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Exploring the Human USP Gene Family and Its Association with Cancer: An In Silico Study

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Advances in Data Science and Computing Technologies (ADSC 2022)

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 1056))

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Abstract

Ubiquitin-specific proteases (USPs) play a major role in the progression of cancers. In this chapter, the presence and relative abundance of paralogous genes in the USP family were studied along with their respective interaction patterns. The effect of the gene duplication events on the overall gene expression in various cancer types was also investigated. Functional divergence of the paralogous genes was evaluated and their corresponding evolution rates were also determined. It was found that the USP family contains an abundance of paralogous genes, among which most paralogous gene pairs display diverging functionalities. Furthermore, higher proportions of genes that promote cancer exist and are thus, implicated in a larger number of protein–protein interaction networks. Also, gene duplication events that lead to the production of noncancerous paralogs were observed to be preferred in this family. Lastly, it was observed that the group of paralogs which display different roles in cancer has the highest rate of evolution among all other paralogs. This evolutionary investigation would provide a further insight into the interconnection of the USP family with the JAK-STAT pathway as well as would inhibit tumorigenesis.

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Acknowledgements

Authors are thankful to the Ms. Alankar Roy (Enrollment no: A91704120067) from Amity Institute of Biotechnology, Amity University, Kolkata for the support. Authors are also grateful to Department of Biochemistry and Biophysics, University of Kalyani, West Bengal for the cooperation.

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Authors and Affiliations

  1. Amity Institute of Biotechnology, Amity University, Kolkata, India

    Sujay Ray

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Arundhati Banerjee

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  1. Sujay Ray
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  2. Arundhati Banerjee
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Correspondence to Sujay Ray .

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Editors and Affiliations

  1. School of Computing, Madanapalle Institute of Technology and Science, Angallu, Andhra Pradesh, India

    Basabi Chakraborty

  2. Kazi Nazrul University, Asansol, West Bengal, India

    Arindam Biswas

  3. A.K. Choudhury School of Information Technology, University of Calcutta, Kolkata, West Bengal, India

    Amlan Chakrabarti

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Ray, S., Banerjee, A. (2023). Exploring the Human USP Gene Family and Its Association with Cancer: An In Silico Study. In: Chakraborty, B., Biswas, A., Chakrabarti, A. (eds) Advances in Data Science and Computing Technologies. ADSC 2022. Lecture Notes in Electrical Engineering, vol 1056. Springer, Singapore. https://doi.org/10.1007/978-981-99-3656-4_70

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