Abstract
Our health is closely related to our environment, such that a healthy environment brings healthy living and vice versa. Pollution due to air is a prime environmental aspect contributing to the burden of different diseases in human and also has considerable economic impact. The total air pollution accounts approximately 7 million deaths globally. Pollutants produced as combustion of particulate matter have demonstrated a time-series effect on human health. The size of inhalable particulate matter (PM10 and PM2.5) affects the mortality and morbidity upon short- and long-term exposure among all population, with highest effect on elderly individuals. Exposure to these pollutants produces the pathological alteration, such as increased inflammatory response, systemic oxidative stress, cardiovascular stress, and change in pulmonary autonomous nervous system activity. These molecular pathological events trigger several pulmonary and cardiovascular manifestations in human. From epidemiology point of view, it has been explored that among different air pollutants, particulate matter, ozone, carbon monoxide, nitrogen dioxide and sulfur dioxide are the major ones. The highest mortality is mainly observed in Asian populations as compared to Europeans and Americans. The top ten countries with the highest mortality are China, India, Pakistan, Bangladesh, Nigeria, the United States, Russia, Brazil, and Philippines, respectively. In this chapter, we reviewed different PM exposure-based epidemiological studies with more focus on high ambient Total Suspended Particulate (TSP) levels. It has also been found that overall absolute risk for mortality due to PM exposure is higher for cardiovascular compared to pulmonary disorders in case of both acute and chronic exposures.
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8.1 Introduction
Human health is closely associated to the environment of its habitat and healthy habitat leads to healthy living (Seymour 2016). The damage done to the current environmental condition of our planet is quite noticeable. Climate change and air pollution due to different pollutants in the air is one of the major concerns all around the world. It has been estimated that a large number leading to premature deaths and adverse health effects are linked to air pollution. According to WHO reports, air pollution is the global, massive, single, and most significant environmental health risk. Health complications as a result of frequent exposure to air pollutants have high considerable economic impact, consequently increasing health care costs and premature deaths (Kelly and Fussell 2015). Pollutants that subsidize to air pollution can be divided into primary and secondary. Primary air pollutants are those which have their own origin such as carbon monoxide, nitrogen oxides, volatile organic compounds (VOC), sulfur dioxide, and particulate matter. Secondary air pollutants are those which are the outcome of primary air pollutants such as ozone and smog (Admassu et al. 2005).
Due to a drastic increase in urbanization and industrialization all over the world, there is a steep rise in the concentrations of various air pollutants. This has led to adverse impact on human existence in various forms like climate change, global warming, and flooding (Admassu et al. 2004). Inefficient pollution control methods, inadequacy of regulations enforcement, uncontrolled vehicular emissions, and increasing deforestation are components responsible for rising environmental air pollutants (McCarthy et al. 2009; Aggarwal and Jain 2015). Inhalation of fine particles causes severe lung disorders due to its high ambient TSP levels along with elevated levels of particulate matters (PM) PM10 and PM2.5 (Carrico et al. 2003; Begum et al. 2008). The most significant contributor of particulate matter is mainly vehicle exhaust (Agarwal et al. 2006). In most of the developing countries and cities, a distinct population of particulate matter is mostly found that are having deleterious impact on different categories of populations. The effect of particulate matter on human health can only be reduced when there is sharp decline in vehicular or construction-based activities (World Bank 2004). The adverse health impact of PM is directly proportional to its size, where PM2.5 and PM0.1 have the most hazardous impact as compared to PM10 (Dockery et al. 1993; Pope et al. 2002). Premature death from heart and lung disease, chronic bronchitis, asthma attacks and respiratory illness are topmost health effects of PM (Smith 2002). Various epidemiological studies have estimated the possible health impacts resulting from different categories of particulate matter locally, regionally, and globally. World health report (2016) also states that ambient particulate matter pollution is capable of 1.4% total annual global mortality with an estimated death of about 0.8 million people.
8.2 Air Pollution and Human Health
Air pollution is known as contagion mixture of both indoor and outdoor surroundings caused by any chemical, biological, or physical agents which tend to alter the air quality (Ji et al. 2017). The substances, either natural or anthropogenic, that contaminate the environment are known as pollutant. Air pollution could be categorized as natural or man-made and stationary or mobile on the basis of source of emissions. Natural sources include volcanic eruption, fires, storm, fog, and mist while man-made sources include vehicular exhaust, industrial emissions, crop residue burning, biomass burning, mining, and domestic activities (Barnes et al. 1999). On the basis of origin, air pollution sources can be of different types like point, area, and line. Point sources are those which have single known source of pollution from which pollutants are discharged such as factory smokestack, pipe, and ditch. Area sources are those sources of pollution which emit a substance from a particular area, for example, open burning and forest fires and evaporation losses from large spills of volatile liquids. Line sources are idealized geometric emitter that can be represented by an emission source consisting of straight line which may be of finite or infinite length, for example, roadway air pollution, aircraft emissions, noise pollution, etc. In 2005, WHO released “WHO Air quality guidelines” that has set up various permissible limits for different air pollutants that directly impact the human health. These guidelines help to reduce air pollutants to a certain level by regular monitoring and evaluation of their concentrations in the air. With the implementation of PM10 guidelines by WHO, there is significant improvement in its concentration from 70 to 20 μg/m3 and subsequently mortality rates were reduced to approximately 15%. This guide code applied worldwide is established through expert appraisal of scientific evidence for particulate matter (PM): limit for PM2.5: 10 μg/m3 annual mean; 25 μg/m3 24-h mean, limits for PM10: 20 μg/m3 annual mean; 50 μg/m3 24-h mean (WHO 2016). Comprehensive infinite risk for mortality due to PM vulnerability is greater for cardiovascular disease (CDV) compared to pulmonary diseases in respect to short- as well as long-term exposures. Even at identical acute relative risk elevations estimated between cardiovascular and pulmonary mortality, CVD account rises by 69%.
Air pollution is regarded as one of the dominant killers worldwide, responsible for 7 million deaths per year, out of which 600,000 are children (Yang et al. 2017). WHO reported that around 300 million children have been affected due to outdoor air pollution at global level. Air pollution is also spreading at a very higher rate in both urban and rural areas, mainly on low and middle income countries. South East Asia and Western Pacific regions had population-based burden of 3.3 million and 2.6 million death toll rate due to indoor and outdoor pollution, respectively (WHO 2012) (Table 8.1). Stronger link between both indoor and outdoor air pollution is associated with increased cardiovascular disease (Endes et al. 2017; Kelly and Fussell 2017; Bhatia et al. 2017), hypertension, diabetes (Vora et al. 2014), rheumatoid arthritis (De Roos et al. 2014), pulmonary diseases like asthma, lung cancer (Dominici et al. 2006; Machado et al. 2014; Bai et al. 2018) oxidative stress, physical disability (Weuve et al. 2016) and inflammation (Møller et al. 2014). Among all the air pollution-associated diseases, cardiovascular tops the chart with the highest incidence of 69% death toll rate. WHO also suggested that the concentrations of particulate matter can be reduced by adopting right policy measures due to which 15% of the lives can be saved at worldwide level.
Among different air pollutants, PM, ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), and sulfur dioxide (SO2) are the major ones (Fröhlich 2017) (Table 8.2). The total air pollution including particulate matter (PM), O3, CO, SO2, NOx, and VOCs accounts for loss of approximately 7 million lives globally. The highest mortality is mainly in Asian countries. Top ten countries with the highest mortality rate due to air pollution are China followed by India, Pakistan, Bangladesh, Nigeria, the United States, Russia, Brazil, and Philippines, respectively.
8.2.1 Particulate Matter (PM)
Particulate matter (PM) is the mixture of solid and liquid droplets suspended in the air and differentiated on the basis of different particle sizes (Manigrasso et al. 2017; Olatunji et al. 2018; Voidazan et al. 2018). PM not only evolves from natural sources such as volcanic eruptions but also through human actions such as burning of fossil fuels, waste disposal, and metal extraction activities. Both natural and artificial sources may emit either precursors like SO2, NO2, VOCs along with favorable meteorological conditions forming PM or can directly emit in the atmosphere through vehicular exhaust and industrial emissions (Olopade et al. 2017; Rahman et al. 2017). Coarse dust particles (PM10) are those having particle size of less than or equal to 10 μm in diameter and are inhalable particles (Fig. 8.1). The main sources for coarse dust particles are large-scale crushing or grinding activities during construction and suspension of road dust due to vehicular activities. It can deposit in thoracic or upper trachea-bronchial region causing severe health problems (Yin et al. 2017). Fine particles (PM2.5) are those having aerodynamic diameter size of 2.5 μm or smaller which are generally invisible and can only be observed using high-resolution microscopes. The prime source includes various types of combustion, motor vehicles, wood burning, and industrial processes (You et al. 2017b) as shown in Fig. 8.1. These are soot particles and are linked to various health impacts and are deposited in deeper lungs.
(a) Coarse Particles (PM10)
Coarse particles are one of the primary air pollutants (solid and liquid particles floating) that are respirable and thus can penetrate deep into the respiratory system. These PM are 5–7 times smaller in diameter compared to human hair (50–70 μm diameter) (Fig. 8.1). The particular matter composition, shape, size, presence of additional pollutants, and metrological factors determine its toxicity and concentration (Patton et al. 2014; Kelly and Fussell 2015). PM10 is one of the significant air pollutants which is the biggest threat to all living organisms. When compared from the era of industrialization to the present time, coarse particles have become a significant air pollutant in urban, suburban, rural, and remote parts of the globe (Fang et al. 2013; Li et al. 2015; Yang et al. 2019). In urban cities of most countries, PM10 level is above the WHO and their respective countries standard (WHO 2016). PM10 lead to inflammatory responses, congenital heart failure, ischemic heart disease, respiratory and circulatory fatality, birth risk, and cancer risk (Hemminki and Pershagen 1994; Zhang et al. 2014; Agay-Shay et al. 2013; Silbajoris et al. 2011). Larger particular matter of and around 10 μm endures solely in the nose and throat part and smaller particles of and around 1 μm easily accumulate in the lower regions of the lungs. The intermediate sizes greater than 1 μm and less than 10 μm reside between the upper part of the respiratory tract. Setiawan et al. (2014) reported the positive strong correlation between higher concentrations of PM10 and their harmful impacts on human beings. As per the global data statistics, prominent higher concentration of PM10 is reported in Asia, followed by Africa and European countries. Moreover, according to 2016 data, top ten polluted countries around the globe are Cameron, Egypt, Mauritania, Niger, Nigeria, Pakistan, Qatar, Saudi Arabia, Tajikistan, and United Arab Emirates, respectively, as shown in Fig. 8.2.
(b) Fine Particles (PM2.5)
Very tiny particles in the atmosphere of and around 2.5 mm wide are denoted as fine particles or PM2.5. These particles originate from dust, dirt, soot, and smoke, very tiny enough and are easily inhaled (Luo et al. 2018). According to Liu et al. (2018), it has been found that PM2.5 have shown stronger correlation with respect to their size range and human health effects. Infants and elderly population are at highest risk due to the inhalation of PM2.5 particles and most susceptible to pulmonary and heart diseases. Vulnerability to fine particulate matter (2.5 μm aerodynamic diameter) contributes to a predicted loss of 915,900 lives in China alone each year. Among these number of deaths, around 15% are attributable to PM2.5 due to transportation activities (Arashiro et al. 2018; Luyts et al. 2018). Severe health risks are associated with ultrafine particles (<0.1 μm) and composing PM2.5 and their main source is vehicular exhaust (Li et al. 2017; Hou et al. 2018; Kim et al. 2018; Kumar et al. 2018). Ultrafine particles can travel extensively deep into the lungs (Baldauf et al. 2016; Fonceca et al. 2018; Boogaard and van Erp 2019) as well as associated with the biomarkers of cardiovascular diseases leading to DNA hypomethylation and mortality (Atkinson et al. 2016; Kim et al. 2016; Simonetti et al. 2018; He et al. 2018; Louwies et al. 2018). PM2.5 components such as black carbon (BC) also have been associated with cardiorespiratory impacts (Donaldson et al. 2001; He et al. 2018). Since research on UFP and BC is not sufficient compared to PM as a whole, their effects are usually not included in mortality estimates (You et al. 2017a; Vreeland et al. 2017).
The annual risk of PM2.5 is increasing with years resulting in 3.0 million deaths (5.2% of global deaths in 2016). More than 50% occur in China and India. Comparative analysis showed that PM2.5 attributed to the increase in deaths by 68% from 1990 to 2016. World data clearly indicates that prominent higher concentration of PM10 is found in Asian followed by African and European countries. According to 2016 data, top ten polluted countries around the globe are Burkina Faso, Cameron, Egypt, Kuwait, Mauritania, Niger, Nigeria, Qatar, Saudi Arabia, and United Arab Emirates, respectively, as shown in Fig. 8.3.
The nature of particulate matter in the atmosphere determines the entry, absorption potential, and deposition of particles in the lungs (Clark et al. 2010). Particles which are larger than PM10 never reach the lungs as they get trapped within the nose and throat. Particles ranging from 10 μm in diameter or less become the most burdensome to the human health. Particles size smaller than 5 μm can be transported to bronchial tubes, while particles size of 2.5 μm or smaller can reside into the lung’s deepest portion (Prospero 1999; Mahowald et al. 2014).
8.2.2 Ozone (O3)
Ozone is the important component of photochemical smog and one of the greenhouse gases (Shi et al. 2016; Tham et al. 2017). It is a highly reactive, oxidative gas responsible for severe lung diseases, cardio-attacks and strokes all around the globe (Nuvolone et al. 2018). Ozone concentrations are mostly higher in summer season due to its photochemical nature and favorable meteorological conditions like high temperature and high solar radiation. Ozone is a secondary pollutant which is formed by its precursors like nitrogen oxides, carbon monoxide, and volatile organic compounds present in the atmosphere (Kan et al. 2012). Moreover, when hydroxyl radical (OH) reacts with trace gases, it leads to high concentration of ozone and hence becomes responsible for global warming. The increasing O3 level gives rise to serious health outcomes like inflammation, respiratory injury, and decreased lung activity (Kinney 1999; Koken et al. 2003).
8.2.3 Carbon Monoxide (CO)
CO is an outcome of carbon-containing fuels formed by mechanism of incomplete combustion (Yang et al. 2016). CO has the property to readily combine with hemoglobin due to its high affinity (200–250 times) as compared to oxygen and forms carboxyhemoglobin (COHb) (Gorman et al. 2003). When concentrations of COHb increases rapidly, oxygen level also sharply decreases and leads to morbidity and mortality (Graber et al. 2007; Pissuwan et al. 2016). CO is regarded as the most toxic inhalable gas which is both outdoor as well as indoor air pollutant and leads to sudden illness and death (Von Burg 1999). CO arises mainly from oxidation of fossil fuels like coal, kerosene, wood, and natural gases. Various forms of tobacco smoke and automobile exhaust also contain large concentration of CO. The level of CO ranges from 0.5 to 100 parts per million (ppm) both in indoor and outdoor environment. The standard range of indoor CO levels ranges from 0.5 to 5 ppm. This value exceeds the standard range in the presence of tobacco smoke in environment, incompetent heating, and ventilation up to 100 ppm (Penney et al. 2010), whereas, in urban zones, levels are typically from 20 to 40 ppm. In the periphery around highways and heavy construction site, the range of CO becomes much higher (Raub 1999). As it reaches to peak or exceeds standard range, the chance of CO poisoning initially shows the acute symptoms of headache, dizziness, and shortness of breath (Gorman et al. 2003; Piantadosi 1999). Further increase in exposure of level from acute to chronic leads to neurotoxicity, unconsciousness, cognitive and visual impairment and ultimately death. Research around years have determined chronic CO exposure as a risk factor for cardiovascular disease (Samoli et al. 2007). The underlining mechanisms for cardiotoxicity are associated with chronic CO risk identified to be directly or indirectly associated with activation and modulation of various intracellular signaling mechanisms. These mechanisms probably include CO-dependent regulation of cell proliferation, lipid-raft associated signaling protein caveolin-1, and modulation of NADPH oxidase (Taillé et al. 2005).
8.2.4 Nitrogen Oxides
The primary source of NO is fossil fuel combustion in motor vehicles and industrial emissions particularly from power generation plants. NO has the ability to react with ammonia, moisture, and other compounds to give rise to small particles (Ibeneme et al. 2016). These tiny particles can aggravate existing severe cardiovascular disease and asthma (Latza et al. 2009; Zhang et al. 2016). NO2 is a one of the criteria pollutant, which is the outcome of lightning, volcanic eruption, oxidation of NO to NO2, power houses, motor vehicles, bacterial source and combustion of fossil fuels (more than 70% of NO2 Production) (WHO). NO2 can affect human health mostly at higher or even at low concentrations. Epidemiological studies show that atmospheric NO2 attributes about 5–7% lungs cancer disease in both smokers and nonsmokers (Goudarzi et al. 2012; Omidi et al. 2016). It has severe acute effects followed by chronic effects like pulmonary as well as chronic obstructive pulmonary diseases (COPD), infant mortality chronic cough, bronchitis, infant mortality, and visibility (Barnett et al. 2005). According to WHO, the annual mean value of NO2 is 40 μg/m3 with respect to human health; however, even short-term exposure to NO2 leads to cardiovascular-related risks to exposed population (Brook 2008).
8.2.5 Sulfur Dioxide (SO2)
The main source of SO2 is from combustion of sulfur-containing fuels, especially in power plants and diesel engines, vehicular exhaust, and fossil fuel combustion (Silva et al. 2017). Sulfur dioxide majorly produces cytotoxic effect on retinal pigment of epithelial cells (Rall 1974; Bose et al. 2016). Short-term effect of SO2 on human health results in respiratory diseases in children (asthma, mainly in winter) (Pikhart et al. 2001; Heinrich et al. 2002) and registered a large number of both morbidity and mortality cases (Katsouyanni et al. 1997). SO2 leads to respiratory aggravation, bronchoconstriction, and most importantly cardiovascular disorders. Initial phase of cardiovascular abnormalities includes reduced heart rate vulnerability (Tunnicliffe et al. 2001). SO2 also causes respiratory symptoms such as shortness of breath, increased risk of asthma, and respiratory mortality (Clark et al. 2010; Chen et al. 2007; Zhao et al. 2008).
8.3 Air Pollution-Induced Cardiovascular Index and Their Consequences to Morbidity and Mortality
Pope and Dockery have highlighted the relationship between cardiovascular manifestation and air pollution. Their findings suggest that short-term daily exposure to particulate matter shows higher risk of cardiovascular-related mortality than all other diseases (Pope and Dockery 2006). Acute PM exposure contributes to 69% CVD-related deaths and 28% pulmonary-related manifestation (Brook et al. 2010). Some more critical studies have also been highlighted and give the addition prospective on exposure time and airborne pathogenesis.
Short-Term Exposure
Shorter exposure with a high level of pollutants is proportionally liked to the CVD-associated mortality. Increase in PM10 quantity by 10 μg/m3 promotes 1–2% surge in cardiovascular and pulmonary disease cases (Schwartz 2001). However, elevated exposure to PM2.5 by 10 μg/m3 increases the risk of myocardial infraction around 2.8%. Particulate matter-based morbidity and mortality are independent of other gaseous co-pollutants (i.e., NO2, SO2, O3, and CO). Acute exposure to O3 causes cardiopulmonary defect in middle-age person with no previous CVD (Bell et al. 2007). 1.0 μg/m3 increase of CO leads to 1.25% cardiovascular-related deaths, and short-term exposure to NO2 also promotes CVD pathogenesis (Samoli et al. 2006, 2007). The particulate matter-associated CVD risks appeared to be more in elderly person, while the younger population are more susceptible to NO2 exposure (Argacha et al. 2016).
Long-Term/Chronic Exposure
High PM level with prolonged exposure shows a greater magnitude than acute exposure. World Health Organization highlighted that constant exposure to PM2.5 leads to 800 thousand premature deaths per year and it ranked as the 13th leading cause of worldwide death (WHO 2002). Several other reports also suggest a strong association between chronic exposure to PM and cardiovascular mortality (Pope et al. 2004a). The annual increase of PM10 by 10 μg/m3 and PM2.5 by 5 μg/m3 promotes the risk of myocardial infarction by 10–13% (Cesaroni et al. 2014). Long-term exposure to PM2.5 causes premature arteriosclerosis and with traffic-related pollutants, it promotes coronary artery calcification (Kaufman et al. 2016). Chronic effect of airborne contaminants on mortality is examined in cohort studies. These studies involve exposure of pollutants and a large number of volunteers, and provide the data related to the impact of the pollutants on human life span (Künzli et al. 2001).
Air pollutants cause considerable alterations in cardiovascular indexes like heart rate, heart rate variability, arrhythmia, heart failure, cardiac arrest, ischemic heart disease, cerebrovascular disease (Stroke), blood pressure, vascular tone atherosclerosis, thrombosis, and coagulation (Table 8.3). These air pollution-induced cardiovascular indexes affect the viability of human life and increase mortality.
8.3.1 Heart Rate (HR) and Heart Rate Variability (HRV)
The increase of PM2.5 by 15.5 μg/m3 reduces the heart rate in old-aged people, while PM10 exposure (100 μg/m3) increases the heart rate by 5–10 beats per minute (POPE et al. 1999; Gold et al. 2000). Heart rate viability is strongly associated with the rate of exposure to particulate matter in both acute and chronic condition. Effect on HRV is correlated with the presence of nickel and iron in airborne particulate matter (Chang et al. 2007).
8.3.2 Arrhythmia, Heart Failure, and Cardiac Arrest
Cohort studies exhibit that arrhythmia, heart failure, and cardiac arrest are associated with increased exposure to PM2.5. Rise of PM2.5 by 10 μg/m3 increases heart failure cases by 1.28% (Dominici et al. 2006). Air pollutants also increase ventricular size and myocardial fibrogenesis that are the causes of cardiac arrhythmia and arrest (Wold et al. 2012).
8.3.3 Ischemic Heart Disease
Several studies have shown the relation between increased level of PM2.5 and ischemic heart disease. Coronary heart disease is a major cause of cardiovascular-related mortality and increase of PM2.5 by 10 μg/m3 promotes coronary heart disease cases (Pope et al. 2004a). PM2.5 along with PM10, NO2, and O3 are key causative factors for myocardial infarction, which is the first manifestation of ischemic heart disease. Patients aged 75 years or above acquire more ST-elevated myocardial infraction on exposure to PM10. However, younger population are more susceptible to fine and ultrafine particulate matter and NO2 exposure (Argacha 2017).
8.3.4 Thrombosis and Coagulation
Exposure of air pollutants to the cardiovascular system promotes hypercoagulability of blood. This physiological effect is either due to the entry of particulate matter into bloodstream or release of PM-induced circulating factors (Brook et al. 2010). Recent study reveals that exposure of concentrated ambient particulates (CAPs) to mice activates its pulmonary autonomous nervous system (ANS), which further stimulates the inflammatory responses and release of cytokines from alveolar macrophages to disseminate prothrombotic state (Chiarella et al. 2014).
8.3.5 Cerebrovascular Disease/Stroke
Data of 188 countries between 1990 and 2013 from Global Burden of Disease database shows 29% of air pollutant-induced cardiac manifestation are contributed only by stroke (Feigin et al. 2016). Many studies have found a positive association between air pollution, stroke, and mortality. Annual increase of air pollution by 5 μg/m3 enhances the risk of stroke up to 19% (Stafoggia et al. 2014). Time-series experiment has highlighted that increased air pollutants (notably PM, NO2, CO, and O3) level is associated with cerebrovascular disease. Air pollution-induced cardiac stroke has good correlation with ischemic, but not exactly with hemorrhagic stroke (Hong et al. 2002). Similar studies have also revealed that PM2.5 and CO-induced stroke mortality is predominant in warm season than the cold season (Kettunen et al. 2007). The short-term elevated level of the gaseous pollutants like O3, NO2, and CO also promotes the risk of stroke (Henrotin et al. 2010).
8.3.6 Blood Pressure, Vascular Tone, and Atherosclerosis
Increase exposure of PM2.5 by 10.5 μg/m3 enhances the diastolic pressure from 2.7 to 2.8 Hg in cardiac patients, and further increase of PM2.5 by 13.9 μg/m3 enhances diastolic pressure by 6.95 Hg without affecting systolic pressure (Zanobetti et al. 2004). Exposure to concentrated ambient particulates (CAPs) by 150 μg/m3 along with O3 (120 parts/billion) causes significant constriction of bronchial artery (up to 0.09 mm) (Brook et al. 2002). Higher exposure to PM2.5 and carbon particulates is correlated with increase in vascular constriction (O’Neill et al. 2005). However, chronic exposure to the fine and ultrafine particulate matter causes severe atherosclerosis. In human, 10 μg/m3 of PM2.5 promotes the carotid artery thickness by 5.9% (Suwa et al. 2002; Künzli et al. 2005). Long-term exposure to traffic-related PM2.5 (22.8 μg/m3) also promotes coronary artery calcification.
8.3.7 Hypertension
Long-term exposure to PM promotes the vascular oxidative stress, activation of ANS, inflammatory responses, increased sensitivity, and release of angiotensin II and endothelin which in turn develop systemic hypertension in animal (Brook et al. 2010; Ying et al. 2014). Controlled acute exposure to the concentrated ambient particles with ozone causes diastolic hypertension due to ANS imbalance (Urch et al. 2005).
8.4 Mechanism of Cardiovascular Toxicity Induced by Air Pollutants
The number of epidemiological studies strongly shows that air pollutants exposure causes a significant impact on the cardiovascular system. Association between cardiovascular complication and air pollution is now supported and asserted by the vast number of studies; however, the exact causative factors of pollutants and the molecular physiology by which airborne pollutants trigger cardiovascular abnormalities are understood to only some extent. Air pollutants which cause cardiovascular stress are gaseous and particulate in nature. Fine (PM2.5) and ultrafine (PM0.1) particulate matter are major components for manifestation of cardiovascular disease (Brook et al. 2010). The acute exposure to air pollutants leads to the development of myocardial infarction and change in heart viability, heart rate, blood pressure, blood coagulability, and vascular tone while prolonging exposure (chronic exposure) disseminates the progression of atherosclerosis (Brook et al. 2010).
Accumulating a number of evidences show that PM causes the chemical modification of oligonucleotides, resulting in the genetic and epigenetic changes which lead to aberrant genomic expression. Along with this it also induces oxidative stress and abnormal secretion of the stress-related hormone. To explain the mechanism of airborne pollutants-induced pathogenesis, three notable hypotheses were proposed, which explain the association between cardiovascular disease and air pollutants exposure (Fig. 8.4):
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PM-induced pulmonary inflammatory responses promote oxidative and cardiovascular stress.
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Exposure to PM leads to autonomic nervous system (ANS) imbalance and pathological alterations.
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Inhaled air pollutants directly translocate in the circulatory system and perturb the distant cell and tissue components of the cardiovascular system.
8.4.1 PM-induced Pulmonary Inflammatory Responses Promote Oxidative and Cardiovascular Stress
Air pollutants initiate a number of inflammatory reactions as soon as they come in contact with the lungs (GHIO et al. 2000). Particulate matter is a mixture of a wide range of particles (0.1–10 μm); these particles are typically composed of combustion originated carbon center, peripheral metal, and hydrocarbon. Larger and fine particulate matter (PM10 and PM2.5) are the major cause of pulmonary stress. PM induces the oxidative stress, inflammation, and pulmonary cell toxicity in the lungs (Donaldson and Stone 2003). Administration of aqueous PM induces the generation of reactive oxygen species (ROS), which increases bronchoalveolar localization of macrophages. Alveolar-localized macrophages release cytokines, interleukins, and TNF and start the inflammatory response. These PM also increase the bronchoalveolar lavage alpha-1 antitrypsin and fibronectin level that are the symptoms of pulmonary necrosis (GHIO and DEVLIN 2001). Prolonged exposure to polycyclic aromatic hydrocarbon-related PM2.5 rises the level of 8-hydroxy-2-deoxyguanosine and etheno-DNA adducts, which are the biomarker for oxidative DNA damage. These DNA adducts are predominant in road traffic workers (Bagryantseva et al. 2010). Air pollutant-induced elevated oxidize plasma LDL, IL-1&6 and TNF modulate the signaling of the cardiovascular system, which leads to the sympathovagal imbalance (Jacobs et al. 2011; Bind et al. 2012).
8.4.2 Exposure of PM Leads to Autonomic Nervous System (ANS) Imbalance and Pathological Alterations
Diesel exhaust (DE) particulate matter increases the heart rate and reduces the heart rate viability; it extends the ventricular depolarization and shortens repolarization, which lead to the development of arrhythmia. DE air pollutants alter the activity of TRP channels of the airway sensory neurons, present in the respiratory system. Functional alteration in these channels stimulates the midbrain which further excites the cortex and preganglionic autonomic neuron, resulting in the imbalance of autonomic nervous system, blood pressure, and heart rate (HR) (Hazari et al. 2011). A recent study has showed that exposure to the concentrated ambient particles (CAPs) stimulates the sympathetic nervous system and induces the secretion of catecholamine which further activates β2-adrenergic receptor of alveolar macrophages. Active β2-adrenergic receptor promotes the release of IL-6 that initiates the hypercoagulability of blood (prothrombotic state) (Chiarella et al. 2014).
8.4.3 Inhaled Air Pollutants Directly Translocate in the Circulatory System and Perturb the Distant Cell and Tissue Components of the Cardiovascular System
Ultrafine particulate matter (UFP) (PM0.1) and gaseous pollutants are directly translocated in the circulatory system and affect the distance organs (e.g., heart) (Nemmar et al. 2002). Injection of isolated UFP from ambient air promotes the left ventricle ejection fraction (LVEF) without affecting the heart rate (HR). UFP exhibits the potentially harmful impact on preexisting coronary disease patients (Wold et al. 2006). UFP-mediated direct acute response triggers the production of ROS, which gives rise to myocardial and endothelial dysfunction (Przyklenk and Kloner 1989). Exposure to PM0.1 also induces the level of circulatory c-Protein and inflammatory factor, which are responsible for increasing blood coagulability, vasoconstriction, and myocardial ischemia (Peters et al. 1997; Brook et al. 2002; Pope et al. 2004b).
8.5 Epidemiology of Air Pollution and Cardiovascular Disease
Ninety-one percent of the global population is living in the area where the air index is below the WHO recommended limits. Level of air pollutants like SO2, NOx, O3, CO, and particulate matter (PM2.5 and PM10) increased with the time, which created a range of harmful effect over human health, vegetation, ecosystem, and climate. Industrial development has been marked as a key transition for the increase in SO2 emission; sulfur pollution was first viewed in Europe, followed by North America. These two continents contribute highest to the emission of sulfur dioxides in the atmosphere; North America’s SO2 emission pick was around 37.7 million tons in 1970 and around 71.2 million tons in Europe in 1980. Though industrial development in Asia and Africa started much later, these regions began SO2 emission in the late twentieth century (Klimont et al. 2013). Another air pollutant NOx (nitrogen oxide), emitted from the combustion of fossil fuel and biomass burning, also contributes to air pollution-induced health problem; NOx emission has been seen high in developing countries. North America and Europe were emitting around 7.0 metric tons of NO2 in the early nineteenth century. However, Asian and African continents had started the emission of NO in the late nineteenth century (Dignon and Hameed 1989). Ozone is another noxious atmospheric pollutant, and its global emission level increased by 7.2% from 1990 to 2015 (0.0568 ppm to 0.0609 ppm). In the most polluted country, i.e., Bangladesh, Brazil, China, India, and Pakistan, the level of ozone was enhanced from 14% to 25% between 1990 and 2015, although exposure of ozone has decreased in the United States and Indonesia by 0.0037 ppm and 0.0065 ppm, respectively (Cohen et al. 2017). These gaseous pollutants work as a precursor for the creation of particulate matter. Level of particulate matter (PM2.5) has increased from 31.5 μg/m3 (1990) to 35.02 μg/m3 (2016), and its concentration has increased more rapidly in highly polluted cities. Level of PM2.5 has remained stable in India and Pakistan, but its concentration in another South Asian country (Bangladesh) has increased since 2010. The highest surge of PM2.5 has been found in Nigeria (African country) after 2015. However, there has been a significant reduction in PM2.5 level reported in China, and a slight decrease in Brazil, Russia, and the United States. Higher concentration of PM2.5 in 2016 was reported in Nigeria (203 μg/m3), Saudi Arabia (187·8 μg/m3), Qatar (148·2 μg/m3), Egypt (126·7 μg/m3), Bangladesh (101·04 μg/m3), Mauritania (123.6 μg/m3), Nepal (78·0 μg/m3), India (75·3 μg/m3), and China (56·4 μg/m3), whereas the lowest PM2.5 exposure in 2016 is reported in Pacific Island countries and territories (PM2.5 ≤ 8·0 μg/m3). The analysis of global PM2.5 air pollution data to different geographical regions shows that the African continent has the highest PM2.5 burden than Asia and North America. However, Europe has the lowest level of PM2.5 (Fig. 8.5).
About 7 million deaths (4.2 million outdoor pollution and 3.8 million household pollution) had happened in the year 2016 due to low air quality. Air pollutants attribute to many diseases like cardiovascular disease, lung cancer, and pulmonary disease, which cause premature death in the population. Most of the airborne-associated mortalities are due to cardiovascular pathogenesis. Particulate matter, SO2 and NOx are the major contaminants, causing the deleterious effect on human cardiovascular system. Studies done in more than 30 different European cities show that elevated level of SO2 and NOx are associated with increased cardiovascular abnormalities and mortality (Katsouyanni et al. 1997; Samoli et al. 2006). Increase in short-term exposure of SO2 and NO2 by 10 ppb enhance the risk of heart disease by 2.36 and 1.70, respectively (Newby et al. 2015). Myocardium is the most sensitive organ for SO2 and its exposure affects the cytochrome c oxidase activity of myocardial mitochondria, which leads to cardiovascular manifestation (Qin et al. 2016). American Heart Association in 2010 had stated that an increase of cardiovascular manifestation is associated with long-term exposure to PM2.5. Increased level of PM2.5 has elevated the mortality rate by 0.7 million (3.5 M to 4.2 M) between 1990 and 2015. Air pollution contributes to 7.5% global mortality and is ranked as the fifth global risk factor for deaths. Air pollutants exposure causes cardiovascular disease (58.4%), lung cancer (16.5%), and lower respiratory infection (24.7%). Cardiovascular disease is the major contributor to death associated with air pollution. PM2.5 exhibits sever effect on male compared to female (1018.6 deaths per 100,000 males, and 703.4 deaths per 100,000 females), and it also displays more impact on older people (aged >70 years) than younger ones (aged ≤5 years) (GBD 2016).
Cardiovascular disease (CVD) is the illness of the heart and blood vessels. It is one of the leading diseases in global health burden, which contributes around 31% of all global deaths. CVD plays a part in deaths of approximately 17.9 million people every year and out of this 80% of CVD deaths occurred due to heart attack and stroke. Air pollution is the major factor for cardiovascular-related abnormalities, and alone it had contributed to around 7 million deaths in 2016. More than 90% of these deaths had occurred in lower-income or middle-income countries. Asian countries (i.e., China, India, Pakistan, and Bangladesh) had highest pollutant-related mortality (2.25 million deaths), in which China was the top contributor with 0.94 million followed by India with 0.84 million deaths. The African region had 0.17 million CVD-associated deaths, in which Nigeria had the highest incident rate. American continent had 0.18 million air pollution-related causalities in 2016, in which the United States, Mexico, and Brazil were the major contributors. In Europe around 0.23 million deaths were reported in 2016 due to air pollution, in which Ukraine had carried the higher burden. Remaining casualties had occurred in Middle East (70,096), Oceania (5872), and Caribbean region (11,484) (Fig. 8.6) (WHO 2016).
8.6 Summary and Recommendations
This chapter summarized the association between prevalence of major air pollutants and cardiovascular manifestation in the population. As per WHO report, four major components of air pollution are PM, O3, NOx, and SO2. Particulate matter is a critical component of air pollution and it contains all the hazardous organic and inorganic constituents. PM exposure causes more sever morbidity and mortality than other pollutants at any concentration. Even though WHO has recommended threshold level of 20 μg/m3 for PM10 and 10 μg/m3 for PM2.5 annually, other gaseous air pollutants like O3, NO2, and SO2 are also very crucial for increased airborne illness. Combination of these gaseous pollutants with particulates matter creates more harmful impact. WHO has also recommended the threshold level for these gaseous pollutants as 100 μg/m3 of O3 for 8 h, 40 μg/m3 of NOx annually, and 20 μg/m3 of SO2 for 24 h. Air pollution is a crucial environmental risk factor for human health and by reducing the air pollution level, countries can reduce disease and socioeconomic burdens. Outdoor pollution in both urban and rural areas caused around 4.2 million deaths in 2016. The case-crossover study done in Germany, the United States, Europe, and China shows that increased exposure to PM10 by 10 μg/m3 induces the 1.0–1.50% increase of cardiovascular cases. In further study on teen and adult population (0.5 million) with 16 years of follow-up shows that consequence of cardiovascular mortality increased by 8–18% for every 10.5 μg/m3 increase of PM2.5 level. Similarly, case-crossover studies done in China and the United States show that increase exposure to SO2 and NO2 by 10 μg/m3 elevates 2.0–3.0% arrhythmia and blood pressure cases. Ozone is also an important component of air pollution; several European studies reported that daily heart-related mortality increases by 0.4 per 10 μg/m3 rise of ozone. To tackle this issue many environment protection and health associated agencies have given the recommendation and guidelines. WHO has given the recommendation to the industries, power generation plant, municipal, agricultural waste management and transport to use clean technology that reduces the industrial emission, use of clean and heavy duty diesel vehicle, fuel with reduced sulfur content, renewable combustion free power source (light, water, and wind) and strict system to reduce the open garbage and biomass burning. Other agencies like EPA have set the limit for the emission of air pollutant from chemical plant, vehicle, and other industries. The European Environment Agency, with a network of 33 countries, gathered the data and made the assessment and policy for environment protection.
As specific therapy for air pollution illness is difficult to pinpoint due to diverse health consequences. The detrimental health impact of pollutants is not confined to the source site, since fine particles can travel further and can therefore affect the health of people living and working in the surrounding areas. Basic and fundamental new directions can enable better predictions for future conditions and scenarios. Joining hands among individuals along with NGOs in coordination with government can implement strong policy to reduce pollutant exposure using environmental education, safe clean technologies, and limiting pollution exposure strategies.
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Prasad, R.R., Paudel, S. (2020). Impacts of Air Pollution on Epidemiology and Cardiovascular Systems. In: Saxena, P., Srivastava, A. (eds) Air Pollution and Environmental Health. Environmental Chemistry for a Sustainable World, vol 20. Springer, Singapore. https://doi.org/10.1007/978-981-15-3481-2_8
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