area to avoid loss of septal support and was directed to meet the medial end of horizontal perforating transverse osteotomy.
The similar procedure was done on the opposite side. Firm pressure was applied with fingers for straightening of nasal vault. The skin stab incision was not sutured any time.
Technique for Placing and Securing Spreader Grafts
Spreader grafts were harvested from autologous septal cartilage and were approximately 1.5–2.5 cm in length, 2–3 mm in width and 1.5–2.5 mm thick. If hump is present, it is excised. Division of upper lateral cartilages from their attachment to the dorsal septum is then undertaken in the sub-mucoperichondrial plane. Placement of spreader grafts is undertaken once hump reduction and osteotomies have been performed. Spreader grafts are then placed in the pockets between upper lateral cartilages and septum (Fig. 3). A typical graft in our case extended from the osseocartilaginous junction to the anterior septal angle. The spreader grafts were secured with 5,0 PDS (polydioxanone) or Monocryl suture. Two horizontal mattress sutures were put to engage all the structures from upper lateral cartilage-to-spreader graft-to-septum-to-spreader graft-to-upper lateral cartilage in position.
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10.
Tip plasty (if required)
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11.
Suturing of incisions.
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12.
Packing, taping and splinting.
After the surgery, patients were shifted to ward. Nasal pack removal was done after 48 hours. Patients were mostly discharged between 3rd and 5th postoperative day on oral antibiotics, anti-inflammatory, normal saline and liquid paraffin nasal drops. Sutures were removed on the 7th postoperative day. Tape and POP (Plaster of Paris) cast was removed between 10th and 14th postoperative day.
Follow-up Care
Patients underwent regular follow-up for 1st, 2nd, 3rd, and then at 6th month postoperatively. Final assessment of preoperative and postoperative result of Group 1 and Group 2 patients was made at the end of 6th month (Fig. 4 and 5).
Statistical Analysis
Difference in preoperative and postoperative data was observed using Student’s paired t test, and the difference was considered statistically significant if p value < 0.05. Data were shown as mean ± SD.
Results
Forty patients with crooked nose deformity admitted for surgical correction were evaluated. Twenty-nine out of 40 patients (72.5%) were in the 18–29 years of age group, indicating it is seen more commonly in young adults (Table 1A). Crooked nose was seen more in males than females (Table 1B). History of trauma was present in 32 out of 40 patients (80%), which was the most important aetiology of crooked nose deformity. Second most common aetiology was developmental in 8 out of 40 patients (20%) (Table 1C).
Associated dorsal hump alone was present in 10 out of 40 patients (25%). Associated tip deformity alone was present in 3 out of 40 patients (7.5%). Associated dorsal hump as well as tip deformity was present in 2 out of 40 patients (5%). Isolated crooked nose deformity without any dorsal hump or tip deformity was present in 25 out of 40 patients (62.5%). Deviated nasal septum and symptom of nasal obstruction (unilateral or bilateral) was present in all patients (100%). Septoplasty and bilateral triple osteotomies were done in all 40 patients (Table 2).
Objective Aesthetic Evaluation
Nasal Deviation Alignment Angle (NDAA)
Pre- and postoperative NDAA of all the patients were measured. Before surgery the range of NDAA in group 1 patients was from 2.8 to 24.6°, while after surgery the range of NDAA was from 0.2 to 7.1°. Similarly, before surgery the range of NDAA in group 2 patients was from 8.8 to 23.6°, while after surgery the range of NDAA was from 0.5 to 5.3°. Mean correction achieved in NDAA of group 1 patients was 10.22 ± 4.6°, while mean correction achieved in NDAA of group 2 patients was 11.7±3.7° (Table 3A), which is greater than group 1 patients.
Maximum patients in both groups achieved a degree correction between 5 and < 15°. Degree of correction range we achieved in group 1 patients varied from 2.4 to 18.9°. Fifteen out of 20 patients (40%) in group 1 achieved the correction range of 5–< 15°. Degree of correction range we achieved in group 2 patients varied from 6.0 to 21.3°. Seventeen out of 20 patients (40%) in group 2 achieved the correction range of 5–<15° (Table 3B).
Preoperative & postoperative digital photographs were assessed with help of Adobe photoshop version CS2 software. Preoperative and postoperative angles were documented & compared.
Nasofrontal Angle
Its normal range is 120–130°. In present study, the mean preoperative and postoperative angles were in normal range. After surgery, there was slight increase in nasofrontal angle in both groups (Table 4A).
Nasolabial Angle (NLA)
Its normal range is 90–105°. In present study, the mean preoperative and postoperative angles were in normal range. After surgery, there was slight increase in nasolabial angle in both groups (Table 4B).
Tip Projection Ratio
Its normal range is 0.55–0.60. In present study, the mean preoperative and postoperative ratios were in normal range. After surgery, there was slight increase in ratio in both groups (Table 4C)
Nasal Deviation Alignment Angle (NDAA)
In Group 1 and 2 patients, the preoperative NDAA was 13.76° and 14.79°, which was corrected after surgery up to 3.5° and 3.06°, respectively. Both values were significant with p value < 0.0001 (Table 4D).
Subjective Aesthetic Evaluation
ROE (Rhinoplasty Outcome Evaluation)
The average ROE score in group 1 patients before surgery was 6 ± 1.02/24. After surgery, it was 15 ± 2.44/24. The difference was statistically significant (p < 0.0001), whereas the average ROE in group 2 patients was also 6 ± 1.2/24 before surgery. After surgery, the average ROE of group 2 patients was better than group 1 patients, and was 18.35 ± 3.02/24, with p < 0.0001 (Table 4E).
Overall, the ROE score improved in all patients. However, there were 3 patients in group 1, and 1 patient in group 2 who had a score of < 12.
Subjective Functional Evaluation by NOSE Score
The average NOSE (Nasal Obstruction Symptom evaluation) score before surgery of Group 1 patients was 62.75/100 [range 40–80, standard deviation (SD) 12.2]. After surgery, it was 21/100 (range 10–35, SD 7.1). There was a statistically significant difference between the preoperative and postoperative values (p < 0.0001). Similarly, the average NOSE score before surgery of Group 2 patients was 69.5/100 (range 40–100, SD 15.4). After surgery, it was 9.75/100 (range 0–20, SD 6.2) (p < 0.0001) (Table 4F).
The spreader graft placement along with septoplasty done in group 2 patients according to us resulted in better functional results of nose, as straightening of nasal septum by septoplasty removes nasal obstruction caused by mechanical obstruction to airway, and placing spreader grafts widens the internal nasal valve area, and prevents its collapse by supporting the valve area relieving the complaints of nasal obstruction caused by narrow internal nasal valve.
Objective Functional Evaluation
Rhinomanometry
Nasal resistance and nasal airflow were recorded of group 1 and group 2 patients by Rhinomanometry test before surgery, and the readings were compared with the readings of the postoperative period. The nasal resistance as well as nasal airflow of each nasal cavity, also the total value of both nasal resistance and airflow was noted. In group 1 patients, the mean resistance of left and right nasal cavity was 3.2 ± 2.2, and 4.2 ± 2.3, which decreased after surgery to 2.3 ± 1.2, and 2.6 ± 1.2, respectively, with p value < 0.001. The total resistance of Group 1 patient was 1.6 ± 0.6, which also decreased to 1.2 ± 0.6 (p < 0.001) (Table 5A).
Similarly, the findings of Group 2 patients were assessed and were observed that the nasal resistance of left and right nasal cavity before surgery was 4.72 ± 7.89 and 1.67 ± 1.89, which decreased after surgery to 1.8 ± 1.19 and 0.58 ± 0.45, respectively. The total resistance also decreased from 0.65 ± 0.45 before surgery to 0.30 ± 0.15 post-surgery (Table 5B).
The nasal airflow of group 1 patients before surgery of left and right nasal cavity was 196.4 ± 139.4 and 292.2 ± 214.9, which increased to 329.2 ± 167.9 and 382.2 ± 202, respectively. The total nasal airflow also improved from 385.9 ± 193.4 before surgery to 426.6 ± 204.9 after surgery (Table 5C).
Similarly, the nasal airflow of group 2 patients before surgery of left and right nasal cavity was 216.9 ± 154.2 and 258.4 ± 176.9, which increased to 250.6 ± 130.8 and 388.1 ± 208.3, respectively (p < 0.001). The total nasal airflow also improved from 356.1 ± 234.4 before surgery to 456.1 ± 219.3 after surgery (Table 5D).
It was observed that irrespective of the group, nasal resistance decreased in all cases, and nasal airflow improved in all the cases after surgery.
Discussion
In the past 20 years, the emphasis on aesthetic outcome has moved into the forefront, not just in plastic surgery but also in the field of facial plastic surgery (as a subspecialty of otorhinolaryngology).
The present study was based on the surgical outcome of 40 patients with crooked deformity of nose. Khullar and Nagar (2006) reported that maximum numbers of patients who had maxillofacial trauma were found in the age group of 20–30 years. In our study, 29 of the 40 patients were in the age group of 18–29 years. The highest incidence in this age group is due to the fact that this age group shows maximum activity in the sports, brawls, and high-speed transportation, and they also are more self-conscious, because of marriageable age [12]. Our observations are comparable with the mentioned study.
Erdam and Ozutran have mentioned that crooked nose is almost always associated with septal deviation [13]. In our study, we also found all 40 patients (100%) had deviated nasal septum.
As per Leong et al. (2008), the mean preoperative nasal deviation angle (NDAA) of the cohort was 35.28°. This angle was reduced to 9.98° (p = 0.001) following surgery, giving a 72 per cent reduction in the mean alignment deformity [6]. In our study, the mean NDAA in preoperative period in group 1 patients was 13.76 ± 5.08° and mean NDAA in postoperative period was 3.5 ± 1.7°. We achieved 74.5% reduction in deformity after surgery in group 1 patients (p < 0.001), whereas in group 2, the mean NDAA in preoperative period was 14.79 ± 3.92° and mean NDAA in postoperative period was 3.06 ± 0.83°, achieving 79.3% reduction in deformity.
Radulesco et al. [8] in 2017 mentioned that all patients in their study experienced improvement in ROE score from an average of 7.5/24 to 18/24. Esteves et al in a separate study on 110 patients also noted that 100% of patients had a higher ROE score after surgery, showing that all patients were more satisfied after the rhinoplasty [14]. Our findings were somewhat consistent with this study and we also found that ROE score improved in all of the patients irrespective of the group. However, there were 3 patients in group 1, and 1 patient in group 2 who had an improvement in ROE score but the score remained below 12 reflecting patients’ some dissatisfaction regarding the aesthetics of their noses. In our study, we have observed an important point that there is difference in surgeon and patient’s satisfaction in terms of aesthetic outcome. This is due to the stubborn concealed human desire of patient wherein the patient not just wants an improved nose but also a perfect nose. We have observed that irrespective of how more or less a patient’s preoperative nose is crooked in shape, they believe that every small or big fault in their noses will be corrected by surgery and they will have an absolutely new flawless nose. This hidden desire of attaining a perfect celebrity type nose leads to development of a hindrance to retrieve a proper unbiased response from the patient. And despite regular patient counselling throughout the treatment, we still speculate that this variable is very difficult to control or abolish, and might alter an unbiased response from the patient. But still, the ROE scale enables an accurate subjective analysis of cosmetic results and quality of life, and has been used and validated in the literature.
Our observations are comparable with the study conducted by Radulesco et al that NOSE score in their study showed statistically significant difference between the preoperative and postoperative values. The average NOSE score noted by them before surgery was 72.5/100. After surgery, it was 22/100 [8]. In our study also, both the groups of patients showed statistically significant difference between the preoperative and postoperative values of NOSE score with significant reduction in score in both groups.
Zahedi et al. [15] in their study mentioned that there were improvements in the nasal resistance during inspiration and expiration in both nasal cavities. Improvement in values of nasal airflow and decrease in the nasal resistance postoperatively can be explained by the correction of septal deformity. Straightening of septum leads to removal of the mechanical blockage, whereas spreader graft helps in patients with concomitant problem of nasal valve collapse.
Jessen and colleagues evaluated the effect of rhinomanometry on 92 patients undergoing rhinoplasty. Rhinomanometry findings revealed an improvement among 56 patients with midline deviation and in 36 patients without any septal deviation [16]. In the study conducted by Broms, Johnson and Malm, comparison of preoperative and postoperative nasal airway resistance showed that there was a significant decrease in total nasal airway resistance (p < 0.01) after functional septoplasty [17]. This is in concordance with our study as we also found that there was reduction in nasal resistance and improvement in nasal airflow in both groups.
Gurlek et al. [18] believed that nasal spreader grafts were not only useful in improving internal nasal valve but they also help in creating pleasant dorsal-nasal lines. While most patients of both groups experienced good results after surgery, we observed that patients in group 2 were more satisfied than group 1 with their aesthetic as well as functional outcome. This is because of the fact that septorhinoplasty in their group comprised of septoplasty that corrected the deviated septum, triple osteotomies that took care of the crooked nasal shape, and spreader graft placement that not just took care of the nasal valve insufficiency but also helped in achieving pleasant nasal dorsal lines which looked aesthetically way more superior.
To our knowledge, we found that there is no data available, and ours is the only study concerning a thorough evaluation of septorhinoplasty where a complete subjective and objective evaluation of functional and aesthetic results of two mentioned techniques is illustrated.
Conclusion
It is very well known to the authors that both osteotomies as well as spreader grafts carry an individual important role in correcting the external nasal deformity. In the hands of experienced rhinoplasty surgeons, isolated osteotomies or combining osteotomies with spreader grafts can give equally good result, and also that many experienced rhinoplasty surgeons can debate in favour or against of this topic. Keeping this is mind, our study concludes that while both techniques improved function as well as cosmetic appearance of nose in both groups, the patients of group 2 who had undergone septoplasty with bilateral triple osteotomies and spreader graft placement were more satisfied in terms of not just the aesthetic appearance of nose but also the breathing function. We suggest that these superior results in group 2 patients were because of the additional step of placement of spreader grafts which not just helped in widening the internal nasal valve area resulting in better breathing, but they also helped in giving a strong support to the nasal dorsum and also aesthetically superior looking nasal dorsum lines which enhances the beauty of the nose and the face.
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Ethical clearance from the institute was taken vide no. IEC/91/14. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Hernot, S., Agrawal, A., Kaintura, M. et al. A Comparative Study of Isolated Osteotomies Versus Osteotomies with Spreader Graft Placement to Correct Primary Deviated Nose. Aesth Plast Surg 46, 818–829 (2022). https://doi.org/10.1007/s00266-021-02531-w
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DOI: https://doi.org/10.1007/s00266-021-02531-w