Abstract
Brain functional connectivity evaluates the statistical dependencies between spatially distributed brain regions. The patterns obtained from this analysis have been related to different cognitive processes and are altered by neurodegenerative diseases. Parkinson’s disease (PD) is the second most frequent neurodegenerative disease and presents a combination of motor and cognitive disturbances. In this study the early changes in connectivity patterns in PD are evaluated.EEG was recordedat resting state with eyes closedin twenty-three patients withPDwithout cognitive decline (PD-CogNL)and twenty three healthy controls. Spectral coherence was estimatedbetween electrode pairs in fronto-parietal and inter-hemispheric regions. Rhythms of interest were: delta (1–4 Hz), theta (4–8 Hz), alpha1 (8–10 Hz), alpha2 (10–13 Hz), beta1 (13–20 Hz), and beta2 (20–30 Hz). Compared to controls, PD-CogNL had an increased coherence in frontal inter-hemisphericelectrodes in delta and theta bands.In the fastest bands were found correlations between connectivity and executive function measured by INECO test.The results of this papershow early changes in frontal inter-hemispheric coupling in PD.
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Carmona, J., Suarez, J., Ochoa, J. (2017). Brain Functional Connectivity in Parkinson’s disease – EEG resting analysis. In: Torres, I., Bustamante, J., Sierra, D. (eds) VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016. IFMBE Proceedings, vol 60. Springer, Singapore. https://doi.org/10.1007/978-981-10-4086-3_47
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