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microRNAs-Mediated Regulation of Voltage Gated Anion Channel 1, a Major Player in ROS Generation and Cancer Progression

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Cancer cells show elevated level of mitochondrial reactive species (mROS) generation. Voltage-dependent anion channel 1(VDAC1), an outer mitochondrial membrane (OMM) protein plays significant role in mitochondrial energy production as well as in metabolism. VDAC1 has been shown to influence the metastatic potential of cancer cells via production of mROS. Therefore, the regulation of VDAC1 expression seems an attractive area of research in cancer biology. Recent researches show that microRNA plays important roles in cancer metastasis by regulating expression of different proteins. In this context regulation of VDAC1 by microRNAs could be an attractive strategy as a therapeutic approach in cancer biology. Therefore, herein, we discuss the tumor suppressor role of several microRNAs in controlling the cancer progression network by targeting VDAC1 expression.

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Authors and Affiliations

  1. Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland

    Kuntal Dey

  2. Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Bern, Switzerland

    Soumasree De

Authors
  1. Kuntal Dey
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  2. Soumasree De
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Corresponding author

Correspondence to Kuntal Dey .

Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India

    Suvendranath Bhattacharyya

  2. Dept of Toxicology, University of Belgrade, Belgrade, Serbia

    Aleksandra Buha Dordevic

  3. Human Genetics Unit, Indian Statistical Institute, Kolkata, West Bengal, India

    Nilabja Sikdar

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Dey, K., De, S. (2022). microRNAs-Mediated Regulation of Voltage Gated Anion Channel 1, a Major Player in ROS Generation and Cancer Progression. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_72-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_72-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-1247-3

  • Online ISBN: 978-981-16-1247-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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