Abstract
Within the past decade, single-incision laparoscopic cholecystectomy (SILC) has become a popular approach for minimally invasive surgeons performing gallbladder removal. However, more recently, the robotic platform has been implemented to overcome the intrinsic limitations of SILC, particularly by improving space constraints and reducing instrument collisions. While most studies analyzing the safety, efficacy, and outcomes of single-incision cholecystectomy are based on the SILC literature, both single-site robotic cholecystectomy (SSRC) and SILC appear to be safe and efficient methods for cholecystectomy that are correlated with improved patient satisfaction, cosmesis, and pain control. In this chapter, we describe an efficient, reproducible SSRC technique that surgeons can use as a guide to decrease operative time while maintaining safe standards. We review the indications, fundamental principles, common reasons to convert, associated morbidity, and the learning curve for integration of SSRC into surgical practice. Nevertheless, this technique is reserved for those experienced in minimally invasive surgery with a baseline proficiency in robotics. Caution must be taken during the surgeon’s initial experience.
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Introduction
Since the advent of laparoscopic cholecystectomy in 1985 by Prof. Dr. Erich Mühe of Germany, surgeons have continued to improve upon its safety, efficacy, and cosmetic results [1]. Minimally invasive surgery has become the gold standard for most thoracic and abdominal operations due to reduced postoperative pain, shorter hospital stays, and improved cosmetic outcomes. As surgeons have become more experienced and efficient with multi-port laparoscopic cholecystectomy (MPLC), the development of single-incision procedures has become a rapidly expanding field. Single-incision laparoscopic cholecystectomy (SILC) was first described in 1997 and, since then, many surgeons have demonstrated the procedure as safe option for cholecystectomy in patients interested in an improved cosmetic outcome [2].
However, difficult instrument maneuverability secondary to space constraints in SILC has lead to the introduction of single-site robotic cholecystectomy (SSRC)—this technology has been shown to reduce instrument collisions, improve retraction, and increase the overall ease of single-incision surgery [3]. Although most studies describing the safety, efficacy, and outcomes of single-incision cholecystectomy are based on the SILC operative platform, many of these findings are directly translatable to SSRC. Therefore, much of this chapter includes aspects of the SILC literature that are directly applicable to the SSRC procedure and its outcomes. Nevertheless, the overall aim of this chapter is to describe an efficient, reproducible single-site robotic cholecystectomy technique that surgeons can use as a guide to decrease operative time while maintaining safe standards.
Indications
Over 300 studies have described or analyzed SILC and SSRC, confirming their increasing popularity. While these studies have varying diagnostic inclusion and exclusion criteria, the indications for SILC and SSRC should be guided by the recommendations set forth by the 1992 National Institutes of Health Consensus Development Conference Statement on Gallstones and Laparoscopic Cholecystectomy [4]. The SSRC procedure itself should typically be reserved for surgeons with a high robotic skill level and patients who desire a nearly “scarless” procedure.
Most studies assessing the safety and efficacy of SILC and SSRC have been in patients with biliary colic or symptomatic cholelithiasis, while excluding acute inflammatory states, such as cholecystitis and pancreatitis, and patients with BMI > 35 kg/m2 or prior upper abdominal surgery [5]. However, several recent SILC studies have included patients with acute cholecystitis: they observed a longer operative time and a potential increased risk for conversion to multiport, but there were no differences in complication rates compared to operations for noninflammatory gallbladder disease [6–10]. Only two SSRC studies have included patients with cholecystitis, but neither was powered to detect differences in outcomes between patients with cholecystitis and noninflammatory biliary disease. While larger prospective trials are needed to confirm the safety of SSRC in acute cholecystitis, both SSRC and SILC are feasible options for treatment, provided there is adequate visualization of vital structures.
In addition to cholecystitis, SILC and SSRC have been proven as safe operations to treat other forms of gallbladder disease. Several prospective randomized studies and meta-analyses defined their SILC inclusion criteria as patients with symptomatic cholelithiasis and have demonstrated safe outcomes with variable operative length and postoperative pain control [11–14]. Similarly, several studies have shown SSRC to be safe for patients with symptomatic cholelithiasis [15–20]. Other indications such as gallbladder polyps and biliary dyskinesia have not been specifically analyzed in the SILC or SSRC literature. Lastly, recent studies have suggested that using the robotic platform can safely be used in obese patients as well [17].
Relative Contraindications
Relative contraindications for the SILC and SSRC approaches are the same as those for MPLC, which are typically severe inflammatory disease states of the gallbladder including gangrenous cholecystitis, gallbladder empyema, perforated gallbladder, cholecystoenteric fistula, and Mirizzi syndrome. These conditions generally confer a more difficult operation secondary to obscured normal anatomy with conversion rates ranging from 35 to 75 %, depending on the condition [21–28]. Furthermore, most of these conditions often present as a severe illness, and are difficult to diagnose preoperatively secondary to imaging modality limitations. Risk factors for these conditions include increased age, marked leukocytosis, and a history of diabetes [21, 29–33]. Historically, these patients usually required percutaneous cholecystostomy or open cholecystectomy, but more recent reports in the literature have demonstrated that urgent MPLC is a safe alternative with improved outcomes and shorter hospital stay [34–38]. However, there are currently no reports of using SILC or SSRC in these patient populations; it is reasonable to initially attempt cautious dissection via single-incision approach, but the surgeon should have a lower threshold to convert to open to avoid inadvertent injury.
Several additional unique conditions warrant caution when considering SILC. Porcelain gallbladder is associated with a difficult dissection secondary to a brittle, calcified gallbladder wall, as well as an associated 7 % incidence of carcinoma [39]. While several studies have described the feasibility of using the MPLC approach for treatment of porcelain gallbladder, only one case report has described using SILC [40–42]; thus, the decision to pursue SILC or SSRC in such cases should be left to the discretion of a skilled minimally invasive surgeon.
Lastly, the pregnant patient with symptomatic gallstones must always be approached carefully. It has been well documented that laparoscopic cholecystectomy is most safe during the second trimester, without any increase in maternal–fetal morbidity [43–48]. On the other hand, first-trimester operations may have deleterious effects on fetal organogenesis, and third-trimester operations are technically limited by the enlarged uterus and may be associated with an increased rate of preterm labor [45]. Only one case report currently exists in the literature documenting success using SILC during pregnancy; thus, the approach must be used with caution in the appropriate clinical setting [49]. If the SILC or SSRC approach is used, we recommend careful port insertion to avoid uterine injury, low insufflation pressures (10–12 mmHg) to minimize pressure on the uterus, and left-lateral positioning to minimize caval compression.
Absolute Contraindications
The absolute contraindications to SILC are also similar to MPLC. These are typically patients who cannot tolerate general anesthesia secondary to severe comorbidities or have an acute critical illness. Patients in septic shock with hemodynamic instability are not candidates for the operating room, and instead require fluid resuscitation, IV antibiotics, ICU monitoring, and percutaneous cholecystostomy (PC) tube placement [50]. Despite non-operative management, the mortality rate in this patient population approaches 25 % [51, 52]. However, patients with calculus cholecystitis who achieve full recovery will have a 45 % risk of recurrence, and thus should undergo elective cholecystectomy if preoperative medical optimization is feasible [52, 53].
Several medical comorbidities may preclude a minimally invasive operation. Patients with severe chronic obstructive pulmonary disease can develop a severe respiratory acidosis because they are unable to clear excess carbon dioxide absorbed from pneumoperitoneum. Patients with congestive heart failure can experience an acute exacerbation from decreased venous return and increased systemic vascular resistance secondary to insufflation, particularly with an ejection fraction <20 % [54]. Severe liver dysfunction and refractory coagulopathy generally precludes any operation, including cholecystectomy, particularly in the setting of hypoalbuminemia. Furthermore, Child-Pugh class C cirrhosis is associated with a high mortality rate, and cholecystectomy should be avoided, potentially using percutaneous cholecystostomy for acute cholecystitis [55]. While laparoscopic cholecystectomy on Child-Pugh classes A and B have been shown to be safe, they are associated with higher conversion rates, longer operative times, bleeding complications, and overall higher morbidity [56–58].
Lastly, known gallbladder carcinoma is a contraindication to minimally invasive approach. Stage Ia gallbladder carcinoma, frequently found incidentally on resection, is the only cancer that can be managed by laparoscopic technique [59, 60]. However, stage Ib and above require a subsequent open operation with potential segment 4B/5 liver resection and portal lymphadenectomy [61–66].
Feasibility and Safety
As single-incision laparoscopic techniques have gained widespread utility in clinical practice, there have been many studies documenting the safety and feasibility of SILC [67–69]. This included several large meta-analyses of randomized control trials which each included over 500 patients [11–13, 70]. These studies concluded that SILC may have longer operative durations; however, complication rates did not increase, and patient satisfaction was improved compared to MPLC. Furthermore, the safety and feasibility of SILC has been also demonstrated in a community setting, which supports its use outside of academic tertiary care centers [67, 71]. Several studies also included patients with acute cholecystitis as part of the inclusion criteria and determined that there may be a slight increase in operative length and conversion to open in an acute inflammatory state; however, there were no increases in complications as compared to MPLC [6, 69]. The SILC technique has been proven to be a safe method for cholecystectomy, while being just as efficacious as MPLC for the treatment of benign gallbladder disease.
Technique
As with any operation, appropriate and reproducible technique is imperative for safety and efficiency. The following is the standard SSRC procedure that we use at our institution, which is based on similar principles used in SILC.
Patient Preparation and Surgeon Positioning
Upon application of sequential compressive devices and administration of appropriate preoperative antibiotics and subcutaneous heparin, the patient is placed in the supine position with both arms tucked. This positioning allows for adequate docking of the robot over the right shoulder, and room for the surgical assistant to stand on the patient’s left once the peritoneal cavity is entered and the single-incision platform is set up (Fig. 8.1). If indocyanine green (ICG) is being used for real-time near-infrared fluorescent cholangiography (see detailed description below), it should be injected 30 min prior to incision. Lastly, during dissection, the patient should be in reverse Trendelenburg position to facilitate inferior displacement of the digestive tract away from the gallbladder and liver.
Incision, Port Placement, and Instrumentation
The patient’s abdomen is prepped and draped in standard sterile fashion. The infra-umbilical crease is incised in a transverse, curvilinear fashion approximately 2–2.5 cm in length (Fig. 8.2a). The subcutaneous fat is dissected off the fascia to allow a 2.5-cm transverse fascial incision. The peritoneum is entered sharply and carefully to avoid intra-abdominal organ injury. The peritoneal cavity is swept with a finger to assess for intra-abdominal adhesions and ensure safe insertion of the multichannel umbilical port. Any local adhesions are lysed sharply to facilitate port insertion.
In order to place several instruments through a single infraumbilical incision, the multichannel da Vinci ® Single-Site ® port platform (Intuitive Surgical Inc., Sunnyvale, CA, USA) is utilized. The port is cylindrical with five lumens that provide access for two working instruments, a 8.5 mm 3D-HD endoscope camera, an assistant’s accessory port, and insufflation adaptor (Fig. 8.2). The working ports cross at the abdominal wall (Fig. 8.2c), so that the right instrument is positioned on the left side of the operative field, and the left instrument is positioned on the right—this arrangement minimizes extracorporeal clashing of the robotic arms. The robotic console corrects for this switch in laterality so that the operating surgeon’s right hand controls the “left extracorporeal” robotic arm, and the left hand controls the “right extracorporeal” arm. This configuration has been shown to improve single-site simulator task performance by eliminating instrument collisions, decreasing camera manipulations, and improving clutching efficiency [72].
After umbilical port placement, the abdomen is insufflated with CO2 to 15 mmHg, and the camera and instruments are inserted under direct vision into the abdominal cavity. Specifically, a laparoscopic grasper is inserted through the accessory port by the assistant at the bedside for cephalad retraction of the gallbladder fundus. The “right extracorporeal” robotic arm (i.e., left intracorporeal instrument) is dedicated for the infundibulum grasper. The “left extracorporeal” robotic arm (i.e., right intracorporeal instrument) is designated for electrocautery (Covidien ForceTriad monopolar electrocautery platform, ValleyLab, Boulder, CO, USA), suction, and the clip applier.
Triangulation and Flexible Instrumentation
Both the SILC and SSRC techniques require the surgeon and assistant to control four instruments in a limited space through a 2.5-cm fascial incision. Thus, it is of utmost importance to employ the spatial principle of triangulation of instrumentation to maximize the operative field. The single-site platform allows the surgeon to direct instruments from a radial position extracorporeally towards an opposite point intracorporeally, thereby crossing the plane of visualization. This crossing vector is not conventional in multi-port laparoscopy; however in SILC and SSRC, it maximizes retraction in the opposite direction of port insertion (Fig. 8.3a). Specifically, a grasper is placed through the assistant’s accessory port to grasp the fundus and retract superiorly, while the endoscope is inserted through the camera port and aimed inferiorly. This triangulation maximizes the angle of cephalad gallbladder retraction through the narrow umbilical incision while maintaining an unobscured view of the operative field.
To minimize instrument collisions, the two working port vectors are crossed at the abdominal wall. Rigid curved cannulas are inserted through the two working ports, through which flexible instruments will be placed (Fig. 8.3b). These crossing vectors maximize the extracorporeal robotic arms’ range of motion, thereby reducing collisions. Additionally, due to the flexibility of the instruments, the rigid curved cannula allows for redirection of the radially oriented instruments back to the center of the operative field [73]. This minimizes intracorporeal instrument collision, provides adequate infundibulum retraction (“right extracorporeal” robotic arm), and facilitates electrocautery dissection (“left extracorporeal” robotic arm).
Approaches to Dissection
There are two main approaches to gallbladder dissection: anterograde (fundus-last) and retrograde (fundus-first). The retrograde approach is commonly used in open cholecystectomy as a safe method of dissection with the visual plane in the anterior–posterior direction. This allows a safe dissection plane from the fundus toward the cystic duct by retracting the gallbladder away from the liver bed, particularly if there is marked cholecystitis obscuring the anatomy. The anterograde approach is the method of choice during minimally invasive procedures. This approach allows safe identification of Calot’s triangle from the laparoscopic field of view, which is directed from the umbilicus in the caudal-cephalad plane.
The anterograde approach for SILC and SSRC is similar to MPLC. It begins with identification of the gallbladder and careful lysing of any adhesions preventing adequate visualization and exposure. The fundus is then grasped through the assistant’s accessory port and retracted superiorly, using the triangulation concept as described above. Adhesions to surrounding structures, such as the duodenum and omentum, are then stripped away until the inferolateral aspect of the gallbladder is completely visualized.
Identification of Calot’s triangle is the next critical step. This is achieved by careful retraction of the infundibulum using the “right extracorporeal” robotic arm and dissection using the “left extracorporeal” arm. The peritoneal reflection is taken down medially and laterally to allow for visualization of Calot’s triangle. The surgeon can dissect with a Maryland forceps, electrocautery, or suction device when appropriate, until the cystic duct, common hepatic duct, and inferior border of the liver are identified. It is imperative to avoid bleeding, as this can obscure the visual field. Ultimately, a window around the cystic duct is created to allow the surgeon to visualize the isolated cystic duct and cystic artery entering the gallbladder. Of note, it is important to minimize the use of electrocautery near Calot’s triangle to avoid thermal injury to the cystic and common hepatic ducts. The cystic duct and artery are each clipped and divided with two clips remaining on each of the in situ structures. The gallbladder is then dissected off the liver bed with electrocautery, being mindful to avoid an aberrant right hepatic artery.
In order to aid in anatomical identification during dissection, the robotic platform allows for near-infrared fluorescent cholangiography using ICG, a low-toxicity fluorescent dye containing sodium iodide that binds plasma proteins and is excreted exclusively in bile. When exposed to near-infrared light by the robotic endoscope, ICG emits light detectable at a peak wavelength of 830 mm, which illuminates the biliary tree and surrounding vasculature [74]. Specifically, three milliliters (mL) of ICG is injected intravenously 30 min prior to incision. Its peak absorption after excretion into the biliary tree occurs 45–60 min postinjection, which aids in identification of the cystic duct, CBD, common hepatic duct, and potential aberrant ducts. Additional 3 mL aliquots can be injected intraoperatively to properly identify surrounding vasculature (e.g., the cystic artery) within 45 s postinjection (Fig. 8.4).
Unlike traditional cholangiography, near-infrared fluorescent cholangiography allows the surgeon to evaluate biliary anatomy in real time without inserting catheters into the cystic duct, and can quickly assist in delineating biliary anatomy during dissection of Calot’s triangle. Although contraindicated in pregnancy and patients with iodide allergies, this technique has been demonstrated as safe and effective for identifying biliary anatomy in both laparoscopic and single-site robotic cholecystectomy—specifically, it identifies the cystic duct, CBD, and common hepatic duct in 97–100 %, 83–100 %, 67–100 % of cases, respectively [75–78]. Moreover, it requires only a simple injection without implementation of a C-arm or exposure to radiation. Therefore, we recommend routine usage of real-time near-infrared cholangiography during SSRC only to aid during anatomical dissection; it is currently not indicated to evaluate for choledocholithiasis. If ICG imaging is negative during SSRC, proceed with careful dissection and employ traditional intraoperative cholangiography as indicated (see below).
A retrograde approach has been described as a safe alternative during laparoscopic cholecystectomy, usually performed in cases with severe inflammation and an inability to safely identify Calot’s triangle [79–86]. This method may reduce the expected conversion-to-open rate without increasing the risk of injury to the biliary tree [79, 83]. It has also been described as a safe option during SILC to obtain a 360° view around the cystic duct before transection [87, 88]; only two case series have reported this approach in SSRC [89, 90]. This method begins with caudal retraction of the gallbladder away from the liver. A fundal dissection plane is started while leaving a small rind of the edematous gallbladder wall on the liver bed. This rind can be grasped and provide retraction of the liver bed away from the gallbladder. The dissection is continued until the cystic duct and artery are identified, while confirming a 360° view around the cystic duct prior to transection. This method is reserved as an attempt to avoid conversion to open; however, if safe dissection is difficult, we recommend converting directly to the open approach. We typically do not convert to a multi-port laparoscopic approach as an intermediate step because it has not been shown to reduce conversion rates after a failed anterograde and retrograde laparoscopic approach, and it will only prolong the operative time. However, during the learning phase, conversion to MPLC may be employed to aid in difficult dissections, or when there is bleeding that cannot be controlled via the single-site platform.
Intraoperative Cholangiography and Choledocholithiasis
Intraoperative cholangiography (IOC) is generally employed to investigate suspected choledocholithiasis or to identify aberrant or obscured anatomy. Specific indications include a clinical history of jaundice, transaminitis, direct hyperbilirubinemia, pancreatitis, increased amylase or lipase levels, ultrasound findings of dilated common duct or intra-ductal stones, or failed preoperative endoscopic retrograde cholangiopancreatography (ERCP) [91–93]. Some groups have concluded hyperbilirubinemia and dilated common duct on preoperative ultrasound should be the sole indications for IOC [94].
If preoperative choledocholithiasis is suspected, there are several management options including preoperative ERCP followed by cholecystectomy (two-stage) or cholecystectomy with common bile duct exploration (single-stage). One study performed a decision tree analysis summarizing the literature and found that single-stage laparoscopic common bile duct exploration during cholecystectomy has lower morbidity and mortality rates compared to preoperative ERCP followed by cholecystectomy [95]. While common bile duct exploration has been well described in MPLC, there has been only one small retrospective review describing 13 patients who underwent successful SILC with common duct exploration [96]. The single-incision CBD exploration technique has not been reproduced by another group yet, and only multi-port robotic CBD explorations have been reported [97, 98].
There are substantial data advocating for routine IOC to be performed during cholecystectomy, suggesting that it decreases the risk of common bile duct injury [99–102]. However, there is conflicting evidence reporting no improvement in bile duct injury, overall morbidity, or mortality with routine IOC [103–105]. One systematic review of eight randomized trials evaluating the ability of IOC to detect choledocholithiasis and biliary injury concluded there is no evidence to support or abandon use of IOC, and the decision to perform IOC should be left to the discretion of the surgeon [106]. Routine IOC during SILC without making a separate incision for the cholangiogram catheter has been demonstrated as safe and feasible [107]. However, while IOC during SSRC has also been reported in the literature [20, 108], it extends operative times, involves a multidisciplinary team, and requires C-arm placement which typically necessitates re-docking at least one robotic arm. Thus, most robotic surgeons do not routinely perform IOC during SSRC, and will selectively pursue it only if there is a clinical suspicion for choledocholithiasis or if the biliary anatomy needs to be clarified before further dissection.
When traditional IOC is indicated in SSRC, a 14-gauge angiocath is placed through 2 mm stab incision in the right upper quadrant under direct visualization. The needle is removed, leaving the angiocath sheath in place to provide access for the cholangiogram catheter. As in MPLC, a small transverse incision is made in the cystic duct with robotic shears. The cholangiogram catheter is then inserted into the cystic duct and secured with a laparoscopic clip applier. Saline is flushed to ensure adequate flow and the IOC is performed using intraoperative fluoroscopy. Typically, the robot will have to be undocked to accommodate the C-arm. Upon completion of the cholangiogram, the clip, cholangiogram catheter, and angiocath are removed and discarded.
If stones are identified in the common hepatic or common bile duct, we recommend completing the cholecystectomy and performing intraoperative or postoperative ERCP for stone retrieval. If this is not possible, a common duct exploration needs to be performed. As mentioned above, CBD exploration has been described via single-incision laparoscopic, multi-port robotic, and open approaches depending on the expertise of the surgeon. However, at this point, further studies analyzing the feasibility, safety, and outcomes of single-incision CBD exploration are warranted before we recommend it for routine usage.
Organ Extraction and Closure
Upon successful completion of gallbladder dissection, and IOC if necessary, the gallbladder is placed in an Endo Catch specimen retrieval bag (Covidien, Mansfield, MA, USA). The liver bed is inspected for hemostasis and the operative field is irrigated with saline. The instruments are then removed from the ports and the abdomen is desufflated. The robotic arms are detached from the instrument ports, the multichannel da Vinci ® Single-Site ® port is removed, and the specimen is extracted through the umbilical incision. Finally, the transverse fascia is closed with at least four 0-vicryl sutures on a GU needle and the skin is closed with a continuous subcuticular 4-0 monofilament absorbable suture.
Aberrant Anatomy
The most common cause of iatrogenic liver and common duct injury is secondary to misperception of anatomy, not a failure in technical skill, knowledge, or judgment [109]. There are several common anatomic variants that the surgeon must be aware of to avoid a catastrophic complication, especially when learning the single-incision and robotic techniques.
Alterations in normal gallbladder geometry can obscure the anatomy. Enlargement of the cystic duct and infundibulum secondary to an obstructing cystic duct stone, also known as the Hartman’s pouch, can obscure the cystic and common bile duct anatomy. The most severe form of this scenario is Mirizzi’s syndrome, where a large stone in Hartman’s pouch causes obstruction, adhesion, or erosion into the common duct [110]. Although the incidence of Mirizzi’s syndrome is only estimated at 0.5–1.0 % of all laparoscopic cholecystectomies, it has a conversion-to-open rate of 40–75 % [22–24].
There are several distinct features of the cystic duct that promote accurate identification. A normal cystic duct is 2–4 cm in length and approximately 5 mm in diameter. The absence of a true cystic duct is extremely rare, thus an inability to identify the duct is likely secondary to obscured anatomy, not an anatomical variant. Additionally, any tubular structure larger than 5 mm should be fully delineated before identifying it as a dilated cystic duct. The incidence of multiple cystic ducts is also quite rare, thus identification of multiple tubular structures near the gallbladder should raise suspicion of a tortuous CBD or accessory ducts. Furthermore, the cystic duct can take a variable course originating from the CBD: it may course perpendicular, parallel, or spiral around the CBD before entering the gallbladder [110]. Regardless of configuration, the best way to identify the cystic duct is by clearly dissecting Calot’s triangle and visualizing the duct fully entering the gallbladder.
Accessory extrahepatic bile ducts draining directly from the liver bed exist in up to 20 % of patients and can be misidentified as the cystic duct during cholecystectomy. An accessory right anterior or right posterior hepatic duct can originate from the right lobe of the liver, cross Calot’s triangle, and insert into the cystic, common hepatic, or common bile ducts [110, 111]. These ducts may be of significant diameter and biliary drainage, thus injury to them may require Roux-en-Y hepaticojejunostomy reconstruction [112]. Real-time near-infrared cholangiography during SSRC could potentially help the surgeon differentiate between these variants.
The cystic artery must be fully isolated before ligation. It originates from the right hepatic artery (RHA) and is commonly found in the center of Calot’s triangle in approximately 85 % of cases. It divides into an anterior and posterior branch near the gallbladder wall, also supplying the cystic duct with a small accessory branch. There are several variants of which the laparoscopic surgeon must be aware. A double cystic artery occurs in 15–25 % of patients, where two vessels originate from the RHA and travel through Calot’s triangle into the gallbladder. Approximately 13 % of patients may have a cystic artery that does not travel through Calot’s triangle secondary to variations in arterial origin. These variant vessels can arise from the gastroduodenal artery, superior mesenteric artery, a replaced right hepatic artery, the left hepatic artery, or directly from the liver parenchyma [113]. Lastly, the cystic artery can be misidentified as the right hepatic artery, which normally courses posterior to the common duct then enters the liver at the superior edge of Calot’s triangle. In up to 5 % of cases, the right hepatic artery may tortuously travel through Calot’s triangle, known as Moynihan’s hump, resulting in a short cystic artery and high risk of vascular injury [114]. These anatomic variants must be properly identified to avoid inadvertent ligation or injury. Since ICG remains intravascular before being excreted by the liver, intravenous injection 45 s prior to clipping could help identify the cystic artery.
Indications for Conversion
Although one of the major benefits of performing SILC or SSRC is to attain a nearly “scarless” cosmetic result, the surgeon must be cognizant to abandon the goal of improved cosmesis and convert to an open procedure for patient safety. The conversion-to-open rate for acute cholecystitis in MPLC is estimated to be 9.0–9.5 %, and is associated with a 1.3-fold increase in morbidity [115, 116]. Similarly, the rate of conversion in SSRC to multi-port or open cholecystectomy (in a patient population including acute cholecystitis) is approximately 6 % [17]. Thus, it is important to understand that this patient population can be very ill, and certain scenarios should be recognized to convince the surgeon to convert to open and minimize operative length and risk for biliary injury.
We typically do not recommend conversion to four-port conventional cholecystectomy since it likely does not confer a higher success rate and may just prolong the operation unnecessarily. Several studies have supported this as a method of avoiding laparotomy during SSRC [17]; however, if dissection is too difficult for a single-incision approach, it is generally safer to convert directly to an open approach. The only scenarios warranting conversion to MPLC is bleeding or assistance during the learning curve.
Severe cholecystitis may be an indication for conversion to avoid biliary or vascular injury, depending on the surgeon’s laparoscopic skill level. However, some centers advocate laparoscopic subtotal cholecystectomy with IOC as a safe, viable method to avoid laparotomy or biliary injury [117–120]. This procedure has been associated with a longer operative time and higher operative blood loss; however, these risks do not necessarily outweigh those of conversion to open [121]. These patients usually require intraoperative drain placement to monitor for biliary leak and potential ERCP with stent placement if one is detected. Nevertheless, there are risks of recurrent cholecystitis in patients with a gallbladder remnant, thus it may be preferable to completely remove the gallbladder even if via laparotomy.
A less common relative indication for conversion to open includes Mirizzi syndrome, which has a 75 % conversion rate, with some patients ultimately requiring a common duct repair intraoperatively or even a Roux-en-Y hepaticojejunostomy reconstruction depending on the degree of CBD involvement [23]. Additionally, there is up to 28 % incidence of gallbladder carcinoma associated with Mirizzi syndrome, thus an open operation with an experienced surgical oncologist should be considered [122].
Morbidity
Two studies have summarized the growing body of literature regarding the safety and morbidity of single-incision cholecystectomy, each evaluating nearly 1200 SILC patients with comparable results [69, 123]. The overall technical success rate without conversion to multi-port or open was over 90 %, but only 60 % for acute cholecystitis. While there were no mortalities reported, major complications requiring intervention or readmission occurred in 2.7 % of patients including retained stones (0.9 %), biliary leak (0.6 %), CBD stricture (0.1 %), and bile duct injury (<0.1 %). The minor complication rate was approximately 3 %, including wound infection (2 %), seroma (1.5 %), and ileus (0.2 %). Notably, the presence of acute cholecystitis did not appear to significantly affect complication rates. Thus, these two large studies have elucidated an acceptably low rate of overall complications, bile duct injury, readmission, and minor complications similar to MPLC provided adequate laparoscopic skills of the operating surgeon.
Nevertheless, there have been reports in the literature documenting higher rates of postoperative incisional hernia after single-incision cholecystectomy. Marks et al. performed a large, prospective, randomized, multicenter study analyzing SILC vs. MPLC [124]. While there was no difference in adverse events between groups, they found a significantly higher incisional hernia rate in the SILC group at 12-month follow-up (8.4 % vs. 1.2 %, p = 0.03). One-half of these hernias required operative repair by the time of publication. However, fascial closure during cholecystectomy was left to surgeon preference and there were not enough patients enrolled to determine if different techniques predisposed to hernia formation. Furthermore, the study noted it included surgeons with prior experience of at least ten SILC operations—since the learning curve may take approximately 20 cases, the study’s outcomes may have varied if it required surgeons with more SILC experience. Indeed, one single-surgeon, prospective study analyzed the incisional hernia rate after SILC with mean follow-up of 17 months and observed a 2 % incisional hernia rate [125], which is comparable to the known MPLC hernia rate of 1.7 % [126]. This lower rate may be a result of using the same closure technique on each patient, which were several interrupted Vicryl-1 (or PDS-1) sutures. Other studies including meta-analyses have also observed no difference in rates of postoperative hernia after single-incision cholecystectomy [12, 13, 70, 127, 128]. However, further prospective long-term studies are warranted to evaluate the optimal orientation of fascial incision and method of closure in order to ensure a low rate postoperative incisional hernia.
The rate of bile duct injury for MPLC has been estimated at 0.5 % and is associated with a more than twofold increased risk for mortality [129]. These patients usually require at minimum an ERCP and biliary stent placement if there is a minor injury, but more commonly these patients require a hepaticojejunostomy reconstruction by an experienced hepatobiliary surgeon. Although there have been over 350 SSRC cases reported in the literature without biliary injury [15–20] and the two SILC reviews discussed above reported <0.1 % rate of bile duct injury, one recent study suggested otherwise [130]. These authors performed a comprehensive literature search of SILC, including 45 studies and 2626 patients. The calculated overall complication rate was 4.2 % with a bile duct injury rate of 0.72 %. This is higher than the expected 0.4–0.5 % bile duct injury rate known for MPLC. There were no comparison groups to assess for statistical significance in this study; however, it is important to conclude that there may be a higher rate of biliary injury with the introduction of a single-incision procedure, and the technique should be reserved to surgeons with capable skills on minimally invasive platforms. It is also important to determine if these complications occur during the learning curve phase or afterwards with experienced surgeons.
Convalescence Data
As the main benefit of the single-incision technique is to be minimally invasive and “scarless,” there are convalescence data now reporting recovery events such as patient satisfaction, postoperative pain, mean hospital stay, and time to resume normal functional capabilities. These findings have been well studied in the SILC population, and will be reviewed here.
Convalescence data has been well documented for MPLC [131, 132]. Pain is most intense for the first 72 h postoperatively, which can be minimized with local anesthesia, oral opioids, or nonsteroidal anti-inflammatory drugs (NSAIDs). Most patients require 1 week until return to work and 2 days until return to recreational activity. Additionally, some studies advocate satisfactory cosmetic outcome based on postoperative patient questionnaire [133].
Now that single-incision cholecystectomy has been a surgical option for over a decade, there are reports in the literature documenting improved patient satisfaction with SILC when compared to MPLC [12]. One prospective trial demonstrated that there was no difference in scar assessment at early postoperative follow-up; however, patients do perceive a statistically significant superior scar assessment at longer-term postoperative follow-up [134]. Another similar randomized prospective trial supported this finding by observing increased patient satisfaction with wound appearance as early as two weeks postoperatively [135]. Other meta-analyses had consistent findings of improved cosmetic outcomes with SILC [11, 13, 70, 136].
The consensus of postoperative pain control has been controversial. Some randomized trials as well as meta-analyses have not found any statistical difference in postoperative pain control between SILC and MPLC [12–14, 70, 135, 137]. On the other hand, several studies and meta-analyses have documented improved pain control postoperatively, especially within 24-h [11, 127, 136, 138, 139]. This discrepancy is likely due to the widely different methods of pain control available, including oral opioids, NSAIDs, subcutaneous injection of local anesthetic, and even epidural anesthesia. We recommend local anesthetic for all patients combined with an oral modality best fit for the individual patient.
As the SILC procedure is a laparoscopic approach, one would expect the length of hospital stay and mean days until return to work to be similar to MPLC. Indeed, several studies have confirmed this hypothesis, finding the mean length-of-stay to be between 0 and 3 days without significant difference when compared to MPLC [11, 12, 14, 70, 128, 140]. Initial SSRC cohorts have reported an average number of days until return to normal activity and work of 4.5 and 7.5, respectively [16].
These comprehensive results are reiterated in one of the largest meta-analyses to date, which analyzed 25 randomized controlled trials including 944 SILC and 897 MPLC patients [136]. They observed that SILC was statistically superior to MPLC in cosmetic score, shorter length of incision, and postoperative pain within 12 h. In conclusion, these data support the use for patients interested in improved cosmesis and possibly improved pain control postoperatively; however, further convalescence data regarding SSRC remains to be elucidated.
Comparison to Standard Laparoscopy
Since no studies have compared SSRC to either SILC or MPLC, this chapter has compared the SILC technique vs. MPLC in several important aspects. With regard to operative times, SILC typically takes about 40–80 min depending on degree of dissection difficulty. This has been shown to be significantly longer compared to MPLC by approximately 15–20 min [13, 136]. Initial SSRC cohorts have reported a mean overall operative time of approximately 70–100, with console time ranging from 30 to 65 min [15–20]. These times will likely decrease as surgeons and dedicated operative room staffs become familiar with the robotic platform.
The overall main benefit of SILC compared to MPLC is improved patient satisfaction, cosmesis, and potentially pain control. Many studies confirm that SILC is as safe and efficacious as MPLC, showing comparable complication rates including minor (e.g., wound infection, seromas) and major complications (e.g., bile duct injury). While some studies report increased rates of bile duct injury and hernia formation, more studies are warranted to confirm these findings. Additionally, it is difficult to control for individual surgeon skill in these analyses. Thus, the literature should only be used as a guideline based on one’s own expertise and comfort level with single-incision surgery.
Integration into Practice
Perhaps the most important aspect of implementing a novel technique is incorporating it into surgical practice safely. Several studies have addressed the observed learning curve of experienced laparoscopic surgeons in developing an efficient operative time for SILC while maintaining patient safety and operative success. The data suggest there is an initial 20-patient SILC training phase, which have the longest operative times. The operative time improves gradually over the subsequent 20 patients. After the 40th case, surgeons’ operative times reach a nadir, stabilize, and become reproducible [141]. These results are analogous to another single surgeon’s initial experience [142]. This study observed that the initial mean operative time for the first 20 patients was 91 min. However, this improved to 81 min for the second 20 patients, followed by 64 min in the final series of patients. Furthermore, other studies describe learning curves that showed an improvement and plateau in operative times after only ten patients [143, 144]. Most importantly, regardless of the learning curve, these studies did not observe any increase in complication rate compared to MPLC.
Several initial SSRC cohorts have described the initial learning curve using the robotic platform. Surgeons in these studies were experienced in minimally invasive operations, and generally agreed that dissection during SSRC was more complex than conventional MPLC but easier than SILC [19]. Operative times were consistent with SILC and MPLC operative times and did not decrease significantly during initial robotic cases—this suggests that surgeons with expertise in minimally invasive and robotic procedures may not necessarily have a significant learning curve for cholecystectomy [19]. However, other studies noted a significant decrease in docking time [17, 20] and port insertion [17] as case number progressed, most notably in obese patients. Thus, these preliminary analyses suggest that the learning curve for SSRC is primarily a function of familiarization with the setup of the system and not necessarily the dissection itself, provided that the surgeon has expertise in minimally invasive platforms and SILC. Nevertheless, larger studies are required to confirm these findings and further define the caseload that a surgeon and operating room staff should expect to reach proficiency when implementing this new technology.
Several studies have analyzed resident training during SILC operations and have demonstrated a short learning curve without disruption of standard operating room procedure [145]. There also were not any complications as a result of resident training. These studies conclude that patient safety and outcomes are preserved without a dramatic increase in operative length, provided the resident has proficiency in basic laparoscopy and is guided with strict supervision by an experienced laparoscopist [146]. These findings need to be explored regarding SSRC.
In summary, single-incision cholecystectomy has become more commonplace for minimally invasive surgeons. The robotic platform has the advantage of overcoming the limitations of SILC, namely improving space constraints and reducing instrument collisions. While most studies analyzing the safety, efficacy, and outcomes of single-incision cholecystectomy are based on the SILC literature, both SSRC and SILC appear to be safe and efficient methods for cholecystectomy that are correlated with improved patient satisfaction, cosmesis, and pain control. This technique is reserved for experienced minimally invasive surgeons whose practice includes patients interested in these specific outcomes. Incorporating this technique into practice requires prior experience in laparoscopy and proficiency in robotics, and one should expect an initial learning curve of approximately 20 operations. Caution must be taken during the surgeon’s initial experience, and scrubbing with another surgeon with SSRC and SILC experience may prove very useful. Furthermore, the surgeon must take away from this chapter the indications for conversion to open surgery to reduce the risk of complications.
References
Reynolds W. The first laparoscopic cholecystectomy. JSLS. 2001;5(1):89–94.
Navarra G, Pozza E, Occhionorelli S, Carcoforo P, Donini I. One-wound laparoscopic cholecystectomy. Br J Surg. 1997;84(5):695.
Kroh M, El-Hayek K, Rosenblatt S, et al. First human surgery with a novel single-port robotic system: cholecystectomy using the da Vinci Single-Site platform. Surg Endosc. 2011;25(11):3566–73.
Gallstones and Laparoscopic Cholecystectomy, NIH Consens Statement. 1992;10(3):1–20.
Carus T. Current advances in single-port laparoscopic surgery. Langenbecks Arch Surg. 2013;398(7):925–9.
Sasaki K, Watanabe G, Matsuda M, Hashimoto M. Original single-incision laparoscopic cholecystectomy for acute inflammation of the gallbladder. World J Gastroenterol. 2012;18(9):944–51.
Jacob D, Raakow R. Single-port versus multi-port cholecystectomy for patients with acute cholecystitis: a retrospective comparative analysis. Hepatobiliary Pancreat Dis Int. 2011;10:521–5.
Bucher P, Pugin F, Buchs NC, Ostermann S, Morel P. Randomized clinical trial of laparoendoscopic single-site versus conventional laparoscopic cholecystectomy. Br J Surg. 2011;98(12):1695–702.
Cao Z, Cai W, Qin M, et al. Randomized clinical trial of single-incision versus conventional laparoscopic cholecystectomy: short-term operative outcomes. Surg Laparosc Endosc Percutan Tech. 2011;21(5):311–3.
Beninato T, Kleiman DA, Soni A, et al. Expanding the indications for single-incision laparoscopic cholecystectomy to all patients with biliary disease: is it safe? Surg Laparosc Endosc Percutan Tech. 2015;25(1):10–4.
Hao L, Liu M, Zhu H, Li Z. Single-incision versus conventional laparoscopic cholecystectomy in patients with uncomplicated gallbladder disease: a meta-analysis. Surg Laparosc Endosc Percutan Tech. 2012;22(6):487–97.
Pisanu A, Reccia I, Porceddu G, Uccheddu A. Meta-analysis of prospective randomized studies comparing single-incision laparoscopic cholecystectomy (SILC) and conventional multiport laparoscopic cholecystectomy (CMLC). J Gastrointest Surg. 2012;16(9):1790–801.
Garg P, Thakur JD, Garg M, Menon GR. Single-incision laparoscopic cholecystectomy vs. conventional laparoscopic cholecystectomy: a meta-analysis of randomized controlled trials. J Gastrointest Surg. 2012;16:1618–28.
Markar SR, Karthikesalingam A, Thrumurthy S, et al. Single-incision laparoscopic surgery (SILS) vs. conventional multiport cholecystectomy: systematic review and meta-analysis. Surg Endosc. 2012;26(5):1205–13.
Wren SM, Curet MJ. Single-port robotic cholecystectomy: results from a first human use clinical study of the new da Vinci single-site surgical platform. Arch Surg. 2011;146(10):1122–7.
Konstantinidis KM, Hirides P, Hirides S, Chrysocheris P, Georgiou M. Cholecystectomy using a novel single-site robotic platform: early experience from 45 consecutive cases. Surg Endosc. 2012;26(9):2687–94.
Vidovszky TJ, Carr AD, Farinholt GN, et al. Single-site robotic cholecystectomy in a broadly inclusive patient population: a prospective study. Ann Surg. 2014;260(1):134–41.
Morel P, Buchs NC, Iranmanesh P, et al. Robotic single-site cholecystectomy. J Hepatobiliary Pancreat Sci. 2014;21(1):18–25.
Pietrabissa A, Sbrana F, Morelli L, et al. Overcoming the challenges of single-incision cholecystectomy with robotic single-site technology. Arch Surg. 2012;147(8):709–14.
Morel P, Hagen ME, Bucher P, Buchs NC, Pugin F. Robotic single-port cholecystectomy using a new platform: initial clinical experience. J Gastrointest Surg. 2011;15(12):2182–6.
Merriam LT, Kanaan SA, Dawes LG, et al. Gangrenous cholecystitis: analysis of risk factors and experience with laparoscopic cholecystectomy. Surgery. 1999;126(4):680–5; discussion 685–6.
Gomez D, Rahman S, Toogood G, et al. Mirizzi’s syndrome—results from a large western experience. HPB (Oxford). 2006;8(6):474–9.
Zhong H, Gong J-P. Mirizzi syndrome: experience in diagnosis and treatment of 25 cases. Am Surg. 2012;78(1):61–5.
Erben Y, Benavente-Chenhalls LA, Donohue JM, et al. Diagnosis and treatment of Mirizzi syndrome: 23-year Mayo Clinic experience. J Am Coll Surg. 2011;213(1):114–9; discussion 120–1.
Angrisani L, Corcione F, Tartaglia A, et al. Cholecystoenteric fistula (CF) is not a contraindication for laparoscopic surgery. Surg Endosc. 2001;15(9):1038–41.
Chowbey PK, Bandyopadhyay SK, Sharma A, et al. Laparoscopic management of cholecystoenteric fistulas. J Laparoendosc Adv Surg Tech A. 2006;16(5):467–72.
Wang W-K, Yeh C-N, Jan Y-Y. Successful laparoscopic management for cholecystoenteric fistula. World J Gastroenterol. 2006;12:772–5.
Carlei F, Lezoche E, Lomanto D, et al. Cholecystoenteric fistula is not a contraindication for laparoscopic cholecystectomy: report of five cases treated by laparoscopic approach. Surg Laparosc Endosc. 1997;7:403–6.
Aydin C, Altaca G, Berber I, et al. Prognostic parameters for the prediction of acute gangrenous cholecystitis. J Hepatobiliary Pancreat Surg. 2006;13(2):155–9.
Fagan SP, Awad SS, Rahwan K, et al. Prognostic factors for the development of gangrenous cholecystitis. Am J Surg. 2003;186(5):481–5.
Stefanidis D, Sirinek KR, Bingener J. Gallbladder perforation: risk factors and outcome. J Surg Res. 2006;131(2):204–8.
Williams N, Scobie T. Perforation of the gallbladder: analysis of 19 cases. Can Med Assoc J. 1976;115(12):1223–5.
Date RS, Thrumurthy SG, Whiteside S, et al. Gallbladder perforation: case series and systematic review. Int J Surg. 2012;10(2):63–8.
Kiviluoto T, Sirén J, Luukkonen P, Kivilaakso E. Randomised trial of laparoscopic versus open cholecystectomy for acute and gangrenous cholecystitis. Lancet. 1998;351(9099):321–5.
Eldar S, Sabo E, Nash E, Abrahamson J, Matter I. Laparoscopic cholecystectomy for acute cholecystitis: prospective trial. World J Surg. 1997;21(5):540–5.
Habib FA, Kolachalam RB, Khilnani R, Preventza O, Mittal VK. Role of laparoscopic cholecystectomy in the management of gangrenous cholecystitis. Am J Surg. 2001;181(1):71–5.
Kwon YJ, Ahn BK, Park HK, Lee KS, Lee KG. What is the optimal time for laparoscopic cholecystectomy in gallbladder empyema? Surg Endosc. 2013;27(10):3776–80.
Lo H-C, Wang Y-C, Su L-T, Hsieh C-H. Can early laparoscopic cholecystectomy be the optimal management of cholecystitis with gallbladder perforation? A single institute experience of 74 cases. Surg Endosc. 2012;26(11):3301–6.
Stephen A, Berger D. Carcinoma in the porcelain gallbladder: a relationship revisited. Surgery. 2001;129(6):699–703.
Kwon A, Inui H, Matsui Y, et al. Laparoscopic cholecystectomy in patients with porcelain gallbladder based on the preoperative ultrasound findings. Hepatogastroenterology. 2004;51(58):950–3.
Lacaine F. Is the laparoscopic approach appropriate for porcelain gallbladder? J Chir (Paris). 2003;140:115–9.
Igami T, Usui H, Ebata T, et al. Single-incision laparoscopic cholecystectomy for porcelain gallbladder: a case report. Asian J Endosc Surg. 2013;6(1):52–4.
Gouldman J, Sticca R, Rippon M, McAlhany J. Laparoscopic cholecystectomy in pregnancy. Am Surg. 1998;64(1):93–8.
Lanzafame RJ. Laparoscopic cholecystectomy during pregnancy. Surgery. 1995;118(4):627–31; discussion 631–3.
Barone JE, Bears S, Chen S, Tsai J, Russell JC. Outcome study of cholecystectomy during pregnancy. Am J Surg. 1999;177(3):232–6.
De Bakker JK, Dijksman LM, Donkervoort SC. Safety and outcome of general surgical open and laparoscopic procedures during pregnancy. Surg Endosc. 2011;25(5):1574–8.
Chohan L, Kilpatrick CC. Laparoscopy in pregnancy: a literature review. Clin Obstet Gynecol. 2009;52(4):557–69.
Pearl J, Price R, Richardson W, Fanelli R. Guidelines for diagnosis, treatment, and use of laparoscopy for surgical problems during pregnancy. Surg Endosc. 2011;25(11):3479–92.
Topgul K, Yuruker SS, Kuru B. Single-incision laparoscopic cholecystectomy in a 6-month pregnant woman: a report of a case. Surg Laparosc Endosc Percutan Tech. 2011;21(2):100–3.
Kortram K, de Vries Reilingh TS, Wiezer MJ, van Ramshorst B, Boerma D. Percutaneous drainage for acute calculous cholecystitis. Surg Endosc. 2011;25(11):3642–6.
Sanjay P, Mittapalli D, Marioud A, et al. Clinical outcomes of a percutaneous cholecystostomy for acute cholecystitis: a multicentre analysis. HPB (Oxford). 2013;15(7):511–6.
Ha J, Tsui K, Tang C, et al. Cholecystectomy or not after percutaneous cholecystostomy for acute calculous cholecystitis in high-risk patients. Hepatogastroenterology. 2008;55(86):1497–502.
McKay A, Abulfaraj M, Lipschitz J. Short- and long-term outcomes following percutaneous cholecystostomy for acute cholecystitis in high-risk patients. Surg Endosc. 2012;26(5):1343–51.
Pappas TN, Fecher AA. Principles of minimally invasive surgery. In: Norton J, editor. Surgery: basic science and clinical evidence. New York: Springer; 2008. p. 771–90.
Curro G, Iapichino G, Melita G, Lorenzini C, Cucinotta E. Laparoscopic cholecystectomy in Child-Pugh class C cirrhotic patients. JSLS. 2005;9(1):311–5.
Puggioni A, Wong LL. A metaanalysis of laparoscopic cholecystectomy in patients with cirrhosis.J Am Coll Surg. 2003;197(6):921–6.
Machado NO. Laparoscopic cholecystectomy in cirrhotics. JSLS. 2012;16(3):392–400.
Cucinotta E, Lazzara S, Melita G. Laparoscopic cholecystectomy in cirrhotic patients. Surg Endosc. 2003;17(12):1958–60.
Misra MC, Guleria S. Management of cancer gallbladder found as a surprise on a resected gallbladder specimen. J Surg Oncol. 2006;93(1):690–8.
Steinert R, Nestler G, Sagynaliev E, et al. Laparoscopic cholecystectomy and gallbladder cancer. J Surg Oncol. 2006;93(1):682–9.
Ouchi K, Mikuni J, Kakugawa Y. Laparoscopic cholecystectomy for gallbladder carcinoma: results of a Japanese survey of 498 patients. J Hepatobiliary Pancreat Surg. 2002;9(2):256–60.
Shoup M, Fong Y. Surgical indications and extent of resection in gallbladder cancer. Surg Oncol Clin N Am. 2002;11:985–94.
Foster JM, Hoshi H, Gibbs JF, et al. Gallbladder cancer: defining the indications for primary radical resection and radical re-resection. Ann Surg Oncol. 2007;14(2):833–40.
Jensen EH, Abraham A, Jarosek S, et al. Lymph node evaluation is associated with improved survival after surgery for early stage gallbladder cancer. Surgery. 2009;146:706–11; discussion 711–3.
Fuks D, Regimbeau JM, Le Treut Y-P, et al. Incidental gallbladder cancer by the AFC-GBC-2009 Study Group. World J Surg. 2011;35(8):1887–97.
Abramson MA, Pandharipande P, Ruan D, Gold JS, Whang EE. Radical resection for T1b gallbladder cancer: a decision analysis. HPB (Oxford). 2009;11:656–63.
Ikeda N, Masato U, Kanamura T, et al. Safety and feasibility for single-incision laparoscopic cholecystectomy in local community hospital: a retrospective comparison with conventional 4-port laparoscopic cholecystectomy. Surg Laparosc Endosc Percutan Tech. 2013;23(1):33–6.
Sasaki K, Watanabe G, Matsuda M, Hashimoto M. Single-incision laparoscopic cholecystectomy: comparison analysis of feasibility and safety. Surg Laparosc Endosc Percutan Tech. 2012;22(2):108–13.
Antoniou SA, Pointner R, Granderath FA. Single-incision laparoscopic cholecystectomy: a systematic review. Surg Endosc. 2011;25(2):367–77.
Trastulli S, Cirocchi R, Desiderio J, et al. Systematic review and meta-analysis of randomized clinical trials comparing single-incision versus conventional laparoscopic cholecystectomy. Br J Surg. 2013;100(2):191–208.
Petrotos AC, Molinelli BM. Single-incision multiport laparoendoscopic (SIMPLE) surgery: early evaluation of SIMPLE cholecystectomy in a community setting. Surg Endosc. 2009;23(11):2631–4.
Joseph RA, Goh AC, Cuevas SP, et al. “Chopstick” surgery: a novel technique improves surgeon performance and eliminates arm collision in robotic single-incision laparoscopic surgery. Surg Endosc. 2010;24(6):1331–5.
Haber GP, White MA, Autorino R, et al. Novel robotic da Vinci instruments for laparoendoscopic single-site surgery. Urology. 2010;76(6):1279–82.
Mordon S, Devoisselle JM, Soulie-Begu S, Desmettre T. Indocyanine green: physicochemical factors affecting its fluorescence in vivo. Microvasc Res. 1998;55(2):146–52.
Ishizawa T, Bandai Y, Ijichi M, et al. Fluorescent cholangiography illuminating the biliary tree during laparoscopic cholecystectomy. Br J Surg. 2010;97(9):1369–77.
Buchs NC, Pugin F, Azagury DE, et al. Real-time near-infrared fluorescent cholangiography could shorten operative time during robotic single-site cholecystectomy. Surg Endosc. 2013;27(10):3897–901.
Spinoglio G, Priora F, Bianchi P, Bianchi PP, et al. Real-time near-infrared (NIR) fluorescent cholangiography in single-site robotic cholecystectomy (SSRC): a single-institutional prospective study. Surg Endosc. 2013;27(6):2156–62.
Buchs NC, Hagen ME, Pugin F, et al. Intra-operative fluorescent cholangiography using indocyanin green during robotic single site cholecystectomy. Int J Med Robot. 2012;8(4):436–40.
Mahmud S, Masaud M, Canna K, Nassar AH. Fundus-first laparoscopic cholecystectomy. Surg Endosc. 2002;16(4):581–4.
Kelly MD. Laparoscopic retrograde (fundus first) cholecystectomy. BMC Surg. 2009;9:19.
Martin I, Dexter S, Marton J, et al. Fundus-first laparoscopic cholecystectomy. Surg Endosc. 1995;9(2):203–6.
Tuveri M, Calò PG, Medas F, Tuveri A, Nicolosi A. Limits and advantages of fundus-first laparoscopic cholecystectomy: lessons learned. J Laparoendosc Adv Surg Tech A. 2008;18(1):69–75.
Gupta A, Agarwal PN, Kant R, Malik V. Evaluation of fundus-first laparoscopic cholecystectomy. JSLS. 2004;8(3):255–8.
Ichihara T, Takada M, Ajiki T, et al. Tape ligature of cystic duct and fundus-down approach for safety laparoscopic cholecystectomy: outcome of 500 patients. Hepatogastroenterology. 2004;51(56):362–4.
Kato K, Kasai S, Matsuda M, et al. A new technique for laparoscopic cholecystectomy—retrograde laparoscopic cholecystectomy: an analysis of 81 cases. Endoscopy. 1996;28:356–9.
Uyama I, Iida S, Ogiwara H, et al. Laparoscopic retrograde cholecystectomy (from fundus downward) facilitated by lifting the liver bed up to the diaphragm for inflammatory gallbladder. Surg Laparosc Endosc. 1995;5:431–6.
Cui H, Kelly JJ, Litwin DEM. Single-incision laparoscopic cholecystectomy using a modified dome-down approach with conventional laparoscopic instruments. Surg Endosc. 2012;26(4):1153–9.
Patel AG, Murgatroyd B, Carswell K, Belgaumkar A. Fundus-first transumbilical single-incision laparoscopic cholecystectomy with a cholangiogram: a feasibility study. Surg Endosc. 2011;25(3):954–7.
Lee SH, Jung MJ, Hwang HK, Kang CM, Lee WJ. The first experiences of robotic single-site cholecystectomy in Asia: a potential way to expand minimally-invasive single-site surgery? Yonsei Med J. 2015;56(1):189–95.
Uras C, Böler DE, Ergüner I, Hamzaoğlu I. Robotic single port cholecystectomy (R-LESS-C): experience in 36 patients. Asian J Surg. 2014;37(3):115–9.
Tabone LE, Sarker S, Fisichella PM, et al. To “gram or not”? Indications for intraoperative cholangiogram. Surgery. 2011;150(4):810–9.
Barkun A, Barkun J, Fried G, et al. Useful predictors of bile duct stones in patients undergoing laparoscopic cholecystectomy. McGill Gallstone Treatment Group. Ann Surg. 1994;220(1):32.
NIH state-of-the-science statement on endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and therapy. NIH Consens State Sci Statements. 2002;19(1):1–26.
Livingston E, Miller J, Coan B, Rege R. Indications for selective intraoperative cholangiography. J Gastrointest Surg. 2005;9(9):1371–7.
Kharbutli B, Velanovich V. Management of preoperatively suspected choledocholithiasis: a decision analysis. J Gastrointest Surg. 2008;12(11):1973–80.
Shibao K, Higure A, Yamaguchi K. Laparoendoscopic single-site common bile duct exploration using the manual manipulator. Surg Endosc. 2013;27(8):3009–15.
Jayaraman S, Davies W, Schlachta CM. Robot-assisted minimally invasive common bile duct exploration: a Canadian first. Can J Surg. 2008;51(4):E92–4.
Alkhamesi NA, Davies WT, Pinto RF, Schlachta CM. Robot-assisted common bile duct exploration as an option for complex choledocholithiasis. Surg Endosc. 2013;27(1):263–6.
Buddingh KT, Weersma RK, Savenije RA, van Dam GM, Nieuwenhuijs VB. Lower rate of major bile duct injury and increased intraoperative management of common bile duct stones after implementation of routine intraoperative cholangiography. J Am Coll Surg. 2011;213(2):267–74.
Buddingh KT, Nieuwenhuijs VB, van Buuren L, et al. Intraoperative assessment of biliary anatomy for prevention of bile duct injury: a review of current and future patient safety interventions. Surg Endosc. 2011;25(8):2449–61.
Fulm D, Dellinger E, Cheadle A, Chan L, Koepsell T. Intraoperative cholangiography and during cholecystectomy. JAMA. 2013;289(13):1639–44.
Nickkholgh A, Soltaniyekta S, Kalbasi H. Routine versus selective intraoperative cholangiography during laparoscopic cholecystectomy: a survey of 2,130 patients undergoing laparoscopic cholecystectomy. Surg Endosc. 2006;20(6):868–74.
Sheffield KM, Riall TS, Han Y, et al. Association between cholecystectomy with vs without intraoperative cholangiography and risk of common duct injury. JAMA. 2013;310(8):812–20.
Hamad MA, Nada AA, Abdel-Atty MY, Kawashti AS. Major biliary complications in 2,714 cases of laparoscopic cholecystectomy without intraoperative cholangiography: a multicenter retrospective study. Surg Endosc. 2011;25(12):3747–51.
Pesce A, Portale T, Minutolo V, et al. Bile duct injury during laparoscopic cholecystectomy without intraoperative cholangiography: a retrospective study on 1,100 selected patients. Dig Surg. 2012;29(4):310–4.
Ford JA, Soop M, Du J, Loveday BPT, Rodgers M. Systematic review of intraoperative cholangiography in cholecystectomy. Br J Surg. 2012;99(2):160–7.
Yeo D, Mackay S, Martin D. Single-incision laparoscopic cholecystectomy with routine intraoperative cholangiography and common bile duct exploration via the umbilical port. Surg Endosc. 2012;26(4):1122–7.
Buzad FA, Corne LM, Brown TC, et al. Single-site robotic cholecystectomy: efficiency and cost analysis. Int J Med Robot. 2013;9(3):365–70.
Way LW, Stewart L, Gantert W, et al. Causes and prevention of laparoscopic bile duct injuries: analysis of 252 cases from a human factors and cognitive psychology perspective. Ann Surg. 2003;237(4):460–9.
Nagral S. Anatomy relevant to cholecystectomy. J Minim Access Surg. 2005;1:53–8.
Balija M, Huis M, Szerda F, Bubnjar J, Stulhofer M. [Laparoscopic cholecystectomy–accessory bile ducts]. Acta Med Croat. 2003;57:105–9.
Adams DB. The importance of extrahepatic biliary anatomy in preventing complications at laparoscopic cholecystectomy. Surg Clin North Am. 1993;73:861–71.
Ding Y-M, Wang B, Wang W-X, Wang P, Yan J-S. New classification of the anatomic variations of cystic artery during laparoscopic cholecystectomy. World J Gastroenterol. 2007;13(42):5629–34.
Jansirani D, Mugunthan N, Phalgunan V, Shiva D. Caterpillar hump of right hepatic artery: incidence and surgical significance. Natl J Clin Anat. 2012;1(3):121–4.
Csikesz N, Ricciardi R, Tseng JF, Shah SA. Current status of surgical management of acute cholecystitis in the United States. World J Surg. 2008;32(10):2230–6.
Kaafarani HM, Smith TS, Neumayer L, et al. Trends, outcomes, and predictors of open and conversion to open cholecystectomy in Veterans Health Administration hospitals. Am J Surg. 2010;200(1):32–40.
Philips JAE, Lawes DA, Cook AJ, et al. The use of laparoscopic subtotal cholecystectomy for complicated cholelithiasis. Surg Endosc. 2008;22:1697–700.
Chowbey PK, Sharma A, Khullar R, et al. Laparoscopic subtotal cholecystectomy: a review of 56 procedures. J Laparoendosc Adv Surg Tech A. 2000;10:31–4.
Kuwabara J, Watanabe Y, Kameoka K, et al. Usefulness of laparoscopic subtotal cholecystectomy with operative cholangiography for severe cholecystitis. Surg Today. 2013;43:675–7. doi:10.1007/s00595-013-0626-1.
Davis B, Castaneda G, Lopez J. Subtotal cholecystectomy versus total cholecystectomy in complicated cholecystitis. Am Surg. 2012;78(7):814–7.
Ji W, Li L-T, Li J-S. Role of laparoscopic subtotal cholecystectomy in the treatment of complicated cholecystitis. Hepatobiliary Pancreat Dis Int. 2006;5:584–9.
Redaelli CA, Biichler MW, Schiiing MK, et al. High coincidence of Mirizzi syndrome and gallbladder carcinoma. Surgery. 1997;121(1):58–63.
Fransen S, Stassen L, Bouvy N. Single incision laparoscopic cholecystectomy: a review on the complications. J Minim Access Surg. 2012;8(1):1–5.
Marks JM, Phillips MS, Tacchino R, et al. Single-incision laparoscopic cholecystectomy is associated with improved cosmesis scoring at the cost of significantly higher hernia rates: 1-year results of a prospective randomized, multicenter, single-blinded trial of traditional multiport laparoscopic. J Am Coll Surg. 2013;216(6):1037–47; discussion 1047–8.
Krajinovic K, Ickrath P, Germer C-T, Reibetanz J. Trocar-site hernia after single-port cholecystectomy: not an exceptional complication? J Laparoendosc Adv Surg Tech A. 2011;21(10):919–21.
Bunting DM. Port-site hernia following laparoscopic cholecystectomy. JSLS. 2010;14(4):490–7.
Madureira FAV, Manso JEF, Madureira Fo D, Iglesias ACG. Randomized clinical study for assessment of incision characteristics and pain associated with LESS versus laparoscopic cholecystectomy. Surg Endosc. 2013;27(3):1009–15.
Gangl O, Hofer W, Tomaselli F, Sautner T, Függer R. Single incision laparoscopic cholecystectomy (SILC) versus laparoscopic cholecystectomy (LC)—a matched pair analysis. Langenbecks Arch Surg. 2011;396(1):819–24.
Flum DR, Cheadle A, Prela C, Dellinger EP, Chan L. Bile duct injury during cholecystectomy and survival in medicare beneficiaries. JAMA. 2003;290(16):2168–73.
Joseph M, Phillips MR, Farrell TM, Rupp CC. Single incision laparoscopic cholecystectomy is associated with a higher bile duct injury rate: a review and a word of caution. Ann Surg. 2012;256(1):1–6.
Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Factors determining convalescence after uncomplicated laparoscopic cholecystectomy. Arch Surg. 2001;136(8):917–21.
Bisgaard T, Kehlet H, Rosenberg J. Pain and convalescence after laparoscopic cholecystectomy. Eur J Surg. 2001;167:84–96.
Bignell M, Hindmarsh A, Nageswaran H, et al. Assessment of cosmetic outcome after laparoscopic cholecystectomy among women 4 years after laparoscopic cholecystectomy: is there a problem? Surg Endosc. 2011;25(8):2574–7.
Ostlie DJ, Sharp NE, Thomas P, et al. Patient scar assessment after single-incision versus four-port laparoscopic cholecystectomy: long-term follow-up from a prospective randomized trial. J Laparoendosc Adv Surg Tech A. 2013;23(6):553–5.
Brown KM, Moore BT, Sorensen GB, et al. Patient-reported outcomes after single-incision versus traditional laparoscopic cholecystectomy: a randomized prospective trial. Surg Endosc. 2013;27(9):3108–15.
Geng L, Sun C, Bai J. Single incision versus conventional laparoscopic cholecystectomy outcomes: a meta-analysis of randomized controlled trials. PLoS One. 2013;8(10), e76530.
Zapf M, Yetasook A, Leung D, et al. Single-incision results in similar pain and quality of life scores compared with multi-incision laparoscopic cholecystectomy: a blinded prospective randomized trial of 100 patients. Surgery. 2013;154(4):662–71.
Tsimoyiannis EC, Tsimogiannis KE, Pappas-Gogos G, et al. Different pain scores in single transumbilical incision laparoscopic cholecystectomy versus classic laparoscopic cholecystectomy: a randomized controlled trial. Surg Endosc. 2010;24(8):1842–8.
Wong JS-W, Cheung Y-S, Fong K-W, et al. Comparison of postoperative pain between single-incision laparoscopic cholecystectomy and conventional laparoscopic cholecystectomy: prospective case-control study. Surg Laparosc Endosc Percutan Tech. 2012;22(1):25–8.
Lai ECH, Yang GPC, Tang CN, et al. Prospective randomized comparative study of single incision laparoscopic cholecystectomy versus conventional four-port laparoscopic cholecystectomy. Am J Surg. 2011;202(3):254–8.
Qiu Z, Sun J, Pu Y, et al. Learning curve of transumbilical single incision laparoscopic cholecystectomy (SILS): a preliminary study of 80 selected patients with benign gallbladder diseases. World J Surg. 2011;35(9):2092–101.
Roberts KE, Solomon D, Duffy AJ, Bell RL. Single-incision laparoscopic cholecystectomy: a surgeon’s initial experience with 56 consecutive cases and a review of the literature. J Gastrointest Surg. 2010;14(3):506–10.
Solomon D, Bell RL, Duffy AJ, Roberts KE. Single-port cholecystectomy: small scar, short learning curve. Surg Endosc. 2010;24(12):2954–7.
Yu W-B, Zhang G-Y, Li F, Yang Q-Y, Hu S-Y. Transumbilical single port laparoscopic cholecystectomy with a simple technique: initial experience of 33 cases. Minim Invasive Ther Allied Technol. 2010;19(6):340–4.
Joseph M, Phillips M, Farrell TM, Rupp CC. Can residents safely and efficiently be taught single incision laparoscopic cholecystectomy? J Surg Educ. 2012;69(4):468–72.
Joseph M, Phillips M, Rupp CC. Single-incision laparoscopic cholecystectomy: a combined analysis of resident and attending learning curves at a single institution. Am Surg. 2012;78:119–24.
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Finnerty, B.M., Afaneh, C., Zarnegar, R. (2015). Robotic Cholecystectomy. In: Eachempati, S., Reed, II, R. (eds) Acute Cholecystitis. Springer, Cham. https://doi.org/10.1007/978-3-319-14824-3_8
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