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Coronary Artery Spasm, Part II Basic Aspects

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PanVascular Medicine

Abstract

Despite considerable research effort, the pathogenesis of coronary vasospasm has not yet been fully elucidated. In this chapter we review the general hypothesis of vasospastic coronary artery behavior, present the current experimental models, and discuss potential clinical applications.

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Abbreviations

Coronary vasospasm:

State of functional hemodynamically relevant narrowing of a coronary artery due to hypercontraction of smooth muscle cells of the coronary artery walls.

References

  • Alessi D, MacDougall LK, Sola MM, Ikebe M, Cohen P (1992) The control of protein phosphatase-1 by targeting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1. Eur J Biochem 210:1023–1035

    Article  PubMed  CAS  Google Scholar 

  • Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T et al (1996) Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem 271:20246–20249

    Article  PubMed  CAS  Google Scholar 

  • Amano M, Chihara K, Nakamura N, Fukata Y, Yano T, Shibata M et al (1998) Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells 3:177–188

    Article  PubMed  CAS  Google Scholar 

  • Beltrame JF, Sasayama S, Maseri A (1999) Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients. J Am Coll Cardiol 33:1442–1452

    Article  PubMed  CAS  Google Scholar 

  • Berrige MJ (1993) Inositol triphosphate and calcium signaling. Nature 361:315–325

    Article  Google Scholar 

  • Butler WE, Peterson JW, Zervas NT, Morgan KG (1996) Intracellular calcium, myosin light chain phosphorylation, and contractile force in experimental cerebral vasospasm. Neurosurgery 38:781–788

    Article  Google Scholar 

  • Campbell GR, Campbell JH (1985) Recent advances in molecular pathology: smooth muscle phenotypic changes in arterial wall homeostasis implications for atherosclerosis. Exp Mol Pathol 42:139–162

    Article  PubMed  CAS  Google Scholar 

  • Chen YH, Chen MX, Alessi DR, Campbell DG, Shanahan C, Cohen P et al (1994) Molecular cloning of cDNA encoding the 110-kDa and 21-kDa regulatory subunits of smooth muscle protein phosphatase 1M. FEBS Lett 356:51–55

    Article  PubMed  CAS  Google Scholar 

  • Chihara K, Amano M, Nakamura N, Yano T, Shibata M, Tokui T et al (1997) Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. J Biol Chem 272:25121–25127

    Article  PubMed  CAS  Google Scholar 

  • Dinarello CA (1988) Biology of interleukin 1. FASEB J 2:108–115

    PubMed  CAS  Google Scholar 

  • Egashira K, Inou T, Yamada A, Hirooka Y, Takeshita A (1992) Preserved endothelium- dependent vasodilation at the vasospastic site in patients with variant angina. J Clin Invest 89:1047–1052

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Eto M, Ohmori T, Suzuki M, Furuya K, Morita F (1995) A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C: isolation from porcine aorta media and characterization. J Biochem 118:1104–1107

    PubMed  CAS  Google Scholar 

  • Eto Y, Shimokawa H, Hiroaki J, Morishige K, Kandabashi T, Matsumoto Y et al (2000) Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury. Am J Physiol 278:H1744–H1750

    CAS  Google Scholar 

  • Forman MB, Oates JA, Robertson D, Robertson RM, Roberts LJ, Virmani R (1985) Increased adventitial mast cells in a patient with coronary spasm. N Engl J Med 313:1138–1141

    Article  PubMed  CAS  Google Scholar 

  • Fukumoto Y, Shimokawa H, Kozai T, Kadokami Y, Kuwata K, Owada MK et al (1996) Tyrosine kinase inhibitor suppresses the (re)stenotic changes of the coronary artery after balloon injury in pigs. Cardiovasc Res 32:1131–1140

    Article  PubMed  CAS  Google Scholar 

  • Fukumoto Y, Shimokawa H, Ito A, Kadokami T, Yonemitsu Y, Aikawa M et al (1997a) Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth muscle phenotypes in pigs. J Cardiovasc Pharmacol 29:222–231

    Article  PubMed  CAS  Google Scholar 

  • Fukumoto Y, Shimokawa H, Kozai T, Kadokami T, Kuwata K, Yonemitsu Y et al (1997b) Vasculoprotective role of inducible nitric oxide synthase at inflammatory coronary lesions induced by chronic treatment with interleukin-1β in pigs in vivo. Circulation 96:3104–3111

    Article  PubMed  CAS  Google Scholar 

  • Fuster V, Badimon L, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes II. N Engl J Med 326:310–318

    Article  PubMed  CAS  Google Scholar 

  • Gong MC, Iizuka K, Nixon G, Browne JP, Hall A, Eccleston JF et al (1996) Role of guanosine nucleotide-binding proteins-ras family or trimeric proteins or both in Ca2+ sensitization of smooth muscle. Proc Natl Acad Sci USA 93:1340–1345

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Hannson GK, Jonasson L, Seifert PS, Stemme S (1989) Immune mechanism in atherosclerosis. Arteriosclerosis 9:567–578

    Article  Google Scholar 

  • Hirata K, Kikuchi A, Sasaki T, Kuroda S, Kaibuchi K, Matsuura Y et al (1992) Involvement of Rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem 267:8719–8722

    PubMed  CAS  Google Scholar 

  • Ikebe M, Brozovich FV (1996) Protein kinase C increases force and slows relaxation in smooth muscle: evidence for regulation of the myosin light chain phosphatase. Biochem Biophys Res Commun 225:370–376

    Article  PubMed  CAS  Google Scholar 

  • Ikebe M, Hartshorne DJ (1985) Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. J Biol Chem 260:10027–10031

    PubMed  CAS  Google Scholar 

  • Ito A, Shimokawa H, Nakaike R, Fukai T, Sakata M, Takayanagi T et al (1994) Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm. Circulation 90:2425–2431

    Article  PubMed  CAS  Google Scholar 

  • Ito A, Shimokawa H, Kadokami T, Fukumoto Y, Owada MK, Shiraishi T et al (1995) Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1β in pigs in vivo. J Clin Invest 96:1288–1294

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Ito A, Shimokawa H, Fukumoto Y, Kadokami T, Nakaike R, Takayanagi T et al (1996) The role of fibroblast growth factor-2 in the vascular effects of interleukin-1β in porcine coronary arteries in vivo. Cardiovasc Res 32:570–579

    PubMed  CAS  Google Scholar 

  • Jougasaki M, Yasue H, Takahashi K (1989) Perivascular nerve lesion of the coronary artery involved in spasm in a patient with variant angina. Pathology 21:304–307

    Article  PubMed  CAS  Google Scholar 

  • Kadokami T, Shimokawa H, Fukumoto Y, Ito A, Takayanagi T, Egashira K et al (1996) Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1β. Circulation 94:190–196

    Article  PubMed  CAS  Google Scholar 

  • Kamm KE, Stull JT (1989) Regulation of smooth muscle contractile elements by second messengers. Annu Rev Physiol 51:299–318

    Article  PubMed  CAS  Google Scholar 

  • Kanazawa K, Suematsu M, Ishida T, Hirata K, Kawashima S, Akita H et al (1997) Disparity between serotonin- and acetylcholine-provoked coronary artery spasm. Clin Cardiol 20:146–152

    Article  PubMed  CAS  Google Scholar 

  • Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y et al (2000) Inhibition of myosin phosphatase by up-regulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β. Circulation 101:1319–1323

    Article  PubMed  CAS  Google Scholar 

  • Katsumata N, Shimokawa H, Seto M, Kozai T, Yamawaki T, Kuwata K et al (1997) Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1β. Circulation 96:4357–4363

    Google Scholar 

  • Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M et al (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273:245–248

    Article  PubMed  CAS  Google Scholar 

  • Kitazawa T, Masuo M, Somlyo AP (1991) G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. Proc Natl Acad Sci USA 88:9307–9310

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Kohchi KS, Takebayashi S, Hiroki T, Nobuyoshi M (1985) Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy. Circulation 71:709–716

    Article  PubMed  CAS  Google Scholar 

  • Kozai T, Shimokawa H, Yamawaki T, Fukumoto Y, Kadokami T, Kuwata K et al (1997a) Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo. Coronary Art Dis 8:423–432

    Article  CAS  Google Scholar 

  • Kozai T, Shimokawa H, Fukumoto Y, Kobayashi S, Owada MK, Kadokami T et al (1997b) Tyrosine kinase inhibitor markedly suppresses the development of coronary lesions induced by chronic treatment with platelet-derived growth factor in pigs in vivo. J Cardiovasc Pharmacol 29:536–545

    Article  PubMed  CAS  Google Scholar 

  • Kuga T, Tagawa H, Tomoike H, Mitsuoka W, Egashira S, Ohara Y et al (1993) Role of coronary artery spasm in progression of organic stenosis and acute myocardial infarction in a swine model. Importance of mode of onset and duration of coronary artery spasm. Circulation 87:573–582

    Article  PubMed  CAS  Google Scholar 

  • Kuga T, Egashira K, Mohri M, Tsutsui H, Harasawa Y, Urabe Y (1995) Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo. Circulation 92:183–189

    Article  PubMed  CAS  Google Scholar 

  • Kuga T, Shimokawa H, Hirakawa Y, Kadokami T, Arai Y, Fukumoto Y et al (2000) Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm. J Cardiovasc Pharmacol 35:822–828

    Article  PubMed  CAS  Google Scholar 

  • Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T et al (1997) Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem 272:12257–12260

    Article  PubMed  CAS  Google Scholar 

  • Lange RA, Cigarroa RG, Yancy CW Jr, Willard JE, Pompa JJ, Sills MN et al (1989) Cocaine-induced coronary artery vasoconstriction. N Engl J Med 321:1557–1562

    Article  PubMed  CAS  Google Scholar 

  • Mark DB, Califf RM, Morris KG, Harrell FE, Pryor DB, Hlatky MA et al (1984) Clinical characteristics and long-term survival of patients with variant angina. Circulation 69:880–888

    Article  PubMed  CAS  Google Scholar 

  • Maseri A, Severi S, Nes MD, L'Abbate A, Chierchia S, Marzilli M et al (1978) “Variant” angina: one aspect of a continuous spectrum of vasospastic myocardial ischemia: pathogenetic mechanisms, estimated incidence and clinical and coronary angiographic findings in 138 patients. Am J Cardiol 42:1019–1035

    Article  PubMed  CAS  Google Scholar 

  • Maseri A, Davies G, Hackett D, Kaski JC (1990) Coronary artery spasm and vasoconstriction. The case for a distinction. Circulation 81:1983–1991

    Article  PubMed  CAS  Google Scholar 

  • Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, Takeshita A (2002) Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 105:1545–1547

    Article  PubMed  CAS  Google Scholar 

  • McFadden EP, Bauters C, Lablanche J-M, Quandalle P, Leroy F, Bertland ME (1993) Response of human coronary arteries to serotonin after injury by coronary angioplasty. Circulation 88:2076–2085

    Article  CAS  Google Scholar 

  • Miwa Y, Hirata K, Matsuda Y, Suematsu M, Kawashima S, Yokoyama M (1994) Augmented receptor-mediated Ca2+ mobilization causes supersensitivity of contractile response to serotonin in atherosclerotic arteries. Circ Res 75:1096–1102

    Article  PubMed  CAS  Google Scholar 

  • Miyata K, Shimokawa H, Yamawaki T, Kunihiro I, Zhou X, Higo T et al (1999) Endothelial vasodilator function is preserved at the spastic/inflammatory coronary lesions in pigs. Circulation 100:1432–1437

    Article  PubMed  CAS  Google Scholar 

  • Miyata K, Shimokawa H, Higo T, Yamawaki T, Katsumata N, Kandabashi T et al (2000) Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model. J Cardiovasc Pharmacol 35:294–301

    Article  PubMed  CAS  Google Scholar 

  • Mohri M, Shimokawa H, Hirakawa Y, Masumoto A, Takeshita A (2003) Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. J Am Coll Cardiol 41:15–19

    Article  PubMed  CAS  Google Scholar 

  • Morishige K, Shimokawa H, Yamawaki T, Miyata K, Eto Y, kandabashi T, Yogo K, Higo T, Egashira K, Ueno H, Takeshita A (2000) Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo. J Am Coll Cardiol 35:1040–1047

    Article  PubMed  CAS  Google Scholar 

  • Moyer CF, Sajuthi D, Tulli H, Williams JK (1991) Synthesis of IL-1α and IL-1β by arterial cells in atherosclerosis. Am J Pathol 138:951–960

    PubMed Central  PubMed  CAS  Google Scholar 

  • Murphy RA (1994) What is special about smooth muscle? The significance of covalent cross bridge regulation. FASEB J 38:781–788

    Google Scholar 

  • Nagasawa K, Tomoike H, Hayashi Y, Yamada A, Yamamoto T, Nakamura M (1989) Intramural hemorrhage and endothelial changes in atherosclerotic coronary artery after repetitive episodes of spasm in X-ray-irradiated hypercholesterolemic pigs. Circ Res 65:272–282

    Article  PubMed  CAS  Google Scholar 

  • Nakamura M (1991) Experimental induction of spasm, sudden progression of organic stenosis and intramural hemorrhage in the epicardial coronary arteries. Basic Res Cardiol 86:159–172

    PubMed  Google Scholar 

  • Nakamura M, Takeshita A, Nose Y (1987) Clinical characteristics associated with myocardial infarction, arrhythmias, and sudden death in patients with vasospastic angina. Circulation 75:1110–1116

    Article  PubMed  CAS  Google Scholar 

  • Noda M, Fukazawa C, Moriishi K, Kato T, Okuda T, Kurokawa K et al (1995) Involvement of rho in GTP-γS-induced enhancement of phosphorylation of 20-kDa myosin light chain vascular smooth muscle cells: inhibition of phosphatase activity. FEBS Lett 367:246–250

    Article  PubMed  CAS  Google Scholar 

  • Okumura K, Yasue H, Ishizaka H, Ogawa H, Fujii H, Yoshimura M (1992) Endothelium- dependent dilator response to substance P in patients with coronary spastic angina. J Am Coll Cardiol 20:838–844

    Article  PubMed  CAS  Google Scholar 

  • Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801–809

    Article  PubMed  CAS  Google Scholar 

  • Satoh S, Tomoike H, Mitsuoka W, Egashira S, Tagawa H, Kuga T et al (1990) Smooth muscles from spastic coronary artery segment show hyperreactivity to histamine. Am J Physiol 259:H9–H13

    PubMed  CAS  Google Scholar 

  • Seto M, Sasaki Y, Sasaki Y (1990) Stimulus-specific patterns of myosin light chain phosphorylation in smooth muscle of rabbit thoracic artery. Eur J Physiol 415:484–489

    Article  CAS  Google Scholar 

  • Seto M, Yano K, Sasaki Y, Azuma H (1993) Intimal hyperplasia enhances myosin phosphorylation in rabbit carotid artery. Exp Mol Pathol 58:1–13

    Article  PubMed  CAS  Google Scholar 

  • Seto M, Sakurada K, Kamm KE, Stull JT, Sasaki Y (1996) Myosin light chain diphosphorylation is enhanced by growth promotion of cultured smooth muscle cells. Eur J Physiol 432:7–13

    Article  CAS  Google Scholar 

  • Severi S, Davies G, Maseri A, Marzullo P, L'Abbate A (1980) Long-term prognosis of “variant” angina with medical treatment. Am J Cardiol 46:226–232

    Article  PubMed  CAS  Google Scholar 

  • Shimizu H, Ito M, Miyahata M, Ichikawa K, Okubo S, Konishi T et al (1994) Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase. J Biol Chem 269:30407–30411

    PubMed  CAS  Google Scholar 

  • Shimokawa H (1999) Primary endothelial dysfunction: atherosclerosis. J Mol Cell Cardiol 31:23–37

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H (2000) Cellular and molecular mechanisms of coronary artery spasm. Lessons from animal models. Jpn Circ J 64:1–12

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Takeshita A (1995) Endothelium-dependent regulation of the cardiovascular system. Intern Med 34:939–946

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Takeshita A (2005) Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25:1767–1775

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Vanhoutte PM (1989a) Hypercholesterolemia causes generalized impairment of endothelium-dependent relaxation to aggregating platelets in porcine coronary arteries. J Am Coll Cardiol 13:1402–1408

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Vanhoutte PM (1989b) Dietary cod-liver oil improves endothelium-dependent relaxations in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation 78:1421–1430

    Article  Google Scholar 

  • Shimokawa H, Tomoike H, Nabeyama S, Yamamoto H, Araki H, Nakamura M et al (1983) Coronary artery spasm induced in atherosclerotic miniature swine. Science 221:560–562

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Tomoike H, Nabeyama S, Yamamoto H, Ishii Y, Tanaka K et al (1985) Coronary artery spasm induced in miniature swine: angiographic evidence and relation to coronary atherosclerosis. Am Heart J 110:300–310

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Aarhus LL, Vanhoutte PM (1987) Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. Circ Res 61:256–270

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Nagasawa K, Irie T, Egashira S, Egashira K, Sagara T (1988) Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populations. Int J Cardiol 18:331–349

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Lam JYT, Chesebro JH, Bowie EJW, Vanhoutte PM (1989a) Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries. Circulation 76:898–905

    Article  Google Scholar 

  • Shimokawa H, Flavahan NA, Shepherd JT, Vanhoutte PM (1989b) Endothelium-dependent inhibition of ergonovine-induced contraction is impaired in porcine coronary arteries with regenerated endothelium. Circulation 80:643–650

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Flavahan NA, Vanhoutte PM (1989c) Natural course of the impairment of endothelium-dependent relaxation after balloon endothelium removal in porcine coronary arteries: possible dysfunction of a pertussis toxin-sensitive G-protein. Circ Res 65:740–753

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Ito A, Fukumoto Y, Kadokami T, Nakaike R, Sakata M et al (1996) Chronic treatment with interleukin-1β induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor. J Clin Invest 97:769–776

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Shimokawa H, Seto M, Katsumata N, Amano M, Kozai T, Yamawaki T et al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res 43:1029–1039

    Article  PubMed  CAS  Google Scholar 

  • Shimokawa H, Hiramori K, Iinuma H, Hosoda S, Kishida H, Osada H, Katagiri T, Yamauchi K, Yui Y, Minamino T, Nakashima M, Kato K (2002) Antianginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study. J Cardiovasc Pharmacol 40:751–761

    Article  PubMed  CAS  Google Scholar 

  • Shiroto T, Yasuda S, Tsuburaya R, Ito Y, Takahashi J, Ito K, Ishibashi-Ueda H, Shimokawa H (2009) Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in pigs in vivo. J Am Coll Cardiol 54:2321–2329

    Article  PubMed  CAS  Google Scholar 

  • Somlyo AP, Somlyo AV (1994) Signal transduction and regulation in smooth muscle. Nature 372:231–236

    Article  PubMed  CAS  Google Scholar 

  • Suzuki Y, Tokunaga S, Ikeguchi S, Miki S, Iwase T, Tomita T et al (1992) Induction of coronary artery spasm by intracoronary acetylcholine: comparison with intracoronary ergonovine. Am Heart J 124:39–47

    Article  PubMed  CAS  Google Scholar 

  • Takemoto M, Sun J, Hiroki J, Shimokawa H, Liao JK (2002) Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 106:57–62

    Article  PubMed  CAS  Google Scholar 

  • Tashiro H, Shimokawa H, Koyanagi S, Takeshita A (1993) Clinical characteristics of patients with spontaneous remission of variant angina. Jpn Circ J 57:117–122

    Article  PubMed  CAS  Google Scholar 

  • Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H (2012) Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: possible involvement of Rho-kinase pathway. Eur Heart J 33:791–799

    Article  PubMed  CAS  Google Scholar 

  • Uehara M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T et al (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389:990–994

    Article  Google Scholar 

  • Vanhoutte PM, Shimokawa H (1989) Endothelium-derived relaxing factor(s) and coronary vasospasm. Circulation 80:1–9

    Article  PubMed  CAS  Google Scholar 

  • Vicari RM, Chaitman B, Keefe D, Smith WB, Chrysant SG, Tonkon MJ, Bittar N, Weiss RJ, Morales-Ballejo H, Thadani U, Fasudil Study Group (2005) Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial. J Am Coll Cardiol 46:1803–1811

    Article  PubMed  CAS  Google Scholar 

  • Waters DD, Miller DD, Szlachcic J, Bouchard A, Méthé M, Kreeft J et al (1983) Factors influencing the long-term prognosis of treated patients with variant angina. Circulation 68:258–265

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto Y, Tomoike H, Egashira K, Nakamura M (1987) Attenuation of endothelium-related relaxation and enhanced responsiveness of vascular smooth muscle to histamine in spastic coronary arterial segments from miniature pigs. Circ Res 61:772–778

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto H, Yoshimura H, Noma M, Kai H, Suzuki S, Tajimi T et al (1992) Preservation of endothelium-dependent vasodilation in the spastic segment of the human epicardial coronary artery by substance P. Am Heart J 123:298–303

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto H, Yoshimura H, Noma M, Suzuki S, Kai H, Tajimi T et al (1995) Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm in patients with variant angina. Jpn Circ J 59:608–616

    Article  PubMed  CAS  Google Scholar 

  • Yasue H, Omote S, Takizawa A, Nagao M (1983) Coronary arterial spasm in ischemic heart disease and its pathogenesis. A review. Circ Res 52:1147–1152

    Google Scholar 

  • Yasue H, Takizawa A, Nagao M, Nishida S, Horie M, Kubota J et al (1988) Long-term prognosis for patients with variant angina and influential factors. Circulation 78:1–9

    Article  PubMed  CAS  Google Scholar 

  • Yogo K, Shimokawa H, Kandabashi T, Miyata K, Okamoto S, Egashira K, Huang PL, Akaike T, Takeshita A (2000) Different vasculoprotective roles of nitric oxide synthase isoforms in the vascular lesion formation in mice. Arterioscler Thromb Vasc Biol 20:e96–e100

    Article  PubMed  CAS  Google Scholar 

  • Yokoyama M, Akita H, Hirata K, Usuki S, Fukuzaki H, Itoh H (1990) Supersensitivity of isolated coronary artery to ergonovine in a patient with variant angina. Am J Med 89:507–515

    Article  PubMed  CAS  Google Scholar 

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Shimokawa, H. (2014). Coronary Artery Spasm, Part II Basic Aspects. In: Lanzer, P. (eds) PanVascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37393-0_59-1

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