Abstract
Formulation of models describing the participation of the basal ganglia (GB) in action selection is limited by suppositions and simplifications necessary to replicate the biological system properties. However, the study of functional connectivity by functional magnetic resonance (RMNf), allow us to characterize the dynamics of the GB-thalamus-cortex circuitry. The aim of the present work is to simulate the GBthalamus- cortex circuitry interaction in motor program selection, supported by functional connectivity pattern obtained by RMNf. Determination of connections weights between neural populations by RMNf, contributed to a more realistic formulation of the model and allowed to describe the participation of the GB in motor program selection and the changes in Parkinson disease. The simulation allowed to demonstrate that a dopamine depletion upper to 40% leads to a loss of action selection ability.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Palabras claves
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Berlin Heidelberg
About this paper
Cite this paper
García-Ramó, K.B., Rojas, R.R., Barreda, M.C. (2013). Modelo Biofísico de la Dinámica Neuronal del Circuito Motor en la Selección de una Acción Basado en Estudios de Resonancia Magnética Nuclear. In: Folgueras Méndez, J., et al. V Latin American Congress on Biomedical Engineering CLAIB 2011 May 16-21, 2011, Habana, Cuba. IFMBE Proceedings, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21198-0_237
Download citation
DOI: https://doi.org/10.1007/978-3-642-21198-0_237
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-21197-3
Online ISBN: 978-3-642-21198-0
eBook Packages: EngineeringEngineering (R0)