Abstract
Much of what we know about the physiology of blood pressure (BP) regulation and the pathogenesis and treatment of human hypertension has been derived from studies in other animal species. This chapter presents a variety of models of experimental hypertension with the intent of providing a background for the interested reader. Many models explore normal and abnormal physiology without genetic manipulation but rather with the use of surgery, infusion of medications, alterations in diet, and application of stressful conditions. In other models, inbreeding or genetic manipulation are used to produce increased (or decreased) BP. The many models available should be considered both for carrying out research and for evaluating published studies.
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Ingelfinger, J.R. (2017). Hypertensive Models and Their Relevance to Pediatric Hypertension. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31420-4_55-1
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DOI: https://doi.org/10.1007/978-3-319-31420-4_55-1
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Hypertensive Models and Their Relevance to Pediatric Hypertension- Published:
- 28 June 2022
DOI: https://doi.org/10.1007/978-3-319-31420-4_55-2
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Hypertensive Models and Their Relevance to Pediatric Hypertension- Published:
- 19 April 2017
DOI: https://doi.org/10.1007/978-3-319-31420-4_55-1