Abstract
Hydroxyapatite (HA) nanopowders were synthesized at 70°C by a co-precipitation method using slaked lime and phosphoric acid solution at different pH values. Ammonia was used to adjust the pH of the aquatic media during synthesis. The prepared powders were dried overnight at 100°C and characterized for their phase composition using Fourier transform infrared spectroscopy (IR) and X-ray diffraction (XRD). Selected powder prepared at pH 11 was used for some investigations for its microstructural features as elucidated by transmission and scanning electron microscopy (TEM, SEM) and then sintered at different temperatures from 1000 to 1250°C to determine its bulk density and apparent porosity of sintered bodies. Results indicated that hydroxyapatite nanopowder was successfully prepared by co-precipitation. A dense microstructure with grain growth of the hydroxyapatite was detected when its sintering temperature was increased. The prepared hydroxyapatite was thermally stable upon heating up to 1100°C; whereas above 1100°C it was slightly dissociated into β-tricalcium phosphate (β-TCP) and CaO. At 1200°C the β-tricalcium phosphate (β-TCP) formed was converted to the α-tricalcium phosphate phase (α-TCP), which was again reconverted to hydroxyapatite and almost dissociated at 1250°C.
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References
Williams, D.F.: The Williams dictionary of biomaterials. Liverpool University Press, Liverpool, UK, (1999) 368–337
Aoki, H.: Science and medical applications of hydroxyapatite. Takayama Press, Tokyo, Japan, (1991)
Driessens, F.C.M. (Ed.).: Bioceramics of calcium phosphates. CRC Press, Boca Raton, FL, (1983)
Prashant, K.N., Sfeir, C., Lee, D.H., Olton, D., Choi, D.: Nanostructured calcium phosphates for biomedical applications: Novel synthesis and characterization. Acta Biomaterialia 1 (2005) 65–83
Elliott J.C.: Structure and chemistry of the apatites and other calcium orthophosphate. Elsevier, Amsterdam, London (1994)
Rodriguez-Lorenzo, L.M., Vallet-Regi, M., Ferreira, J.M.F.: Fabrication of hydroxyapatite bodies by uniaxial pressing from a precipitated powder. Biomaterials 22 (2001) 583–588
Suchanek, W., Yoshimura, M.: Processing and properties of hydroxyapatite: Based biomaterials for use as hard tissue replacement implants. J. Mater. Res. 13 (1998) [1] 94–117
Kanazawa, T.: Hydroxyapatite. In: Inorganic phosphate materials. Materials Science Monographs, Elsevier, Tokyo, 52 (1989) 30
Hench, L.L.: Bioceramics: From concept to clinic. J. Am. Ceram. Soc. 74 (1991) 1487–1510
Liu, Y., Hou, D., Wang, G.: A simple wet chemical synthesis and characterization of hydroxyapatite nanorods. Mater. Chem. and Phys. 86 (2004) 69–73
Kim, W., Zhang, Q.W., Saito, F.: Mechanochemical synthesis of hydroxyapatite from Ca(OH)2-P2O5 and CaO-Ca(OH)2-P2O5. J. Mater. Sci. 35 (2000) 5401–5405
Tas, A.C.: Combustion synthesis of calcium phosphate bioceramic powders. J. Eur. Ceram. Soc. 20 (2000) 2389–2394
Jarcho, M., Bolen, C.H., Thomas, M.B., Bobick, J., Kay, J.F., Doremus, R.H.: Hydroxyapatite synthesis and characterization in dense polycrystalline form. J. Mater. Sci. 11 (1976) 2027–2035
Huang, L.Y., Xu, K.W., Lu, J.: A study of the process and kinetics of electrochemical deposition and the hydrothermal synthesis of hydroxyapatite coatings. J. Mater. Sci. Mater. Med. 11 (2000) 667–673
Weng, W.J., Baptista, J.L.: Alkoxide route for preparing hydroxyapatite and its coatings. Biomaterials 19 (1998) 125–131
Katsuki, H., Furuta, S., Komarneni, S.: Microwave versus conventional hydrothermal synthesis of hydroxyapatite crystals from Gypsum. J. Am. Ceram. Soc. 82 (1999) 2257–2259
Lim, G.K., Wang, J., Ng, S.C., Gan, L.M.: Formation of nanocrystalline hydroxyapatite in non-ionic surfactant emulsions. Langmuir 15 (1999) 7472–7477
Pang, Y.X., Bao, X.: Influence of temperature, ripening time and calcination on the morphology and crystallinity of hydroxyapatite nanoparticles. J. Eur. Ceram. Soc. 23 (2003) 1697–1704
Varma, H.K., Babu, S.S.: Synthesis of calcium phosphate bioceramics by citrate gel pyrolysis method. Ceram. Int. 31 (2005) 109–114
Joris, S.J., Amberg, C.H.: Nature of deficiency in nonstoichiometric hydroxyapatites. II. Spectroscopic studies of calcium and strontium hydroxyapatites. J. Phys. Chem. 75 (1971) 3172–3178
Fowler, B.O.: Infrared spectra of apatite. In: W.E. Brown, R.A. Young (Eds.), International Symposium on Structural Properties of Hydroxyapatite and Related Compounds, Chapter 7, Gaithersburg, MD, (1968), unpublished, but copies of Chapter 7 are available from B.O. Fowler
Ishikawa, T., Wakamura, M., Kondo, S.: Surface characterization of calcium hydroxylapatite by Fourier transform infrared spectroscopy. Langmuir 5 (1989) 140–144
Monma, H., Ueno, S., Kanazawa, T.: Properties of hydroxyapatite prepared by the hydrolysis of tricalcium phosphate. J. Chem. Tech. Biotechnol. 31 (1981) 15–24
Bouyer, E., Gitzhofer, F., Boulos, M.I.: Morphological study of hydroxyapatite nanocrystal suspension. J. Mater. Sci. Mater. Med. 11 (2000) 523–531
Fathi, M.H., Hanifia, A., Mortazavi, V.B.: Preparation and bioactivity evaluation of bone-like hydroxyapatite nanopowder. J. Mater. Proc. Tech. 202 (2008) 536–542
Ryu, H.S., Youn, H.J., Hong, K.S., Chang, B.S., Lee, C.K., Chung, S.S.: An improvement in sintering property of β-tricalcium phosphate by addition of calcium pyrophosphate. Biomaterials 23 (2002) 909–914
Wang, J., Shaw, L.: Morphology enhanced low temperature sintering of nanocrystalline hydroxyapatite. Adv. Mater. 19 (2007) [2] 364–369
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Khalil, A.A., Zawrah, M.F., Saad, E.A. et al. Synthesis and Properties of Hydroxyapatite Nanorods. Interceram. - Int. Ceram. Rev. 64, 358–362 (2015). https://doi.org/10.1007/BF03401143
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DOI: https://doi.org/10.1007/BF03401143