Abstract
This communication presents efficient focusing of radiofrequency for the non-invasive local hyperthermia treatment (HT) of breast tumors. Hyperthermia technique is used to raise the tumor temperature from 42–45 °C. In this combinational therapy, controlled heating at tumor site plays a vital role in the success of HT; else it creates hotspots on surrounding area of the treatment site. In this communication we are presenting mathematical analysis for the temperature distribution during the HT, Computational complexity for effective focusing of radio waves on tumor sites, and 2D modeling of breast model for testing the feasibility of HT. Pennes bio-heat equation is used for thermal analysis of tumor and healthy tissue in MATLAB environment, whereas thermal conduction parameters of 2D breast model are acquired from finite element method by imposing radiation, and convection boundary conditions. Heat flow modeling and electrostatic modeling of the 2D breast model with two tumors is carried out. 2D modeling result shows that HT is safe and reliable if temperature parameters are maintained in the safe limit, avoids hotspots on healthy surrounding tissue and reduces toxicity to a greater extent. Also, the obtained results for magnitude of electric flux density, heat flow in the tumors shows higher efficiency, with minimized hotspots.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Zee JV (2002) Heating the patient: a promising approach? Ann Oncol 13:1173–1184
Wust P, Hildebrandt B, Sreenivasa G (2002) Hyperthermia in combined treatment of cancer. Lancet Oncol 8487–497
Dewhirst MW, Viglianti BL, Lora-Michiels M, Hanson M, Hoopes PJ (2003) Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia. Int J Hyperth 19:267–294
Kok H et al (2015) Current state of the art of regional hyperthermia treatment planning: a review. Radiat Oncol 10
Falk MH, Issels RD (2001) Hyperthermia in oncology. Int J Hyperth 17:267–294
Cancer facts and figures 2018. Amer Cancer Soc Atlanta, GA, USA, 1–10, 2018
Nguyen PT, Abbosh A, Crozier S (2017) 3-D focused microwave hyperthermia for breast cancer treatment with experimental validation. IEEE Trans Antennas Propag 65:3489–3499
Nguyen PT, Crozier S, Abbosh A (2014) Realistic simulation environment to test microwave to test microwave hyperthermia treatment of breast cancer. In: IEEE Antennas and propagation society international symposium (APSURSI), 1188–1189
Nguyen PT, Abbosh A, Crozier S (2015) Microwave hyperthermia for breast cancer treatment using electromagnetic and thermal focusing tested on realistic breast models and antenna arrays. IEEE Trans Antennas Propag 63(10):4426–4434
Nguyen PT, Abbosh AM (2015) Focusing techniques in breast cancer treatment using non-invasive microwave hyperthermia. In: 2015 International symposium on antennas and propagation (ISAP), Hobart, TAS, 1–3
Nguyen PT, Crozier S, Abbosh A (2015) Thermo-dielectric breast phantom for experimental studies of microwave hyperthermia. IEEE Antennas Wirel Propag Lett, 476–479
Nguyen PT, Crozier S, Abbosh A (2017) Three-dimensional microwave hyperthermia for breast cancer in a realistic environment using particle swarm optimization. IEEE Trans Biomed Eng 64(6):1335–1344
Huilgol NG, Gupta S, Sridhar CR (2010) Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial. J Cancer Res Ther 6(4):492–496 Oct–Dec. https://doi.org/10.4103/0973-1482.77101. PMID: 21358087
Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 85:5–34
Patankar SV (1980) Numerical heat transfer and fluid flow. CRC Press.1, 137–139
Parker KJ (1985) Effects of heat conduction and sample size on ultrasonic absorption measurements. J Acoust Soc Am 77:719–725. https://doi.org/10.1121/1.392340
Rajput JL, Nandgaonkar AB, Nalbalwar SL, Wagh AE (2019) Design study and feasibility of hyperthermia technique. In: Computing in Engineering and Technology, vol. 1025, 721–732, Oct. https://doi.org/10.1007/978-981-32-9515-5_68.
Dielectric properties of body tissues. https://itis.swiss/virtualpopulation/tissue-properties/database/dielectric-properties
Acknowledgment
The authors would like to thank management and Principal, Ramrao Adik Institute of Technology, Nerul, Navi Mumbai, and Dr BATU for the research facility and support provided in the research.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Rajput, J., Nandgaonkar, A., Nalbalwar, S., Wagh, A., Huilgol, N. (2022). Feasibility Study for Local Hyperthermia of Breast Tumors: A 2D Modeling Approach. In: Balas, V.E., Semwal, V.B., Khandare, A. (eds) Intelligent Computing and Networking. Lecture Notes in Networks and Systems, vol 301. Springer, Singapore. https://doi.org/10.1007/978-981-16-4863-2_22
Download citation
DOI: https://doi.org/10.1007/978-981-16-4863-2_22
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-4862-5
Online ISBN: 978-981-16-4863-2
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)