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The Role of the Bone Marrow for Adaptive Immunity in Old Age

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Handbook of Immunosenescence

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Abstract

Most studies on age-related changes of the human adaptive immune system have so far been performed using peripheral blood which contains less than 2% of the total body lymphocyte pool. Only few studies have addressed this issue in lymphatic organs. The human BM represents an organ which has only recently been recognized as an important site for the regulation and maintenance of immunological memory. Intrinsic changes in adaptive immune cells as well as changes in BM niches may be of relevance for changes in the immunological memory in old age. It is the goal of this review to summarize what is known about the effect of age on BM immune cells and their niches in mice and humans.

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Authors and Affiliations

  1. Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria

    Beatrix Grubeck-Loebenstein & Luca Pangrazzi

Authors
  1. Beatrix Grubeck-Loebenstein
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  2. Luca Pangrazzi
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Corresponding author

Correspondence to Beatrix Grubeck-Loebenstein .

Editor information

Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

Section Editor information

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Grubeck-Loebenstein, B., Pangrazzi, L. (2018). The Role of the Bone Marrow for Adaptive Immunity in Old Age. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_170-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_170-1

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  • Print ISBN: 978-3-319-64597-1

  • Online ISBN: 978-3-319-64597-1

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