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Biofluid Markers Unveiling Cancer Diagnosis and Prognosis: With Special Reference to Oxidative Stress

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Cancer cells have an inherent elevated reactive oxygen species level. Cancer biomarkers include macromolecules such as DNA, RNA, proteins, and certain metabolites; gene; microRNA; immunological, epigenetic biomarkers; and trace elements. This chapter briefly covers up certain biofluids used to analyze cancer biomarkers related to oxidative stress. Oxidative boots can be studied over wide range of biofluids like blood, urine, breath, cerebrospinal fluid, pleural effusions, saliva, tears, and sweat. Biofluids clarify the mechanisms of biological flow and their interrelationships with physiological processes, in health and disease. Biofluid analyses of clinical relevance offer more chances to conduct studies on a large scale as biofluid sample collections are easily accessible, noninvasive, and of easy storage.

Biofluid miRNA profiling, high-precision quantitation using direct mass spectrometry, microfluidic devices, organotypic culture models, cell culture effluent methods employed in biomarker analyses, and the advancements in proteomic/genomic/transcriptomic technologies are highly fruitful. It reflects normal biological functioning, extent of the pathogenic processes, or therapeutic outcomes. Biofluidic diagnostics are scientifically credible. Owing to the biomarker capability in cancer diagnosis and prognosis, necessity for further research is felt.

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Author information

Authors and Affiliations

  1. Department of Life Sciences, School of Natural Sciences, University of Suwon, Hwaseong-si, Republic of Korea

    Sonaa Elango

  2. Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, South Korea

    Karpagam Veerappan

  3. Human Genetics Research Centre, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education & Research, Chennai, India

    Usha Subbiah

Authors
  1. Sonaa Elango
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  2. Karpagam Veerappan
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  3. Usha Subbiah
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Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Chair and Department of Toxicology, Jagiellonian University Collegium Medicum, Kraków, Polska

    Maria Walczak

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

    Pulak Kar

  4. University of Burdwan, Bardhaman, West Bengal, India

    Somasri Dam

  5. Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland

    Kuntal Dey

  6. Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA

    Muthusamy Kunnimalaiyaan

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Elango, S., Veerappan, K., Subbiah, U. (2022). Biofluid Markers Unveiling Cancer Diagnosis and Prognosis: With Special Reference to Oxidative Stress. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_279-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_279-1

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  • Print ISBN: 978-981-16-1247-3

  • Online ISBN: 978-981-16-1247-3

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