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Systemic Lupus Erythematosus

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Albert and Jakobiec's Principles and Practice of Ophthalmology

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Abstract

Systemic lupus erythematosus (SLE) is a chronic, systemic, immunologically mediated disease of unknown etiology characterized by the presence of pathogenic autoantibodies and immune complexes. Systemic manifestations are varied and include cutaneous, renal, synovial, hematologic, and neurologic disease. Ophthalmic manifestations are similarly varied and include, most commonly, keratoconjunctivitis sicca. Retinal arteritis is a pathognomonic presentation. A variety of other neurophthalmic and uveitic presentations have also been documented. Treatment of ocular manifestations of SLE is directed at controlling the underlying autoimmune process with anti-inflammatory agents.

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Author information

Authors and Affiliations

  1. Founder and President Massachusetts Eye Research and Surgery Institution (MERSI) Ocular Immunology and Uveitis Foundation (OIUF), Waltham, MA, USA

    C. Stephen Foster

  2. Clinical Professor of Ophthalmology Harvard Medical School, Boston, MA, USA

    C. Stephen Foster

  3. Department of Ophthalmology and Visual Sciences SUNY Upstate Medical University, Syracuse, NY, USA

    Jordan Ueberroth

  4. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA

    Lucia Sobrin

Authors
  1. C. Stephen Foster
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  2. Jordan Ueberroth
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  3. Lucia Sobrin
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Corresponding author

Correspondence to C. Stephen Foster .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Oregon Health & Science University Department of Ophthalmology, Portland, OR, USA

    Daniel Albert

  2. Massachusetts Eye and Ear, Boston, MA, USA

    Joan Miller

  3. Department of Ophthalmology, University of Illinois at Chicago Department of Ophthalmology, Chicago, IL, USA

    Dimitri Azar

  4. Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

    Lucy H. Young

Section Editor information

  1. Penn State College of Medicine, Penn State Eye Center, Hershey, Pennsylvania, USA

    Jeffrey M. Sundstrom

  2. Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania, USA

    David A. Quillen

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Foster, C.S., Ueberroth, J., Sobrin, L. (2021). Systemic Lupus Erythematosus. In: Albert, D., Miller, J., Azar, D., Young, L.H. (eds) Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-90495-5_297-1

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  • DOI: https://doi.org/10.1007/978-3-319-90495-5_297-1

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