Abstract
From 1954 when the first patient was treated at Berkeley to now, tumor therapy using ion beams has developed to high-technology application. In order to achieve an extreme tumor conform irradiation, a fine pencil beam is guided over a three-dimensional grid of pixels that fills the target volume. A main problem is the quality assurance before, during, and after patient irradiation where different types of detectors and monitors are used. In this chapter, the basic principles of ion beam therapy are given and the monitor systems are described more in their functionality rather than in the individual specifications that differ between the various therapy units.
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References
Barkas HW (1963) Nuclear research emulsions, vol I. Academic, New York/London
Bethe H (1930) Zur Theorie des Durchgangs schneller Korpuskularstrahlen durch Materie. Ann Phys 5:325
Blakely EA, Tobias CA, Ngo FQH, Curtis SB (1980) Physical and cellular radiobiological properties of heavy ions in relation to cancer therapy. In: Pirucello MD, Tobias CA (eds) Biological and medical research with accelerated heavy ions at the Bevalac. Lawrence Berkeley Laboratory, Berkeley, p 73
Bloch F (1933) Zur Bremsung rasch bewegter Teilchen beim Durchgang durch Materie. Ann Phys 5:285
Chu WT, Ludewigt BA, Renner TR (1993) Instrumentation for treatment of cancer using proton and light-ion beams. Rev Sci Instrum 64:2055
De Vita VT, Hellmann S, Rosenberg SA (1997) Cancer: principles and practice of oncology. Lippincott-Raven, Philadelphia
Durante M, Loeffler JS (2010) Charged particles in radiation oncology. Nat Rev Clin Oncol 7:37–43
Elsässer T, Weyrather WK, Friedrichs T et al (2010) Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning. Int J Radiat Oncol Biol Phys 78:1177–1183
Enghardt WK, Fromm WD, Geissel H, Keller H, Kraft G, Magel A, Manfrass P, Munzenberg G, Nickel F, Pawelke J, Schardt D, Scheidenberger C, Sobiella M (1992) The spatial distribution of positron-emitting nuclei generated by relativistic light ion beams in organic matter. Phys Med Biol 37:2127
Enghardt WK, Debus J, Haberer T, Hasch B, Hinz R, Jkel O, Krmer M, Lauckner K, Pawelke J (1999) The application of PET to quality assurance of heavy-ion tumor therapy. Strahlenther Onkol 175:S33
Geiss O, Kramer M, Kraft G (1999) Efficiency of thermoluminescent detectors to heavy-charged particles. Nucl Inst Methods Phys Res B 142:592
Gottschalk B, Koehler AM, Schneider RJ, Sisterson JM, Wagner MS (1993) Multiple Coulomb scattering of 160 MeV protons. Nucl Inst Methods A 330:467
Haberer T, Becher W, Schardt D, Kraft G (1993) Magnetic scanning system for heavy ion therapy. Nucl Inst Methods Phys Res A 330:296
Haettner E, Iwase H, Schardt D (2006) Experimental fragmentation studies with 12C therapy beams. Radiat Prot Dosim 122:485
Hall E (1994) Radiobiology for the radiologist. Lipincott Company, Philadelphia
Hüfner J (1985) Heavy fragments produced in proton–nucleus and nucleus–nucleus collisions at relativistic energies. Phys Rep 125:129
Jäkel O, Hartmann G, Karger C, Heeg P (1999) A quality assurance program for heavy ion treatment planning. Radiother Oncol 51:13
Kanai T, Furusawa Y, Fukutsu K, Itsukaichi H, Eguchi-Kasai K, Ohara H (1997) Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy. Radiat Res 147:78
Kanai T et al (1999) Characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int J Radiat Oncol Biol Phys 44:201
Karger CP, Peschke P, Sanchez-Brandelik R, Scholz M, Debus J (2006) Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: experimental results and clinical implication. Int J Radiat Oncol Biol Phys 66:1488
Kraft G (2000) Tumor therapy with heavy charged particles. Prog Part Nucl Phys 45:473
Kraft G, Kraft SD (2009) Research needed for improving heavy-ion therapy. New J Phys 11:025001
Krämer M, Kraft G (1994) Calculations of heavy track structure. Radiat Environ Biophys 33:91
Krämer M, Jäkel O, Haberer T, Kraft G, Schardt D, Weber U (2000) Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization. Phys Med Biol 45:3299
Krämer M, Wang JF, Weyrather WK (2003a) Biological dosimetry of complex ion eradiation fields. Phys Med Biol 48:2063
Krämer M, Weyrather WK, Scholz M (2003b) The increased biological effectiveness of heavy charged particles: from radiobiology to treatment planning. Technol Cancer Res Treat 2:427
Molière G (1948) Theorie der Streuung schneller geladener Teilchen II, Mehrfach- und Vielfachstreuung. Z Naturforsch 3a:78
Parodi K et al (2007) Patient tomography and computed tomography imaging after proton therapy. J Radiat Oncol Biol Phys 68:920
Pedroni E, Blattmann H, Böhringer T, Coray A, Lin S, Scheib S, Schneider U (1991) Voxel scanning for proton therapy. In: Itano A, Kanai T (eds) Proceedings of the NIRS international workshop on heavy charged particle therapy and related subjects, Anagawa
Scholz M, Kraft G (1994) Calculation of heavy ion inactivation probabilities based on track structure, X-ray sensitivity and target size. Radiat Prot Dosim 52:29
Schulz-Ertner D, Tsujii H (2007) Particle radiation therapy using proton and heavier ion beams. J Clin Oncol 25:953
Spielberger B, Kramer M, Kraft G (2003) Three-dimensional dose verification in complex particle radiation fields based on X-ray films. Phys Med Biol 48:497
Tsujii H et al (2004) Overview of clinical experience on carbon therapy at NIRS radiotherapy and oncology. Radiother Oncol 73:S41
Weber U, Kraft G (2009) Comparison of carbon ions versus protons. Cancer J 15:325
Weyrather WK, Kraft G (2004) RBE of carbon ions: experimental data and the strategy of RBE calculation for treatment planning. Radiother Oncol 73:S161
Wilson RR (1946) Radiological use of fast protons. Radiology 47:325
Further Reading
Kraft G (2000b) Tumor therapy with heavy charged particles. Prog Part Nucl Phys 45:473
Schardt D, Elsässer T, Schulz-Ertner D (2010) Heavy-ion tumor therapy: physical and radiobiological benefits. Rev Mod Phys 82:383
Schulz-Ertner D, Tsujii H (2007b) Particle radiation therapy using proton and heavier ion beams. J Clin Oncol 25:953
Suit H, DeLaney T, Goldberg S et al (2010) Proton versus carbon ion beams in the definitive treatment of cancer patients. Radiother Oncol 95:3
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Kraft, G., Weber, U. (2020). Tumor Therapy with Ion Beams. In: Fleck, I., Titov, M., Grupen, C., Buvat, I. (eds) Handbook of Particle Detection and Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-47999-6_47-2
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DOI: https://doi.org/10.1007/978-3-319-47999-6_47-2
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