Abstract
Recent studies show that carbon nanotubes possess a potent antimicrobial activity against various pathogens, from bacteria to fungi and even protozoa. The current increase in drug-resistant pathogens, causing many infections, motivates the research in the carbon nanotube route to attack the microorganism drug-resistance. The molecular interaction between these nanomaterials and the microbes could provide the answers to elucidate the action’s mechanisms involved as antimicrobial agents. Carbon nanotubes exhibit unique properties that can be used as bio-targets to circumvent the microbial action or even eliminate them. Diverse research groups have implemented successful routes to discriminate and categorize these carbon nanomaterial’s effects on pathogenic organisms based on their physical or chemical properties. In this focused review, the advances on carbon nanotube’s antimicrobial activity based on their size, shape, and chemical surface are discussed. Furthermore, preliminary results on antimicrobial activity obtained by our research group are presented as examples of our advances in this field.
Similar content being viewed by others
References
Akasaka T, Watari F (2009) Capture of bacteria by flexible carbon nanotubes. Acta Biomater 5:607–612. https://doi.org/10.1016/j.actbio.2008.08.014
Albini A, Pagani A, Pulze L et al (2015) Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition. Int J Nanomedicine 10:6133–6145. https://doi.org/10.2147/IJN.S85275
Alpatova AL, Shan W, Babica P et al (2010) Single-walled carbon nanotubes dispersed in aqueous media via non-covalent functionalization: effect of dispersant on the stability, cytotoxicity, and epigenetic toxicity of nanotube suspensions. Water Res 44:505–520. https://doi.org/10.1016/j.watres.2009.09.042
Arias LR, Yang L (2009) Inactivation of bacterial pathogens by carbon nanotubes in suspensions. Langmuir 25:3003–3012. https://doi.org/10.1021/la802769m
Aslan S, Loebick CZ, Kang S et al (2010) Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid). Nanoscale 2:1789–1794. https://doi.org/10.1039/C0NR00329H
Bachtold A, Hadley P, Nakanishi T, Cees D (2001) Logic circuits with carbon nanotube transistors. Science 294:1317–1320. https://doi.org/10.1126/science.1065824
Bai Y, Zhang Y, Zhang J et al (2010) Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility. Nat Nanotechnol 5:683–689. https://doi.org/10.1038/nnano.2010.153
Brady-Estévez AS, Kang S, Elimelech M (2008) A single-walled-carbon-nanotube filter for removal of viral and bacterial pathogens. Small Weinh Bergstr Ger 4:481–484. https://doi.org/10.1002/smll.200700863
Brady-Estévez AS, Nguyen TH, Gutierrez L, Elimelech M (2010) Impact of solution chemistry on viral removal by a single-walled carbon nanotube filter. Water Res 44:3773–3780. https://doi.org/10.1016/j.watres.2010.04.023
Chen H, Wang B, Gao D et al (2013) Broad-spectrum antibacterial activity of carbon nanotubes to human gut bacteria. Small Weinh Bergstr Ger 9:2735–2746. https://doi.org/10.1002/smll.201202792
Créach V, Baudoux AC, Bertru G, Rouzic BL (2003) Direct estimate of active bacteria: CTC use and limitations. J Microbiol Methods 52:19–28. https://doi.org/10.1016/s0167-7012(02)00128-8
Cui H-F, Vashist SK, Al-Rubeaan K et al (2010) Interfacing carbon nanotubes with living mammalian cells and cytotoxicity issues. Chem Res Toxicol 23:1131–1147. https://doi.org/10.1021/tx100050h
Dai H (2002) Carbon nanotubes: opportunities and challenges. Surf Sci 500:218–241. https://doi.org/10.1016/S0039-6028(01)01558-8
Dong L, Henderson A, Field C (2012) Antimicrobial activity of single-walled carbon nanotubes suspended in different surfactants. J Nanotechnol 2012. https://doi.org/10.1155/2012/928924
Endo M, Takeuchi K, Kim YA et al (2008) Simple synthesis of multiwalled carbon nanotubes from natural resources. ChemSusChem 1:820–822. https://doi.org/10.1002/cssc.200800150
Firme C, Bandaru P (2009) Toxicity issues in the application of carbon nanotubes to biological systems. Nanomed Nanotechnol Biol Med 6:245–256. https://doi.org/10.1016/j.nano.2009.07.003
Fujita K, Fukuda M, Endoh S et al (2015) Size effects of single-walled carbon nanotubes on in vivo and in vitro pulmonary toxicity. Inhal Toxicol 27:207–223. https://doi.org/10.3109/08958378.2015.1026620
Gorczyca A, Kasprowicz MJ, Lemek T (2014) The physiological effects of multi-walled carbon nanotubes (MWCNTs) on conidia and the development of the entomopathogenic fungus, Metarhizium anisopliae (Metsch.) Sorok. J Environ Sci Health Part A Tox Hazard Subst Environ Eng 49:741–752. https://doi.org/10.1080/10934529.2014.867217
Gurunathan S, Han JW, Dayem AA et al (2012) Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa. Int J Nanomedicine 7:5901–5914. https://doi.org/10.2147/IJN.S37397
Hsieh H-S, Wu R, Jafvert CT (2014) Light-independent reactive oxygen species (ROS) formation through electron transfer from carboxylated single-Walled carbon nanotubes in Water. Environ Sci Technol 48:11330–11336. https://doi.org/10.1021/es503163w
Iijima S (1991) Helical microtubules of graphitic carbon. Nature 354:56–58. https://doi.org/10.1038/354056a0
Kagan VE, Tyurina YY, Tyurin VA et al (2006) Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron. Toxicol Lett 165:88–100. https://doi.org/10.1016/j.toxlet.2006.02.001
Kang S, Herzberg M, Rodrigues DF, Elimelech M (2008a) Antibacterial effects of carbon nanotubes: size does matter! Langmuir 24:6409–6413. https://doi.org/10.1021/la800951v
Kang S, Mauter MS, Elimelech M (2008b) Physicochemical determinants of multiwalled carbon nanotube bacterial cytotoxicity. Environ Sci Technol 42:7528–7534. https://doi.org/10.1021/es8010173
Kang S, Mauter MS, Elimelech M (2009) Microbial cytotoxicity of carbon-based nanomaterials: implications for river water and wastewater effluent. Environ Sci Technol 43:2648–2653. https://doi.org/10.1021/es8031506
Karimi M, Solati N, Ghasemi A et al (2015) Carbon nanotubes part II: a remarkable carrier for drug and gene delivery. Expert Opin Drug Deliv 12:1089–1105. https://doi.org/10.1517/17425247.2015.1004309
Kim J-W, Shashkov EV, Galanzha EI et al (2007) Photothermal antimicrobial nanotherapy and nanodiagnostics with self-assembling carbon nanotube clusters. Lasers Surg Med 39:622–634. https://doi.org/10.1002/lsm.20534
Krishnamoorthy K, Umasuthan N, Mohan R et al (2012) Antibacterial activity of graphene oxide nanosheets. Sci Adv Mater 4:1–7. https://doi.org/10.1166/sam.2012.1402
Lara-Romero J, Campos-García J, Dasgupta-Schubert N et al (2017) Biological effects of carbon nanotubes generated in forest wildfire ecosystems rich in resinous trees on native plants. PeerJ 5. https://doi.org/10.7717/peerj.3658
Lawrence JR, Waiser MJ, Swerhone GDW et al (2016) Effects of fullerene (C60), multi-wall carbon nanotubes (MWCNT), single wall carbon nanotubes (SWCNT) and hydroxyl and carboxyl modified single wall carbon nanotubes on riverine microbial communities. Environ Sci Pollut Res Int 23:10090–10102. https://doi.org/10.1007/s11356-016-6244-x
Li C, Wang X, Chen F et al (2013) The antifungal activity of graphene oxide–silver nanocomposites. Biomaterials 34:3882–3890. https://doi.org/10.1016/j.biomaterials.2013.02.001
Liu X, Gurel V, Morris D et al (2007) Bioavailability of nickel in single-wall carbon nanotubes. Adv Mater 19:2790–2796. https://doi.org/10.1002/adma.200602696
Liu S, Wei L, Hao L et al (2009a) Sharper and faster “nano darts” kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube. ACS Nano 3:3891–3902. https://doi.org/10.1021/nn901252r
Liu Z, Tabakman S, Welsher K, Dai H (2009b) Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Res 2:85–120. https://doi.org/10.1007/s12274-009-9009-8
Liu X, Zhang Y, Li J et al (2014) Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid. Int J Nanomedicine 9:823–839. https://doi.org/10.2147/IJN.S56339
Liu D, Mao Y, Ding L (2018) Carbon nanotubes as antimicrobial agents for water disinfection and pathogen control. J Water Health 16:171–180. https://doi.org/10.2166/wh.2018.228
Lynch I, Dawson KA (2008) Protein-nanoparticle interactions. Nano Today 3:40–47. https://doi.org/10.1016/S1748-0132(08)70014-8
Maas M (2016) Carbon nanomaterials as antibacterial colloids. Materials (Basel) 9. https://doi.org/10.3390/ma9080617
Mangadlao JD, Santos CM, Felipe MJL et al (2015) On the antibacterial mechanism of graphene oxide (GO) Langmuir-Blodgett films. Chem Commun 51:2886–2889. https://doi.org/10.1039/c4cc07836e
Mingeot-Leclercq M-P, Décout J-L (2016) Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides. MedChemComm 7:586–611. https://doi.org/10.1039/C5MD00503E
Munguia-Lopez JG, Juarez R, Muñoz-Sandoval E et al (2019) Biocompatibility of nitrogen-doped multiwalled carbon nanotubes with murine fibroblasts and human hematopoietic stem cells. J Nanopart Res 21:193. https://doi.org/10.1007/s11051-019-4637-8
Olivi M, Zanni E, Bellis GD et al (2013) Inhibition of microbial growth by carbon nanotube networks. Nanoscale 5:9023–9029. https://doi.org/10.1039/C3NR02091F
Patel A, Tiwari S, Parihar P et al (2019) Chapter 2 – Carbon nanotubes as plant growth regulators: impacts on growth, reproductive system, and soil microbial community. In: Tripathi DK, Ahmad P, Sharma S et al (eds) Nanomaterials in plants, algae and microorganisms. Academic Press, Cambridge, Massachusetts. United States. pp 23–42
Piperigkou Z, Karamanou K, Engin AB et al (2016) Emerging aspects of nanotoxicology in health and disease: from agriculture and food sector to cancer therapeutics. Food Chem Toxicol 91:42–57. https://doi.org/10.1016/j.fct.2016.03.003
Poland CA, Duffin R, Kinloch I et al (2008) Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3:423–428. https://doi.org/10.1038/nnano.2008.111
Radushkevich LV, Lukyanovich VM (1952) The structure of carbon forming in thermal decomposition of carbon monoxide on an iron catalyst. Russ J Phys Chem 26:88–95
Raghunath A, Perumal E (2017) Metal oxide nanoparticles as antimicrobial agents: a promise for the future. Int J Antimicrob Agents 49:137–152. https://doi.org/10.1016/j.ijantimicag.2016.11.011
Shakoor S, Sun L, Wang D (2016) Multi-walled carbon nanotubes enhanced fungal colonization and suppressed innate immune response to fungal infection in nematodes. Toxicol Res 5:492–499. https://doi.org/10.1039/C5TX00373C
Toh RJ, Ambrosi A, Pumera M (2012) Bioavailability of metallic impurities in carbon nanotubes is greatly enhanced by ultrasonication. Chem Weinh Bergstr Ger 18:11593–11596. https://doi.org/10.1002/chem.201201955
Travlou N, Giannakoudakis DA, Algarra M et al (2018) S- and N-doped carbon quantum dots: Surface chemistry dependent antibacterial activity. Carbon 135:104. https://doi.org/10.1016/j.carbon.2018.04.018
Usenko CY, Harper SL, Tanguay RL (2007) In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon 45:1891–1898. https://doi.org/10.1016/j.carbon.2007.04.021
Vatansever F, de Melo WCMA, Avci P et al (2013) Antimicrobial strategies centered around reactive oxygen species – bactericidal antibiotics, photodynamic therapy and beyond. FEMS Microbiol Rev 37:955–989. https://doi.org/10.1111/1574-6976.12026
Vecitis CD, Zodrow KR, Kang S, Elimelech M (2010) Electronic-structure-dependent bacterial cytotoxicity of single-walled carbon nanotubes. ACS Nano 4:5471–5479. https://doi.org/10.1021/nn101558x
Veetil JV, Ye K (2009) Tailored carbon nanotubes for tissue engineering applications. Biotechnol Prog 25:709–721. https://doi.org/10.1002/bp.165
Wang X, Liu X, Han H (2013) Evaluation of antibacterial effects of carbon nanomaterials against copper-resistant Ralstonia solanacearum. Colloids Surf B Biointerfaces 103:136–142. https://doi.org/10.1016/j.colsurfb.2012.09.044
Wang X, Jiao C, Wang T, Yu Z (2016) Study on DNA damage induced by the reactive oxygen species generated in situ based on the multi-walled carbon nanotubes and hemoglobin. J Electroanal Chem 767:182–187. https://doi.org/10.1016/j.jelechem.2016.02.030
Xin Q, Liu Q, Geng L et al (2017) Chiral nanoparticle as a new efficient antimicrobial nanoagent. Adv Healthc Mater 6. https://doi.org/10.1002/adhm.201601011
Xin Q, Shah H, Nawaz A et al (2019) Antibacterial carbon-based nanomaterials. Adv Mater 31:1804838. https://doi.org/10.1002/adma.201804838
Yang K, Ma Y-Q (2010) Computer simulation of the translocation of nanoparticles with different shapes across a lipid bilayer. Nat Nanotechnol 5:579–583. https://doi.org/10.1038/nnano.2010.141
Yang W, Thordarson P, Gooding JJ et al (2007) Carbon nanotubes for biological and biomedical applications. Nanotechnology 18:412001. https://doi.org/10.1088/0957-4484/18/41/412001
Yang C, Mamouni J, Tang Y, Yang L (2010) Antimicrobial activity of single-walled carbon nanotubes: length effect. Langmuir ACS J Surf Colloids 26:16013–16019. https://doi.org/10.1021/la103110g
Zardini HZ, Amiri A, Shanbedi M et al (2012) Enhanced antibacterial activity of amino acids-functionalized multi walled carbon nanotubes by a simple method. Colloids Surf B Biointerfaces 92:196–202. https://doi.org/10.1016/j.colsurfb.2011.11.045
Zhang M, Li J (2009) Carbon nanotube in different shapes. Mater Today 12:12–18. https://doi.org/10.1016/S1369-7021(09)70176-2
Zhu W, von dem Bussche A, Yi X et al (2016) Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles. Proc Natl Acad Sci 113:12374–12379. https://doi.org/10.1073/pnas.1605030113
Zou X, Zhang L, Wang Z, Luo Y (2016) Mechanisms of the antimicrobial activities of graphene materials. J Am Chem Soc 138:2064–2077. https://doi.org/10.1021/jacs.5b11411
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this entry
Cite this entry
de Jesús Barraza-García, F., Pérez-Miranda, S., Munguia-Lopez, J.G., Lopez-Urias, F., Muñoz-Sandoval, E. (2021). Carbon Nanotubes as Antimicrobial Agents: Trends and Perspectives. In: Abraham, J., Thomas, S., Kalarikkal, N. (eds) Handbook of Carbon Nanotubes. Springer, Cham. https://doi.org/10.1007/978-3-319-70614-6_47-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-70614-6_47-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-70614-6
Online ISBN: 978-3-319-70614-6
eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics