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Hirntumoren

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NeuroIntensiv

Zusammenfassung

Hirntumoren treten entweder als primäre Erkrankungen des Nervensystems oder sekundär als Komplikation metastatischer, primär extrazerebraler Tumorerkrankungen auf. Die Prognose der primären Tumoren ist in Abhängigkeit von Histologie und Erkrankungsalter sehr unterschiedlich. Etwa 20 % aller Patienten mit extrazerebralen Tumoren entwickeln Hirnmetastasen. Diese tragen erheblich zur Morbidität bei und sind eine häufige Todesursache.

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Literatur

Zu 34.1

  1. Anderson GD, Lin YX, Berge C, Ojemann GA (1997) Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment. J Neurosurg 87:252–256

    Article  CAS  PubMed  Google Scholar 

  2. Brandsma D, Stalpers L, Taal W, Sminia P, Van den Bent MJ (2008) Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9:453–461

    Article  PubMed  Google Scholar 

  3. Carden CP, Larkin JMG, Rosenthal MA (2008) What is the risk of intracranial bleeding during anti-VEGF therapy? Neuro-Oncology 10:624–630

    Article  PubMed  PubMed Central  Google Scholar 

  4. Deutsche Gesellschaft für Neurologie, Diener HC, Weimar C, Berlit P, Deuschl G, Elger C, Gold R, Hacke W, Hufschmidt A, Mattle H, Meier U, Oertel WH, Reichmann H, Schmutzhard E, Wallesch CW, Weller M (Hrsg) (2012) Leitlinien für Diagnostik und Therapie in der Neurologie. Gliome. Thieme, Stuttgart, S 922–940

    Google Scholar 

  5. Fischer L, Martus P, Weller M, Klasen HA, Rohden B, Röth A, Storek B, Hummel M, Nägele T, Thiel E, Korfel A (2008) Meningeal dissemination in primary CNS lymphoma: Prospective evaluation of 282 patients. Neurology 71:1102–1108

    Article  CAS  PubMed  Google Scholar 

  6. Juergens A, Pels H, Rogowski S, Fliessbach K, Glasmacher A, Engert A, Reiser M, Diehl V, Vogt-Schaden M, Egerer G, Schackert G, Reichmann H, Kroschinsky F, Bode U, Herrlinger U, Linnebank M, Deckert M, Fimmers R, Schmidt-Wolf IG, Schlegel U (2010) Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma. Ann Neurol 67:182–189

    Article  CAS  PubMed  Google Scholar 

  7. Kalfas IH, Little JR (1988) Postoperative hemorrhage: a survey of 4992 intracranial procedures. Neurosurgery 23:343–347

    Article  CAS  PubMed  Google Scholar 

  8. Leonard IE, Cunningham AJ (2002) The sitting position in neurosurgery – not yet obsolete! Br J Anaesth 88:1–3

    Article  CAS  PubMed  Google Scholar 

  9. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer B, Kleihues P (2007) WHO Classification of Tumours of the Central Nervous System. IARC Press, Lyon

    Google Scholar 

  10. Macdonald DR, Cascino TL, Schold SC, Cairncross JG (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277–1280

    CAS  PubMed  Google Scholar 

  11. Sawaya R, Hammoud M, Schoppa D, Hess KR, Wu SZ, Shi WM, Wildrick DM (1998) Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery 42:1044–1055

    Article  CAS  PubMed  Google Scholar 

  12. Stummer W, Pichlmeier U, Meinel T, Wiestler O, Zanella F, Reulen R (2006) Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncology 7:392–401 (for the ALA-Glioma Study Group)

    Article  CAS  PubMed  Google Scholar 

  13. Weller M, Martus P, Roth P, Thiel E, Korfel A (2012) Surgery for primary CNS lymphoma? Challenging a paradigm. Neuro-Oncology 14:1481–1484 (for the German PCNSL Study Group)

    Article  PubMed  PubMed Central  Google Scholar 

  14. Weller M, Stupp R, Wick W (2012) Epilepsy meets cancer: when, why, and what to do about it? Lancet Oncol 13:e375–e382

    Article  PubMed  Google Scholar 

  15. Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, De Groot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM (2010) Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28 1963–1972 28:1963–1972

    Article  Google Scholar 

Zu 34.2

  1. Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr. (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672

    Article  PubMed  Google Scholar 

  2. Maranzano E, Bellavita R, Rossi R, De Angelis V, Frattegiani A, Bagnoli R, Mignogna M, Beneventi S, Lupattelli M, Ponticelli P, Biti GP, Latini P (2005) Short-course versus split-course radiotherapy in metastaticspinal cord compression. Results of a phase III, randomized, multicenter trial. J Clin Oncol 23:3358–3365

    Article  PubMed  Google Scholar 

  3. Deutsche Gesellschaft für Neurologie, Diener HC, Weimar C, Berlit P, Deuschl G, Elger C, Gold R, Hacke W, Hufschmidt A, Mattle H, Meier U, Oertel WH, Reichmann H, Schmutzhard E, Wallesch CW, Weller M (Hrsg) (2012) Leitlinien für Diagnostik und Therapie in der Neurologie. Metastasen und Meningeosis neoplastica. Thieme, Stuttgart, S 941–958

    Google Scholar 

  4. Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert B, Fariselli L, Tzuk-Shina T, Kortmann R-D, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Collette S, Collete L, Mueller RP (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952–26001 Study. J Clin Oncol 29:134–141

    Article  PubMed  Google Scholar 

  5. Mintz AH, Kestle J, Rathbone MP, Gaspar L, Hugenholtz H, Fisher B, Duncan G, Skingley P, Foster G, Levine M (1996) A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 78:1470–1476

    Article  CAS  PubMed  Google Scholar 

  6. Obbens EAMT, Leavens ME, Beal JW, Lee Y (1985) Ommaya reservoir in 387 cancer patients: a 15-year experience. Neurology 35:1274–1278

    Article  CAS  PubMed  Google Scholar 

  7. Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500

    Article  CAS  PubMed  Google Scholar 

  8. Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B (1998) Postoperative radiotherapy in the treatment of single metastases to the brain. A randomized trial. J Am Med Assoc 280:1485–1489

    Article  CAS  Google Scholar 

  9. Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer. A randomized trial. Lancet 366:643–648

    Article  PubMed  Google Scholar 

  10. Schellinger PD, Meinck HM, Thron A (1999) Diagnostic reach of mri compared to cct in patients with brain metastases. J Neuro-Oncol 44:275–281

    Article  CAS  Google Scholar 

  11. Shaw EG, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N (2000) Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90–05. Int J Radiat Oncol Biol Phys 47:291–298

    Article  CAS  PubMed  Google Scholar 

  12. Vecht CJ, Haaxma-Reiche H, Noordijk EM, Padberg GW, Voormolen JHC, Hoekstra FH, Tans JTJ, Lambooij N, Metsaars JAL, Wattendorff AR, Brand R, Hermans J (1993) Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33:583–590

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Michael Weller Prof. Dr. .

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Weller, M., Schlegel, U., Schmieder, K. (2015). Hirntumoren. In: Schwab, S., Schellinger, P., Werner, C., Unterberg, A., Hacke, W. (eds) NeuroIntensiv. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46500-4_34

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  • DOI: https://doi.org/10.1007/978-3-662-46500-4_34

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