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Emerging Metabolic Regulation of Redox Status in Cancer Stem Cells Progression and Metastasis

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Emerging research revealed a role of energy metabolism in maintaining stemness in cancer stem cells (CSCs). In CSCs, metabolic heterogeneity provides the flexibility to deal with endogenous mitochondrial stress and exogenous milieu. In metabolism, both the normal stem cells (SCs) and CSCs have increased glycolysis. CSCs not only increase metabolic activity, i.e., predominantly glycolysis for self-renewal, but also increase the antioxidant levels, i.e., low ROS levels, which maintains the stem cell fate. However, OXPHOS is also shown to increase in CSCs of few cancers. Traditionally, persistent metabolic ROS production causes oxidative damage, which accelerates cellular mortality. Thus, redox status control is critical for cellular activities. Hitherto, it has been unclear as how CSCs maintain low ROS levels and secondly, how ROS-dependent signaling pathways contribute to CSC activity is poorly understood? We focus on ROS-dependent cellular process in CSCs that regulates various metabolic signaling pathways and transcriptional activity.

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Acknowledgments

This work was supported by DST-SERB funding, Ministry of Science and Technology, India. DM is supported by ACTREC fellowship.

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Authors and Affiliations

  1. Stem Cell Biology Group, Waghmare Lab, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, India

    Darshan Mehta & Sanjeev K. Waghmare

  2. Homi Bhabha National Institute, Mumbai, Maharashtra, India

    Darshan Mehta & Sanjeev K. Waghmare

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  1. Darshan Mehta
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  2. Sanjeev K. Waghmare
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Correspondence to Sanjeev K. Waghmare .

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Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Mehta, D., Waghmare, S.K. (2022). Emerging Metabolic Regulation of Redox Status in Cancer Stem Cells Progression and Metastasis. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_112-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_112-1

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