Nomenclature
EC number
4.1.2.46
Systematic name
(2R)-2-hydroxy-2-methylbutanenitrile butan-2-one lyase (cyanide forming)
Recommended name
aliphatic (R)-hydroxynitrile lyase
Synonyms
(R)-HNL <3> [7]
(R)-oxynitrilase <1,2> [2,3]
(R)-hydroxynitrile lyase <3> [7]
acetone cyanohydrin lyase <1,3> [1,6]
hydroxynitrile lyase <1,2,3> [5,6]
LuHNL <1,2,3> [4,5,6,9,10]
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Xu, L.L.; Singh, B.K.; Conn, E.E.: Purification and characterization of acetone cyanohydrin lyase from Linum usitatissimum. Arch. Biochem. Bio-phys., 263, 256-263 (1988)
Albrecht, J.; Jansen, I.; Kula, M.R.: Improved purification of an (R)-oxyni-trilase from Linum usitatissimum (flax) and investigation of the substrate range. Biotechnol. Appl. Biochem., 17, 191-203 (1993)
de Gonzalo, G.; Brieva, R.; Gotor, V.: (R)-Oxynitrilase-catalyzed transformation of ω-hydroxyalkanals. J. Mol. Catal. B, 19-20, 223-230 (2002)
Fechter, M.H.; Griengl, H.: Hydroxynitrile lyases: biological sources and application as biocatalysts. Food Technol. Biotechnol., 42, 287-294 (2004)
Cabirol, F.L.; Tan, P.L.; Tay, B.; Cheng, S.; Hanefeld, U.; Sheldon, R.A.: Li-num usitatissimum hydroxynitrile lyase cross-linked enzyme aggregates: arecyclable enantioselective catalyst. Adv. Synth. Catal., 350, 2329-2338 (2008)
Trummler, K.; Wajant, H.: Molecular cloning of acetone cyanohydrin lyase from flax (Linum usitatissimum). Definition of a novel class of hydroxyni-trile lyases. J. Biol. Chem., 272, 4770-4774 (1997)
Breithaupt, H.; Pohl, M.; Bönigk, W.; Heim, P.; Schimz, K.-L.; Kula, M.-R.: Cloning and expression of (R)-hydroxynitrile lyase from Linum usitatissi-mum (flax). J. Mol. Catal. B, 6, 315-332 (1999)
Wajant, H.; Riedel, D.; Benz, S.; Mundry, K.-W.: Immunocytological localization of hydroxynitrile lyases from Sorghum bicolor L. and Linum usita-tissimum L.. Plant Sci., 103, 145-154 (1994)
Trummler, K.; Roos, J.; Schwaneberg, U.; Effenberger, F.; Förster, S.; Pfizenmaier, K.; Wajant, H.: Expression of the Zn2+-containing hydroxynitrilelyase from flax (Linum usitatissimum) in Pichia pastoris - utilization of the recombinant enzyme for enzymatic analysis and site-directed mutagenesis. Plant Sci., 139, 19-27 (1998)
Roberge, D.; Fleitz, F.; Pollard, D.; Devine, P.: Synthesis of optically active cyanohydrins from aromatic ketones: evidence of an increased substrate range and inverted stereoselectivity for the hydroxynitrile lyase from Linum usitatissimum. Tetrahedron Asymmetry, 18, 208-214 (2007)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Schomburg, D., Schomburg, I. (2013). aliphatic (R)-hydroxynitrile lyase 4.1.2.46. In: Schomburg, D., Schomburg, I. (eds) Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Springer Handbook of Enzymes, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36260-6_36
Download citation
DOI: https://doi.org/10.1007/978-3-642-36260-6_36
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-36259-0
Online ISBN: 978-3-642-36260-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)