Abstract
Epidemiological classification of methicillin-resistant Staphylococcus aureus (MRSA) as hospital-associated MRSA (HA-MRSA), community-associated MRSA (CA-MRSA), and livestock-associated MRSA (LA-MRSA) has become more complex and unclear. Nevertheless, the global burden of LA-MRSA and its clinical complications have been increased to unprecedented levels. The improper use of antibiotics contributed to the emergence of MRSA in the livestock sector. Apart from infections, asymptomatic colonization of MRSA in humans and animals can result in the humanosis and/or zoonosis. The LA-MRSA studies drew attention because of its unique properties of harboring the mecC locus (an analogue of mecA) as the methicillin resistance determinant and varying staphylococcal cassette chromosome mec (SCCmec) elements. The peculiar feature of LA-MRSA which is non-typeable by SmaI-pulsed-field gel electrophoresis (SmaI-PFGE) has opened different vistas in LA-MRSA research. The present chapter focused on the prevalence, history of evolution, clonal expansion, and epidemiological characteristics of LA-MRSA from global perspectives. Concerted efforts were made to encompass the major aspects of LA-MRSA by analyzing the related studies. Over the years, LA-MRSA gained special attention owing to its widespread and zoonotic potential.
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Aklilu, E., & Hui Ying, C. (2020). First mecC and mecA positive livestock-associated Methicillin resistant Staphylococcus aureus (mecC MRSA/LA-MRSA) from dairy cattle in Malaysia. Microorganisms, 8(2), 147.
Alba, P., Feltrin, F., Cordaro, G., Porrero, M. C., Kraushaar, B., Argudín, M. A., Nykäsenoja, S., Monaco, M., Stegger, M., Aarestrup, F. M., & Butaye, P. (2015). Livestock-associated methicillin resistant and methicillin susceptible Staphylococcus aureus sequence type (CC) 1 in European farmed animals: High genetic relatedness of isolates from Italian cattle herds and humans. PloS one, 10(8), e0137143.
Argudín, M. A., Rodicio, M. R., & Guerra, B. (2010). The emerging methicillin-resistant Staphylococcus aureus ST398 clone can easily be typed using the Cfr9I SmaI-neoschizomer. Letters in Applied Microbiology, 50(1), 127–130.
Armand-Lefevre, L., Ruimy, R., & Andremont, A. (2005). Clonal comparison of Staphylococcus aureus isolates from healthy pig farmers, human controls, and pigs. Emerging Infectious Diseases, 11(5), 711.
Aspiroz, C., Lozano, C., Vindel, A., Lasarte, J. J., Zarazaga, M., & Torres, C. (2010). Skin lesion caused by ST398 and ST1 MRSA, Spain. Emerging Infectious Diseases, 16(1), 157.
Basanisi, M. G., La Bella, G., Nobili, G., Franconieri, I., & La Salandra, G. (2017). Genotyping of methicillin-resistant Staphylococcus aureus (MRSA) isolated from milk and dairy products in South Italy. Food Microbiology, 62, 141–146.
Battisti, A., Franco, A., Merialdi, G., Hasman, H., Iurescia, M., Lorenzetti, R., Feltrin, F., Zini, M., & Aarestrup, F. M. (2010). Heterogeneity among methicillin-resistant Staphylococcus aureus from Italian pig finishing holdings. Veterinary Microbiology, 142(3–4), 361–366.
Bens, C. C., Voss, A., & Klaassen, C. H. (2006). Presence of a novel DNA methylation enzyme in methicillin-resistant Staphylococcus aureus isolates associated with pig farming leads to uninterpretable results in standard pulsed-field gel electrophoresis analysis. Journal of Clinical Microbiology, 44(5), 1875–1876.
Boswihi, S. S., Udo, E. E., Mathew, B., Noronha, B., Verghese, T., & Tappa, S. B. (2020). Livestock-associated methicillin-resistant Staphylococcus aureus in patients admitted to Kuwait Hospitals in 2016–2017. Frontiers in Microbiology, 10, 2912.
Butaye, P., Argudín, M. A., & Smith, T. C. (2016). Livestock-associated MRSA and its current evolution. Current Clinical Microbiology Reports, 3(1), 19–31.
Cardoso, M., & Schwarz, S. (1992). Chloramphenicol resistance plasmids in Staphylococcus aureus isolated from bovine subclinical mastitis. Veterinary Microbiology, 30(2–3), 223–232.
Chandrasekaran, D., Venkatesan, P., Tirumurugaan, K. G., Gowri, B., Subapriya, S., & Thirunavukkarasu, S. (2014). Sub-acute mastitis associated with Methicillin Resistant Staphylococcus aureus in a cow: A case report. Journal of Advanced Veterinary and Animal Research, 1(4), 235–237.
Chaturvedi, R., & Kumar, Y. (2017). Prevalence of Staphylococcus aureus in bulk tank milk collected from dairies of district Allahabad India. International Journal of Current Microbiology and Applied Science, 6, 1297–1303.
Chen, C., & Wu, F. (2020). Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) colonisation and infection among livestock workers and veterinarians: A systematic review and meta-analysis. Occupational and Environmental Medicine.
Chopra, I., & Roberts, M. (2001). Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiology and Molecular Biology Reviews, 65(2), 232–260.
Chuang, Y. Y., & Huang, Y. C. (2015). Livestock-associated meticillin-resistant Staphylococcus aureus in Asia: An emerging issue? International Journal of Antimicrobial Agents, 45(4), 334–340.
Cuny, C., Köck, R., & Witte, W. (2013). Livestock associated MRSA (LA-MRSA) and its relevance for humans in Germany. International Journal of Medical Microbiology, 303(6–7), 331–337.
Cuny, C., Wieler, L. H., & Witte, W. (2015). Livestock-associated MRSA: The impact on humans. Antibiotics, 4(4), 521–543.
Declercq, P., Petre, D., Gordts, B., & Voss, A. (2008). Complicated community-acquired soft tissue infection by MRSA from porcine origin. Infection, 36(6), 590–592.
DeLeo, F. R., Otto, M., Kreiswirth, B. N., & Chambers, H. F. (2010). Community-associated meticillin-resistant Staphylococcus aureus. The Lancet, 375(9725), 1557–1568.
Derbise, A., Dyke, K. G., & El Solh, N. (1996). Characterization of a Staphylococcus aureus Transposon, Tn5405, located within Tn5404 and carrying the aminoglycoside resistance genes, aphA-3 and aadE. Plasmid, 35(3), 174–188.
Dhup, V., Kearns, A. M., Pichon, B., & Foster, H. A. (2015). First report of identification of livestock-associated MRSA ST9 in retail meat in England. Epidemiology & Infection, 143(14), 2989–2992.
Dweba, C. C., Zishiri, O. T., & El Zowalaty, M. E. (2018). Methicillin-resistant Staphylococcus aureus: Livestock-associated, antimicrobial, and heavy metal resistance. Infection and Drug Resistance, 11, 2497.
Espinosa-Gongora, C., Moodley, A., Lipinska, U., Broens, E. M., Hermans, K., Butaye, P., Devriese, L. A., Haesebrouck, F., & Guardabassi, L. (2014). Phenotypes and genotypes of old and contemporary porcine strains indicate a temporal change in the S. aureus population structure in pigs. PLoS One, 9(7), e101988.
Feingold, B. J., Silbergeld, E. K., Curriero, F. C., van Cleef, B. A., Heck, M. E., & Kluytmans, J. A. (2012). Livestock density as risk factor for livestock-associated methicillin-resistant Staphylococcus aureus, The Netherlands. Emerging infectious diseases, 18(11), 1841.
Fernández, M., Conde, S., de la Torre, J., Molina-Santiago, C., Ramos, J. L., & Duque, E. (2012). Mechanisms of resistance to chloramphenicol in Pseudomonas putida KT2440. Antimicrobial Agents and Chemotherapy, 56(2), 1001–1009.
Feßler, A., Scott, C., Kadlec, K., Ehricht, R., Monecke, S., & Schwarz, S. (2010). Characterization of methicillin-resistant Staphylococcus aureus ST398 from cases of bovine mastitis. Journal of Antimicrobial Chemotherapy, 65(4), 619–625.
Feßler, A. T., Kadlec, K., Hassel, M., Hauschild, T., Eidam, C., Ehricht, R., Monecke, S., & Schwarz, S. (2011). Characterization of methicillin-resistant Staphylococcus aureus isolates from food and food products of poultry origin in Germany. Applied and Environmental Microbiology, 77(20), 7151–7157.
Ganai, A. W., Kotwal, S. K., Malik, M. A., Sharma, H. K., Wani, N., & Jeelani, R. (2015). Prevalence of Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus (MRSA) in clinical setting and dairy farm environment of Jammu. Journal of Animal Research, 5(3), 539.
Ganai, A. W., Kotwal, S. K., Wani, N., Malik, M. A., Jeelani, R. I. Z. W. A. N., Kour, S., & Zargar, R. (2016). Detection of mecA gene of methicillin resistant Staphylococcus aureus by PCR assay from raw milk. Indian Journal of Animal Sciences, 86(5), 508–511.
Gómez-Sanz, E., Torres, C., Lozano, C., Sáenz, Y., & Zarazaga, M. (2011). Detection and characterization of methicillin-resistant Staphylococcus pseudintermedius in healthy dogs in La Rioja, Spain. Comparative Immunology, Microbiology and Infectious Diseases, 34(5), 447–453.
Hamid, S., Bhat, M. A., Mir, I. A., Taku, A., Badroo, G. A., Nazki, S., & Malik, A. (2017). Phenotypic and genotypic characterization of methicillin-resistant Staphylococcus aureus from bovine mastitis. Veterinary World, 10(3), 363.
Harrison, E. M., Weinert, L. A., Holden, M. T., Welch, J. J., Wilson, K., Morgan, F. J., Harris, S. R., Loeffler, A., Boag, A. K., Peacock, S. J., & Paterson, G. K. (2014). A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals. MBio, 5(3).
Hartmeyer, G. N., Gahrn-Hansen, B., Skov, R. L., & Kolmos, H. J. (2010). Pig-associated methicillin-resistant Staphylococcus aureus: Family transmission and severe pneumonia in a newborn. Scandinavian Journal of Infectious Diseases, 42(4), 318–320.
Hauschild, T., Vuković, D., Dakić, I., Ježek, P., Djukić, S., Dimitrijević, V., Stepanović, S., & Schwarz, S. (2007). Aminoglycoside resistance in members of the Staphylococcus sciuri group. Microbial Drug Resistance, 13(2), 77–84.
Huijsdens, X. W., Van Dijke, B. J., Spalburg, E., van Santen-Verheuvel, M. G., Heck, M. E., Pluister, G. N., Voss, A., Wannet, W. J., & De Neeling, A. J. (2006). Community-acquired MRSA and pig-farming. Annals of Clinical Microbiology and Antimicrobials, 5(1), 1–4.
Ito, T., Katayama, Y., & Hiramatsu, K. (1999). Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrobial Agents and Chemotherapy, 43(6), 1449–1458.
Ito, T., Katayama, Y., Asada, K., Mori, N., Tsutsumimoto, K., Tiensasitorn, C., & Hiramatsu, K. (2001). Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 45(5), 1323–1336.
Ito, T., Ma, X. X., Takeuchi, F., Okuma, K., Yuzawa, H., & Hiramatsu, K. (2004). Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrobial Agents and Chemotherapy, 48(7), 2637–2651.
Juretzek, T., Porta, M. A., Buehling, A., Haubold, R., Pohle, M., Schwab, F., & Bär, W. (2011). Epidemiology of methicillin-resistant Staphylococcus aureus at hospital admission in South Brandenburg, Germany. International Journal of Medical Microbiology, 301, 100.
Kadlec, K., & Schwarz, S. (2009a). Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet (L). Antimicrobial Agents and Chemotherapy, 53(2), 776–778.
Kadlec, K., & Schwarz, S. (2009b). Novel ABC transporter gene, vga (C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. Antimicrobial Agents and Chemotherapy, 53(8), 3589–3591.
Khan, A. A., Ali, A., Tharmalingam, N., Mylonakis, E., & Zahra, R. (2020). First report of mecC gene in clinical methicillin resistant S. aureus (MRSA) from tertiary care hospital Islamabad, Pakistan. Journal of Infection and Public Health, 13(10), 1501–1507.
Krukowski, H., Bakuła, Z., Iskra, M., Olender, A., Bis-Wencel, H., & Jagielski, T. (2020). The first outbreak of methicillin-resistant Staphylococcus aureus in dairy cattle in Poland with evidence of on-farm and intrahousehold transmission. Journal of Dairy Science, 103(11), 10577–10584.
Kumar, R., Yadav, B. R., & Singh, R. S. (2010). Genetic determinants of antibiotic resistance in Staphylococcus aureus isolates from milk of mastitic crossbred cattle. Current Microbiology, 60(5), 379–386.
Kumar, R., Yadav, B. R., & Singh, R. S. (2011). Antibiotic resistance and pathogenicity factors in Staphylococcus aureus isolated from mastitic Sahiwal cattle. Journal of Biosciences, 36(1), 175–188.
Kutar, K., Verma, A. K., Sharma, B., Amit, K., & Yadav, S. K. (2015). Analysis of mecA gene and antibiotic resistance in Staphylococcus aureus isolates from bovine mastitis. Indian Journal of Comparative Microbiology, Immunology and Infectious Diseases, 36(1), 22–27.
Liu, Y., Li, W., Dong, Q., Liu, Y., & Ye, X. (2021). Livestock-associated and non-livestock-associated Staphylococcus aureus carriage in humans is associated with pig exposure in a dose–response manner. Infection and Drug Resistance, 14, 173.
Loncaric, I., Lepuschitz, S., Ruppitsch, W., Trstan, A., Andreadis, T., Bouchlis, N., Marbach, H., Schauer, B., Szostak, M. P., Feßler, A. T., & Künzel, F. (2019). Increased genetic diversity of methicillin-resistant Staphylococcus aureus (MRSA) isolated from companion animals. Veterinary Microbiology, 235, 118–126.
Lozano, C., Aspiroz, C., Charlez, L., Gomez-Sanz, E., Toledo, M., Zarazaga, M., & Torres, C. (2011). Skin lesion by methicillin-resistant Staphylococcus aureus ST398-t1451 in a Spanish pig farmer: Possible transmission from animals to humans. Vector-Borne and Zoonotic Diseases, 11(6), 605–607.
Ma, X. X., Ito, T., Tiensasitorn, C., Jamklang, M., Chongtrakool, P., Boyle-Vavra, S., Daum, R. S., & Hiramatsu, K. (2002). Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrobial Agents and Chemotherapy, 46(4), 1147–1152.
Magro, G., Rebolini, M., Beretta, D., & Piccinini, R. (2018). Methicillin-resistant Staphylococcus aureus CC22-MRSA-IV as an agent of dairy cow intramammary infections. Veterinary Microbiology, 227, 29–33.
McKenzie, T., Hoshino, T., Tanaka, T., & Sueoka, N. (1987). Correction.A revision of the nucleotide sequence and functional map of pUB110. Plasmid, 17(1), 83–85.
Mistry, H., Sharma, P., Mahato, S., Saravanan, R., Kumar, P. A., & Bhandari, V. (2016). Prevalence and characterization of oxacillin susceptible mecA-positive clinical isolates of Staphylococcus aureus causing bovine mastitis in India. PLoS One, 11(9), e0162256.
Molla, B., Byrne, M., Abley, M., Mathews, J., Jackson, C. R., Fedorka-Cray, P., Sreevatsan, S., Wang, P., & Gebreyes, W. A. (2012). Epidemiology and genotypic characteristics of methicillin-resistant Staphylococcus aureus strains of porcine origin. Journal of Clinical Microbiology, 50(11), 3687–3693.
Oliveira, D. C., Tomasz, A., & de Lencastre, H. (2001). The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: Identification of two ancestral genetic backgrounds and the associated mec elements. Microbial Drug Resistance, 7(4), 349–361.
Pan, A., Battisti, A., Zoncada, A., Bernieri, F., Boldini, M., Franco, A., Giorgi, M., Iurescia, M., Lorenzotti, S., Martinotti, M., & Monaci, M. (2009). Community-acquired methicillin-resistant Staphylococcus aureus ST398 infection, Italy. Emerging Infectious Diseases, 15(5), 845.
Patel, S. A., Savalia, C. V., Kumar, R., Gamit, M. A., Nair, S., Patel, R. K., & Patel, N. G. (2017). Incidence of methicillin resistant Staphylococcus aureus in the milk of Surti goats. International Journal of Agricultural Science, 9, 3637–3639.
Perreten, V., Kadlec, K., Schwarz, S., GrönlundAndersson, U., Finn, M., Greko, C., Moodley, A., Kania, S. A., Frank, L. A., Bemis, D. A., & Franco, A. (2010). Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: An international multicentre study. Journal of Antimicrobial Chemotherapy, 65(6), 1145–1154.
Pilla, R., Castiglioni, V., Gelain, M. E., Scanziani, E., Lorenzi, V., Anjum, M., & Piccinini, R. (2012). Long-term study of MRSA ST1, t127 mastitis in a dairy cow. Veterinary Record, 170.
Porrero, M. C., Wassenaar, T. M., Gómez-Barrero, S., García, M., Bárcena, C., Alvarez, J., Sáez-Llorente, J. L., Fernández-Garayzábal, J. F., Moreno, M. A., & Domínguez, L. (2012). Detection of methicillin-resistant Staphylococcus aureus in Iberian pigs. Letters in Applied Microbiology, 54(4), 280–285.
Price, L. B., Stegger, M., Hasman, H., Aziz, M., Larsen, J., Andersen, P. S., Pearson, T., Waters, A. E., Foster, J. T., Schupp, J., & Gillece, J. (2012). Staphylococcus aureus CC398: Host adaptation and emergence of methicillin resistance in livestock. MBio, 3(1).
Roger, C., Roberts, J. A., & Muller, L. (2018). Clinical pharmacokinetics and pharmacodynamics of oxazolidinones. Clinical Pharmacokinetics, 57(5), 559–575.
Rolo, J., Miragaia, M., Turlej-Rogacka, A., Empel, J., Bouchami, O., Faria, N. A., Tavares, A., Hryniewicz, W., Fluit, A. C., De Lencastre, H., & CONCORD Working Group. (2012). High genetic diversity among community-associated Staphylococcus aureus in Europe: Results from a multicenter study. PloS One, 7(4), e34768.
Rowland, S. J., & Dyke, K. G. (1989). Characterization of the staphylococcal beta-lactamase transposon Tn552. The EMBO Journal, 8(9), 2761–2773.
Ruhlmann, C. H., Kolmos, H. J., Kristiansen, J. E., & Skov, R. (2008). Pigs as an infection source for methicillin resistant Staphylococcus aureus infections in humans. Ugeskrift for Laeger, 170(43), 3436–3436.
Ruiz-Ripa, L., Bellés-Bellés, A., Fernández-Fernández, R., García, M., Vilaró, A., Zarazaga, M., & Torres, C. (2021). Linezolid-resistant MRSA-CC398 carrying the cfrgene, and MRSA-CC9 isolates from pigs with signs of infection in Spain. Journal of Applied Microbiology, 131, 615.
Santos, V., Gomes, A., Ruiz-Ripa, L., Mama, O. M., Sabença, C., Sousa, M., Silva, V., Sousa, T., Vieira-Pinto, M., Igrejas, G., & Torres, C. (2020). Methicillin-resistant Staphylococcus aureus CC398 in purulent lesions of piglets and fattening pigs in Portugal. Microbial Drug Resistance, 26(7), 850–856.
Schifano, J. M., Edifor, R., Sharp, J. D., Ouyang, M., Konkimalla, A., Husson, R. N., & Woychik, N. A. (2013). Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site. Proceedings of the National Academy of Sciences, 110(21), 8501–8506.
Schwarz, S., Kehrenberg, C., Doublet, B., & Cloeckaert, A. (2004). Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiology Reviews, 28(5), 519–542.
Schwarz, S. T. E. F. A. N., & Cardoso, M. A. R. I. S. A. (1991). Molecular cloning, purification, and properties of a plasmid-encoded chloramphenicol acetyltransferase from Staphylococcus haemolyticus. Antimicrobial Agents and Chemotherapy, 35(7), 1277–1283.
Scott, G. M., Thomson, R., Malone-Lee, J., & Ridgway, G. L. (1988). Cross-infection between animals and man: Possible feline transmission of Staphylococcus aureus infection in humans? Journal of Hospital Infection, 12(1), 29–34.
Shanmathy, M., Gopi, M., & Beulah, P. (2018). Contribution of animal husbandry to Indian economy, its characteristics and future: A review. Asian Journal of Agricultural Extension, Economics & Sociology, 27, 1–7.
Sharma, M., Nunez-Garcia, J., Kearns, A. M., Doumith, M., Butaye, P. R., Argudín, M., Lahuerta-Marin, A., Pichon, B., AbuOun, M., Rogers, J., & Ellis, R. J. (2016). Livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) clonal complex (CC) 398 isolated from UK animals belong to European lineages. Frontiers in Microbiology, 7, 1741.
Speer, B. S., Shoemaker, N. B., & Salyers, A. A. (1992). Bacterial resistance to tetracycline: Mechanisms, transfer, and clinical significance. Clinical Microbiology Reviews, 5(4), 387–399.
Stegger, M., Lindsay, J. A., Sørum, M., Gould, K. A., & Skov, R. (2010). Genetic diversity in CC398 methicillin-resistant Staphylococcus aureus isolates of different geographical origin. Clinical Microbiology and Infection, 16(7), 1017–1019.
Stegger, M., Liu, C. M., Larsen, J., Soldanova, K., Aziz, M., Contente-Cuomo, T., Petersen, A., Vandendriessche, S., Jimenez, J. N., Mammina, C., & Van Belkum, A. (2013). Rapid differentiation between livestock-associated and livestock-independent Staphylococcus aureus CC398 clades. PloS One, 8(11), e79645.
Takano, T., Higuchi, W., Otsuka, T., Baranovich, T., Enany, S., Saito, K., Isobe, H., Dohmae, S., Ozaki, K., Takano, M., & Iwao, Y. (2008). Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan. Antimicrobial Agents and Chemotherapy, 52(3), 837–845.
Tooke, C. L., Hinchliffe, P., Bragginton, E. C., Colenso, C. K., Hirvonen, V. H., Takebayashi, Y., & Spencer, J. (2019). β-Lactamases and β-lactamase inhibitors in the 21st century. Journal of Molecular Biology, 431(18), 3472–3500.
Tsiodras, S., Gold, H. S., Sakoulas, G., Eliopoulos, G. M., Wennersten, C., Venkataraman, L., Moellering, R. C., Jr., & Ferraro, M. J. (2001). Linezolid resistance in a clinical isolate of Staphylococcus aureus. The Lancet, 358(9277), 207–208.
Vincze, S., Stamm, I., Kopp, P. A., Hermes, J., Adlhoch, C., Semmler, T., Wieler, L. H., Lübke-Becker, A., & Walther, B. (2014). Alarming proportions of methicillin-resistant Staphylococcus aureus (MRSA) in wound samples from companion animals, Germany 2010–2012. PloS One, 9(1), e85656.
Voss, A., Loeffen, F., Bakker, J., Klaassen, C., & Wulf, M. (2005). Methicillin-resistant Staphylococcus aureus in pig farming. Emerging Infectious diseases, 11(12), 1965.
Wan, M. T., Lauderdale, T. L., & Chou, C. C. (2013). Characteristics and virulence factors of livestock associated ST9 methicillin-resistant Staphylococcus aureus with a novel recombinant staphylocoagulase type. Veterinary Microbiology, 162(2–4), 779–784.
Wendlandt, S., Feßler, A. T., Monecke, S., Ehricht, R., Schwarz, S., & Kadlec, K. (2013). The diversity of antimicrobial resistance genes among staphylococci of animal origin. International Journal of Medical Microbiology, 303(6–7), 338–349.
Zakour, N. L. B., Bannoehr, J., van den Broek, A. H., Thoday, K. L., & Fitzgerald, J. R. (2011). Complete genome sequence of the canine pathogen Staphylococcus pseudintermedius. Journal of Bacteriology, 193(9), 2363–2364.
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Hamza, M., Sivaraman, G.K., Mothadaka, M.P. (2023). Evolution, Characteristics, and Clonal Expansion of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA): Global Perspectives. In: Mothadaka, M.P., Vaiyapuri, M., Rao Badireddy, M., Nagarajrao Ravishankar, C., Bhatia, R., Jena, J. (eds) Handbook on Antimicrobial Resistance. Springer, Singapore. https://doi.org/10.1007/978-981-16-9723-4_23-1
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