Zusammenfassung
Psychische Erkrankungen weisen eine komplexe Pathopysiologie auf, die bis heute nur ansatzweise geklärt ist. Neben Veränderungen von Neurotransmittersystemen und Rezeptoren als deren Effektorsysteme, die dann auf nachgeschaltete Signaltransduktionsprozesse einwirken, mehren sich Hinweise, dass neuroendokrinologische Mechanismen eine wichtige Rolle in der Pathophysiologie psychischer Erkrankungen spielen. Mittlerweile gibt es auch erste Ansätze, die versuchen, derartige Mechanismen im Sinne von neuartigen Therapiestrategien nutzbar zu machen.
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Literatur
Anacker C, Zunszain PA, Cavalho LA, PAriante CM (2011) The glucocorticoid receptor: pivot of depression and antidepressant treatment? Psychoneuroendocrinology 36:415–425
Bauer M, Hellweg R, Gräf KJ, Baumgartner A (1998) Treatment of refractory depression with high-dose thyroxine. Neuropsychopharmacology 18:444–455
Baulieu EE (1991) Neurosteroids: a new function in the brain. Biol Cell 71:3–10
Behl C, Skutella T, Lezoualc’H F et al (1997) Neuroprotection of against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 51:535–541
Binder E, Salyakina D, Lichtner P et al (2004) Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 36:1319–1325
Binneman B, Feltner D, Kolluri S et al (2008) A 6-week randomized, placebo-controlled trial of CP-316,311 (a selective CRH1 antagonist) in the treatment of major depression. Am J Psychiatry 165:617–620
Brockington IF, Meakin CJ (1994) Clinical clues to the aetiology of puerperal psychosis. Prog Neuropsychopharmacol Biol Psychiatry 18:417–429
Checkley SA, Wieck A, Marks M et al (1992) Neuroendocrine studies of the aetiology of puerperal psychosis. Clin Neuropharmacol 15:212–213
Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889–895
Flood JF, Smith GE, Roberts E (1988) Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res 447:269–278
Friess E, Trachsel L, Guldner J et al (1995) DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. Am J Physiol 268:E107–E113
Friess E, Tagaya H, Trachsel L et al (1997) Progesterone-induced changes in sleep in male subjects. Am J Physiol 272:E885–E891
Ghadirian AM, Engelsmann F, Dhar V et al (1995) The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment. Biol Psychiatry 37:369–375
Gold PW, Loriaux DL, Roy A et al (1986) Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease. N Engl J Med 314:1329–1335
Gregoire AJP, Kumar R, Everitt B et al (1996) Transdermal oestrogen for treatment of severe postnatal depression. Lancet 347:930–933
Häfner H, Nowotny B (1995) Epidemiology of early-onset schizophrenia. Eur Arch Psychiatry Clin Neurosci 245:80–92
Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23:477–501
Holsboer F, Barden N (1996) Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 17:187–205
Holsboer F, von Bardeleben U, Gerken A et al (1984) Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. N Engl J Med 311:1127
Hudson JI, Hudson MS (1984) Endocrine dysfunction in anorexia nervosa and bulimia: comparison with abnormalities in other psychiatric disorders and disturbances due to metabolic factors. Psychiatr Dev 2:237–272
Ising M, Lucae S, Binder EB et al (2009) A genomewide association study points to multiple loci that predict antidepressant treatment response. Arch Gen Psychiatry 66:966–975
Jahn H, Schick M, Kiefer F et al (2004) Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. Arch Gen Psychiatry 61:1235–1244
Kellner M, Herzog L, Yassouridis A et al (1995) Possible role of atrial natriuretic hormoe in pituitary adrenocortical unresponsiveness in lactate-induced panic. Am J Psychiatry 152:1365–1367
Krieg J-C, Lauer CJ, Hermle L et al (1990) Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders. Neuropsychobiology 23:57–67
Kulkarni J, Riedel A, de Castella AR et al (2001) Estrogen – a potential treatment for schizophrenia. Schizophr Res 48:137–144
Kulkarni J, Gavrilidis E, Wang W, Worsley R, Fitzgerald PB, Gurvich C, van Rheenen T, Berk M, Burger H (2015) Estradiol for treatment-resistant schizohprehnia: a large-scale randomized-controlled trial in women of child-bearing age. Mol Psychiatry 20:695–702
Lancel M, Faulhaber J, Holsboer F, Rupprecht R (1996) Progesterone induces changes in sleep EEG comparable to those of agonistic GABAA receptor modulators. Am J Physiol 271:E763–E772
Lesch KP, Rupprecht R (1989) Psychoneuroendocrine research in depression: II. Hormonal responses to releasing hormones as a probe for hypothalamic-pituitary-endorgan dysfunction. J Neural Transm 75:179–194
Lesch KP, Ihl R, Frölich L et al (1990) Endocrine responses to growth hormone releasing hormone and corticotropin releasing hormone in early onset Alzheimer’s disease. Psychiatry Res 33:107–112
Murphy BEP, Dhar V, Ghadirian AM et al (1991) Response to steroid suppression in major depression resistant to antidepressant therapy. J Clin Psychopharmacol 11:121–126
Nemeroff CB, Widerlöv E, Bisette G et al (1984) Elevated concentrations of CSF corticotropin-releasing-factor-like immunoreactivity in depressed patients. Science 226:1342–1343
Neuhauser H, Laakmann G (1988) Stimulation of growth hormone by GHRH as compared to DMI in depressed patients. Pharmacopsychiatry 21:443–444
O’Dwyer A-M, Lightman SL, Marks MN, Checkley SA (1995) Treatment of major depression with metyrapone and hydrocortisone. J Affect Disord 33:123–128
Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311–2322
Rao ML, Strebel B, Halaris A et al (1995) Circadian rhythm of vital signs, norepinephrine, epinephrine, thyroid hormones, and cortisol in schizophrenia. Psychiatry Res 57:21–39
Rupprecht R (1997) The neuropsychopharmacological potential of neuroactive steroids. J Psychiatr Res 31(3):297–314
Rupprecht R (2003) Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology 28:139–168
Rupprecht R, Lesch KP (1989) Psychoneuroendocrine research in depression: I. Hormone levels of different neuroendocrine axes and the dexamethasone suppression test. J Neural Transm 75:167–178
Rupprecht R, Lesch KP, Müller U et al (1989a) Blunted adrenocorticotropin but normal beta-endorphin release after human corticotropin-releasing hormone administration in depression. J Clin Endocrinol Metab 69:600–603
Rupprecht R, Rupprecht C, Rupprecht M et al (1989b) Triiodothyronine, thyroxine and TSH response to dexamethasone in depressed patients and normal controls. Biol Psychiatry 25:22–32
Rupprecht R, Baghai TC, Möller HJ (2004) Neuentwicklungen in der Pharmakotherapie der Depression. Nervenarzt 75:273–280
Rupprecht R, Rammes G, Eser D et al (2009) Translocator protein (18 kDa) as target for anxiolytics without benzodiazepine-like side effects. Science 325:490–493
Schatzberg AF (2015) The role of the hypothalamic-pituitary-adrenal (HPA) axis in the pathogenesis of psychotic major depression. World J Biol Psyhciatry 16:2–11
Schreiber W, Lauer CJ, Krumrey K et al (1996) Dysregulation of the hypothalamic-pituitary-adrenocortical system in panic disorder. Neuropsychopharmacology 15:7–15
Schüle C, Baghai TC, Eser D et al (2009a) The combined dexamethasone/CRH test (DEX/CRH test) and prediction of acute treatment response in major depression. PLoS One 4:e4324
Schüle C, Baghai TC, Eser D, Rupprecht R (2009b) Hypothalamic-pituitary-adrenocortical (HPA) system regulation and new treatment strategies in depression. Exp Rev Neurother 9:1005–1019
Starkmann MN, Schteingart DE (1981) Neuropsychiatric manifestations of patients with Cushing’s syndrome. Relationship to cortisol and adrenocorticotropic hormone levels. Arch Intern Med 141:215–219
Steiger A (1995) Schlafendokrinologie. Nervenarzt 66:15–27
Steiger A, Guldner J, Colla-Müller M et al (1994) Growth hormone-releasing hormone (GHRH)-induced effects on sleep EEG and nocturnal secretion of growth hormone, cortisol and ACTH in patients with major depression. Psychiatr Res 28:225–238
Unden F, Ljunggren JG, Kjellman BF et al (1986) Twenty-four-hour serum levels and decreased TSH response to TRH in affective disorders. Acta Psychiatr Scand 73:358–365
Voderholzer U, Laakmann G, Wittman R et al (1993) Profiles of spontaneous 24-hour and stimulated growth hormone secretion in male patients with endogenous depression. Psychiatry Res 47:215–227
von Bardeleben U, Stalla GK, Müller OA, Holsboer F (1988) Blunting of corticotropin response to corticotropin-releasing hormone in depressed patients is avoided by metyrapone pretreatment. Biol Psychiatry 24:782–786
Wolkowitz OM, Reus VI, Manfredi F et al (1993) Ketoconazole administration in hypercortisolemic depression. Am J Psychiatry 150:810–812
Zobel AW, Yassouridis A, Frieboes RM, Holsboer F (1999) Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am J Psychiatry 156:949–951
Zobel AW, Nickel T, Kunzel HE et al (2000) Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res 34:171–181
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Rupprecht, R. (2017). Psychoneuroendokrinologische Grundlagen psychischer Erkrankungen. In: Möller, HJ., Laux, G., Kapfhammer, HP. (eds) Psychiatrie, Psychosomatik, Psychotherapie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49295-6_9
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