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The Role of C-Type Lectin Receptors in the Host Defense Against Microbial Pathogens

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Glycoscience: Biology and Medicine

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Abstract

C-type lectin receptors (CLRs) are a group of pattern recognition receptors (PRRs) that recognize carbohydrate structures in microbes, including fungi and bacteria, as pathogen-associated molecular patterns (PAMPs). They are expressed mainly in dendritic cells (DCs) and macrophages, and among these CLRs, DC-associated C-type lectin-1 (Dectin-1), DC-associated C-type lectin-2 (Dectin-2), macrophage-inducible C-type lectin (Mincle), and macrophage C-type lectin (Mcl) transduce their signaling through phosphorylation of spleen tyrosine kinase (Syk). On the other hand, human DC-specific intracellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and its mouse homologue SIGN-related gene 3 (SIGNR3), members of the DC-SIGN superfamily of CLRs, transduce their signaling through intracellular tyrosine-containing motif. In addition to pathogen recognition, Mincle, DC-SIGN, and SIGNR3 have been shown to recognize molecules from self, suggesting pleiotropic roles of CLRs in the homeostasis of the body. Here, we review each of these receptors in detail describing their expression, ligand recognition, signaling, and associated human diseases.

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Author information

Authors and Affiliations

  1. Center for Animal Disease Models, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, 278-0022, Noda, Chiba, Japan

    Rikio Yabe & Yoichiro Iwakura

  2. Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, 1-8-1 Inohoana Chuo-ku, 260-8679, Chiba, Japan

    Rikio Yabe & Shinobu Saijo

  3. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honmachi Kawaguchi City, 332-0012, Saitama, Japan

    Yoichiro Iwakura

  4. Precursory Research for Embryonic Science and Technology (PRESTO), JST, 4-1-8 Honmachi Kawaguchi City, 332-0012, Saitama, Japan

    Shinobu Saijo

Authors
  1. Rikio Yabe
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  2. Yoichiro Iwakura
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  3. Shinobu Saijo
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Corresponding author

Correspondence to Shinobu Saijo .

Editor information

Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Tamao Endo

  2. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Academia Sinica, Nankang, Taipei, Taiwan

    Chi-Huey Wong

  5. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

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© 2014 Springer Japan

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Yabe, R., Iwakura, Y., Saijo, S. (2014). The Role of C-Type Lectin Receptors in the Host Defense Against Microbial Pathogens . In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_180-1

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  • DOI: https://doi.org/10.1007/978-4-431-54836-2_180-1

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  • Publisher Name: Springer, Tokyo

  • Online ISBN: 978-4-431-54836-2

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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