Abstract
To provide diagnosis and therapy for dysfunction in the nervous system, various biomaterials and/or medical devices serve as platforms to communicate with the system and regulate dysfunctional neuronal circuits. Recent advances in nanotechnology enable the construction of nanostructured platforms with ultrasmall feature size and superior material property at the nanoscale, targeted at interfacing with the nervous system seamlessly. The chapter provides an overview of nanostructured neural platforms and introduces three main kinds of platforms: nanoelectronics, nanofibers, and nanoparticles. The potential neural applications of the nanostructured platforms are discussed, including neural recording, neural modulation, neural regeneration, and imaging. The interactions between the platforms and the neural cells in vitro and in vivo are also briefly reviewed. The chapter ends with a discussion on existing barriers to clinical translation and future research directions of the platforms.
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Abbreviations
- BMSC:
-
Bone marrow stem cell
- CNT:
-
Carbon nanotube
- CP:
-
Conducting polymer
- DRG:
-
Dorsal root ganglion
- ECM:
-
Extracellular matrix
- ESC:
-
Embryonic stem cell
- FET:
-
Field-effect transistor
- GO:
-
Graphene oxide
- MAP:
-
Mussel adhesive protein
- NIR:
-
Near-infrared
- NP:
-
Nanoparticle
- NPC:
-
Neural progenitor cell
- NSC:
-
Neural stem cell
- PEDOT:
-
Poly(3,4-ethylenedioxythiophene)
- PLGA:
-
Poly(lactic-co-glycolic acid)
- SC:
-
Schwann cell
- SEM:
-
Scanning electron microscopy
- SNR:
-
Signal-to-noise ratio
- UCNP:
-
Upconversion nanoparticle
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Chen, N., Ramakrishna, S., Thakor, N.V. (2021). Nanostructured Platforms Interfacing with Nervous System. In: Thakor, N.V. (eds) Handbook of Neuroengineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-2848-4_17-1
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