Abstract
Skin is a dynamic complex organ, which accomplishes versatile functions and thus plays a key role in the maintenance of the homeostasis of the organism. At birth, the development of the skin is not fully complete. The beginning of the postnatal life is a period for active adaptation and maturation of the cutaneous structure and functions. The environment around the skin changes drastically after birth: a newborn infant goes from the warm, wet, sterile, and safe womb to a cooler, dry, bacteria-laden nursery; concurrently the baby begins the journey to self-sufficiency by breathing air, taking nutrition, and maintaining body temperature. Newborn skin is critical to this transition and performs many functions (barrier to water loss, light, and irritants; infection control and immunosurveillance; resilience to mechanical trauma; sensation and tactile discrimination; thermal regulation; and acid mantle formation).
A variety of normal and abnormal lesions may be present on newborn skin surface (including adnexa, oral mucosa, and genito-anal area). Although these findings are often benign, it is important to distinguish them and to be aware about the nature of the disease, to manage them properly.
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Abass K, Saad H, Kherala M, Abd-Elsayed AA (2008) Successful treatment of Kasabach-Merritt syndrome with vincristine and surgery: a case report and review of literature. Cases J 1:9
Akin C, Valent P (2014) Diagnostic criteria and classification of mastocytosis in 2014. Immunol Allergy Clin N Am 34(2):207–218
Aloulou H, Chaari W, Khanfir S et al (2008) Aplasia cutis congenita of the scalp (5 observations). Arch Pediatr 15:382–387
Alper JC (1986) The genodermatoses and their significance in pediatric dermatology. Pediatr Dermatol Clin 4:45–54
Babu NA, Rajesh E, Krupaa J, Gnananandar G (2015) Genodermatoses. J Pharm Bioallied Sci 7(1):S203–S206
Batta K (2000) Management of large birthmarks. Semin Neonatol 5:325–332
Bedocs PM, Kumar V, Mahon MJ (2009) Pemphigoid gestationis: a rare case and review. Arch Gynecol Obstet 279:235–238
Bethel J (2014) Identification and treatment of scabies in infants. Emerg Nurse 22(4):24–27
Bloom DC, Perkins JA, Manning SC (2004) Management of lymphatic malformations. Curr Opin Otolaryngol Head Neck Surg 12:500–504
Boralevi F, Diallo A, Miquel J, Guerin-Moreau M, Bessis D, Chiavérini C, Plantin P, Hubiche T, Maruani A, Lassalle M, Boursault L, Ezzedine K, Groupe de Recherche Clinique en Dermatologie Pédiatrique (2014) Clinical phenotype of scabies by age. Pediatrics 133(4):e910–e916
Burkhead A, Poindexter G, Morrell DS (2009) A case of extensive aplasia cutis congenita with underlying skull defect and central nervous system malformation: discussion of large skin defects, complications, treatment and outcome. J Perinatol 29:582–584
Burstein F, Seier H, Hudgins PA, Zapiach L (2005) Neurocutaneous melanosis. J Craniofac Surg 16:874–876
Ch’ng S, Tan ST (2008) Facial port-wine stains – clinical stratification and risks of neuro-ocular involvement. J Plast Reconstr Aesthet Surg 61:889–893
Chang JT, Chiu PC, Chen YY et al (2008) Multiple clinical manifestations and diagnostic challenges of incontinentia pigmenti-12 years’ experience in a medical center. J Chin Med Assoc 71:455–460
Cohn MS, Mahon MJ (1994) Telangiectasia macularis eruptiva perstans. J Am Osteopath Assoc 94:246–248
Courjon J, Hubiche T, Phan A, Tristan A, Bès M, Vandenesch F, Etienne J, Del Giudice P, Gillet Y (2013) Skin findings of Staphylococcus aureus toxin-mediated infection in relation to toxin encoding genes. Pediatr Infect Dis J 32(7):727–730
Curatolo P, Bombardieri R, Jozwiak S (2008) Tuberous sclerosis. Lancet 372:657–668
Das JK, Sengupta S, Gangopadhyay A (2009) Pachyonychia congenita type 2. Indian J Adv Dermatol Venereol Leprol 75:321–322
Denoyelle F, Leboulanger N, Enjolras O et al (2009) Role of propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol 73:1168–1172
Dhar S, Banerjee R, Malakar R (2012) Neonatal erythroderma: diagnostic and therapeutic challenges. Indian J Dermatol 57(6):475–478
Fine JD, Bruckner-Tuderman L, Eady RA et al (2014) Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification. J Am Acad Dermatol 70(6):1103–1126
Fistarol SK, Itin PH (2002) Nail changes in genodermatoses. Eur J Dermatol 12:119–128
Freeman AF, Holland SM (2009) Clinical manifestations, etiology, and pathogenesis of the hyper-IgE syndromes. Pediatr Res 65:32R–37R
Freeman AF, Domingo DL, Holland SM (2009) Hyper IgE (Job’s) syndrome: a primary immune deficiency with oral manifestations. Oral Dis 15:2–7
Ghosh S (2015) Neonatal pustular dermatosis: an overview. Indian J Dermatol 60(2):211
Goldfarb CA, Sathienkijkanchai A, Robin NH (2009) Amniotic constriction band: a multidisciplinary assessment of etiology and clinical presentation. J Bone Joint Surg Am 91:S68–S75
Gómez-Lado C, Eirís-Puñal J, Blanco-Barca O et al (2004) Hypomelanosis of Ito. A possibly under-diagnosed heterogeneous neurocutaneous syndrome. Rev Neurol 38:223–228
Greenberg RG, Benjamin DK Jr (2014) Neonatal candidiasis: diagnosis, prevention, and treatment. J Infect 69(Suppl (1)):S19–S22
Gross U, Hoffmann GF, Doss MO (2000) Erythropoietic and hepatic porphyrias. J Inherit Metab Dis 23:641–661
Gushi M, Yamamoto Y, Mine Y et al (2008) Neonatal pemphigus vulgaris. J Dermatol 35:529–535
Happle R (2006) X-chromosome inactivation: role in skin disease expression. Acta Paediatr Suppl 95:16–23
Harrison-Balestra C, Gugic D, Vincek V et al (2007) Clinically distinct form of acquired dermal melanocytosis with review of published work. J Dermatol 34:178–182
Has C, Kiritsi D (2015) Therapies for inherited skin fragility disorders. Exp Dermatol 24(5):325–331
Hennedige AA, Quaba AA, Al-Nakib K (2008) Sturge-Weber syndrome and dermatomal facial port-wine stains: incidence, association with glaucoma, and pulsed tunable dye laser treatment effectiveness. Plast Reconstr Surg 121:1173–1180
Hersh JH (2008) Health supervision for children with neurofibromatosis. American Academy of pediatrics committee on genetics. Pediatrics 121:633–642
Hoeger PH, Harper JI (1998) Neonatal erythroderma: differential diagnosis and management of the “red baby”. Arch Dis Child 79:186–191
Hull S, Arno G, Thomson P et al (2015) Somatic mosaicism of a novel IKBKG mutation in a male patient with incontinentia pigmenti. Am J Med Genet A 167(7):1601–1604
Inzinger M, Salmhofer W, Binder B (2012) Neonatal lupus erythematosus and its clinical variability. J Dtsch Dermatol Ges 10(6):407–411
James SH, Kimberlin DW (2015) Neonatal herpes simplex virus infection: epidemiology and treatment. Clin Perinatol 42(1):47–59
Januário G, Salgado M (2011) The Harlequin phenomenon. J Eur Acad Dermatol Venereol 25(12):1381–1384
Karim Z, Lyoumi S, Nicolas G et al (2015) Porphyrias: a 2015 update. Clin Res Hepatol Gastroenterol 39(4):412–425
Katugampola RP, Anstey AV, Finlay AY et al (2012) A management algorithm for congenital erythropoietic porphyria derived from a study of 29 cases. Br J Dermatol 167(4):888–900
Kilborn TN, Teh J, Goodman TR (2003) Paediatric manifestation of Langerhans cell histiocytosis: a review of clinical and radiological findings. Clin Radiol 58:269–278
Koch BL (2005) Cystic malformations of the neck in children. Pediatr Radiol 35:463–477
Krengel S, Hauschild A, Schäfer T (2006) Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol 155:1–8
Kucinskiene V, Sutkute A, Valiukeviciene S (2014) Cutaneous fungal infection in a neonatal intensive care unit patient: a case report and literature review. Pediatr Dermatol 31(3):267–270
Kwak J, Lamprecht C (2015) A review of the guidelines for the evaluation and treatment of congenital syphilis. Pediatr Ann 44(5):e108–e114
Lakdawala N, Grant-Kels JM (2015) Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). Clin Dermatol 33(4):414–419
Lenane P, Pope E, Krafchik B (2005) Congenital alopecia areata. J Am Acad Dermatol 52:S8–S11
Lichon V, Khachemoune A (2007) Xeroderma pigmentosum: beyond skin cancer. J Drugs Dermatol 6:281–288
Lorente Lavirgen AI, Bernabeu-Wittel J, Dominguez-Cruz J, Conejo-Mir J (2012) Neonatal pemphigus foliaceus. J Pediatr 161(4):768
Mallory SB (1991) Neonatal skin disorders. Pediatr Clin N Am 38:745–761
Mancini AJ, Sookdeo-Drost S, Madison KC et al (1994) Semipermeable dressings improve epidermal barrier function in premature infants. Pediatr Res 36:306–314
Méni C, Bruneau J, Georgin-Lavialle S et al (2015) Paediatric mastocytosis: a systematic review of 1747 cases. Br J Dermatol 172(3):642–651
Meurer M (2009) Pemphigus diseases in children and adolescents. Hautarzt 60:208–216
Minić S, Trpinac D, Obradović M (2014) Incontinentia pigmenti diagnostic criteria update. Clin Genet 85(6):536–542
Monteagudo B, Labandeira J, Cabanillas M, Acevedo A, Toribio J (2012) Prospective study of erythema toxicum neonatorum: epidemiology and predisposing factors. Pediatr Dermatol 29(2):166–168
Moure C, Reynaert G, Lehmman P et al (2007) Classification of vascular tumors and malformations: basis for classification and clinical purpose. Rev Stomatol Chir Maxillofac 108:201–209
Nelson DL (2006) NEMO, NFkappaB signaling and incontinentia pigmenti. Curr Opin Genet Dev 16:282–288
Neylon O, O’Connell NH, Slevin B, Powell J, Monahan R, Boyle L, Whyte D, Mannix M, McElligott F, Kearns AM, Philip RK (2010) Neonatal staphylococcal scalded skin syndrome: clinical and outbreak containment review. Eur J Pediatr 169(12):1503–1509
Ott H, Hütten M, Baron JM et al (2008) Neonatal and infantile erythrodermas. J Dtsch Dermatol Ges 6(12):1070–1085
Panko J, Florell SR, Hadley J et al (2009) Neonatal pemphigus in an infant born to a mother with serologic evidence of both pemphigus vulgaris and gestational pemphigoid. J Am Acad Dermatol 60(6):1057–1062
Requena L (1992) Erythrodermic mastocytosis. Cutis 49:189–192
Rosa PA, Hirsch DL, Dierks EJ (2008) Congenital neck masses. Oral Maxillofac Surg Clin N Am 20:339–352
Ruiz-Maldonado R (2007) Hypomelanotic conditions of the newborn and infant. Dermatol Clin 25:373–382
Sa J, Khachemoune A, Guldbakke KK (2007) Piebaldism: a case report and a concise review of the literature. Cutis 80:411–414
Scheck O, Horny HP, Ruck P et al (1987) Solitary mastocytoma of the eyelid. A case report with special reference to the immunocytology of human tissue mast cells, and a review of the literature. Virchows Arch 412:31–36
Serna-Tamayo C, Janniger CK, Micali G, Schwartz RA (2014) Neonatal and infantile acne vulgaris: an update. Cutis 94(1):13–16
Simko SJ, Garmezy B, Abhyankar H et al (2014) Differentiating skin-limited and multisystem langerhans cell histiocytosis. J Pediatr 165(5):990–996
Singalavanija S, Limpongsanurak W, Aoongern S (2014) Neonatal lupus erythematosus: a 20-year retrospective study. J Med Assoc Thai 97(6):S74–S82
Sinha S, Cohen PJ, Schwartz RA (2008) Nevus of Ota in children. Cutis 82:25–29
Sket KV, Giachetti A, Sojo M, Garrido D, Lupo E, Brener P (2013) Congenital cutaneous candidiasis. Arch Argent Pediatr 111(6):556–558
Smith CK, Arvin AM (2009) Varicella in the fetus and newborn. Semin Fetal Neonatal Med 14:209–217
Smolinski KN, Yan AC (2005) Hemangiomas of infancy: clinical and biological characteristics. Clin Pediatr (Phila) 44:747–766
Summers CG (2009) Albinism: classification, clinical characteristics, and recent findings. Optom Vis Sci 86:659–662
Visscher MO, Adam R, Brink S, Odio M (2015) Newborn infant skin: physiology, development, and care. Clin Dermatol 33(3):271–280
Wiechers T, Rabenhorst A, Schick T et al (2015) Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis. J Allergy Clin Immunol 136(6):1581–1590
Yang B, Li L, Zhang LX et al (2015) Clinical characteristics and treatment options of infantile. Medicine 94(40):1–9
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Fimiani, M. et al. (2016). Neonatal Skin Disorders. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-18159-2_285-1
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DOI: https://doi.org/10.1007/978-3-319-18159-2_285-1
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