Abstract
Cancer is the second leading cause of death and cervical cancer is one of the most common cancer types and ranks fourth largest for both incidence and mortality in females. Chemoradiation is a standard therapeutic model used to treat cervical cancer patients and often has shown to effect the haematopoietic system. Therefore, in this paper, we present the effect of chemoradiation on haematological parameters such as White Blood Cell (WBC), Platelets and Haemoglobin (Hgb). Eighteen subjects were enrolled from Basavatarakam Indo-American Cancer Hospital, Hyderabad, diagnosed with squamous cell carcinoma of the cervix. The study group received a combination of external beam radiation therapy (EBRT) (50 Gy in 25 fractions at 2 Gy per fraction), brachytherapy (21 Gy in 3 fractions at 30 gy, 40 gy and 50gy of EBRT), weekly cisplatin (40 mg/m2) chemotherapy for 5 days a week for about 5 weeks. For estimating the changes in haematological parameters the clinical blood samples were collected from the patients before, and after the chemoradiation treatment regime. We found 17 patients in WBC, 17 patients in platelet, and 16 patients in Hgb in reference ranges. The reference range for WBC is 4–10 × 109 g/L, platelet is 150–410 × 109 g/L and Hbg is 120–150 g/L. Following therapy, patients were counselled to monitor the clinical complications. We found that the patients’ low haemoglobin suffered stomach pain, heavy white vaginal discharge problems post-treatment, and patients under high haemoglobin group reported to be healthy with no post-treatment complications.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Murphy ME, The HSP70 family and cancer. https://doi.org/10.1093/carcin/bgt111
Ikwegbue PC, Masamba P, Oyinloye BE, Kappo AP (2018) Roles of heat shock proteins in apoptosis, oxidative stress, human inflammatory diseases, and cancer. https://doi.org/10.3390/ph11010002
https://www.texaschildrens.org/health/stem-cells-blood-and-immune-system
Etim N (2014) Haematological parameters and factors affecting their values. Agric Sci 2:37–47. https://doi.org/10.12735/as.v2i1p37
Gennigens C, De Cuypere M, Seidel L et al (2020) Correlation between hematological parameters and outcome in patients with locally advanced cervical cancer treated by concomitant chemoradiotherapy. Cancer Med 9:8432–8443. https://doi.org/10.1002/cam4.3465
F Bellati, M. Pernice, N. Manci et al Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors. https://doi.org/10.1093/annonc/mdl491
Barbalato L, Pillarisetty LS (2020) Histology, “red blood cell”, treasure Island. Stat Pearls Publishing, FL
Msdmanuals, blood disorders biology of blood formation of blood cells, https://www.msdmanuals.com/en-in/home/blood-disorders/biology-of-blood/formation-of-blood-cells#:~:text=Red%20blood%20cells%2C%20most%20white,mature%20in%20the%20thymus%20gland
van Meir H, Nout RA, Welters MJ, et al (2016) Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients. Oncoimmunology 6(2):e1267095. Published 2016 Dec 23. https://doi.org/10.1080/2162402X.2016.1267095
Chemocare.com. 2015. Cancer cells and chemotherapy: http://chemocare.com/chemotherapy/what-is-chemotherapy/cancer-cells-chemotherapy.aspx#:~:text=If%20the%20cancer%20cells%20are,self-death%20or%20apoptosis
Vitzthum Lucas K et al (2020) Comparison of hematologic toxicity and bone marrow compensatory response in head and neck vs. cervical cancer patients undergoing chemoradiotherap. Front Oncol. https://doi.org/10.3389/fonc.2020.01179
Araújo, David Felipe B et al (2020) Hematological and biochemical toxicity analysis of chemotherapy in women diagnosed with cervical cancer. J Bras Patol e Med Lab, 56, e1772020. Epub July 01, 2020.https://doi.org/10.5935/1676-2444.20200038
American Cancer Society: https://www.cancer.org/cancer/cervical-cancer/treating/radiation.html
Bachtiary B, Herbacek I, Zideck T, Knocke TH, Dimopoulos J, Poetter R, Micksche M (2005) Impact of radiotherapy with and without concurrent cisplatin on lymphocyte subpopulations in cervical cancer patients. Anticancer Res. Nov-Dec;25(6C):4673–4678. PMID: 16334159
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Sai Lalitha, B., Malini, M., Botlagunta, M. (2021). Effect of Chemoradiation on Haematological Parameters in Cervical Cancer. In: Jyothi, S., Mamatha, D.M., Zhang, YD., Raju, K.S. (eds) Proceedings of the 2nd International Conference on Computational and Bio Engineering . Lecture Notes in Networks and Systems, vol 215. Springer, Singapore. https://doi.org/10.1007/978-981-16-1941-0_59
Download citation
DOI: https://doi.org/10.1007/978-981-16-1941-0_59
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-1940-3
Online ISBN: 978-981-16-1941-0
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)