Abstract
Phylloid tumor, formerly called cystosarcoma phylloides, is a very unusual neoplasia. It accounts for <0.5 % of all breast neoplasms and approximately 2.5 % of fibro-epithelial tumors. Like fibroadenoma, it consists of two tissue types, with the connective tissue predominating. Genomic mutations seem to be involved in the progression of fibroadenoma to phylloid tumor. There is also a high local recurrence rate, independent of the degree of malignancy. Consequently, surgical therapy should always consist of a complete resection, with tumor-free margins.
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Phylloid tumor, formerly called cystosarcoma phylloides, is a very unusual neoplasia. It accounts for <0.5 % of all breast neoplasms and approximately 2.5 % of fibro-epithelial tumors [1–3]. Like fibroadenoma, it histologically comprises two components, in which connective tissue predominates [3–5]. Hodges et al. studied the genome of a synchronous fibroadenoma and a phylloid tumor placed in the same breast mass and found that both neoplasms had an allelic loss at D7S522. However, in the phylloid tumor but not in the fibroadenoma, allelic losses also occurred at TP53 and D22S264. These latter mutations were suggested to be involved in the progression of fibroadenoma to phylloid tumor [5].
Phylloid neoplasias may be benign, borderline, or malignant [3]. They are generally seen in adult women and only rarely in girls (Fig. 15.1). In the study of Bässler and Zahner, 133 tumors occurred in the female and only 1 in the male breast [6]. In 1998, Blanckaert et al. described a case in an 11-year-old child, in whom the tumor presented as a painless, voluminous (6-cm diameter), and rapidly growing mass [4]. Among the clinical characteristics of phylloid tumor is a high local recurrence rate, independent of the tumor’s degree of malignancy [1, 2]. Consequently, surgical therapy, either conservative or radical depending not only on the tumor grade and growth rate but also on the size of the neoplasm and the breast, should always consist of a complete resection, with tumor-free margins [1, 2, 6].
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Cucinotta, M., Cistaro, A. (2014). Phylloid Tumor of the Breast. In: Cistaro, A. (eds) Atlas of PET/CT in Pediatric Patients. Springer, Milano. https://doi.org/10.1007/978-88-470-5358-8_15
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DOI: https://doi.org/10.1007/978-88-470-5358-8_15
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