Abstract
Endovascular techniques are now at the forefront of the treatment of many neurovascular pathologies. Despite profound technological advances in noninvasive imaging, diagnostic cerebral angiography remains the gold standard in the evaluation of the cerebral vasculature. Endovascular therapy is often the definitive therapeutic option for the treatment of a dural arteriovenous fistula (DAVF). While the role of endovascular therapy in the treatment of an intracranial arteriovenous malformation (AVM) is less well defined, it remains a necessary adjunct in a comprehensive therapeutic approach. In this chapter, we present an introductory overview to cerebral angiography and the therapeutic approach to DAVFs and AVMs.
Access provided by CONRICYT-eBooks. Download chapter PDF
Similar content being viewed by others
Keywords
- Dural arteriovenous fistula
- Arteriovenous malformation
- N-butyl cyanoacrylate
- Ethylene vinyl alcohol
- Endovascular treatment
- Stereotactic radiosurgery
Pathophysiology
Arteriovenous Malformations (AVM)
Intracranial arteriovenous malformations (AVMs) are abnormal communications between pial arteries and veins with an intervening abnormal tangle of vessels termed a “nidus .” The abnormal vessels are prone to bleeding and rupture. The lack of normal intervening capillaries increases pressure in the draining veins, which further potentiates the risk of rupture. The cause of intracranial AVMs is unknown but is thought to be either secondary to abnormal intrauterine vascular development or as a response to a prior vascular insult [1]. Symptomatic AVMs are estimated to occur in approximately 1 in 100,000 people [2]. Many AVMs occur sporadically; however some familial syndromes predispose to their development, i.e., hereditary hemorrhagic telangiectasia. Presenting symptoms are often nonspecific and include headaches, seizures, and intracranial hemorrhage (ICH). Certain AVM features are associated with an increased risk of rupture including prior hemorrhage, deep venous drainage, and perinidal or intranidal aneurysm [3]. AVMs are classified utilizing the Spetzler-Martin grading system, which stratifies lesions based on surgical risk (Table 47.1). Larger lesions, those with drainage to the deep venous system and those which occur in eloquent areas of the brain, are at increased risk of surgical complications during resection [4].
Dural Arteriovenous Fistulas (DAVF)
Dural arteriovenous fistulas (DAVF) are abnormal communications between meningeal arteries and dural venous sinuses. DAVF account for approximately 10–15% of intracranial vascular malformations. DAVF can be idiopathic, posttraumatic, and postsurgical, or they can occur following dural venous thrombosis in hypercoagulable individuals. Patients can present with very specific clinical symptoms, which can often help localize the lesion, including unilateral pulsatile tinnitus or unilateral scleral injection, eye pain, proptosis, or visual changes [5]. In some cases, symptoms can be very nonspecific such as altered mental status, headaches, or ICH. “Benign” DAVF only result in irritating symptoms for the patient, whereas “malignant” DAVF place the patient at a very high risk of ICH. There are two main grading systems of DAVF, the Borden classification system and the Cognard classification system (Table 47.2) [6, 7]. DAVF grade is predominantly determined by the venous drainage pattern. Lesions with retrograde or direct flow into cortical veins place patients at higher risk of ICH. If these draining cortical veins are ectatic (dilated), patients are at an even greater risk of intracranial hemorrhage [8, 9]. AVM and DAVF are compared in Table 47.3.
Key Point
-
Intracranial AVM = communication between pial arteries and veins with intervening nidus.
-
Dural AVF = communication between meningeal arteries and dural venous sinuses
Clinical Indication
AVM
AVMs are often found incidentally on cerebral imaging or found when the patient presents with seizure or ICH. While a variety of neurologic exam findings can be seen with ruptured AVM, unruptured AVMs are often asymptomatic. CTA and MRI/MRA can show hypertrophied feeding arteries and draining veins and a characteristic “bag of worms” appearance [10, 11]. MRI can also show prominent flow voids in the area of the lesion. Catheter-based digital subtraction angiography (DSA) is the gold standard technique for the evaluation of AVM because it allows for intricate assessment of the AVM nidus, identification of all feeding arteries and draining veins, and it is sensitive for the detection of any related aneurysms (Fig. 47.1). Indications for treatment include prior rupture/ICH, significant clinical symptoms, and, in some cases, coexistent aneurysms [12]. Treatment of symptomatic lesions (those with prior hemorrhage) is indicated to prevent rerupture. Treatment of asymptomatic lesions remains controversial and varies widely by institution.
DAVF
The diagnosis of DAVF commonly occurs when patients present with new onset of neurologic symptoms. Physical exam findings may be generalized such as headache or localized; localized symptoms can often elucidate the location of the lesion. Pulsatile tinnitus or diminished hearing may indicate a fistula near the internal auditory canal. A caroticocavernous fistula may produce visual symptoms such as proptosis, conjunctival injection, and optic disc herniation [13]. Patients with malignant lesions may demonstrate symptoms related to ICH including altered mental status, somnolence, asymmetric pupillary dilation, and papilledema [14]. CT and MRI can show malignant features such as dural venous sinus thrombosis, venous infarct, ICH, brain parenchymal edema, and hypertrophied external carotid branches [5] (Fig. 47.2). The gold standard imaging test remains catheter-based DSA as it can define the fistulous point, dynamically evaluate flow patterns, and assess for any cortical venous drainage. Indications for treatment include ICH, malignant features on imaging, and intractable debilitating symptoms.
Key Point
The grade of DAVF depends predominantly on venous drainage.
Conventional Therapy
AVM
Surgery remains the first-line treatment option in surgically accessible lesions as it has a success rate approaching 100% and has acceptable complication rates [15, 16]. During surgery, arterial feeding vessels and draining veins are identified. Arterial feeders are disconnected from the AVM nidus using coagulation and surgical ligation. Following disconnection of arterial feeders, the draining veins are resected near the end of excision. Stereotactic radiosurgery (SRS) remains the treatment of choice if the AVM is unresectable [12]. In some cases, combination therapy with open surgery, endovascular intervention, and/or SRS can be used.
DAVF
Benign DAVF are often managed expectantly. In some cases, spontaneous regression may occur [17]. Intermittent manual compression of the ipsilateral carotid artery can also be performed, as this can lead to fistulous occlusion [18]. Rarely, benign DAVF can progress to malignant lesions, but this is usually accompanied by a change in symptoms [19]. In the past, surgery has been the treatment of choice for malignant DAVF, by aiming to surgically transect the abnormal communication by ligating the fistulous communication. With advances in technology, endovascular therapy has surpassed surgery as the standard treatment for DAVF.
Interventional Therapy
AVM and DAVF
Endovascular therapy for AVM is usually used as an adjunct to surgery or SRS [20]. Endovascular therapy is often directed at occluding specific feeding vessels or portions of the AVM which are not accessible to the operative surgeon or SRS. Additionally, endovascular therapy can be used to target perinidal aneurysms which are at increased risk of rupture [21]. Endovascular AVM treatment usually employs liquid embolic agents which penetrate and occlude the AVM nidus.
For DAVF, endovascular treatment is often the best treatment option. Treatment of DAVF can be achieved via arterial or venous approaches. Venous approaches aim to occlude the venous pouch at the fistulous point with coils. Arterial approaches utilize liquid embolic agents to penetrate and occlude the fistulous communication. Advances in endovascular technology have allowed for high success rates and low complication rates in the treatment of DAVF [22].
AVM and DAVF should be evaluated with catheter-based DSA prior to treatment to fully delineate arterial feeders and venous flow patterns. Often, cases are presented at multidisciplinary conference to obtain multi-specialty consensus on the best treatment approach. Standard preoperative labs for arterial intervention should be performed including CBC, coagulation labs, and a BMP. Procedural risks should be discussed with the patient and/or health care provider and should include non-target embolization resulting in stroke, intracranial vessel injury resulting in ICH, and lesional rupture resulting in ICH. Cranial nerve injuries should be a focus in DAVF , as meningeal vasculature often contributes to cranial nerve blood supply.
Key Point
Complications of AVM and DAVF treatment:
-
Stroke from nontarget embolization
-
ICH from vessel injury or lesion rupture
-
Cranial nerve injury for DAVF treatment
Key Point
Diagnostic cerebral angiogram consists of visualizing six vessels:
-
Bilateral internal carotid arteries
-
Bilateral external carotid arteries
-
Bilateral vertebral arteries
Key Point
Treatment goals:
-
AVM = penetration and occlusion of the nidus.
-
DAVF = occlusion of the fistulous point with treatment of all malignant features
Key Point
Lesions with cortical venous drainage must be treated until all cortical drainage is cured.
Imaging follow-up should be performed at regular intervals; timing is institutional specific but typically begins at 6 months post-treatment. Any recurrence or change in symptoms should prompt rapid reevaluation as this could indicate lesional progression or recurrence.
References
Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl. 2011;111:83–92.
Berman MF, Sciacca RR, Pile-Spellman J, Stapf C, Connolly ES Jr, Mohr JP, et al. The epidemiology of brain arteriovenous malformations. Neurosurgery. 2000;47:389–96; discussion 97.
Stapf C, Mast H, Sciacca RR, Choi JH, Khaw AV, Connolly ES, et al. Predictors of hemorrhage in patients with untreated brain arteriovenous malformation. Neurology. 2006;66:1350–5.
Spetzler RF, Martin NA. A proposed grading system for arteriovenous malformations. J Neurosurg. 1986;65:476–83.
Geibprasert S, Pongpech S, Jiarakongmun P, Shroff MM, Armstrong DC, Krings T. Radiologic assessment of brain arteriovenous malformations: what clinicians need to know. Radiographics. 2010;30:483–501.
Borden JA, JK W, Shucart WA. A proposed classification for spinal and cranial dural arteriovenous fistulous malformations and implications for treatment. J Neurosurg. 1995;82:166–79.
Cognard C, Gobin YP, Pierot L, Bailly AL, Houdart E, Casasco A, et al. Cerebral dural arteriovenous fistulas: clinical and angiographic correlation with a revised classification of venous drainage. Radiology. 1995;194:671–80.
Awad IA, Little JR, Akarawi WP, Ahl J. Intracranial dural arteriovenous malformations: factors predisposing to an aggressive neurological course. J Neurosurg. 1990;72:839–50.
Bulters DO, Mathad N, Culliford D, Millar J, Sparrow OC. The natural history of cranial dural arteriovenous fistulae with cortical venous reflux--the significance of venous ectasia. Neurosurgery. 2012;70:312–8; discussion 8–9.
Gross BA, Frerichs KU, Du R. Sensitivity of CT angiography, T2-weighted MRI, and magnetic resonance angiography in detecting cerebral arteriovenous malformations and associated aneurysms. J Clin Neurosci. 2012;19:1093–5.
Tanaka H, Numaguchi Y, Konno S, Shrier DA, Shibata DK, Patel U. Initial experience with helical CT and 3D reconstruction in therapeutic planning of cerebral AVMs: comparison with 3D time-of-flight MRA and digital subtraction angiography. J Comput Assist Tomogr. 1997;21:811–7.
Braksick SA, Fugate JE. Management of brain arteriovenous malformations. Curr Treat Options Neurol. 2015;17:358.
Chaudhary N, Griauzde J, Gemmete JJ, Pandey AS, Trobe JD. Issues in the diagnosis and management of the papilledema shunt. J Neuroophthalmol. 2014;34:259–63.
Lasjaunias P, Chiu M, ter Brugge K, Tolia A, Hurth M, Bernstein M. Neurological manifestations of intracranial dural arteriovenous malformations. J Neurosurg. 1986;64:724–30.
Pik JH, Morgan MK. Microsurgery for small arteriovenous malformations of the brain: results in 110 consecutive patients. Neurosurgery. 2000;47:571–5; discussion 5–7.
Morgan MK, Rochford AM, Tsahtsarlis A, Little N, Faulder KC. Surgical risks associated with the management of Grade I and II brain arteriovenous malformations. Neurosurgery. 2004;54:832–7; discussion 7–9.
Olutola PS, Eliam M, Molot M, Talalla A. Spontaneous regression of a dural arteriovenous malformation. Neurosurgery. 1983;12:687–90.
Halbach VV, Higashida RT, Hieshima GB, Goto K, Norman D, Newton TH. Dural fistulas involving the transverse and sigmoid sinuses: results of treatment in 28 patients. Radiology. 1987;163:443–7.
Kim DJ, terBrugge K, Krings T, Willinsky R, Wallace C. Spontaneous angiographic conversion of intracranial dural arteriovenous shunt: long-term follow-up in nontreated patients. Stroke. 2010;41:1489–94.
Deruty R, Pelissou-Guyotat I, Amat D, Mottolese C, Bascoulergue Y, Turjman F, et al. Multidisciplinary treatment of cerebral arteriovenous malformations. Neurol Res. 1995;17:169–77.
Marks MP, Lane B, Steinberg GK, Snipes GJ. Intranidal aneurysms in cerebral arteriovenous malformations: evaluation and endovascular treatment. Radiology. 1992;183:355–60.
Rangel-Castilla L, Barber SM, Klucznik R, Diaz O. Mid and long term outcomes of dural arteriovenous fistula endovascular management with Onyx. Experience of a single tertiary center. J Neurointerv Surg. 2014;6:607–13.
Rabinov JD, Yoo AJ, Ogilvy CS, Carter BS, Hirsch JA. ONYX versus n-BCA for embolization of cranial dural arteriovenous fistulas. J Neurointerv Surg. 2013;5:306–10.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Griauzde, J., Gemmete, J.J. (2018). Cerebral Angiography: Arteriovenous Malformations and Dural Arteriovenous Fistulae. In: Keefe, N., Haskal, Z., Park, A., Angle, J. (eds) IR Playbook. Springer, Cham. https://doi.org/10.1007/978-3-319-71300-7_47
Download citation
DOI: https://doi.org/10.1007/978-3-319-71300-7_47
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-71299-4
Online ISBN: 978-3-319-71300-7
eBook Packages: MedicineMedicine (R0)