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Non-cryopreserved Peripheral Stem Cell Autograft for Multiple Myeloma and Lymphoma in Countries with Low Resources

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Handbook of Stem Cell Therapy

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Abstract

Autologous peripheral blood progenitor cell (PBPC) transplant is a standard indication in the multiple myeloma (MM) and lymphoma. The use of non-cryopreserved PBPCs is not usual despite its safety, feasibility, and efficacy. Few data exists in the literature regarding the procedures for non-cryopreserved autologous PBSCs transplant in countries with limited resources. The bibliographical research of this work was limited on sites like PubMed, Google scholar; using the following articles on the non-cryopreserved autologous PBPCs in hematological malignancies in developing countries have been selected. These papers were analyzed in terms of mobilization, apheresis, preservation and viability, conditioning regimen, engraftment, response, and finally survival. This chapter sums up experience from 17 transplant centers which carried out autografts with non-cryopreserved PBPCs in 1541 patients suffering from hematologic malignancies. The results in terms of mobilization showed a median CD34+ = 3.94 × 106/kg (range, 0.32–24.6), a viability >90% and >75% respectively in MM and lymphomas after a conservation of 24–144 h at +4 °C. The engraftment (mean neutrophils = 12.38 (6–86) days, mean platelets = 15.57 (7–89) days, and TRM (4.39%) were very satisfactory. In conclusion, this method is easy, efficient, and safe, and it is expected to grow in developing countries due to its low production cost and procedure simplicity.

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Abbreviations

AfBMT:

African Blood and Marrow Transplantation

ASCT:

Autologous stem cell transplantation

BEAM:

BCNU-Etoposide-Aracytine-Melphalan

BM:

Bone marrow

BMPCs:

Bone marrow progenitor cells

CBV:

Cyclophosphamide-BCNU-Etoposide/VP16

CEC:

Cyclophosphamide, Etoposide, Carboplatin

DFS:

Disease-free survival

DLBCL:

Diffuse large B cell lymphoma

DMSO:

Dimethyl sulfoxide

EMBMTG:

Eastern Mediterranean Bone Marrow Transplantation Group

G-CSF:

Granulocyte-colony stimulating factor

HPCs:

Hematopoietic progenitor cells

LK:

Leukapheresis

MEL/VP16:

Melphalan, Etoposide

NE:

Neutrophil engraftment

OS:

Overall survival

PBSCs:

Peripheral blood stem cells

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Authors and Affiliations

  1. Department of Hematology and Stem Cell Therapy, Etablissement Hospitalier Universitaire 1st November, Ahmed Benbella 1 University, Oran, Algeria

    Mohamed Amine Bekadja

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  1. Mohamed Amine Bekadja
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Editors and Affiliations

  1. Department of Basic Sciences, Sulaiman AlRajhi University, Al Bukairiyah, Saudi Arabia

    Khawaja H. Haider

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  1. Department of Basic Sciences, Sulaiman AlRajhi University, Al Bukairiyah, Saudi Arabia

    Khawaja H. Haider

  2. University of Modena and Reggio Emilia, Modena, Italy

    Beatrice Aramini

  3. Interamerican Open University, Buenos Aires, Argentina

    Elio A. Prieto Gonzalez

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Bekadja, M.A. (2022). Non-cryopreserved Peripheral Stem Cell Autograft for Multiple Myeloma and Lymphoma in Countries with Low Resources. In: Haider, K.H. (eds) Handbook of Stem Cell Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-16-6016-0_52-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-6016-0

  • Online ISBN: 978-981-16-6016-0

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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