Abstract
Cancer has become a serious public health problem worldwide. The selection of applicable experimental animal models is essential for the transfer of basic scientific knowledge about cancer in treatment interventions in humans. In vivo analysis is essential for the life science, especially for the development of diagnostic drugs. Mouse-supported cancer models are known to be widely used in cancer research. Mouse models have transformed the ability to study in vivo gene and protein activities and gain a deeper knowledge of their molecular pathways and processes. Grafts, including chemically or genetically modified mouse tumors, are the most used rodent cancer models.
This chapter describes the most common cancer animal models and therapeutic molecular targets focusing their compatibility and shortcomings.
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Hritcu, L., Cioanca, O. (2022). Therapeutic Molecular Targets of Cancer and Animal Models: Adequacy and Drawbacks. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-1282-5_42-1
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