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Zusammenfassung

Grundlage der Behandlung der Osteoporose sind nichtmedikamentöse Maßnahmen und eine ausreichende Zufuhr von Calcium und Vitamin D als Basistherapie (Rizzoli et al. 2008). Bei niedrigem Frakturrisiko reichen sie zur Prophylaxe von osteoporotischen Frakturen aus. Ab einem 10-Jahresfrakturrisiko von 30% ist eine spezifische Osteoporosetherapie indiziert (Dachverband Osteologie 2014).

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Literatur

  • Arzneimittelkommission der Deutschen Ärzteschaft (2008): Empfehlungen zur Therapie und Prophylaxe der Osteoporose. Arzneiverordnung in der Praxis (Sonderheft 34S), 2. Auflage. Im Internet: www.akdae.de/35/83_Osteoporose_2008_2Auflage.pdf

  • Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG, Hercz G, Cunningham J, Abu-Alfa AK, Messa P, Coyne DW, Locatelli F, Cohen RM, Evenepoel P, Moe SM, Fournier A, Braun J, McCary LC, Zani VJ, Olson KA, Drueke TB, Goodman WG (2004): Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 350: 1516–1525

    Google Scholar 

  • Bolland MJ, Grey A, Reid IR (2013): Calcium supplements and cardiovascular risk: 5 years on. Ther Adv Drug Saf 4: 199–210

    Google Scholar 

  • Bone HG, Hosking D, Devogelaer JP, Tucci JR, Emkey RD, Tonino RP, Rodriguez-Portales JA, Downs RW, Gupta J, Santora AC, Liberman UA; Alendronate Phase III Osteoporosis Treatment Study Group (2004): Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 350: 1189–1199

    Google Scholar 

  • Brown JE, Coleman RE (2012): Denosumab in patients with cancer-a surgical strike against the osteoclast. Nat Rev Clin Oncol 9: 110–118

    Google Scholar 

  • Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; FREEDOM Trial (2009): Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361: 756–765

    Google Scholar 

  • Dachverband Osteologie (2014): Prophylaxe, Diagnostik und Therapie der Osteoporose bei Männern ab dem 60. Lebensjahr und bei postmenopausalen Frauen. S3-Leitlinie des Dachverbands der Deutschsprachigen Wissenschaftlichen Osteologischen Gesellschaften e.V. – Kurzfassung und Langfassung. Internet: http://www.dv-osteologie.org/dvo_leitlinien/osteoporose-leitlinie-2014

  • Drüeke TB (2007): Lanthanum carbonate as a first-line phosphate binder: the „cons”. Semin Dial 20: 329–332

    Google Scholar 

  • Edwards BJ, Sun M, West DP, Guindani M, Lin YH, Lu H, Hu M, Barcenas C, Bird J, Feng C, Saraykar S, Tripathy D, Hortobagyi GN, Gagel R, Murphy WA (2016): Incidence of atypical femur fractures in cancer patients: The MD Anderson Cancer Center Experience. J Bone Miner Res 31: 1569–1576

    Google Scholar 

  • Favia G, Pilolli GP, Maiorano E (2009): Histologic and histomorphometric features of bisphosphonate-related osteonecrosis of the jaws: an analysis of 31 cases with confocal laser scanning microscopy. Bone 45: 406–413

    Google Scholar 

  • Food and Drug Administration (2013): FDA Drug Safety Communication: Pediatric clinical studies of Sensipar (cinacalcet hydrochloride) suspended after report of death. Internet: http://www.fda.gov/Drugs/DrugSafety/ucm340551.htm

  • Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE et al.; Women’s Health Initiative Investigators (2006): Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354: 669–683

    Google Scholar 

  • Lamy O (2012): Knochenanabole Therapie mit Teriparatid. Ther Umsch 69: 187–191

    Google Scholar 

  • Lyles KW, Colon-Emeric CS, Magaziner JS, Adachi JP, Pieger CF, Mautalen C, Hyldstrup L, Recknor C, Nordsletten L, Moore KA, Lavecchia C, Zhang J, Mesenbrink P, Hodgson PK, Abrams K, Orloff JJ, Horowitz Z, Eriksen EF, Boonen S; HORIZON Recurrent Fracture Trial (2007): Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 357: 1799–1810

    Google Scholar 

  • Malberti F (2013): Hyperphosphataemia: treatment options. Drugs 73: 673–688

    Google Scholar 

  • Manns B, Klarenbach S, Lee H, Culleton B, Shrive F, Tonelli M (2007): Economic evaluation of sevelamer in patients with end-stage renal disease. Nephrol Dial Transplant 22: 2867–2878

    Google Scholar 

  • Navaneethan SD, Palmer SC, Vecchio M, Craig JC, Elder GJ, Strippoli GF (2011): Phosphate binders for preventing and treating bone disease in chronic kidney disease patients. Cochrane Database Syst Rev. 2011 Feb 16; (2): CD006023

    Google Scholar 

  • NIH Consensus Conference (1994): Optimal calcium intake. JAMA 272: 1942–1948

    Google Scholar 

  • Pazianas M, Compston J, Huang CL (2010): Atrial fibrillation and bisphosphonate therapy. J Bone Miner Res 25: 2–10.

    Google Scholar 

  • Rachner TD, Khosla S, Hofbauer LC (2011): Osteoporosis: now and the future. Lancet 377: 1276–1287

    Google Scholar 

  • Rizzoli R, Boonen S, Brandi ML, Burlet N, Delmas P, Reginster JY (2008): The role of calcium and vitamin D in the management of osteoporosis. Bone 42: 246–249

    Google Scholar 

  • Servier (2014): Neue eingeschränkte Indikation und Empfehlungen zu Kontrollen bei der Einnahme von Protelos (Strontiumranelat). Internet: http://www.akdae.de/Arzneimittelsicherheit/RHB/Archiv/2014/index.html

  • Servier (2017): Protelos®: Einstellung der Produktion ab August 2017. Internet: http://www.servier.de/news/protelosr-einstellung-der-produktion-ab-august-2017

  • Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O’Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M; American Society for Bone and Mineral Research (2010): Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 25: 2267–2294

    Google Scholar 

  • Straub DA (2007): Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract 22: 286–296

    Google Scholar 

  • Suki W, Zabaneh R, CangianoJ, Reed J, Fischer D, Garrett L, Ling B, Chasan-Taber S, Dillon M, Blair A, Burke S (2006): A prospective, randomized trial assessing the impact on outcomes of sevelamer in dialysis patients. The DCOR trial. Nephrol Dial Transplant 21 (Suppl 4): 145–146

    Google Scholar 

  • The EVOLVE Trial Investigators (2012): Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 367: 2482–2494

    Google Scholar 

  • Wade SW, Curtis JR, Yu J, White J, Stolshek BS, Merinar C, Balasubramanian A, Kallich JD, Adams JL, Viswanathan HN (2012): Medication adherence and fracture risk among patients on bisphosphonate therapy in a large United States health plan. Bone 50: 870–875

    Google Scholar 

  • Ziegler R (2002): Osteoporose: aktuelle Diagnostik und Therapie. Orthopädische Praxis 38: 570–577

    Google Scholar 

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Correspondence to Christian Kasperk .

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Kasperk, C., Ziegler, R. (2017). Osteoporosemittel. In: Schwabe, U., Paffrath, D., Ludwig, WD., Klauber, J. (eds) Arzneiverordnungs-Report 2017. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54630-7_39

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  • DOI: https://doi.org/10.1007/978-3-662-54630-7_39

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