Zusammenfassung
Hypnotika werden sowohl zur Narkoseeinleitung und -aufrechterhaltung im Rahmen einer totalen intravenösen Anästhesie (TIVA) als auch zur Sedierung auf Intensivstationen eingesetzt. Entsprechend hoch ist ihr Stellenwert in der Anästhesie. Das Kapitel gibt einen Überblick über den grundsätzlichen Wirkmechanismus der Hypnotika sowie die Pharmakokinetik, Pharmakodynamik und die klinischen Anwendungsgebiete der einzelnen Hypnotika.
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Literatur
Franks NP, Lieb WR (1997) Inhibitory synapses. Anaesthetics set their sites on ion channels. Nature 389:334–335
Brown EN, Lydic R, Schiff ND (2010) General anesthesia, sleep, and coma. N Engl J Med 363:2638–2650
Price HL (1960) A dynamic concept of the distribution of thiopental in the human body. Anesthesiology 21:40–45
Hudson RJ, Stanski DR, Burch PG (1983) Pharmacokinetics of methohexital and thiopental in surgical patients. Anesthesiology 59:215–219
Hempel V (1994) 60 years thiopental. Anästhesiol Intensivmed Notfallmed Schmerzther: AINS 29:400–407
Van Hamme MJ, Ghoneim MM, Ambre JJ (1978) Pharmacokinetics of etomidate, a new intravenous anesthetic. Anesthesiology 49:274–277
Vanlersberghe C, Camu F (2008) Etomidate and other non-barbiturates. Handb Exp Pharmacol 182:267–282
Roberts I (2000) Barbiturates for acute traumatic brain injury. Cochrane Database Syst Rev (12):CD000033
Eames WO, Rooke GA, Wu RS, Bishop MJ (1996) Comparison of the effects of etomidate, propofol, and thiopental on respiratory resistance after tracheal intubation. Anesthesiology 84:1307–1311
Avram MJ, Sanghvi R, Henthorn TK et al (1993) Determinants of thiopental induction dose requirements. Anesth Analg 76:10–17
Masui K, Upton RN, Doufas AG et al (2010) The performance of compartmental and physiologically based recirculatory pharmacokinetic models for propofol: a comparison using bolus, continuous, and target-controlled infusion data. Anesth Analg 111:368–379
Eleveld DJ et al (2014) A general purpose pharmacokinetic model for propofol. Anesth Analg 118(6):1221–1237. doi:10.1213/ANE.0000000000000165
Smith I, White PF, Nathanson M, Gouldson R (1994) Propofol. An update on its clinical use. Anesthesiology 81:1005–1043
Hoymork SC, Raeder J (2005) Why do women wake up faster than men from propofol anaesthesia? Br J Anaesth 95:627–633
Hiraoka H, Yamamoto K, Miyoshi S et al (2005) Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain. Br J Clin Pharmacol 60:176–182
Takizawa D, Hiraoka H, Goto F et al (2005) Human kidneys play an important role in the elimination of propofol. Anesthesiology 102:327–330
He YL, Ueyama H, Tashiro C et al (2000) Pulmonary disposition of propofol in surgical patients. Anesthesiology 93:986–991
Apfel CC, Korttila K, Abdalla M et al (2004) A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 350:2441–2451
Barann M, Linden I, Witten S, Urban BW (2008) Molecular actions of propofol on human 5-HT3A receptors: enhancement as well as inhibition by closely related phenol derivatives. Anesth Analg 106:846–857
Schelling G, Hauer D, Azad SC et al (2006) Effects of general anesthesia on anandamide blood levels in humans. Anesthesiology 104:273–277
Borgeat A, Wilder-Smith OH, Saiah M, Rifat K (1992) Subhypnotic doses of propofol possess direct antiemetic properties. Anesth Analg 74:539–541
Doenicke AW, Roizen MF, Rau J et al (1996) Reducing pain during propofol injection: the role of the solvent. Anesth Analg 82:472–474
Jalota L, Kalira V, George E et al (2011) Prevention of pain on injection of propofol: systematic review and meta-analysis. BMJ 342:d1110
Picard P, Tramer MR (2000) Prevention of pain on injection with propofol: a quantitative systematic review. Anesth Analg 90:963–969
Bennett SN, McNeil MM, Bland LA et al (1995) Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 333:147–154
Matot I, Neely CF, Katz RY, Marshall BE (1994) Fentanyl and propofol uptake by the lung: effect of time between injections. Acta Anaesthesiol Scand 38:711–715
Nitsun M, Szokol JW, Saleh HJ et al (2006) Pharmacokinetics of midazolam, propofol, and fentanyl transfer to human breast milk. Clin Pharmacol Ther 79:549–557
Schmidt H (1998) Intubation anesthesia and nursing. Anaesthesist 47:81–82
Reinhold P, Kraus G, Schlüter E (1998) Propofol for anesthesia and short-term sedation. The final word on use in children under three years. Anaesthesist 47:229–237
De Smet T, Struys MM, Neckebroek MM et al (2008) The accuracy and clinical feasibility of a new bayesian-based closed-loop control system for propofol administration using the bispectral index as a controlled variable. Anesth Analg 107:1200–1210
Hemmerling (2013) Evaluation of a novel closed-loop total intravenous anaesthesia drug delivery system: a randomizedcontrolled trial. Br J Anaesth 110(6):1031–1039
Hornuss C, Praun S, Villinger J et al (2007) Real-time monitoring of propofol in expired air in humans undergoing total intravenous anesthesia. Anesthesiology 106:665–674
Takita A, Masui K, Kazama T (2007) On-line monitoring of end-tidal propofol concentration in anesthetized patients. Anesthesiology 106:659–664
Cremer OL, Moons KG, Bouman EA et al (2001) Long-term propofol infusion and cardiac failure in adult head-injured patients. Lancet 357:117–118
Bray RJ (1998) Propofol infusion syndrome in children. Paediatr Anaesth 8:491–499
Fudickar A, Bein B, Tonner PH (2006) Propofol infusion syndrome in anaesthesia and intensive care medicine. Curr Opin Anaesthesiol 19:404–410
Lamberts SW, Bons EG, Bruining HA, de Jong FH (1987) Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells. J Pharmacol Exp Ther 240:259–264
Fragen RJ, Shanks CA, Molteni A, Avram MJ (1984) Effects of etomidate on hormonal responses to surgical stress. Anesthesiology 61:652–656
Cuthbertson BH, Sprung CL, Annane D et al (2009) The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 35:1868–1876
Fechner J, Ihmsen H, Jeleazcov C, Schuttler J (2009) Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol). Expert Opin Investig Drugs 18:1565–1571
Struys MM, Fechner J, Schuttler J, Schwilden H (2010) Erroneously published fospropofol pharmacokinetic-pharmacodynamic data and retraction of the affected publications. Anesthesiology 112:1056–1057
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Bayer, A., Hornuß, C. (2016). Hypnotika in der Anästhesiologie: Barbiturate, Propofol, Etomidat. In: Rossaint, R., Werner, C., Zwißler, B. (eds) Die Anästhesiologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45539-5_15-1
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DOI: https://doi.org/10.1007/978-3-662-45539-5_15-1
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