Abstract
Background
Alloplastic materials in facial surgery have been used successfully for various applications in the reconstructive restoration or aesthetic augmentation of the facial skeleton. The objective of this study was to conduct a comprehensive systematic review of alloplastic implant materials utilized to augment the facial skeleton stratified by anatomical distribution, indication, specific material used, and respective outcomes.
Methods
A comprehensive systematic review on alloplastic facial implant data was conducted utilizing Medline/PubMed database. Articles were stratified by (1) anatomic localization in the face, as well as (2) alloplastic material.
Results
A total of 17 studies (n = 2100 patients, follow-up range = 1 month–27 years) were included. Overall, mersilene mesh implants were associated with the highest risk of infection (3.38%). Methyl methacrylate implants were associated with the highest rate of hematoma (5.98%). Implants placed in the malar region (2.67%) and frontal bones (2.50%) were associated with the highest rates of infection. Implants placed in the periorbital region were associated with the highest rate of inflammation (8.0%), explantation (8.0%), and poor cosmetic outcome (17.0%). Porous implants were shown to be more likely to potentiate infection than non-porous implant types.
Conclusions
Alloplastic facial implants are a reliable means of restoring facial symmetry and achieving facial skeletal augmentation with a relatively low complication profile. It is important for plastic surgeons to understand the relative risks for each type of implant to develop postoperative complications or poor long-term cosmetic results. Interestingly, porous implants were shown to be more likely to potentiate infection than non-porous implant types.
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Introduction
Facial implants are used in a variety of applications including post-traumatic reconstruction, correction of congenital abnormalities, and aesthetic augmentation or enhancement [1]. Commonly augmented facial sites include the nasal dorsum, malar eminence, and chin, in diverse applications that include rhinoplasty, orbital floor reconstruction, and augmentation of the facial skeleton [2]. While facial skeletal augmentation was traditionally achieved by utilizing autogenous bone grafts, advancements in materials engineering have allowed for the development of alloplastic materials better suited for certain surgical applications. These alloplastic facial implants offer a variety of advantages, including increased implant availability and the avoidance of donor-site morbidities seen with autogenous bone grafts such as scar alopecia and graft resorption [3]. The use of alloplastic facial implants may also offer the surgeon a number of advantages by avoiding difficulties in graft shaping that may result in increased surgical time and complexity [1].
Despite these advantages, alloplastic facial implants are not without their problems. Though a variety of implant material types exist, the ideal implant should possess a balance between structural integrity and pliability, and should be bioinert, to avoid inflammation [1, 2]. The absence of any one of these characteristics may result in complications which include postoperative infection or inflammation, graft explantation or migration, local hematoma or wound dehiscence, and ultimately poor cosmetic outcome. For example, implants made of porous materials such as porous high-density polyethylene (pHDPE) allow for the promotion of tissue ingrowth, but may also allow a site for bacteria to evade the host immune surveillance [2, 4]. Alternatively, uniformly solid implants that do not promote tissue growth may result in fibrotic encapsulation or migration of the implant [1]. For this reason, certain types of facial implants may be better suited based on procedure or anatomical site.
Though complications associated with alloplastic implants are well documented, studies have shown discrepancy regarding the rate of complications associated with certain implants [5,6,7,8]. A comprehensive analysis of facial implant complication rates and how they affect aesthetic outcome is essential. In this study, the authors conduct a systematic review and meta-analysis of pooled data of alloplastic implant materials utilized to augment the facial skeleton stratified by anatomical distribution, indication, specific material used, and respective outcomes.
Methods
Search Strategy
Two authors (first author and second author) independently conducted the electronic searches using Ovid Medline/PubMed database without timeframe limitations. Disagreements in regard to article identification and final selection for inclusion in this pooled analysis of the literature were resolved by the senior author. The following were used as either keywords or Medical Subject Headings (MeSH) in all combinations in the search strategy: [(alloplastic) AND face] and [(implant) AND (alloplastic) AND face]. The compiled reference lists were compared and reviewed for potential relevance. The bibliographies of included studies were also searched for articles not acquired through initial search queries. After all authors had completed systematic literature review, additional verification utilizing a medical librarian trained in systematic reviews was requested and received to ensure the most comprehensive review of all published studies meeting these criteria was performed. This study complied with the guidelines outlined in the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA). See Fig. 1 (flow chart).
Selection Criteria
Eligibility criteria included the following: clinical outcomes studies reporting data from alloplastic materials with anatomic localization in the face, including the zygoma, nose, mandible, orbit, frontal bone, maxilla, and glabella, for either reconstructive or aesthetic indications. Abstracts, presentations, non-English language papers, animal studies, non-clinical studies, ex vivo studies, reviews, meta-analyses, and single case reports were excluded.
Data Extraction and Processing
The extracted data included demographics, such as year of study, study design, country, follow-up duration, anatomical localization of alloplastic material, and surgical complications (including infection, inflammation, graft migration, need for explantation, hematoma, wound dehiscence, and cosmetic outcome). Data extraction from articles, tables, and figures was performed by one reviewer (second author) with accuracy of data entry confirmed by an additional reviewer (first author).
Analysis was designed to compare outcomes between (1) each alloplastic material studied and (2) different materials stratified by anatomical location in the face.
Results
A total of 2100 patients were featured in 17 case series [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25] (follow-up range 1 month–27 years) (Table 1). The alloplastic implants analyzed were found to have an overall complication rate of 10.03% across all procedures and materials used. The most common overall complication was poor-reported aesthetic outcome with a pooled rate of 3.62%.
Overall, mersilene mesh implants were associated with the highest risk of infection (3.38%) followed by methyl methacrylate (2.43%) and silicone (1.58%). Methyl methacrylate implants were associated with the highest rate of hematoma (5.98%). Over half of all patients (21/41) requiring graft explantation received mersilene mesh implants; 12 received silicone implants. Migration was only reported in silicone and mersilene mesh implants. Only one patient with a silicone implant and two with Medpor implants were found to have postoperative wound dehiscence. Poor cosmetic outcomes had the highest rates respective to number of patients with Lactosorb, irradiated cartilage, and methyl methacrylate. The largest number of patients experiencing aesthetic complications was with methyl methacrylate (n = 28), followed by Medpor, mersilene mesh, and silicone (Table 2).
With regard to location, infection rates were highest in malar (2.67%), frontal (2.5%), and nasal (1.5%) implants in our analysis of pooled data from the literature. Inflammation was also reported in 13 (2.5%) patients with frontal implants. Orbital implants reported an 8% rate of inflammation and graft explantation. After orbital implant explantation, the next most common locations for explant were in nasal (2.38%) and mandibular (1.83%) implants. Migration was only noted as a complication in mandibular implants (1.08%), one of the less commonly reported complications overall. Implants placed in the frontal bone region reported a 6% (n = 32) likelihood of hematoma postoperatively. Wound dehiscence most often occurred with nasal implants (0.63%). The anatomic locations with the highest rates of poor aesthetic outcomes were orbital (17%), frontal (5.2%), and nasal (4.5%) (Table 3). Interestingly, porous implants were shown to be more likely to potentiate infection than non-porous implant types.
For completion, Supplemental Table 4 includes a listing of data collected from all case reports identified in the literature [26,27,28,29,30,31,32,33,34,35,36,37,38] as well as other case series that did not meet study inclusion criteria reporting outcomes in alloplastic facial implants, although we did not include these in our pooled data analysis.
See Figs. 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 and 17 for illustrative examples of alloplastic facial implants commonly used in facial skeletal augmentation.
Discussion
Though autogenous bone transfer has long been utilized in a variety of applications involving facial reconstruction and aesthetic enhancement, limitations in tissue supply and associated morbidities such as graft resorption and scar alopecia have resulted in the development of a number of alloplastic implants [39]. As various types of alloplastic facial implants exist, factors that influence selection of alloplastic implant material include site and type of surgery, desired aesthetic outcome, and risk of complications. In this study, the authors performed a systematic review of alloplastic implant materials utilized in the face stratified by anatomical distribution, indication, specific material used, and respective outcomes.
To avoid excessive tissue inflammation, the ideal alloplastic implant should have excellent biocompatibility and should thus retain characteristics of the tissue it replaces or augments. The proper implant should therefore be non-allergenic, non-carcinogenic, and designed so that even in the setting of implant degradation, any associated breakdown products remain non-toxic [39]. However, even a well-tolerated alloplastic implant will function as a foreign body and thus evoke a response by the host. Soon after implantation, host proteins adhere to the surface of the implant, denature, and precipitate an inflammatory response characterized by local infiltration of inflammatory mediators and resultant collagen deposition on and around the implant [40]. Uncontrolled or persistent inflammatory response may result in further morbidity surrounding the implantation site. For example, silicone and methyl methacrylate implants have both been shown to cause significant bone resorption surrounding the site of implantation as well as thinning of the overlying skin [1, 41,42,43]. In one case series, 75% (n = 9/12) of silicone implants used for mandibular augmentation resulted in significant mandibular resorption [44]. This bone resorption is thought to be the result of a foreign body giant cell reaction that occurs between the implant and the bone, as well as, in the case of mandibular implants, pressure placed on the implant by the mentalis muscle. Due to the use of newer implants designed and placed to extend pressure over a greater anatomic surface area, significant bone resorption has become a less common complication though minimal self-limiting bone erosion continues to be a common result of the use of alloplastic implants [2]. Due to its significant inflammatory burden as well as other possible complications including extrusion, translucency and displacement, silicone is infrequently used for augmentation of facial areas other than the mandible, though solid silicone rubber, or Silastic, has been well documented in nasal augmentation procedures within Eastern societies [45,46,47]. In our review, silicone presented a minimal but not insubstantial inflammatory burden (0.33%; 1/443). Some reports state that methyl methacrylate has also been shown to cause significant bone resorption, though this is non-uniform with other reports crediting methyl methacrylate for its limited inflammatory potential [1, 39, 42, 48]. Methyl methacrylate was associated in this review with a relatively higher rate of inflammation (2.50%; n = 13/535). Lactosorb was also associated with a higher rate of inflammation (8%; n = 1/12), though this finding was limited to one study. More research is required to further elucidate the inflammatory potential of Lactosorb implants. Frontal implants were associated with an increased risk of inflammation (2.50%, n = 13/535) as well as poor overall cosmetic outcome (5.20%, n = 28/535). Inflammation and poor cosmetic outcome were also prevalent in orbital implants, though these findings were limited to one small case series.
Infection imposes a significant risk to early implant failure. Thus, the ideal implant should also maintain characteristics that limit invasion of the implant by microbial agents and maximize the host’s ability to combat infections that may arise [39]. Porous materials such as polytetrafluoroethylene, mesh-type materials, and hydroxyapatite are often used to design implants because they promote ingrowth of host tissue into the implant and may offer a decreased risk of implant migration [1, 4]. However, the presence of pores in the implant may also offer an increased risk of microbial invasion and resultant infection. Pore size is thought to be a determining factor for risk of infection. While a pore size of over 1 µm allows for the penetration of the pore by microbial substances, a pore size of over 50 µm is necessary for the penetration of the pore by host macrophages and other immune mediators. Thus, pore sizes between 1 and 50 µm may theoretically impose a more serious burden of infection as this would allow for invasion by bacterial mediators but not host immune cells [2, 39]. It is also thought that surface irregularity on the implant may confer additional energy that results in the increased adhesion of bacteria and other inflammatory mediators [2]. Disagreement exists whether porous implants potentiate infection over their solid counterparts [39, 49]. For example, reports have cited infection and inflammation as common complications associated with polytetrafluoroethylene implants, which feature microporous architecture composed of pores between 10 and 30 µm [45]. Conversely, it has also been reported that solid implants that do not promote tissue ingrowth, such as silicone, may increase risk of infection due to the formation of dead space between the graft and surrounding host tissues [50]. In our study, some, but not all, porous materials were associated with higher rates of infection. The alloplastic implant with the highest associated infection rate was mersilene resorbable mesh (3.40%, n = 18/533). Increased infection rate was also found in other porous materials such as methyl methacrylate (2.50%, n = 13/535), polytetrafluoroethylene (3%, n = 1/35), and Medpor (high-density polyethylene) (0.57%, n = 3/257). Though non-porous, silicone was associated with an infection rate of 1.67% (n = 7/443). In regard to location, the highest rate of infection was noted in patients receiving malar implants (2.67%, n = 3/123). The increased risk of complications associated with malar implants in comparison with other facial implants has been attributed to the observation that patients usually receive two malar implants, rather than the one implant obtained for, say, an isolated chin implant [2]. It has also been hypothesized that the thin wall of the anterior maxilla may provide a site of possible erosion of the implants, further increasing risk of infection [51].
Fixation of the implant is important for a number of reasons beyond maintaining aesthetic value. Continued movement of the implant within the tissue may cause continued tissue injury with resultant local inflammation and edema. Migration of the implant may also leave spaces between the implant and surrounding tissue that may serve as a space for hematoma, seroma, or microbial invasion and infection [2, 51]. The same porous characteristics thought to promote infection are also thought to promote fibrous ingrowth of host collagen into the implant, which lends to implant stability. Namely, the presence of pores greater than 50 µm in size allows for the migration of inflammatory mediators necessary for tissue ingrowth [39, 52]. If fibrous ingrowth does not occur, the implant can become encapsulated, which lends to easier migration of the implant within the tissue. Therefore, smooth non-porous implants such as silicone have been associated with higher rates of migration [42]. Other factors influencing migration within the tissue include implant shape and method of fixation [53]. In our review, migration was a relatively rare complication, but seen with both non-porous silicone (0.83%, n = 4/443) and porous mersilene resorbable mesh (0.75%, n = 4/533). Of note, migration was only seen as a complication in patients receiving mandibular implants (1.08%, n = 7/623), though reports reveal that migration may also be commonly associated with nasal implants [46]. Increased migration of mandibular implants may be a result of increased use of silicone materials within the area as well as increased influence of surrounding muscle on mandibular implants. More research may be required to elucidate the effects of porous architecture and on implant migration.
As with all systematic reviews, this study has several limitations. First, the cumulative outcomes analyzed were only as complete and accurate as each individual study included. Not all outcomes of interest were often available or mentioned despite large case volumes. Another limitation was the lack of large-volume studies across all implant types; thus, we felt that thorough statistical analyses could not be performed, as any conclusions drawn from such a deep statistical analysis would not be powered by the numbers reported. Additionally, while the primary objective of this particular study was to identify implant types which augment the bony skeletal features of the face, we recognize that there are other implants in the facial region (e.g., lip implants) which were not included in this analysis. Nevertheless, we feel that our study reports valuable pooled data, particularly pertaining to relative complication rates among material types and anatomic locations.
An important limitation of the reported results of this study is the relative quality and quantity of complications data published by our colleagues in all regions of the globe. For example, we are known that nasal implants are very often inserted for depressed middle vault defects in a diverse ethnic demographic; however, there are concerns that the accurate incidence of actual complications resulting from such implant placements may not be readily available in the primary literature for inclusion in this study. Thus, we must accept this as a weakness of our analysis based upon the paucity of literature available on complications.
It is a limitation of systematic review to adapt the language and categories that the included studies use. It is likely that more studies remain involving outcomes in alloplastic facial implants outside the scope of English language literature. Furthermore, there is a potential for bias in interpreting the data reported in each study, as it is possible that not all studies captured reliable comorbidity data or outcomes over a long period of time. Follow-up times are also a limitation of the study, as follow-up was limited to what the literature allows for follow-up measures. Also for this reason, we felt it prudent to avoid meta-analytic statistical measures to draw firm conclusions on the associations drawn from this study. Larger, randomized, multicenter studies are warranted to validate the associations found from this systematic review of the literature.
Conclusions
This study reaffirms that alloplastic facial implants are a reliable means of restoring facial symmetry and achieving facial skeletal augmentation with a relatively low complication profile across all implant types. The results of this systematic review indicated that some, but not all, porous materials were associated with higher rates of infection, a previously debated topic among surgeons. Furthermore, the results indicated migration to be a rarely reported complication of facial implant placement, equally reported in both porous and non-porous implant types. It is important for plastic surgeons to understand the relative risks for each type of implant to develop postoperative complications or poor long-term cosmetic results.
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Oliver, J.D., Eells, A.C., Saba, E.S. et al. Alloplastic Facial Implants: A Systematic Review and Meta-Analysis on Outcomes and Uses in Aesthetic and Reconstructive Plastic Surgery. Aesth Plast Surg 43, 625–636 (2019). https://doi.org/10.1007/s00266-019-01370-0
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DOI: https://doi.org/10.1007/s00266-019-01370-0