Abstract
Current treatment choices for intrahepatic cholestasis are rather limited. Ursodiol is used in the management of cholestasis resulting from primary biliary cirrhosis, and can also be considered in the management of primary sclerosing cholangitis.
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Keywords
Primary Biliary Cirrhosis
Ursodiol (UCDA)
Brand names: URSO Forte, Actigall
Manufacturer: Generic; URSO Forte-Axcan Pharma; Actigall-Watson Pharmaceuticals
Dosage:
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Primary biliary cirrhosis: 13–15 mg/kg po qd
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Primary sclerosing cholangitis: ~20 mg/kg po qd (do NOT use doses >28 mg/kg po qd)
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Autoimmune hepatitis: Use with the initial therapy to induce remission as well as during continuation phase: 10 mg/kg po qd
Contraindications/cautions:
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Hypersensitivity to drug or bile acids
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Gallstones: Calcified cholesterol, radiopaque stones, radiolucent bile pigment stones
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Unremitting acute cholecystitis
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Acute cholangitis
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Biliary obstruction
Adverse effects :
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Gastrointestinal: Diarrhea, nausea, vomiting
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Musculoskeletal: Backache
Drug interactions:
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Concomitant fibric acid derivatives, oral contraceptives, bile acid binding resins and antacids may decrease ursodiol efficacy
Pregnancy category: B
Lactation: Safety unknown
Relative cost: $$$ (generic available: $$–$$$)
Primary sclerosing cholangitis
UDCA
See above.
Suggested Reading
Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote J. Primary biliary cirrhosis. Hepatology. 2009;50(1):291–308.
Lindor KD, Kowdley KV, Harrison ME. ACG clinical guideline: primary sclerosing cholangitis. Am J Gastroenterol. 2015;110:646–59.
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© 2016 Springer International Publishing Switzerland
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Bath, R.K. (2016). Cholestasis. In: Wu, G. (eds) Pocket Handbook of GI Pharmacotherapeutics. Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-33317-5_10
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DOI: https://doi.org/10.1007/978-3-319-33317-5_10
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Publisher Name: Humana Press, Cham
Print ISBN: 978-3-319-33315-1
Online ISBN: 978-3-319-33317-5
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