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Advances in Spray Drying Technology for Nanoparticle Formation

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Handbook of Nanoparticles

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Abstract

The biggest societal impact of pharmaceutical nanotechnology is related to “nanomedicine,” a promising new drug delivery mode which provides a higher therapeutic efficacy than conventional dosage forms due to increased drug bioavailability. Spray drying is commonly used in the pharmaceutical industry to convert a liquid phase (solution, emulsion, suspension, slurry, paste, or melt) into a dry, solid powder. In conventional spray drying, a feed product is atomized into a fine spray and dried by a hot inlet air stream. The contact between the hot inlet air stream and spray causes evaporation of solvent and drying of the spray into solid product in a single-step process. The widespread research investigation of nanoparticles as a mode of drug delivery has translated to the late development of spray drying technique with advancement focuses on atomization mechanism to produce discrete dried nanoparticles. This chapter describes spray drying processes and processors for particle production from micro- to nanoscale and highlights advantages of using spray drying as the process of nanoparticle manufacture, characteristics of spray-dried nanoparticles, and limitations of spray drying in drug targeting device manufacture.

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Acknowledgments

The authors wish to thank Micheal Whelehan, Stefanie Meyer, and the Ministry of Science, Technology and Innovation (Nanofund) for technical support.

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Authors and Affiliations

  1. Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, 42300, Selangor, Malaysia

    Tin Wui Wong

  2. Non-Destructive Biomedical and Pharmaceutical Research Centre, Universiti Teknologi MARA, Puncak Alam, 42300, Selangor, Malaysia

    Tin Wui Wong

  3. BÜCHI Labortechnik AG, Meierseggstr, 40, Postfach, CH-9230, Flawil, Switzerland

    Philipp John

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  1. Tin Wui Wong
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Correspondence to Tin Wui Wong .

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Editors and Affiliations

  1. Materials Engineering, Tarbiat Modares University, Tehran, Iran

    Mahmood Aliofkhazraei

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Wong, T.W., John, P. (2015). Advances in Spray Drying Technology for Nanoparticle Formation. In: Aliofkhazraei, M. (eds) Handbook of Nanoparticles. Springer, Cham. https://doi.org/10.1007/978-3-319-13188-7_18-1

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  • DOI: https://doi.org/10.1007/978-3-319-13188-7_18-1

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