Abstract
Toxicokinetics describes by means of mathematical functions the time- and dose-dependent processes of absorption, distribution, and elimination of a chemical substance and metabolites thereof in animals and humans. For this purpose, classical compartment open models and physiologically based toxicokinetic models are used. Both are applied to fit concentration-time data and to predict concentration-time courses of a parent chemical and metabolites usually in blood or plasma for repeated or continuous exposures; the latter models enable additionally to predict such time courses in various tissues and organs. An introduction is given into toxicokinetic modeling exemplified by two classical compartment open models and a physiologically based toxicokinetic model.
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Filser, J.G. (2021). Toxicokinetic Models. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36206-4_49-2
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DOI: https://doi.org/10.1007/978-3-642-36206-4_49-2
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